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1.
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11 p, 1.9 MB |
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma
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Recasens-Zorzo, C. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Cardesa-Salzmann, T. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Petazzi, Paolo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ros-Blanco, L. (Grup d'Enginyeria Molecular. IQS School of Engineering. Universitat Ramon Llull) ;
Esteve-Arenys, A. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Clot, G. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Guerrero-Hernández, M. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Rodríguez, V. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Soldini, D. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Valera, A. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Moros, A. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Climent, F. (Pathology Department. Hospital Universitari de Bellvitge) ;
González-Barca, E. (Institut Català d'Oncologia) ;
Mercadal, S. (Institut Català d'Oncologia) ;
Arenillas, Leonor (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Calvo, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mate, J.L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gutiérrez-García, G. (Department of Hematology. Hospital Clinic) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Sanjuan-Pla, A. (Hematology Research Group. Health Research Institute La Fe) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez, A. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Colomer, D. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Tejedor, R.E. (Grup d'Enginyeria Molecular. IQS School of Engineering. Universitat Ramon Llull) ;
Teixidó, J. (Grup d'Enginyeria Molecular. IQS School of Engineering. Universitat Ramon Llull) ;
Campo, E. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
López-Guillermo, A. (Department of Hematology. Hospital Clinic) ;
Borrell, J.I. (Grup d'Enginyeria Molecular. IQS School of Engineering. Universitat Ramon Llull) ;
Colomo, Luís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-Galán, P. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Roué, Gaël (VHIO) ;
Universitat Autònoma de Barcelona
Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor progression, invasion, and chemotherapy resistance in different cancer subtypes. Although the CXCR4 pathway has recently been suggested as an adverse prognostic marker in diffuse large B-cell lymphoma, its biological relevance in this disease remains underexplored. [...]
2019 -  10.3324/haematol.2017.180505
Haematologica, Vol. 104 Núm. 4 (31 2019) , p. 778-788
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2.
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11 p, 5.7 MB |
Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope
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Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zanetti, SR (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roca Ho, Heleia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Petazzi, Paolo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez-Martínez, D. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Baroni, Matteo Libero (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fuster, J.L. (Sección de Oncohematología Pediátrica. Hosp. Clin. Universitario Virgen de la Arrixaca and Instituto Murciano de Investigacion Biosanitaria) ;
Ballerini, P. (Department of Pediatric Hemato-oncology. Armand-Trousseau Childrens Hospital) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez-Fuentes, N. (Department of Biosciences. Universitat de Vic - Universitat Central de Catalunya) ;
Engel, P. (Department of Biomedicine. School of Medicine. University of Barcelona) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Background There are few therapeutic options available for patients with B-cell acute lymphoblastic leukemia (B-ALL) relapsing as CD19 - either after chemotherapy or CD19-targeted immunotherapies. CD22-chimeric antigen receptor (CAR) T cells represent an attractive addition to CD19-CAR T cell therapy because they will target both CD22 + CD19 - B-ALL relapses and CD19 - preleukemic cells. [...]
2020 - 10.1136/jitc-2020-000896
Journal for immunotherapy of cancer, Vol. 8 Núm. 2 (november 2020) , p. e000896
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3.
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32 p, 1.2 MB |
Release of targeted protein nanoparticles from functional bacterial amyloids : A death star-like approach
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Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Rita (Institut d'Investigació Biomèdica Sant Pau) ;
Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Pesarrodona Roches, Mireia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano-Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Seras-Franzoso, Joaquín (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Sustained release of drug delivery systems (DDS) has the capacity to increase cancer treatment efficiency in terms of drug dosage reduction and subsequent decrease of deleterious side effects. In this regard, many biomaterials are being investigated but none offers morphometric and functional plasticity and versatility comparable to protein-based nanoparticles (pNPs). [...]
2018 - 10.1016/j.jconrel.2018.04.004
Journal of Controlled Release, Vol. 279 (June 2018) , p. 29-39
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4.
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19 p, 2.1 MB |
Effects of Rifaximin on Luminal and Wall-Adhered Gut Commensal Microbiota in Mice
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Ferrer Clotas, Marina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Aguilera Pujabet, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Rifaximin is a broad-spectrum antibiotic that ameliorates symptomatology in inflammatory/functional gastrointestinal disorders. We assessed changes in gut commensal microbiota (GCM) and Toll-like receptors (TLRs) associated to rifaximin treatment in mice. [...]
2021 - 10.3390/ijms22020500
International journal of molecular sciences, Vol. 22, Núm. 2 (January 2021) , art. 500
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5.
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23 p, 4.3 MB |
Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
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Larramona-Arcas, Raquel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
González-Arias, Candela (Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC)) ;
Perea, Gertrudis (Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC)) ;
Gutiérrez, Antonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ;
Vitorica, Javier (Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular) ;
García-Barrera, Tamara (Universidad de Huelva. Departamento de Química, Facultad de Ciencias Experimentales) ;
Gómez-Ariza, José Luis (Universidad de Huelva. Departamento de Química, Facultad de Ciencias Experimentales) ;
Pascua-Maestro, Raquel (Instituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC. Departamento de Bioquímica y Biología Molecular y Fisiología) ;
Ganfornina, María Dolores (Instituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC. Departamento de Bioquímica y Biología Molecular y Fisiología) ;
Kara, Eleanna (Present Address: Institute of Neuropathology, University Hospital of Zurich) ;
Hudry, Eloise (Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School) ;
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Masgrau Juanola, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)
The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alzheimer's disease (LOAD). [...]
2020 - 10.1186/s13024-020-00382-8
Molecular neurodegeneration, Vol. 15 (june 2020)
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6.
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20 p, 3.2 MB |
Expression of Melatonin and Dopamine D Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension
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Reyes-Resina, Irene (Instituto de Salud Carlos III. Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed) ;
Awad Alkozi, Hanan (University Complutense of Madrid. Faculty of Optics and Optometry. Department of Biochemistry) ;
del Ser-Badia, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Sánchez-Naves, Juan (Balearic Islands Institute of Ophthalmology. Department of Ophthalmology) ;
Lillo, Jaume (Instituto de Salud Carlos III. Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed) ;
Jiménez, Jasmina (Instituto de Salud Carlos III. Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed) ;
Pintor, Jesús (University Complutense of Madrid. Faculty of Optics and Optometry. Department of Biochemistry and Molecular Biology) ;
Navarro, Gemma (Universitat de Barcelona. School of Pharmacy and Food Sciences. Department of Biochemistry and Physiology) ;
Franco, Rafael (Universitat de Barcelona. School of Chemistry) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Background: Experiments in the late nineties showed an inverse relationship in the eye levels of melatonin and dopamine, thereby constituting an example of eye parameters that are prone to circadian variations. [...]
2020 - 10.3390/cells9010152
Cells, Vol. 9, Num. 1 (January 2020) , art. 152
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7.
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4 p, 2.2 MB |
The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles
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Sánchez García, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serna Romero, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mattanovich, M. (University of Natural Resources and Life Sciences. Department of Biotechnology) ;
Cazzanelli, P. (University of Natural Resources and Life Sciences. Department of Biotechnology) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cortés, Fran (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona
We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. [...]
2017 - 10.1039/c6cc09900a
Chemical communications, Vol. 53, issue 33 (April 2017) , p. 4565-4568
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8.
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11 p, 3.5 MB |
Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors
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Aparicio Alarcón, David (Institut de Biologia Molecular de Barcelona) ;
Torres Puig, Sergi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ratera, Mercè (Institut de Biologia Molecular de Barcelona) ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Quijada Pich, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Fita Rodríguez, Ignasi (Institut de Biologia Molecular de Barcelona)
Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the cell membrane. [...]
2018 - 10.1038/s41467-018-06963-y
Nature communications, Vol. 9 (2018) , art. 4471
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9.
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17 p, 1.7 MB |
Intradomain confinement of disulfides in the folding of two consecutive modules of the LDL receptor
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Martínez-Oliván, Juan (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ;
Fraga, Hugo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Arias-Moreno, Xabier (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Sancho, Javier (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular)
The LDL receptor internalizes circulating LDL and VLDL particles for degradation. Its extracellular binding domain contains ten (seven LA and three EGF) cysteine-rich modules, each bearing three disulfide bonds. [...]
2015 - 10.1371/journal.pone.0132141
PloS one, Vol. 10, issue 7 (2015) , art. e0132141
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10.
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Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy
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Wang, Julie T. W. (King's College London. Institute of Pharmaceutical Science) ;
Spinato, Cinzia (Université de Strasbourg. Centre national de la recherche scientifique) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Costa, Pedro M. (King's College London. Institute of Pharmaceutical Science) ;
Martincic, Markus (Institut de Ciència de Materials de Barcelona) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Pérez Ruiz De Garibay, Aritz (Université de Strasbourg. Centre national de la recherche scientifique) ;
Ménard-Moyon, Cécilia (Université de Strasbourg. Centre national de la recherche scientifique) ;
Feldman, Robert (Cis Bio International Ion Beam Applications SA) ;
Michel, Yves (Cis Bio International Ion Beam Applications SA) ;
Šefl, Martin (University of Ioannina Medical School) ;
Kyriakou, Ioanna (University of Ioannina Medical School) ;
Emfietzoglou, Dimitris (University of Ioannina Medical School) ;
Saccavini, Jean-Claude (Cis Bio International Ion Beam Applications SA) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Tobias, Gerard (Institut de Ciència de Materials de Barcelona) ;
Bianco, Alberto (Université de Strasbourg. Centre national de la recherche scientifique) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science)
Radiotherapy is a cancer treatment utilising high doses of ionizing radiation to destroy cancer cells. Our team has pioneered neutron activation of Sm, filled and sealed into single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), to create stable and high-dose radioactive carbon nanocapsules for cancer radiotherapy. [...]
2020 - 10.1016/j.carbon.2020.02.060
Carbon, Vol. 162 (June 2020) , p. 410-422
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