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1.
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13 p, 849.9 KB |
Altered T-cell subset distribution in the viral reservoir in HIV-1-infected individuals with extremely low proviral DNA (LoViReTs)
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Gálvez, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Guerrero, María del Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernal, Sílvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Benet, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bailón, Lucía (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nieto Gil-Ortega, Aroa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Leal, Lorna (Hospital Clínic i Provincial de Barcelona) ;
García, Felipe (Hospital Clínic i Provincial de Barcelona) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Salgado, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
HIV cure strategies aim to eliminate viral reservoirs that persist despite successful antiretroviral therapy (ART). We have previously described that 9% of HIV-infected individuals who receive ART harbor low levels of provirus (LoViReTs). [...]
2022 -  10.1111/joim.13484
Journal of Internal Medicine, Vol. 292 (march 2022) , p. 308-320
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2.
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25 p, 1.8 MB |
Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response
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Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron) ;
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron) ;
Suanzes, Paula (Hospital Universitari Vall d'Hebron) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous cell reservoirs, which can be maintained by different mechanisms including cellular proliferation, and represent the main obstacle to curing the infection. [...]
2022 - 10.7554/eLife.78294
eLife, Vol. 11 (may 2022)
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3.
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12 p, 524.6 KB |
Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells
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Huyveneers, Laura E. P. (University Medical Center Utrecht) ;
Bruns, Anke (University Medical Center Utrecht) ;
Stam, Arjen (University Medical Center Utrecht) ;
Ellerbroek, Pauline (University Medical Center Utrecht) ;
de Jong, Dorien (University Medical Center Utrecht) ;
Nagy, Noémi A. (University Medical Center Utrecht) ;
Gumbs, Stephanie B. H. (University Medical Center Utrecht) ;
Tesselaar, Kiki (University Medical Center Utrecht) ;
Bosman, Kobus (University Medical Center Utrecht) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hütter, Gero (DKMS CC) ;
Brosens, Lodewijk A. A. (University Medical Center Utrecht) ;
Kwon, Mi (Hospital General Universitario Gregorio Marañón) ;
Diez Martin, Jose (Hospital General Universitario Gregorio Marañón) ;
van der Meer, Jan T. M. (Amsterdam UMC) ;
de Kort, Theun M. (Leiden University Medical Center) ;
Sáez-Cirión, Asier (Université Paris Cité) ;
Schulze zur Wiesch, Julian (UMC Hamburg-Eppendorf) ;
Boelens, Jaap Jan (Memorial Sloan Kettering Cancer Center) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kuball, Jurgen (University Medical Center Utrecht) ;
Wensing, Annemarie M. J. (University Medical Center Utrecht) ;
Nijhuis, Monique (University Medical Center Utrecht)
Allo-HSCT with CCR5Δ32/Δ32 donor cells is the only curative HIV-1 intervention. We investigated the impact of allo-HSCT on the viral reservoir in PBMCs and post-mortem tissue in two patients. IciS-05 and IciS-11 both received a CCR5Δ32/Δ32 allo-HSCT. [...]
2022 - 10.3390/v14092069
Viruses, Vol. 14 (september 2022)
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4.
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17 p, 4.5 MB |
Genomic Characterization of Staphylococcus aureus in Wildlife
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Martínez-Seijas, Carmen (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Mascarós, Patricia (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Lizana, Victor (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Martí-Marco, Alba (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Arnau-Bonachera, Alberto (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Chillida-Martínez, Eva (Universidad CEU Cardenal Herrera. Servicio de Análisis, Investigación, Gestión de Animales Silvestres) ;
Cardells-Peris, Jesús (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Selva, Laura (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Viana, David (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Corpa Arenas, Juan Manuel (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico)
Staphylococcus aureus is both a commensal and opportunistic pathogen that colonizes human and animal skin and mucosal membranes. It is widely acknowledged that livestock can act as a reservoir for human strains and genetic traits, but less is known about the epidemiological significance of wild animals. [...]
2023 - 10.3390/ani13061064
Animals, Vol. 13 (march 2023)
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5.
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17 p, 3.2 MB |
Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction
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Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Kawana-Tachikawa, Ai (National Institute of Infectious Diseases (Tokio)) ;
Prats, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Zalacain, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ;
Kobayashi-Ishihara, Mie (Universitat Pompeu Fabra) ;
Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Silva-Arrieta, Sandra (Silva-Arrieta, Sandra) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Centro de Investigaciones Tecnologicas Biomedicas y Medioambientales (Perú)) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hartigan-O'Connor, Dennis (University of California. Department of Medical Microbiology and Immunology) ;
Wyss-Coray, Tony (Stanford University School of Medicine. Department of Neurology and Neurological Science) ;
Meyerhans, Andreas (University of Gothenburg. Department of Infectious Diseases) ;
Gisslén, Magnus (University of Gothenburg. Department of Infectious Diseases) ;
Price, Richard W. (University of California San Francisco. Department of Neurology) ;
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Muñoz-Moreno, José Antonio (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The implementation and access to combined antiretroviral treatment (cART) have dramatically improved the quality of life of people living with HIV (PLWH). However, some comorbidities, such as neurological disorders associated with HIV infection still represent a serious clinical challenge. [...]
2023 - 10.1128/jvi.01655-22
Journal of Virology, Vol. 97 (January 2023)
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7.
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15 p, 4.3 MB |
Gut microbiome signatures linked to HIV-1 reservoir size and viremia control
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Borgognone, Alessandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya) ;
Oriol, Bruna (Universitat Autònoma de Barcelona) ;
Noël-Romas, Laura (University of Manitoba) ;
Ruiz-Riol, Marta (CIBERINFEC (Madrid)) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Parera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Casadellà, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Universitat Autònoma de Barcelona) ;
Puertas, Maria C. (CIBERINFEC, Madrid, Spain) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
De Leon, Marlon (Case Western Reserve University) ;
Knodel, Samantha (University of Manitoba) ;
Birse, Kenzie (University of Manitoba) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Miró, José M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Moltó, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Burgener, Adam (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Paredes, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The potential role of the gut microbiome as a predictor of immune-mediated HIV-1 control in the absence of antiretroviral therapy (ART) is still unknown. In the BCN02 clinical trial, which combined the MVA. [...]
2022 - 10.1186/s40168-022-01247-6
Microbiome, Vol. 10 (april 2022)
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11 p, 2.0 MB |
Enhancement of Antiviral CD8 + T-Cell Responses and Complete Remission of Metastatic Melanoma in an HIV-1-Infected Subject Treated with Pembrolizumab
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Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Revollo, Boris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llibre, Josep M.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Manzano, José Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boada, Aram (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
E. Speiser, Daniel (University of Lausanne, Switzerland) ;
Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
G. Prado, Julia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Pembrolizumab is an immune checkpoint inhibitor against programmed cell death protein-1 (PD-1) approved for therapy in metastatic melanoma. PD-1 expression is associated with a diminished functionality in HIV-1 specific-CD8 + T cells. [...]
2019 - 10.3390/jcm8122089
Journal of clinical medicine, Vol. 8 (december 2019)
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12 p, 1.1 MB |
Extremely low viral reservoir in treated chronically HIV-1-infected individuals
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Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez Valero, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Monceaux, Valérie (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Huot, Nicolas (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Leal, Lorna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
González Soler, Victoria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
González-Cao, María (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Müller-Trutwin, Michaela (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Sáez-Cirión, Asier (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
García, Felipe (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Small viral reservoirs are found predominantly in HIV-1 controllers and individuals treated during acute/early HIV-1 infection. However, other HIV + individuals could naturally also harbour low viral reservoirs. [...]
2020 - 10.1016/j.ebiom.2020.102830
EBioMedicine, Vol. 57 (june 2020)
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