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9 p, 821.4 KB |
Efficacy and Safety of CT-P10 Versus Rituximab in Untreated Low-Tumor-Burden Follicular Lymphoma : Final Results of a Randomized Phase III Study
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Kwak, Larry W. (Comprehensive Cancer Center, Duarte) ;
Sancho, Juan Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cho, Seok Goo (The Catholic University of Korea, Seoul, South Korea) ;
Nakazawa, Hideyuki (Shinshu University School of Medicine, Nagano, Japan) ;
Suzumiya, Junji (Shimane University Hospital, Innovative Cancer Center/Oncology-Hematology, Izumo, Japan) ;
Tumyan, Gayane (Division of Hematology and Bone Marrow Transplantation, Blokhin Russian Cancer) ;
Kim, Jin Seok (Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea) ;
Menne, Tobias (Newcastle University, UK) ;
Mariz, José (Instituto Português de Oncología do Porto) ;
Ilyin, Nikolai (Ministry of Health of the Russian Federation) ;
Jurczak, Wojciech (Maria Sklodowska-Curie National Research Institute of Oncology, Kraków, Poland) ;
Lopez Martinez, Aurelio (Hospital Arnau de Vilanova (València)) ;
Samoilova, Olga (Nizhniy Novgorod Region Clinical Hospital, Nizhniy Novgorod, Russia) ;
Zhavrid, Edvard (N. N. Alexandrov Republican Scientific and Practical Centre of Oncology and Medical Radiology, Belarus) ;
Yañez Ruiz, Eduardo (Universidad de la Frontera, Temuco, Chile) ;
Trneny, Marek (Charles University, Czech Republic) ;
Popplewell, Leslie (Toni Stephenson Lymphoma Cancer Center and Department of Hematology and Hematopoietic Cell Transplantation, Duarte, CA) ;
Ogura, Michinori (Kasugai Municipal Hospital, Aichi 486-8510, Japan.) ;
Kim, Wong Seog (Sungkyunkwan University School of Medicine, Seoul, South Korea) ;
Lee, Sang Joon (Celltrion. Inc, South Korea) ;
Kim, Sung Hyun (Celltrion. Inc, South Korea) ;
Ahn, Keum Young (Celltrion. Inc, South Korea) ;
Buske, Christian (University Hospital of Ulm, Germany)
Introduction: This double-blind, parallel-group, active-controlled phase III trial (NCT02260804) assessed CT-P10 and rituximab safety and efficacy in patients with previously untreated low-tumor-burden follicular lymphoma (LTBFL), including after a single switch from rituximab to CT-P10. [...]
2022 -  10.1016/j.clml.2021.08.005
Clinical Lymphoma, Myeloma & Leukemia, Vol. 22 Núm. 2 (february 2022) , p. 89-97
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16 p, 586.7 KB |
Quantifying In-Host Quasispecies Evolution
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Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ibañez-Lligoña, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
What takes decades, centuries or millennia to happen with a natural ecosystem, it takes only days, weeks or months with a replicating viral quasispecies in a host, especially when under treatment. Some methods to quantify the evolution of a quasispecies are introduced and discussed, along with simple simulated examples to help in the interpretation and understanding of the results. [...]
2023 - 10.3390/ijms24021301
International journal of molecular sciences, Vol. 24 (january 2023)
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12 p, 248.7 KB |
Storia di un sodalizio : sull'amicizia tra Leonardo Sciascia ed Antonio Castelli
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Saja, Giuseppe (Ricercatore indipendente)
Analizzare l'amicizia tra Leonardo Sciascia e Antonio Castelli (1923-1988) permette non solo di illuminare un sodalizio fatto di discrezione, sensibilità e virtù intellettuali, ma anche di sostanziare un altro aspetto della poliedrica attività culturale dello scrittore di Racalmuto: quello di talent-scout e di estimatore di autori del passato o contemporanei. [...]
L'anàlisi de l'amistat entre Leonardo Sciascia i Antonio Castelli (1923-1988) ens permet no només il·luminar una col·laboració feta de discreció, sensibilitat i virtuts intel·lectuals, sinó també materialitzar un altre aspecte de la polifacètica activitat cultural de l'escriptor de Racalmuto: que de talent: explorador i admirador d'autors passats o contemporanis. [...]
Retracing the friendship between Leonardo Sciascia and Antonio Castelli (1923-1988) leads us not only to illuminate a fellowship made up of discretion, sensitivity and intellectual virtues; but it also allows us to substantiate another aspect of the multifaceted cultural activity of the writer: that of the discoverer and admirer of authors from the past or contemporary to him. [...]
Analizar la amistad entre Leonardo Sciascia y Antonio Castelli (1923-1988) permite no sólo iluminar una sociedad hecha de discreción, sensibilidad y virtudes intelectuales, sino también fundamentar otro aspecto de la polifacética actividad cultural del escritor racalmutino: que de talento - explorador y admirador de autores pasados o contemporáneos. [...]
2022 - 10.5565/rev/qdi.547
Quaderns d'Italià, Vol. 27 (2022) , p. 71-82 (Dossier 1)
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Gene fusions derived by transcriptional readthrough are driven by segmental duplication in human
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McCartney, Ann M. (Dublin City University. Bioinformatics and Molecular Evolution Group) ;
Hyland, Edel M. (Queens University Belfast. Institute for Global Food Security) ;
Cormican, Paul (Animal and Grassland Research and Innovation Centre (Irlanda)) ;
Moran, Raymond J. (Dublin City University. Bioinformatics and Molecular Evolution Group) ;
Webb, Andrew E. (Dublin City University. Bioinformatics and Molecular Evolution Group) ;
Lee, Kate D. (Massey University (New Zealand)) ;
Hernandez Rodriguez, Jessica (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Prado-Martinez, Javier (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Creevey, Christopher J. (Aberystwyth University. Institute of Biological, Environmental and Rural Sciences) ;
Aspden, Julie L. (University of Leeds. School of Molecular and Cellular Biology) ;
McInerney, James O. (University of Nottingham. School of Life Sciences) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
O'Connell, Mary J. (University of Nottingham. School of Life Sciences)
Gene fusion occurs when two or more individual genes with independent open reading frames becoming juxtaposed under the same open reading frame creating a new fused gene. A small number of gene fusions described in detail have been associated with novel functions, for example, the hominid-specific PIPSL gene, TNFSF12, and the TWE-PRIL gene family. [...]
2019 - 10.1093/gbe/evz163
Genome biology and evolution, Vol. 11, Issue 9 (September 2019) , p. 2678-2690
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Relaciones entre el conocimiento de la enseñanza y el conocimiento de las características del aprendizaje de las matemáticas : caso de una profesora de secundaria
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Zakaryan, Diana (Pontificia Universidad Católica de Valparaíso) ;
Estrella Romero, María Soledad (Pontificia Universidad Católica de Valparaíso) ;
Espinoza-Vásquez, Gonzalo (Pontificia Universidad Católica de Valparaíso) ;
Morales, Sergio (Pontificia Universidad Católica de Valparaíso) ;
Olfos, Raimundo (Pontificia Universidad Católica de Valparaíso) ;
Flores-Medrano, Eric (Universidad Popular Autónoma del Estado de Puebla (Mèxic)) ;
Carrillo-Yáñez, José (Universidad de Huelva. Departamento de Didácticas Integradas)
El conocimiento del profesor es reconocido como un factor relevante de su desempeño profesional y para promover el aprendizaje de la matemática de sus alumnos. Este artículo profundiza en el conocimiento del profesor y estudia las relaciones entre subdominios del conocimiento didáctico del contenido del modelo Mathematics Teachers' Specialized Knowledge. [...]
A teacher's knowledge is considered a significant factor contributing to their classroom performance and the promotion of mathematics learning in their students. This paper examines the knowledge deployed by a secondary teacher when working on the topic of similarity of triangles, focusing on the connections between subdomains within Pedagogical Content Knowledge in the model Mathematics Teachers' Specialized Knowledge. [...]
2018 - 10.5565/rev/ensciencias.2260
Enseñanza de las ciencias, Vol. 36 Núm. 2 (2018) , p. 105-123 (Investigaciones Didácticas)
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