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1.
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11 p, 2.7 MB |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control
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Masip, Jenifer (Hospital Universitari Joan XXIII de Tarragona) ;
Rallón, Norma (Hospital Universitario Rey Juan Carlos (Madrid)) ;
Yeregui, Elena (Hospital Universitari Joan XXIII de Tarragona) ;
Olona, Montserrat (Hospital Universitari Joan XXIII de Tarragona) ;
Resino, Salvador (Instituto de Salud Carlos III) ;
Benito, José M. (Hospital Universitario Rey Juan Carlos (Madrid)) ;
Viladés, Consuelo (Instituto de Salud Carlos III) ;
García-Pardo, Graciano (Hospital Universitari Joan XXIII de Tarragona) ;
Alcami, Jose (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ruiz-Mateos, Ezequiel (Universidad de Sevilla) ;
Gómez-Bertomeu, Frederic (Hospital Universitari Joan XXIII de Tarragona) ;
Vargas, Montserrat (Hospital Universitari Joan XXIII de Tarragona) ;
Navarro, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Oteo, José A. (Hospital Universitario San Pedro) ;
Pineda, Juan A. (Unidad de Investigación Hospital Universitario de Valme) ;
Martí, Anna (Hospital Universitari Joan XXIII de Tarragona) ;
Alba, Verónica (Hospital Universitari Joan XXIII de Tarragona) ;
Vidal, Francesc (Instituto de Salud Carlos III) ;
Peraire, Joaquin (Instituto de Salud Carlos III) ;
Rull, Anna (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. [...]
2022 -  10.3389/fimmu.2022.822272
Frontiers in immunology, Vol. 13 (april 2022)
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2.
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9 p, 534.4 KB |
Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)
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Villena-Ortiz, Yolanda (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Castellote, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Sánchez, Luisa María (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Benítez-Carabante, María I. (Vall d'Hebron Institut de Recerca. Departament d'Hematologia i Oncologia Pediàtrica) ;
Miarons, Marta (Vall d'Hebron Institut de Recerca. Departament de Farmàcia) ;
Vima-Bofarull, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barquin-DelPino, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Paciucci, Rosanna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casis-Saez, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
López-Hellín, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Objectives: Administration of busulfan is extending rapidly as a part of a conditioning regimen in patients undergoing hematopoietic stem cell transplantation (HSCT). Monitoring blood plasma levels of busulfan is recommended for identifying the optimal dose in patients and for minimizing toxicity. [...]
2022 - 10.1515/almed-2022-0016
Advances in Laboratory Medicine, Vol. 3, Issue 3 (September 2022) , p. 263-271
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3.
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9 p, 3.8 MB |
Correlative radioimaging and mass spectrometry imaging : a powerful combination to study 14C-graphene oxide in vivo biodistribution
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Cazier, Hélène (Université Paris Saclay) ;
Malgorn, Carole (Université Paris Saclay) ;
Georgin, Dominique (Université Paris Saclay) ;
Fresneau, Nathalie (Université Paris Saclay) ;
Beau, Fabrice (Université Paris Saclay) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (University of Manchester) ;
Campidelli, Stéphane (Université Paris Saclay) ;
Pinault, Mathieu (Université Paris-Saclay) ;
Mayne-L'Hermite, Martine (Université Paris-Saclay) ;
Taran, Frédéric (Université Paris Saclay) ;
Junot, Christophe (Université Paris Saclay) ;
Fenaille, François (Université Paris Saclay) ;
Sallustrau, Antoine (Université Paris Saclay) ;
Colsch, Benoit (Université Paris Saclay)
Research on graphene based nanomaterials has flourished in the last decade due their unique properties and emerging socio-economic impact. In the context of their potential exploitation for biomedical applications, there is a growing need for the development of more efficient imaging techniques to track the fate of these materials. [...]
2023 - 10.1039/d2nr06753f
Nanoscale, Vol. 15, Issue 11 (March 2023) , p. 5510-5518
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4.
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15 p, 1.9 MB |
GC-MS/MS Determination of Synthetic Cathinones : 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study
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Nuñez-Montero, Melani (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lombroni, Claudia (Univesità degli Studi di Torino) ;
Maida, Nunzia La (Istituto Superiore di Sanità) ;
Rotolo, Maria Concetta (Istituto Superiore di Sanità) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ventura, Mireia (Associació Benestar i Desenvolupament) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marchei, Emilia (Istituto Superiore di Sanità) ;
Universitat Autònoma de Barcelona
This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. [...]
2023 - 10.3390/ijms24119387
International journal of molecular sciences, Vol. 24 (may 2023)
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5.
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14 p, 4.3 MB |
Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation
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Llanos-González, Emilio (Universidad de Castilla-La Mancha) ;
Sancho-Bielsa, Francisco J. (Universidad de Castilla-La Mancha) ;
Frontiñán-Rubio, Javier (Universidad de Castilla-La Mancha) ;
Rabanal-Ruíz, Yoana (Universidad de Castilla-La Mancha) ;
García-Carpintero, Sonia (Universidad de Castilla-La Mancha) ;
Chicano, Eduardo (Universidad de Córdoba) ;
Úbeda-Banon, Isabel (Universidad de Castilla-La Mancha) ;
Flores-Cuadrado, Alicia (Universidad de Castilla-La Mancha) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona) ;
Alcaín, Francisco Javier (Universidad de Castilla-La Mancha) ;
Peinado, Juan Ramón (Universidad de Castilla-La Mancha) ;
Durán-Prado, Mario (Universidad de Castilla-La Mancha)
Despite its robust proteopathic nature, the spatiotemporal signature of disrupted protein modules in sporadic Alzheimer's disease (AD) brains remains poorly understood. This considered oxidative stress contributes to AD progression and early intervention with coenzyme Q10 or its reduced form, ubiquinol, delays the progression of the disease. [...]
2023 - 10.3390/antiox12030747
Antioxidants, Vol. 12 (march 2023)
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6.
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10 p, 912.2 KB |
Pharmacokinetic analysis of omomyc shows lasting structural integrity and long terminal half-Life in tumor tissue
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Beaulieu, Marie-Eve (Peptomyc SL) ;
Martínez-Martín, Sandra (Peptomyc SL) ;
Kaur, Jastrinjan (Vall d'Hebron Institut d'Oncologia) ;
Castillo Cano, Virginia (Peptomyc SL) ;
Massó Vallés, Daniel (Peptomyc SL) ;
Foradada Felip, Laia (Peptomyc SL) ;
López-Estévez, Sergio (Peptomyc SL) ;
Serrano del Pozo, Erika (Vall d'Hebron Institut d'Oncologia) ;
Thabussot, Hugo (Peptomyc SL) ;
Soucek, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
MYC is an oncoprotein causally involved in the majority of human cancers and a most wanted target for cancer treatment. Omomyc is the best-characterized MYC dominant negative to date. In the last years, it has been developed into a therapeutic miniprotein for solid tumor treatment and recently reached clinical stage. [...]
2023 - 10.3390/cancers15030826
Cancers, Vol. 15, Issue 3 (February 2023) , art. 826
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7.
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11 p, 5.8 MB |
Chemicals of emerging concern in coastal aquifers : Assessment along the land-ocean interface
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Gutiérrez-Martín, Daniel (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Gil-Solsona, Rubén (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Saaltink, Maarten W. (Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental) ;
Rodellas, Valentí (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
López-Serna, Rebeca (Universidad de Valladolid. Instituto de Procesos Sustentables) ;
Folch, Albert (Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental) ;
Carrera, Jesús (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Gago-Ferrero, Pablo (Institut de Diagnòstic Ambiental i Estudis de l'Aigua)
Submarine Groundwater Discharge (SGD) is recognized as a relevant source of pollutants to the sea, but little is known about its relevance as a source of chemicals of emerging concern (CECs). Here, both the presence and distribution of a wide range of CECs have been evaluated in the most comprehensive manner to date, in a well-characterized Mediterranean coastal aquifer near Barcelona (Spain). [...]
2023 - 10.1016/j.jhazmat.2023.130876
Journal of hazardous materials, Vol. 448 (April 2023) , art. 130876
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9.
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22 p, 444.8 KB |
Inhibition equivalency factors for microcystin variants in recombinant and wild-type protein phosphatase 1 and 2A assays
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Garibo, Diana (Institut de Recerca i Tecnologia Agroalimentàries) ;
Flores, Cintia (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Cetó Alsedà, Xavier (Universitat Autònoma de Barcelona. Departament de Química) ;
Prieto-Simón, Beatriz (Universitat Autònoma de Barcelona. Departament de Química) ;
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química) ;
Caixach, Josep (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Diogène, Jorge (Institut de Recerca i Tecnologia Agroalimentàries) ;
Campàs i Homs, Mònica (Institut de Recerca i Tecnologia Agroalimentàries)
In this work, protein phosphatase inhibition assays (PPIAs) have been used to evaluate the performance of recombinant PP1 and recombinant and wild-type PP2As. The enzymes have been compared using microcystins-LR (MC-LR) as a model cyanotoxin. [...]
2014 - 10.1007/s11356-014-3065-7
Environmental Science and Pollution Research International, Vol. 21, Issue 18 (September 2014) , p. 10652-10660
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