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Articles, 2 records found
Articles 2 records found  
1.
13 p, 3.0 MB Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q / Ademà, Vera (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Walter, Wencke (Munich Leukemia Laboratory) ; Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hutter, Stephan (Munich Leukemia Laboratory) ; La Framboise, Thomas (Department of Genetics and Genome Sciences. Case Western Reserve University) ; Arenillas, Leonor (Institut Hospital del Mar d'Investigacions Mèdiques) ; Meggendorfer, Manja (Munich Leukemia Laboratory) ; Radivoyevitch, Tomas (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Pellagatti, Andrea (Blood Cancer UK Molecular Haematology Unit. Nuffield Division of Clinical Laboratory Sciences. Radcliffe Department of Medicine. University of Oxford and Oxford BRC Haematology Theme) ; Haferlach, Claudia (Munich Leukemia Laboratory) ; Boultwood, Jacqueline (University of Oxford. Radcliffe Department of Medicine) ; Kern, Wolfgang (Munich Leukemia Laboratory) ; Visconte, Valeria (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Sekeres, Mikkael (Leukemia Program. Department of Hematology and Medical Oncology. Cleveland Clinic. Cleveland Clinic Taussig Cancer Institute) ; Barnard, John (Department of Quantitative Health Sciences. Cleveland Clinic. Lerner Research Institute) ; Haferlach, Torsten (Munich Leukemia Laboratory) ; Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Maciejewski, Jaroslaw (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute)
Background: Haploinsufficiency (HI) resulting from deletion of the long arm of chromosome 5 [del(5q)] and the accompanied loss of heterozygosity are likely key pathogenic factors in del(5q) myeloid neoplasia (MN) although the consequences of del(5q) have not been yet clarified. [...]
2022 - 10.1016/j.ebiom.2022.104059
EBioMedicine, Vol. 80 (june 2022) , art. 104059  
Detailed record - Creative Commons
2.
7 p, 4.6 MB Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions / Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Collado, Rosa (Hospital General Universitario de Valencia) ; Calasanz, M.J (Universidad de Navarra. Departamento de Bioquímica y Genética) ; Ortega, Margarita (Hospital Universitari Vall d'Hebron) ; Ruiz-Xivillé, Neus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rivas-Delgado, Alfredo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Luño, Elisa (Hospital Universitario Central de Asturias) ; González, Teresa (Fundación Pública Galega de Medicina Xenómica) ; Navarro, Blanca (Hospital Clínic Universitari (València)) ; García-Malo, MaDolores (Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain) ; Valiente, Alberto (Complejo Hospitalario de Navarra) ; Hernández, José Ángel (Hospital Universitario Infanta Leonor) ; Ardanaz, María Teresa (Servicio de Hematología, Hospital Txagorritxu, Vitoria, Spain) ; Piñan, María Ángeles (Hospital Universitario de Cruces (Barakaldo, País Basc)) ; Blanco, María Laura (Institut d'Investigació Biomèdica Sant Pau) ; Hernández-Sánchez, María (Hospital Universitario de Salamanca. Centro de Investigación del Cáncer) ; Batlle Lopez, Ana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Salgado Sánchez, Rocío Nieves (Laboratorio de Citogenética, Servicio de Hematología, Fundación Jiménez Díaz, Madrid, Spain) ; Salido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ; Ferrer, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ; Abrisqueta, Pau (Hospital Universitari Vall d'Hebron) ; Gimeno, Eva (Hospital del Mar (Barcelona, Catalunya)) ; Abella Monreal, Eugenia (Hospital del Mar (Barcelona, Catalunya)) ; Ferrá, Christelle (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Terol, María José (Hospital Clínic Universitari (València)) ; Ortuño, Francisco (Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, IMIB-Arrixaca, Murcia, Spain) ; Costa, Dolors (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ; Carbonell, Félix (Hospital General Universitario de Valencia) ; Bosch José, Francesc Xavier 1947- (Hospital Universitari Vall d'Hebron) ; Delgado, Julio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Espinet i Solà, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ; Universitat Autònoma de Barcelona
Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex karyotypes (CK) with or without high-risk FISH deletions (ATM and/or TP53, HR-FISH) in a cohort of 1045 untreated MBL/CLL patients. [...]
2017 - 10.18632/oncotarget.17350
Oncotarget, Vol. 8 (april 2017) , p. 54297-54303  
Detailed record - Creative Commons

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