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19 p, 6.1 MB |
TREM2 expression in the brain and biological fluids in prion diseases
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Diaz-Lucena, Daniela (Institut d'Investigació Biomèdica de Bellvitge) ;
Kruse, Niels (University Medical Center Göttingen. Institute of Neuropathology) ;
Thüne, Katrin (University Medical Center Göttingen. Department of Neurology) ;
Schmitz, Matthias (German Center for Neurodegenerative Diseases) ;
Villar-Piqué, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
da Cunha, Jose Eriton Gomes (Universidade Federal de Pernambuco. Keizo Asami Laboratory) ;
Hermann, Peter (University Medical Center Göttingen. Department of Neurology) ;
López-Pérez, Óscar (Institut d'Investigació Biomèdica de Bellvitge) ;
Andrés-Benito, P (Institut d'Investigació Biomèdica de Bellvitge) ;
Ladogana, Anna (Istituto Superiore Di Sanità. Department of Neurosciences) ;
Calero, Miguel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries) ;
Riggert, Joachim (University Medical School. Department of Transfusion Medicine) ;
Pineau, Hailey (University of Alberta. Department of Medicine-Division of Neurology) ;
Sim, Valerie (University of Alberta. Department of Medicine-Division of Neurology) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Blennow, Kaj (Sahlgrenska University Hospital. Clinical Neurochemistry Laboratory) ;
Del Rio, Jose Antonio (Universitat de Barcelona. Institut de Neurociències) ;
Marín-Moreno, Alba (Centro de Investigación en Sanidad Animal. CISA-INIA) ;
Espinosa, Juan Carlos (Centro de Investigación en Sanidad Animal. CISA-INIA) ;
Torres, Juan María (Centro de Investigación en Sanidad Animal. CISA-INIA) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mollenhauer, Brit (University Medical Centre Göttingen. Department of Neurology) ;
Ferrer, Isidro (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ;
Zerr, Inga (German Center for Neurodegenerative Diseases) ;
Llorens, Franc (University Medical Center Göttingen. Department of Neurology)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several neurodegenerative diseases. [...]
2021 -  10.1007/s00401-021-02296-1
Acta Neuropathologica, Vol. 141 (april 2021) , p. 841-859
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14 p, 1.2 MB |
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
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Suárez Calvet, Marc (Ludwig-Maximilians-Universität München) ;
Morenas-Rodríguez, Estrella (Institut d'Investigació Biomèdica Sant Pau) ;
Kleinberger, Gernot (Ludwig-Maximilians-Universität München) ;
Schlepckow, Kai (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-Universität München) ;
Franzmeier, Nicolai (Ludwig-Maximilians-Universität München) ;
Capell, Anja (Ludwig-Maximilians-Universität München) ;
Fellerer, Katrin (Ludwig-Maximilians-Universität München) ;
Nuscher, Brigitte (Ludwig-Maximilians-Universität München) ;
Eren, Erden (Ludwig-Maximilians-Universität München) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Deming, Yuetiva (Washington University School of Medicine) ;
Piccio, Laura (Washington University School of Medicine) ;
Karch, Celeste M. (Washington University School of Medicine) ;
Cruchaga, Carlos (Washington University School of Medicine) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Trojanowski, John Q.. (University of Pennsylvania) ;
Weiner, Michael (University of California at San Francisco) ;
Ewers, Michael (Ludwig-Maximilians-Universität München) ;
Haass, Christian (Ludwig-Maximilians-Universität München) ;
Universitat Autònoma de Barcelona
TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). [...]
2019 - 10.1186/s13024-018-0301-5
Molecular neurodegeneration, Vol. 14 (january 2019)
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21 p, 965.2 KB |
CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
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Suárez-Calvet, Marc (Ludwig-Maximilians-Universität München) ;
Capell, Anja (Ludwig-Maximilians-Universität München) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-Universität München) ;
Morenas-Rodríguez, Estrella (Universitat Autònoma de Barcelona) ;
Fellerer, Katrin (Ludwig-Maximilians-Universität München) ;
Franzmeier, Nicolai (Ludwig-Maximilians-Universität München) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ;
Eren, Erden (Dokuz Eylul University, Turkey) ;
Deming, Yuetiva (Washington University School of Medicine) ;
Piccio, Laura (Washington University School of Medicine) ;
Karch, Celeste M. (Washington University School of Medicine) ;
Cruchaga, Carlos (Washington University School of Medicine) ;
Paumier, Katrina (Washington University School of Medicine) ;
Bateman, Randall J. (Washington University School of Medicine) ;
Fagan, Anne M. (Washington University School of Medicine) ;
Morris, John C. (Washington University School of Medicine) ;
Levin, Johannes (Ludwig-Maximilians-Universität München) ;
Danek, Adrian (Ludwig-Maximilians-Universität München) ;
Jucker, Mathias (University of Tübingen) ;
Masters, Colin L. (University of Melbourne) ;
Rossor, Martin N. (UCL Institute of Neurology (Regne Unit)) ;
Ringman, John M. (University of Southern California) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Trojanowski, John Q.. (University of Pennsylvania) ;
Weiner, Michael (University of California at San Francisco) ;
Ewers, Michael (Ludwig-Maximilians-Universität München) ;
Haass, Christian (Munich Cluster for Systems Neurology (SyNergy))
Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether expression is changed in a disease severity-specific manner in . [...]
2018 - 10.15252/emmm.201809712
EMBO Molecular Medicine, Vol. 10 (november 2018)
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10 p, 838.9 KB |
The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
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Gispert, Juan Domingo (Universitat Pompeu Fabra) ;
Monté, Gemma C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany) ;
Falcon, Carles (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Tucholka, Alan (Barcelonaβeta Brain Research Center (BBRC)) ;
Rojas, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Llado Plarrumani, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Haass, Christian (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD). [...]
2016 - 10.1016/j.dadm.2016.12.002
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 6 (december 2016) , p. 50-59
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11 p, 519.1 KB |
2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
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Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-University Munich) ;
Brendel, Matthias (Ludwig-Maximilians-University Munich) ;
Rominger, Axel (Ludwig-Maximilians-University Munich) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Gispert, Juan Domingo (Institut d'Investigació Biomèdica Sant Pau) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Antonell, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Brosseron, Frederic (German Center for Neurodegenerative Diseases (DZNE)) ;
Traschütz, Andreas (Universitätsklinikum Bonn) ;
Heneka, Michael T. (Universitätsklinikum Bonn) ;
Struyfs, Hanne (University Hospital Antwerp (Bèlgica)) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ;
Van Broeckhoven, Christine (University of Antwerp. Institute Born-Bunge) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Nellgård, Bengt (Gothenburg University. Sahlgrenska Academy. Institute of Clinical Sciences) ;
Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg. Institute of Neuroscience and Physiology) ;
Crispin, Alexander (Institute of Medical Informatics, Biometry, and Epidemiology) ;
Ewers, Michael (Ludwig-Maximilians-University Munich) ;
Haass, Christian (BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich) ;
Universitat Autònoma de Barcelona
2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (2), which can be measured in the cerebrospinal fluid (). [...]
2016 - 10.15252/emmm.201506123
EMBO Molecular Medicine, Vol. 8 (march 2016) , p. 466-476
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6.
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14 p, 18.8 MB |
Differential modulation of TREM2 protein during postnatal brain development in mice
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Chertoff, Mariela (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Shrivastava, Kalpana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Acarín Pérez, Laia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
During postnatal development, microglia, the resident innate immune cells of the central nervous system are constantly monitoring the brain parenchyma, cleaning the cell debris, the synaptic contacts overproduced and also maintaining the brain homeostasis. [...]
2013 - 10.1371/journal.pone.0072083
PloS one, Vol. 8 Issue 8 (August 2013) , p. 1-14
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