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11 p, 948.3 KB |
Barriers to making recommendations about medical tests : a qualitative study of European guideline developers
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Gopalakrishna, Gowri (University of Amsterdam) ;
Leeflang, Mariska M.G. (University of Amsterdam) ;
Davenport, Clare (University of Birmingham) ;
Sanabria, Andrea Juliana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
McCaffery, Kirsten (Sydney Medical School) ;
Bossuyt, Patrick (University of Amsterdam) ;
Langendam, Miranda W. (University of Amsterdam) ;
Universitat Autònoma de Barcelona
Development of medical test guidelines differs from intervention guideline development. These differences can pose unique challenges in building evidence-based recommendations to guide clinical practice. [...]
2016 -  10.1136/BMJOPEN-2015-010549
BMJ open, Vol. 6 Núm. 9 (2016) , p. e010549
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8 p, 1.1 MB |
Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy
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Sonnenschein, Kristina (Hannover Medical School. Department of Cardiology and Angiology) ;
Wilczek, Adriana Luisa (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ;
Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau) ;
Pfanne, Angelika (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ;
Derda, Anselm Arthur (Hannover Medical School. Department of Cardiology and Angiology) ;
Zwadlo, Carolin (Hannover Medical School. Department of Cardiology and Angiology) ;
Bavendiek, Udo (Hannover Medical School. Department of Cardiology and Angiology) ;
Bauersachs, Johann (REBIRTH Center of Translational Regenerative Medicine. Hannover Medical School) ;
Fiedler, Jan (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ;
Thum, Thomas (REBIRTH Center of Translational Regenerative Medicine. Hannover Medical School)
Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and is associated with a high risk of sudden cardiac death. HCM is characterized by pronounced hypertrophy of cardiomyocytes, fiber disarray and development of fibrosis and can be divided into a non-obstructive (HNCM) and obstructive form (HOCM) therefore requiring personalized therapeutic therapies. [...]
2019 - 10.1038/s41598-019-56617-2
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 20350
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11 p, 732.4 KB |
Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis
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Kontaxis, Spyridon (Universidad de Zaragoza) ;
Laporta, Estela (Universidad de Zaragoza) ;
Garcia, Esther (Universitat Autònoma de Barcelona. Departament de Microelectrònica i Sistemes Electrònics) ;
Martinis, Matteo (University Vita-Salute and Hospital San Raffaele) ;
Leocani, Letizia (University Vita-Salute and Hospital San Raffaele) ;
Roselli, Lucia (University Vita-Salute and Hospital San Raffaele) ;
Buron, Mathias Due (Copenhagen University Hospital Rigshospitalet) ;
Guerrero, Ana Isabel (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Cummins, Nicholas (King's College London) ;
Vairavan, Srinivasan (Janssen Research and Development) ;
Hotopf, Matthew (King's College London) ;
Dobson, Richard J. B. (University College London) ;
Narayan, Vaibhav A. (Davos Alzheimer's Collaborative) ;
La Porta, Maria Libera (University Vita-Salute and Hospital San Raffaele) ;
Costa, Gloria Dalla (University Vita-Salute and Hospital San Raffaele) ;
Magyari, Melinda (Copenhagen University Hospital Rigshospitalet) ;
Sørensen, Per Soelberg (Copenhagen University Hospital Rigshospitalet) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Bailón, Raquel (Universidad de Zaragoza) ;
Comi, Giancarlo (Casa di Cura del Policlinico (Milà, Itàlia))
The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). For 154 pwMS, MS-related clinical outcomes as well as the 2MWDs as evaluated by clinicians and derived from accelerometer data were collected from a total of 323 periodic clinical visits. [...]
2023 - 10.3390/s23136017
Sensors (Basel, Switzerland), Vol. 23 (june 2023)
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19 p, 7.0 MB |
Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study
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Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron) ;
Álvarez-Sierra, Daniel (Hospital Universitari Vall d'Hebron) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron) ;
Perurena-Prieto, Janire (Hospital Universitari Vall d'Hebron) ;
Arrese-Muñoz, Iria (Hospital Universitari Vall d'Hebron) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Espinosa-Pereiro, Juan (Hospital Universitari Vall d'Hebron) ;
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron) ;
Martínez Gómez, Xavier (Hospital Universitari Vall d'Hebron) ;
Antón, Andrés (Hospital Universitari Vall d'Hebron) ;
Martínez-Valle, Ferran (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Blanco-Grau, Albert (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Castellano-Escuder, Pol (Universitat de Barcelona) ;
Poyatos Cantón, E (Hospital Universitari de Bellvitge) ;
Bas, Jordi (Hospital Universitari de Bellvitge) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron) ;
Zurera Egea, Coral (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-González, Manuel (Hospital Universitari Vall d'Hebron) ;
Pujol-Borrell, Ricardo (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Two years since the onset of the COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms the contribution of laboratory variables is limited. [...]
2022 - 10.3389/fimmu.2022.902837
Frontiers in immunology, Vol. 13 (june 2022)
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9 p, 2.2 MB |
Effect of Ozanimod on Symbol Digit Modalities Test Performance in Relapsing MS
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DeLuca, John (Rutgers - The State University of New Jersey, Newark) ;
Schippling, Sven (University of Zurich) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Kappos, Ludwig (University of Basel) ;
Cree, Bruce A. C (University of California, San Francisco) ;
Comi, Giancarlo (Vita-Salute San Raffaele University) ;
Arnold, Douglas Lorne (McGill University, Montreal) ;
Hartung, Hans Peter (Heinrich Heine University Düsseldorf) ;
Sheffield, James K. (Bristol-Myers Squibb Company) ;
Liu, Hongjuan (Bristol-Myers Squibb Company) ;
Silva, Diego (Bristol-Myers Squibb Company) ;
Cohen, Jeffrey A. (Neurological Institute, Cleveland Clinic) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Cognitive dysfunction, including slowed cognitive processing speed (CPS), is one of the most disabling symptoms of multiple sclerosis (MS). The Symbol Digit Modalities Test (SDMT) is a preferred measure of CPS for MS trials and routine screening. [...]
2021 - 10.1016/j.msard.2020.102673
Multiple Sclerosis and Related Disorders, Vol. 48 (2021) , p. 102673
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24 p, 266.9 KB |
Teaching as affective labour in a datafied world : a scoping review of the relationship between performance-based accountability and teachers' emotions
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Camphuijsen, Marjolein (Vrije Universiteit Amsterdam) ;
Levatino, Antonina (Universitat Autònoma de Barcelona. Departament de Sociologia) ;
Mentini, Laura (Universitat Autònoma de Barcelona. Departament de Sociologia) ;
Parcerisa, Lluís (Universitat de Barcelona)
Research has shown that in many contexts, the transformation of the public sector associated with new public management (NPM) reforms and performance-based accountability (PBA) has had profound implications for public sector workers' practices, identities and emotional experiences. [...]
La investigación han demostrado que, en muchos contextos, la transformación del sector público asociada con las reformas de la nueva gestión pública (NPM) y la rendición de cuentas basada en el desempeño (PBA) ha tenido profundas implicaciones para las prácticas, identidades y experiencias emocionales de los trabajadores del sector público. [...]
2022 - 10.14516/fde.1023
Foro de educación, Vol. 20 Núm. 2 (2022) , p. 61-84
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12 p, 2.0 MB |
A multicentre validation study of the diagnostic value of plasma neurofilament light
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Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health (Londres, Regne Unit)) ;
Janelidze, Shorena (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ;
Al Khleifat, Ahmad (Department of Basic and Clinical Neuroscience. Maurice Wohl Clinical Neuroscience Institute. King's College London) ;
Leuzy, Antoine (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ;
van der Ende, Emma L. (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ;
Karikari, Thomas K (Department of Psychiatry and Neurochemistry. Institute of Neuroscience & Physiology. The Sahlgrenska Academy at the University of Gothenburg) ;
Benedet, AndreaL. (Montreal Neurological Institute) ;
Pascoal, Tharick A. (Montreal Neurological Institute) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Parnetti, Lucilla (Laboratory of Clinical Neurochemistry. Neurology Clinic. University of Perugia) ;
Galimberti, Daniela (University of Milan) ;
Bonanni, Laura (Department of Neuroscience. Imaging and Clinical Sciences. University G.d'Annunzio of Chieti-Pescara) ;
Pilotto, Andrea (Parkinson's Disease Rehabilitation Centre. FERB ONLUS) ;
Padovani, Alessandro (Neurology Unit. Department of Clinical and Experimental Sciences. University of Brescia) ;
Lycke, Jan (Sahlgrenska University Hospital (Suècia)) ;
Novakova, Lenka (Sahlgrenska University Hospital (Suècia)) ;
Axelsson, Markus (Sahlgrenska University Hospital (Suècia)) ;
Velayudhan, Latha (Department of Health Sciences. University of Leicester) ;
Rabinovici, Gil D. (Department of Radiology & Biomedical Imaging. University of California) ;
Miller, Bruce L. (University of California San Francisco. Memory and Aging Center) ;
Pariante, Carmine M (Stress. Psychiatry and Immunology Lab & Perinatal Psychiatry. Maurice Wohl Clinical Neuroscience Institute. King's College London) ;
Nikkheslat, Naghmeh (King's College London (Regne Unit)) ;
Resnick, Susan M. (Brain Aging and Behavior Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ;
Thambisetty, Madhav (Clinical and Translational Neuroscience Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ;
Schöll, Michael (Department of Neurodegenerative Disease. Queen Square Institute of Neurology. University College London) ;
Fernández-Eulate, Gorka (Department of Neurology. Donostia University Hospital. Osakidetza) ;
Gil-Bea, Francisco J. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
López de Munain, Adolfo (Universidad del País Vasco. Departamento de Neurociencias) ;
Al-Chalabi, Ammar (King's College Hospital NHS Foundation Trust) ;
Rosa-Neto, Pedro (Montreal Neurological Institute) ;
Strydom, Andre (London Down Syndrome Consortium (LonDowns)) ;
Svenningsson, Per (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Stomrud, Erik (Skåne University Hospital (Suècia)) ;
Santillo, Alexander (Lund University. Department of Clinical Sciences Malmö) ;
Aarsland, Dag (Stavanger University Hospital) ;
van Swieten, John C. (Erasmus University Medical Center) ;
Palmqvist, Sebastian (Lund University. Skåne University Hospital) ;
Zetterberg, Henrik (University College London. UK Dementia Research Institute) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Hye, Abdul (Stavanger University Hospital) ;
Hansson, Oskar (Skåne University Hospital (Suècia))
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). [...]
2021 - 10.1038/s41467-021-23620-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 3400
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14 p, 3.9 MB |
Combined analysis of miR-200 family and its significance for breast cancer
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Fontana, Andrea (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Barbano, Raffaela (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Dama, Elisa (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Pasculli, Barbara (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Rendina, Michelina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Morritti, Maria Grazia (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Melocchi, Valentina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Castelvetere, Marina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Valori, Vanna Maria (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Ravaioli, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS) ;
Bravaccini, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS) ;
Ciuffreda, Luigi (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Graziano, Paolo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Maiello, Evaristo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Copetti, Massimiliano (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Fazio, Vito Michele (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bianchi, Fabrizio (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Parrella, Paola (Fondazione IRCCS Casa Sollievo della Sofferenza)
While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. [...]
2021 - 10.1038/s41598-021-82286-1
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 2980
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