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18 p, 2.5 MB |
Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator
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Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
González-Larreategui, Íñigo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Figa-Martín, Neus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barallat, Jaume (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fondelli, Federico (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sellés-Rius, Ares (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Teniente Serra, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The use of autologous tolerogenic dendritic cells (tolDC) has become a promising strategy to re-establish immune tolerance in autoimmune diseases. Among the different strategies available, the use of vitamin D3 for the generation of tolDC (VitD3-tolDC) has been widely tested because of their immune regulatory properties. [...]
2021 -  10.3390/ijms22147363
International journal of molecular sciences, Vol. 22, Num. 14 (July 2021) , art. 7363
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14 p, 1.3 MB |
Vitamin D3-Induced Tolerogenic Dendritic Cells Modulate the Transcriptomic Profile of T CD4 + Cells Towards a Functional Hyporesponsiveness
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Navarro-Barriuso, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Teniente Serra, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Cáceres, Eva M. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The use of autologous tolerogenic dendritic cells (tolDC) has become a promising alternative for the treatment of autoimmune diseases. Among the different strategies available, the use of vitamin D3 for the generation of tolDC (vitD3-tolDC) constitutes one of the most robust approaches due to their immune regulatory properties, which are currently being tested in clinical trials. [...]
2021 - 10.3389/fimmu.2020.599623
Frontiers in immunology, Vol. 11 (january 2021)
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14 p, 1.9 MB |
MAP7 and MUCL1 are biomarkers of Vitamin D3-induced tolerogenic dendritic cells in multiple sclerosis patients
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Navarro-Barriuso, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ardiaca-Martínez, Alicia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Teniente Serra, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Presas-Rodríguez, Silvia (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ten Brinke, Anja (Amsterdam UMC. University Medical Center) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The administration of autologous tolerogenic dendritic cells (tolDC) has become a promising alternative for the treatment of autoimmune diseases, such as multiple sclerosis (MS). Specifically, the use of vitamin D3 for the generation of tolDC (vitD3-tolDC) constitutes one of the most widely studied approaches, as it has evidenced significant immune regulatory properties, both in vitro and in vivo. [...]
2019 - 10.3389/fimmu.2019.01251
Frontiers in immunology, Vol. 10 (June 2019) , art. 1251
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20 p, 3.2 MB |
Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA
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Derdelinckx, Judith (University Hospital Antwerp (Bèlgica)) ;
Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
De Laere, Maxime (University of Antwerp. Laboratory of Experimental Hematology) ;
Lee, Wai-Ping (University Hospital Antwerp (Bèlgica)) ;
Navarro-Barriuso, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Wens, Inez (University of Antwerp. Laboratory of Experimental Hematology) ;
Nkansah, Irene (University of Antwerp. Laboratory of Experimental Hematology) ;
Daans, Jasmijn (University of Antwerp. Laboratory of Experimental Hematology) ;
De Reu, Hans (University of Antwerp. Laboratory of Experimental Hematology) ;
Jolanta Keliris, Aneta (University of Antwerp. Bio-Imaging Lab) ;
Van Audekerke, Johan (University of Antwerp. Bio-Imaging Lab) ;
Vanreusel, Verdi (University of Antwerp. Bio-Imaging Lab) ;
Pieters, Zoë (University of Antwerp. Laboratory of Experimental Hematology) ;
Van Der Linden, Annemie (University of Antwerp. Bio-Imaging Lab) ;
Verhoye, Maraleen (University of Antwerp. Bio-Imaging Lab) ;
Molenberghs, Geert (L-BioStat. I-BioStat. KU Leuven) ;
Hens, Niel (University of Antwerp. Centre for Health Economics Research and Modelling Infectious Diseases) ;
Goossens, Herman (University of Antwerp. Laboratory of Medical Microbiology) ;
Willekens, Barbara (University Hospital Antwerp (Bèlgica)) ;
Cras, Patrick (University of Antwerp. Born Bunge Institute) ;
Ponsaerts, Peter (University of Antwerp. Laboratory of Experimental Hematology) ;
Berneman, Zwi (University Hospital Antwerp (Bèlgica)) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cools, Nathalie (University Hospital Antwerp (Bèlgica))
Background: Although effective in reducing relapse rate and delaying progression, current therapies for multiple sclerosis (MS) do not completely halt disease progression. T cell autoimmunity to myelin antigens is considered one of the main mechanisms driving MS. [...]
2019 - 10.1186/s12974-019-1541-1
Journal of neuroinflammation, Vol. 16 (August 2019) , art. 167
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14 p, 516.6 KB |
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies
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Lord, Phillip (Newcastle University. School of Computing Science) ;
Spiering, Rachel (Newcastle University. Institute of Cellular Medicine) ;
Aguillon, Juan C. (Universidad de Chile. Instituto de Ciencias Biomédicas (ICBM)) ;
Anderson, Amy E. (Newcastle University. Institute of Cellular Medicine) ;
Appel, Silke (University of Bergen. Broegelmann Research Laboratory) ;
Benítez Ribas, Daniel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Brinke, Anja ten (Sanquin Research (Amsterdam)) ;
Broere, Femke (Utrecht University) ;
Cools, Nathalie (University of Antwerp. Vaccine & Infectious Disease Institute) ;
Cuturi, Maria Cristina (Center for Research in Transplantation and Immunology (Nantes, França)) ;
Diboll, Julie (Newcastle University. Institute of Cellular Medicine) ;
Geissler, Edward K. (University Hospital Regensburg. Department of Surgery) ;
Giannoukakis, Nick (Institute of Cellular Therapeutics (Pittsburgh, Estats Units d'Amèrica)) ;
Gregori, Silvia (San Raffaele Telethon Institute for Gene Therapy (Milà, Itàlia)) ;
Ham, S. Marieke van (Sanquin Research (Amsterdam)) ;
Lattimer, Staci (Newcastle University. School of Computing Science) ;
Marshall, Lindsay (Newcastle University. School of Computing Science) ;
Harry, Rachel A. (Newcastle University. Institute of Cellular Medicine) ;
Hutchinson, James A. (University Hospital Regensburg. Department of Surgery) ;
Isaacs, John D. (Newcastle University. Institute of Cellular Medicine) ;
Joosten, Irma (Radboud University Medical Centre) ;
Kooten, Cees van (Leiden University Medical Centre) ;
López Díaz de Cerio, Ascensión (Clínica Universidad de Navarra) ;
Nikolic, Tatjana (Leiden University Medical Centre) ;
Oral, Haluk Barbaros (Uludag University. Faculty of Medicine) ;
Sofronic Milosavljevic, Ljiljana (University of Belgrade. Institute for the Application of Nuclear Energy) ;
Ritter, Thomas (National University of Ireland) ;
Riquelme, Paloma (University Hospital Regensburg. Department of Surgery) ;
Thomson, Angus W. (University of Pittsburgh School of Medicine) ;
Trucco, Massimo (Institute of Cellular Therapeutics (Pittsburgh, Estats Units d'Amèrica)) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hilkens, Catharien M. U. (Newcastle University. Institute of Cellular Medicine)
Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. [...]
2016 - 10.7717/peerj.2300
PeerJ, Vol. 4 (August 2016) , p. e2300
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11 p, 1.5 MB |
Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients
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Mansilla Lopez, Maria Jose (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Contreras-Cardone, Raian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cools, Nathalie (University of Antwerp. Vaccine & Infectious Disease Institute) ;
Berneman, Zwi (University of Antwerp. Vaccine & Infectious Disease Institute) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
BACKGROUND: Tolerogenic dendritic cells (tolDC) have been postulated as a potent immunoregulatory therapy for autoimmune diseases such as multiple sclerosis (MS). In a previous study, we demonstrated that the administration of antigen-specific vitamin D3 (vitD3) tolDC in mice showing clinical signs of experimental autoimmune encephalomyelitis (EAE; the animal model of MS) resulted in abrogation of disease progression. [...]
2016 - 10.1186/s12974-016-0584-9
Journal of neuroinflammation, Vol. 13, No. 113 (May 2016)
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