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16 p, 2.1 MB |
Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies : a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology
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Grávalos, Cristina (Hospital Universitario 12 de Octubre (Madrid)) ;
Sanmartín, O. (Fundació Institut Valencià d'Oncologia) ;
Gúrpide, A. (Clínica Universidad de Navarra) ;
España, A. (Clínica Universidad de Navarra) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Suh Oh, H.J. (Complejo Hospitalario Universitario de Pontevedra) ;
Aragón, I. (Complejo Hospitalario Universitario de Huelva) ;
Segura, S. (Hospital del Mar (Barcelona, Catalunya)) ;
Beato, C. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Botella, R. (Instituto de Investigación Sanitaria La Fe) ;
Universitat Autònoma de Barcelona
Progress in the understanding of many tumors has enabled the development of new therapies, such as those targeted at specific molecules involved in cell growth (targeted therapies) or intended to modulate the immune system (immunotherapy). [...]
2019 - 10.1007/s12094-018-1953-x
Clinical & Translational Oncology, Vol. 21 Núm. 5 (january 2019) , p. 556-571
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7 p, 468.8 KB |
ABCB1 Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients
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Riera, Pau (Institut d'Investigació Biomèdica Sant Pau) ;
Artigas-Baleri, Alícia (Institut d'Investigació Biomèdica Sant Pau) ;
Salazar, Juliana (Institut d'Investigació Biomèdica Sant Pau) ;
Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Virgili Manrique, Anna Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Arranz, M.J. (Fundació Docència i Investigació Mútua Terrassa) ;
Páez, D. (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. [...]
2020 - 10.3389/fphar.2020.00973
Frontiers in Pharmacology, Vol. 11 (30 2020) , p. 973
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10 p, 1.1 MB |
SEOM clinical guideline for the management of immune-related adverse events in patients treated with immune checkpoint inhibitors (2019)
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Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
García-Martínez, E. (Hospital Universitario Morales Meseguer) ;
Martinez, M. (Hospital del Mar (Barcelona, Catalunya)) ;
Muñoz Couselo, Eva (Vall d'Hebron Institut d'Oncologia) ;
Rodriguez-Abreu, D. (C.H.U. Insular-Materno Infantil de Gran Canaria) ;
Alvarez, R. (Hospital Virgen de la Salud (Toledo)) ;
Arance, Ana (Hospital Clínic i Provincial de Barcelona) ;
Berrocal, A. (Hospital General Universitario de Valencia) ;
de la Cruz Merino, Luis (Universidad de Sevilla) ;
Lopez-Martin, Jose A (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Universitat Autònoma de Barcelona
The use of immune checkpoint inhibitors has emerged as an effective treatment option for patients with several tumor types. By increasing the activity of the immune system, they can induce inflammatory side effects, which are often termed immune-related adverse events. [...]
2020 - 10.1007/s12094-019-02273-x
Clinical & Translational Oncology, Vol. 22 Núm. 2 (january 2020) , p. 213-222
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13 p, 4.5 MB |
Bees exposed to climate change are more sensitive to pesticides
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Albacete, Sergio (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Sancho Blanco, Gonzalo (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Azpiazu, Celeste (Universitat Autònoma de Barcelona) ;
Rodrigo Domínguez, Anselm (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Molowny-Horas, Roberto (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Sgolastra, Fabio (Alma Mater Studiorum Università di Bologna. Dipartimento di Scienze e Tecnologie Agro-Alimentari) ;
Bosch, Jordi 1961- (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Bee populations are exposed to multiple stressors, including land-use change, biological invasions, climate change, and pesticide exposure, that may interact synergistically. We analyze the combined effects of climate warming and sublethal insecticide exposure in the solitary bee Osmia cornuta. [...]
2023 - 10.1111/gcb.16928
Global change biology, Vol. 29, Issue 22 (November 2023) , p. 6157-6433
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7 p, 264.1 KB |
European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment
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Lee, G.A. (Division of Applied Technology for Clinical Care. Florence Nightingale Faculty of Nursing. Midwifery & Palliative Care. King's College London) ;
Aktaa, S. (Department of Cardiology. Leeds Teaching Hospitals NHS Trust) ;
Baker, E. (Division of Applied Technology for Clinical Care. Florence Nightingale Faculty of Nursing. Midwifery & Palliative Care. King's College London) ;
Gale, C.P. (Department of Cardiology. Leeds Teaching Hospitals NHS Trust) ;
Yaseen, I.F. (Scientific Council of Cardiology. Iraqi Board for Medical Specializations) ;
Gulati, G. (Oslo University Hospital (Oslo, Noruega)) ;
Asteggiano, R. (LARC (Laboratorio Analisi e Ricerca Clinica)) ;
Szmit, S. (Institute of Hematology and Transfusion Medicine) ;
Cohen-Solal, A. (Cardiology Department. Hôpitaux de Paris. Hôpital Lariboisière 2 Rue Ambroise Paré) ;
Abdin, A. (Department of Internal Medicine III. Cardiology. Angiology. Intensive Care Medicine. Saarland University Medical Center) ;
Jurczak, W. (MSC National Research Institute of Oncology) ;
Garrido, Pilar (Jefe Servicio Oncología Médica. Hospital Ramón y Cajal) ;
Sverdlov, A.L. (Newcastle Centre of Excellence in Cardio-Oncology. Calvary Mater Newcastle. Hunter Medical Research Institute. John Hunter Hospital. University of Newcastle) ;
Tocchetti, C.G. (Cardio-Oncology Unit. Department of Translational Medical Sciences (DISMET). Center for Basic and Clinical Immunology Research (CISI). Interdepartmental Center for Clinical and Translational Research (CIRCET). Interdepartmental Hypertension Research Center (CIRIAPA). Federico II University) ;
Barac, A. (Cardio-oncology Program. MedStar Heart and Vascular Institute) ;
Parrini, I. (Department of Cardiology. Mauriziano Hospital) ;
Zamorano, P. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Iakobishvili, Z. (Faculty of Health Sciences. Ben Gurion University of the Negev) ;
Pudil, R. (University Hospital Hradec Králové. Sokolská) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Kirby, A.M. (Royal Marsden NHS Trust. Institute of Cancer Research) ;
Blaes, A.H. (Division of Hematology/Oncology/Transplantation. University of Minnesota) ;
Farmakis, D. (University of Cyprus Medical School) ;
Curigliano, Giuseppe (IRCCS. European Institute of Oncology) ;
Stephens, R. (Patient Advocate) ;
Lyon, A.R. (National Heart and Lung Institute. Imperial College London. Cardio-Oncology Service. Royal Brompton Hospital) ;
Lopez-Fernandez, T. (Hospital Universitario La Paz. Instituto de Investigación IdiPAZ. Servicio de Cardiología)
Aims To develop quality indicators (QIs) for the evaluation of the prevention and management of cancer therapy-related cardiovascular toxicity. Methods and results We followed the European Society of Cardiology (ESC) methodology for QI development which comprises (i) identifying the key domains of care for the prevention and management of cancer therapy-related cardiovascular toxicity in patients on cancer treatment, (ii) performing a systematic review of the literature to develop candidate QIs, and (iii) selecting of the final set of QIs using a modified Delphi process. [...]
2023 - 10.1093/ehjqcco/qcac070
European Heart Journal - Quality of Care and Clinical Outcomes, Vol. 9 Núm. 1 (january 2023) , p. 1-7
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18 p, 1.2 MB |
A new critical social science research agenda on pesticides
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Mansfield, Becky (Ohio State University) ;
Werner, Marion (University at Buffalo) ;
Berndt, Christian (University of Zurich) ;
Shattuck, Annie (Indiana University Bloomington) ;
Galt, Ryan (University of California at Davis) ;
Williams, Bryan (Mississippi State University) ;
Argüelles, Lucía (Universitat Oberta de Catalunya) ;
Barri, Fernando Rafael (Universidad Nacional de Córdoba) ;
Ishii, Marcia (Pesticide Action Network North America) ;
Kunin, Johana (Consejo Nacional de Investigaciones Científicas y Técnicas) ;
Lapegna, Pablo (University of Georgia) ;
Romero, Adam (University of Washington) ;
Caicedo, Andres (University of California, Berkeley (UC Berkeley)) ;
Abhigya (Indian Institute of Technology Delhi) ;
Castro-Vargas, María Soledad (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Marquez, Emily (Pesticide Action Network North America) ;
Ojeda, Diana (University of The Andes, Colombia (UniAndes)) ;
Ramirez, Fernando (University of Costa Rica) ;
Tittor, Anne (University of Jena)
The global pesticide complex has transformed over the past two decades, but social science research has not kept pace. The rise of an enormous generics sector, shifts in geographies of pesticide production, and dynamics of agrarian change have led to more pesticide use, expanding to farm systems that hitherto used few such inputs. [...]
2023 - 10.1007/s10460-023-10492-w
Agriculture and Human Values, (August 2023)
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