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12 p, 1.9 MB |
Selenite downregulates STAT3 expression and provokes lymphocytosis in the liver of chronically exposed Syrian golden hamsters
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Camacho Moll, Maria Elena (Centro de Investigación Biomédica del Noreste (Nuevo León, Mèxic)) ;
Sampayo-Reyes, Adriana (Universidad Autónoma de Nuevo León. Facultad de Ciencias Biológicas) ;
Castorena-Torres, Fabiola (Tecnológico de Monterrey. Escuela de Medicina) ;
Lozano-Garza, Gerardo (Centro de Investigación Biomédica del Noreste (Nuevo León, Mèxic)) ;
Alarcón-Galván, Gabriela (Universidad de Monterrey. Departamento de Ciencias Básicas) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Alcocer-González, Juan (Universidad Autónoma de Nuevo León. Facultad de Ciencias Biológicas) ;
Tamez-Guerra, Reyes (Universidad Autónoma de Nuevo León. Facultad de Ciencias Biológicas) ;
León, Mario Bermúdez de (Centro de Investigación Biomédica del Noreste (Nuevo León, Mèxic))
Arsenic is considered a worldwide pollutant that can be present in drinking water. Arsenic exposure is associated with various diseases, including cancer. Antioxidants as selenite and α-tocopherol-succinate have been shown to modulate arsenic toxic effects. [...]
2021 -  10.3390/molecules26185614
Molecules, Vol. 26, issue 18 (Sep. 2021) , art. 5614
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16 p, 2.7 MB |
Treatment with the delta opioid agonist UFP-512 alleviates chronic inflammatory and neuropathic pain : Mechanisms implicated
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Polo, S. (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz, Andrés Felipe (Institut d'Investigació Biomèdica Sant Pau) ;
Gallardo, Núria (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leánez, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Balboni, G. (Department of Life and Environmental Sciences. Unit of Pharmaceutical. Pharmacological and Nutraceutical Sciences. University of Cagliari) ;
Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associated with persistent neuropathic pain. [...]
2019 - 10.3389/fphar.2019.00283
Frontiers in Pharmacology, Vol. 10 Núm. MAR (2019) , p. 283
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15 p, 4.6 MB |
Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
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Zarei, Mohammad (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Barroso, Emma (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Palomer, Xavier (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Dai, Jianli (University of the Chinese Academy of Sciences. Institute for Nutritional Sciences. Key Laboratory of Nutrition and Metabolism) ;
Rada, Patricia (Instituto de Salud Carlos III. Centro de Investigación Biomédica en Red) ;
Quesada-López, Tania (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Escola-Gil, Joan Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cedó, Lidia (Institut d'Investigació Biomèdica Sant Pau) ;
Zali, Mohammad Reza (Shahid Beheshti University of Medical Sciences. Research Institute for Gastroenterology and Liver Diseases) ;
Molaei, Mahsa (Shahid Beheshti University of Medical Sciences. Research Institute for Gastroenterology and Liver Diseases) ;
Dabiri, Reza (Semnan University of Medical Sciences. lnternal Medicine Department) ;
Vázquez Cruz, Santiago (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Pujol, Eugènia (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Valverde, Ángela M. (nstituto de Investigaciones Biomédicas "Alberto Sols") ;
Villarroya, Francesc (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Liu, Yong (Wuhan University. Institute for Advanced Studies) ;
Wahli, Walter (Nanyang Technological University. Lee Kong Chian School of Medicine) ;
Vázquez-Carrera, Manuel (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Universitat Autònoma de Barcelona
The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated the role of Peroxisome Proliferator-Activated Receptor (PPAR)β/δ and fibroblast growth factor 21 (FGF21) in hepatic VLDLR regulation. [...]
2018 - 10.1016/j.molmet.2017.12.008
Molecular metabolism, Vol. 8 (Feb. 2018) , p. 117-131
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8 p, 1.1 MB |
Expression of REG family genes in human inflammatory bowel diseases and its regulation
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Tsuchida, Chikatsugu (Saiseikai Nara Hospital, Japan) ;
Sakuramoto-Tsuchida, Sumiyo (Department of Biochemistry, Nara Medical University) ;
Taked, Maiko (Department of Laboratory Medicine and Pathology, National Hospital Organization Kinki-chuo Chest Medical Center) ;
Itaya-Hironaka, Asako (Department of Biochemistry, Nara Medical University) ;
Yamauchi, Akiyo (Department of Biochemistry, Nara Medical University) ;
Misu, Masayasu (Department of Biochemistry, Nara Medical University) ;
Shobatake, Ryogo (Department of Biochemistry, Nara Medical University) ;
Uchiyama, Tomoko (Department of Diagnostic Pathology, Nara Medical University) ;
Makino, Mai (Department of Biochemistry, Nara Medical University) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ohbayashi, Chiho (Department of Diagnostic Pathology, Nara Medical University) ;
Takasawa, Shin (Department of Biochemistry, Nara Medical University)
The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn's disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. [...]
2017 - 10.1016/j.bbrep.2017.10.003
Biochemistry and Biophysics Reports, Vol. 12 (october 2017) , p. 198-205
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18 p, 2.2 MB |
Aberrant epigenome in -derived dopaminergic neurons from Parkinson's disease patients
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Fernández-Santiago, Rubén (Universitat de Barcelona) ;
Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castellano, Giancarlo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Torrent, Roger (Universitat de Barcelona. Institut de Biomedicina) ;
Richaud, Yvonne (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Sánchez-Danés, Adriana (Universitat de Barcelona. Institut de Biomedicina) ;
Vilarrasa-Blasi, Roser (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sánchez-Pla, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mosquera, José Luis (Universitat de Barcelona) ;
Soriano, Jordi (Universitat de Barcelona) ;
López-Barneo, José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Canals, Josep M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alberch i Vié, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ;
Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Consiglio, Antonella (University of Brescia and National Institute of Neuroscience) ;
Martín-Subero, José I (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ezquerra, Mario (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tolosa, Eduardo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
The epigenomic landscape of Parkinson's disease () remains unknown. We performed a genomewide methylation and a transcriptome studies in induced pluripotent stem cell ()-derived dopaminergic neurons (n) generated by cell reprogramming of somatic skin cells from patients with monogenic 2-associated (L2) or sporadic (), and healthy subjects. [...]
2015 - 10.15252/emmm.201505439
EMBO Molecular Medicine, Vol. 7, Núm. 12 (October 2015) , p. 1529-1546
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11 p, 2.1 MB |
Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle
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Cardoso, Tainã Figueiredo (Centre de Recerca en Agrigenòmica) ;
Quintanilla, Raquel (Institut de Recerca i Tecnologia Agroalimentàries) ;
Tibau, Joan (Institut de Recerca i Tecnologia Agroalimentàries) ;
Gil, Marta (Institut de Recerca i Tecnologia Agroalimentàries) ;
Mármol-Sánchez, Emilio (Centre de Recerca en Agrigenòmica) ;
González-Rodríguez, Olga (Capes Foundation) ;
González Prendes, Rayner (Centre de Recerca en Agrigenòmica) ;
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica)
Background: The genetic basis of muscle fat deposition in pigs is not well known. So far, we have only identified a limited number of genes involved in the absorption, transport, storage and catabolism of lipids. [...]
2017 - 10.1186/s12864-017-3986-x
BMC genomics, Vol. 18 (Aug. 2017) , art. 603
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66 p, 4.7 MB |
ETHQV6.3 is involved in melon climacteric fruit ripening and is encoded by a NAC domain transcription factor
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Ríos Rodríguez, Pablo (Centre de Recerca en Agrigenòmica) ;
Argyris, Jason (Centre de Recerca en Agrigenòmica) ;
Vegas Renedo, Juan (Centre de Recerca en Agrigenòmica) ;
Leida, Carmen (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya)) ;
Kenigswald, Merav (Minhal ha-meḥḳar ha-ḥaḳlaʼi (Israel)) ;
Tzuri, Galil (Minhal ha-meḥḳar ha-ḥaḳlaʼi (Israel)) ;
Troadec,Christelle (Institute of Plant Sciences Paris-Saclay) ;
Bendahmane, Abdelhafid (Institute of Plant Sciences Paris-Saclay) ;
Katzir, Nurit (Minhal ha-meḥḳar ha-ḥaḳlaʼi (Israel)) ;
Picó, Belén (Centro de Conservación y Mejora de la Agrodiversidad Valenciana) ;
Monforte, Antonio J. (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya)) ;
Garcia-Mas, Jordi (Centre de Recerca en Agrigenòmica)
Fruit ripening is divided into climacteric and non-climacteric types depending on the presence or absence of a transient rise in respiration rate and the production of autocatalytic ethylene. Melon is ideal for the study of fruit ripening, as both climacteric and non-climacteric varieties exist. [...]
2017 - 10.1111/tpj.13596
Plant journal, Vol. 91, issue 4 (Aug. 2017) , p. 671-683
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15 p, 1.6 MB |
From SNP co-association to RNA co-expression : novel insights into gene networks for intramuscular fatty acid composition in porcine
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Ramayo-Caldas, Yuliaxis (Centre de Recerca en Agrigenòmica) ;
Ballester Devis, Maria (Centre de Recerca en Agrigenòmica) ;
Fortes, Marina R. S. (The University of Queensland. Center for Animal Science) ;
Esteve-Codina, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Castelló Farré, Anna (Centre de Recerca en Agrigenòmica) ;
Noguera Jiménez, José Luis (Institut de Recerca i Tecnologia Agroalimentàries) ;
Fernández Ávila, Ana Isabel (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria) ;
Perez-Enciso, Miguel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Reverter, Antonio (Commonwealth Scientific and Industrial Research Organisation. Division of Animal, Food and Health Sciences) ;
Folch, Josep M (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Background: Fatty acids (FA) play a critical role in energy homeostasis and metabolic diseases; in the context of livestock species, their profile also impacts on meat quality for healthy human consumption. [...]
2014 - 10.1186/1471-2164-15-232
BMC genomics, Vol. 15 N. 232 (March 2014) , p. 1-15
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