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1.
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4 p, 185.6 KB |
Real-time quantitative PCR-based system for determining transgene copy number in transgenic animals
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Ballester Devis, Maria (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Castelló Farré, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Ibáñez, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Folch, Josep M. (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
In this paper, we describe a rapid and accurate real-time quantitative PCR-based system to determine transgene copy number in transgenic animals. We used the 2 method to analyze different transgenic lines without the requirement of a control sample previously determined by Southern blot analysis. [...]
2004 -  10.2144/04374st06
BioTechniques, Vol. 37 Núm. 4 (october 2004) , p. 610-613
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2.
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14 p, 7.4 MB |
Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice
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Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
López-Figueroa, Carlos (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Rodon, Jordi (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Pérez, Mónica (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Brustolin, Marco (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Cantero, Guillermo (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Guallar, Victor (Institució Catalana de Recerca i Estudis Avançats) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Clotet Sala, Bonaventura (Universitat de Vic - Universitat Central de Catalunya) ;
Vergara-Alert, Júlia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes respiratory disease, but it can also affect other organs including the central nervous system. Several animal models have been developed to address different key questions related to Coronavirus Disease 2019 (COVID-19). [...]
2021 - 10.1177/03009858211066841
Veterinary Pathology, Vol. 59 (december 2021) , p. 613-626
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3.
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18 p, 28.9 MB |
Evidence of p75 Neurotrophin Receptor Involvement in the Central Nervous System Pathogenesis of Classical Scrapie in Sheep and a Transgenic Mouse Model
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Barrio, Tomás (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes) ;
Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Betancor, Marina (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes) ;
Otero García, Alicia (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes) ;
Martín-Burriel, Inmaculada (Instituto Agroalimentario de Aragón. Laboratorio de Genética Bioquímica) ;
Monzón, Marta (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes) ;
Monleón, Eva (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes) ;
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Badiola, Juan José (Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes)
Neurotrophins constitute a group of growth factor that exerts important functions in the nervous system of vertebrates. They act through two classes of transmembrane receptors: tyrosine-kinase receptors and the p75 neurotrophin receptor (p75 NTR). [...]
2021 - 10.3390/ijms22052714
International journal of molecular sciences, Vol. 22 (march 2021)
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4.
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8 p, 4.7 MB |
Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract
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Peng, Guotao (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine) ;
Montenegro, Marcelo F. (Karolinska Institutet (Estocolm, Suècia). Department of Physiology and Pharmacology) ;
Ntola, Chifundo N. M. (University of Manchester. National Graphene Institute) ;
Vranic, Sandra (University of Manchester. National Graphene Institute) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Vogt, Carmen (Kungl. Tekniska högskolan (Estocolm (Suècia)) ;
Toprak, Muhammet S. (Kungl. Tekniska högskolan (Estocolm (Suècia)) ;
Duan, Tianbo (Uppsala University. Department of Engineering Sciences) ;
Leifer, Klaus (Uppsala University. Department of Engineering Sciences) ;
Bräutigam, Lars (Karolinska Institutet (Estocolm, Suècia)) ;
Lundberg, Jon O. (Karolinska Institutet (Estocolm, Suècia). Department of Physiology and Pharmacology) ;
Fadeel, Bengt (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine)
Understanding the biological fate of graphene-based materials such as graphene oxide (GO) is crucial to assess adverse effects following intentional or inadvertent exposure. Here we provide first evidence of biodegradation of GO in the gastrointestinal tract using zebrafish as a model. [...]
2020 - 10.1039/d0nr03675g
Nanoscale, Vol. 12, Issue 32 (August 2020) , p. 16730-16737
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5.
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13 p, 1.1 MB |
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
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Sant'Anna, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gallego Alonso, Pablo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Robinson, Lei Z. (Scripps Research Institute) ;
Pereira-Henriques, Alda (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ;
Ferreira, Nelson (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Esperante, Sebastián (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Huertas, Oscar (SOM-Biotech) ;
Almeida, Maria Rosário (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ;
Reixach, Natàlia (Scripps Research Institute) ;
Insa, Raul (SOM-Biotech) ;
Velazquez-Campoy, Adrián (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ;
Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Reig, Núria (SOM-Biotech) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. [...]
2016 - 10.1038/ncomms10787
Nature communications, Vol. 7 (2016) , art. 10787
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6.
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12 p, 7.0 MB |
ATR is a multifunctional regulator of male mouse meiosis
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Widger, Alexander (The Francis Crick Institute) ;
Mahadevaiah, Shantha K. (Francis Crick Institute) ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Elinati, Elias (The Francis Crick Institute) ;
Zohren, Jasmin (The Francis Crick Institute) ;
Hirota, Takayuki (The Francis Crick Institute) ;
Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Stanzione, Marcello (TU Dresden. Faculty of Medicine) ;
Ojarikre, Obah (The Francis Crick Institute) ;
Maciulyte, Valdone (The Francis Crick Institute) ;
De Rooij, Dirk G.. (University of Amsterdam. Center for Reproductive Medicine) ;
Tóth, Attila (TU Dresden. Faculty of Medicine) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Turner, James M. A. (Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. [...]
2018 - 10.1038/s41467-018-04850-0
Nature communications, Vol. 9 (2018) , art. 2621
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7.
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33 p, 2.7 MB |
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
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Eraña, Hasier (ATLAS Molecular Pharma S. L.) ;
Charco, Jorge M. (CIC bioGUNE) ;
Di Bari, Michele Angelo (CIC bioGUNE) ;
Díaz-Domínguez, Carlos M. (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
López-Moreno, R. (CIC bioGUNE) ;
Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
González-Miranda, E. (CIC bioGUNE) ;
Pérez-Castro, Miguel A. (CIC bioGUNE) ;
García-Martínez, Sandra (ATLAS Molecular Pharma S. L.) ;
Bravo Lopez, Susana Belén (Proteomics Lab. IDIS) ;
Fernández-Borges, Natalia (CIC bioGUNE) ;
Geijo, Maria V. (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
D'Agostino, C. (Department of Veterinary Public Health and Food Safety. Istituto Superiore di Sanità) ;
Garrido, Joseba M (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
Bian, J. (Colorado State University. Prion Research Center (PRC).) ;
König, A. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Uluca-Yazgi, B. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Sabate, R. (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ;
Khaychuk, V. (Colorado State University. Prion Research Center (PRC).) ;
Vanni, Ilaria (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
Telling, G. C. (Colorado State University. Prion Research Center (PRC).) ;
Heise, Henrike (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Nonno, Romolo (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
Requena, Jesús R (Universidade de Santiago de Compostela) ;
Castilla, Joaquín (IKERBasque. Basque Foundation for Science)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of these proteinaceous pathogens. [...]
2019 - 10.1371/journal.ppat.1008117
PLOS pathogens, Vol. 15 Núm. 10 (2019) , p. e1008117
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8.
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19 p, 6.1 MB |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis
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Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Romero-Giménez, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cuadros, Thais (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Parent, Annabelle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González Sepúlveda, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peñuelas, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torra, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Galván, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ballabio, Andrea (Telethon Institute of Genetics and Medicine (TIGEM)) ;
Hasegawa, Takafumi (Department of Neurology. Tohoku University School of Medicin) ;
Bortolozzi, Analía (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gelpi, Ellen (Institute of Neurology. Medical University of Vienna) ;
Vila Bover, Miquel (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
2019 - 10.1038/s41467-019-08858-y
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 973
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9.
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11 p, 5.0 MB |
B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes
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Egia-Mendikute, Leire (Institut de Recerca Biomèdica de Lleida) ;
Arpa, Berta (Institut de Recerca Biomèdica de Lleida) ;
Rosell-Mases, Estela (Institut de Recerca Biomèdica de Lleida) ;
Corral-Pujol, Marta (Institut de Recerca Biomèdica de Lleida) ;
Carrascal, Jorge (Institut de Recerca Biomèdica de Lleida) ;
Carrillo, Jorge (Institut de Recerca Biomèdica de Lleida) ;
Mora, Conchi (Institut de Recerca Biomèdica de Lleida) ;
Chapman, Harold (Jackson Laboratory) ;
Panosa, Anaïs (Institut de Recerca Biomèdica de Lleida) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stratmann, Thomas (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Serreze, David (Jackson Laboratory) ;
Verdaguer, Joan (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and the 116C-NOD mice. [...]
2019 - 10.3389/fimmu.2019.01732
Frontiers in immunology, Vol. 10 (2019) , p. 1732
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10.
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26 p, 3.5 MB |
A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs
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Cho, In-Cheol (Rural Development Administration. National Institute of Animal Science) ;
Park, Hee-Bok (Kongju National University. College of Industrial Sciences. Department of Animal Resources Science) ;
Ahn, Jin Seop (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ;
Han, Sang-Hyun (Jeju National University. Educational Science Research Institute) ;
Lee, JaeBong (Chonbuk National University. Korea Zoonosis Research Institute) ;
Lim, Hyun-Tae (Gyeongsang National University. College of Agriculture and Life Sciences) ;
Yoo, Chae-Kyoung (Gyeongsang National University. Institute of Agriculture and Life Science.) ;
Jung, Eun-Ji (Bio-Medical Science Co., Ltd) ;
Kim, Dong-Hwan (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ;
Sun, Wu-Sheng (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ;
Ramayo-Caldas, Yuliaxis (Institut de Recerca i Tecnologia Agroalimentàries) ;
Kim, Sang-Geum (Rural Development Administration. National Institute of Animal Science) ;
Kang, Yong-Jun (Rural Development Administration. National Institute of Animal Science) ;
Kim, YooKyung (Jeju National University. Educational Science Research Institute) ;
Shin, Hyun-Sook (Rural Development Administration. National Institute of Animal Science) ;
Seong, Pil-Nam (Rural Development Administration. National Institute of Animal Science) ;
Hwang, In-Sul (Rural Development Administration. National Institute of Animal Science) ;
Park, Beom-Young (Rural Development Administration. National Institute of Animal Science) ;
Hwang, Seongsoo (Rural Development Administration. National Institute of Animal Science) ;
Lee, Sung-Soo (Rural Development Administration. National Institute of Animal Science) ;
Ryu, Youn-Chul (Jeju National University. Division of Biotechnology. SARI) ;
Lee, Jun-Heon (Chungnam National University. Division of Animal and Dairy Science) ;
Ko, MoonSuck (Rural Development Administration. National Institute of Animal Science) ;
Lee, Kichoon (Ohio State University. College of Food Agricultural and Environmental Sciences) ;
Andersson, Göran (Swedish University of Agricultural Sciences. Department of Animal Breeding and Genetics) ;
Perez-Enciso, Miguel (Centre de Recerca en Agrigenòmica) ;
Lee, JeongWoong (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center)
Muscle development and lipid accumulation in muscle critically affect meat quality of livestock. However, the genetic factors underlying myofiber-type specification and intramuscular fat (IMF) accumulation remain to be elucidated. [...]
2019 - 10.1371/journal.pgen.1008279
PLoS Genetics, Vol. 15, Núm. 10 (October 2019) , art. e1008279
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