Results overview: Found 2 records in 0.02 seconds.
Articles, 2 records found
Articles 2 records found  
1.
10 p, 1.8 MB Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease / González-Marrero, Ibrahim (Universidad de La Laguna. Departamento de Anatomía Humana) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Johanson, Conrad E. (Alpert Medical School at Brown University. Department of Neurosurgery) ; Carmona-Calero, Emilia María (Universidad de La Laguna. Departamento de Anatomía Humana) ; Castañeyra-Ruiz, Leandro (Universidad de La Laguna. Departamento de Anatomía Humana) ; Brito-Armas, José Miguel (Universidad de La Laguna. Departamento de Psicología) ; Castañeyra-Perdomo, Agustín (Universidad de La Laguna. Departamento de Anatomía Humana) ; Castro-Fuentes, Rafael (Universidad de La Laguna. Departamento de Psicología) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Aβ) peptides at the blood-CSF barrier (BCSFB), contribute to complications of Alzheimer's disease (AD). [...]
2015 - 10.3389/fncel.2015.00017
Frontiers in cellular neuroscience, Vol. 9 (February 2015) , art. 17  
2.
14 p, 3.1 MB The importance of a gatekeeper residue on the aggregation of transthyretin / Sant'Anna, Ricardo (Instituto de Bioquímica Médica Leopoldo de Meis) ; Braga, Carolina (Instituto de Bioquímica Médica Leopoldo de Meis) ; Varejão, Nathalia (Instituto de Bioquímica Médica Leopoldo de Meis) ; Pimenta, Karinne M. (Instituto de Bioquímica Médica Leopoldo de Meis) ; Graña Montes, Ricardo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Alves, Aline (Instituto de Bioquímica Médica Leopoldo de Meis) ; Cortines, Juliana (Instituto de Microbiologia Professor Paulo de Goés) ; Cordeiro, Yraima (Universidade Federal do Rio de Janeiro. Faculdade de Farmácia) ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Foguel, Debora (From the Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural)
Background: Proteins have adopted negative design to diminish aggregation. Results: The replacement of Lys-35 by Leu increases the amyloidogenicity of the 26-57 segment of TTR as well as the entire protein. [...]
2014 - 10.1074/jbc.M114.563981
The Journal of biological chemistry, Vol. 289, no. 41 (Oct. 2014) , p. 28324-28337  

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