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34 p, 677.3 KB |
Identification of Trypanosoma cruzi Discrete Typing Units (DTUs) in Latin-American migrants in Barcelona (Spain)
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Abras, Alba (Universitat de Girona. Departament de Biologia) ;
Gállego Culleré, M. (Montserrat) (Institut de Salut Global de Barcelona) ;
Muñoz-Batet, Carmen (Institut d'Investigació Biomèdica Sant Pau) ;
Juiz, Natalia A. (Laboratorio de Biología Molecular de la Enfermedad de Chagas) ;
Ramírez, Juan Carlos (Laboratorio de Biología Molecular de la Enfermedad de Chagas) ;
Cura, Carolina I. (Laboratorio de Biología Molecular de la Enfermedad de Chagas) ;
Tebar, Silvia (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient) ;
Fernández-Arévalo, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Pinazo, María-Jesus (Institut de Salut Global de Barcelona) ;
de la Torre, Leonardo (Institut de Salut Global de Barcelona) ;
Posada, Elizabeth (Institut de Salut Global de Barcelona) ;
Navarro Risueño, Ferran (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Espinal, Paula (Institut d'Investigació Biomèdica Sant Pau) ;
Ballart, Cristina (Institut de Salut Global de Barcelona) ;
Portús, Montserrat (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient) ;
Gascon, Joaquim (Institut de Salut Global de Barcelona) ;
Schijman, Alejandro G. (Laboratorio de Biología Molecular de la Enfermedad de Chagas)
Trypanosoma cruzi, the causative agent of Chagas disease, is divided into six Discrete Typing Units (DTUs): TcI-TcVI. We aimed to identify T. cruzi DTUs in Latin-American migrants in the Barcelona area (Spain) and to assess different molecular typing approaches for the characterization of T. [...]
2017 -  10.1016/j.parint.2016.12.003
Parasitology International, Vol. 66, Issue 2 (April 2017) , p. 83-88
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15 p, 2.5 MB |
Parasitemia Levels in Trypanosoma cruzi Infection in Spain, an Area Where the Disease Is Not Endemic : Trends by Different Molecular Approaches
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Flores-Chavez, Maria (Fundación Mundo Sano-España) ;
Abras, Alba (Universitat de Girona. Departament de Biologia) ;
Ballart, Cristina (Universitat de Barcelona. Secció de Parasitologia. Departament de Biologia Sanitat i Medi Ambient. Facultat de Farmàcia i Ciències de l'Alimentació) ;
Ibáñez-Perez, Ismael (National Centre for Microbiology. Instituto de Salud Carlos III) ;
Perez-Gordillo, Pilar (National Centre for Microbiology. Instituto de Salud Carlos III) ;
Gállego Culleré, M. (Montserrat) (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Muñoz-Batet, Carmen (Institut d'Investigació Biomèdica Sant Pau) ;
Moure García, Zaira (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron) ;
Nieto, Javier (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
García Diez, Emilia (National Centre for Microbiology. Instituto de Salud Carlos III) ;
Simón, Lorena (National Centre of Epidemiology. Instituto de Salud Carlos III) ;
Cruz, Israel (Foundation for Innovative New Diagnostics (FIND)) ;
Picado, Alberto (Foundation for Innovative New Diagnostics (FIND)) ;
Universitat Autònoma de Barcelona
Trypanosoma cruzi infection has expanded globally through human migration. In Spain, the mother-to-child route is the mode of transmission contributing to autochthonous Chagas disease (CD); however, most people acquired the infection in their country of origin and were diagnosed in the chronic phase (imported chronic CD). [...]
2022 - 10.1128/spectrum.02628-22
Microbiology Spectrum, Vol. 10 Núm. 5 (september 2022)
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10 p, 1.3 MB |
Benznidazole Treatment : Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain
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Fonseca, Kátia da Silva (Federal University of Ouro Preto) ;
Perin, Luísa (University of Ouro Preto) ;
de Paiva, Nívia Carolina Nogueira (Federal University of Ouro Preto) ;
da Silva, Beatriz Cristiane (Federal University of Ouro Preto) ;
Duarte, Thays Helena Chaves (Federal University of Ouro Pretotment of Biological Sciences, Nucleus of Biological Sciences Research) ;
Marques, Flávia de Souza (Federal University of Ouro Preto) ;
Costa, Guilherme de Paula (Federal University of Ouro Preto) ;
Molina Romero, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Correa-Oliveira, Rodrigo (Fundação Oswaldo Cruz (Brasil)) ;
Vieira, Paula Melo de Abreu (Federal University of Ouro Preto) ;
Carneiro, Cláudia Martins (Federal University of Ouro Preto) ;
Universitat Autònoma de Barcelona
As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. [...]
2021 - 10.3390/pathogens10060729
Pathogens, Vol. 10 (june 2021)
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9 p, 1.2 MB |
Intra-Discrete Typing Unit TcV Genetic Variability of Trypanosoma cruzi in Chronic Chagas' Disease Bolivian Immigrant Patients in Barcelona, Spain
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de Oliveira, Maykon Tavares (University of São Paulo) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
da Silva, Maria Cláudia (University of São Paulo) ;
Silgado, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Lana, Marta (Federal University of Ouro Preto) ;
da Silva, João Santana (Fiocruz-Bi-Institutional Translational Medicine Plataform) ;
Molina Romero, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Marin-Neto, J. Antônio (University of São Paulo) ;
Universitat Autònoma de Barcelona
Background: Trypanosoma cruzi has a high rate of biological and genetic variability, and its population structure is divided into seven distinct genetic groups (TcI-TcVI and Tcbat). Due to immigration, Chagas disease (ChD), caused by T. [...]
2021 - 10.3389/fcvm.2021.665624
Frontiers in Cardiovascular Medicine, Vol. 8 (may 2021)
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16 p, 2.8 MB |
Anti-Trypanosoma cruzi Activity of Metabolism Modifier Compounds
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Martinez-Peinado, Nieves (Institut de Salut Global de Barcelona) ;
Cortés Serra, Núria (Institut de Salut Global de Barcelona) ;
Sherman, Julian (New York University School of Medicine. Department of Microbiology) ;
Rodriguez, Ana (New York University School of Medicine. Department of Microbiology) ;
Gascon, Joaquim (Barcelona Institute for Global Health (ISGlobal)) ;
Alberola, Jordi (Alberola i Domingo) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pinazo, Maria-Jesus (Institut de Salut Global de Barcelona) ;
Rodríguez-Cortés, Alhelí (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Alonso-Padilla, Julio (Institut de Salut Global de Barcelona) ;
Martori Muntsant, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects over 6 million people worldwide. Development of new drugs to treat this disease remains a priority since those currently available have variable efficacy and frequent adverse effects, especially during the long regimens required for treating the chronic stage of the disease. [...]
2021 - 10.3390/ijms22020688
International journal of molecular sciences, Vol. 22 Núm. 2 (2021) , p. 688
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13 p, 335.7 KB |
Screening for Trypanosoma cruzi infection in immigrants and refugees : Systematic review and recommendations from the Spanish Society of Infectious Diseases and Clinical Microbiology
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Velasco, María (Hospital Universitario Fundación Alcorcón) ;
Gimeno-Feliu, Luis Andrés (Health Services Research on Chronic Patients Network (REDISSEC), Instituto de Salud Carlos III, Madrid, Spain) ;
Molina Romero, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salas-Coronas, Joaquín (Tropical Medicine Unit. Hospital de Poniente, El Ejido, Almería, Spain) ;
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Monge-Maillo, Begoña (National Referral Centre for Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain) ;
Torrús-Tendero, Diego (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Caylà, Joan A.. (Fundació de la Unitat d'Investigació en Tuberculosi de Barcelona) ;
de Guzmán, Ena Niño (Institut d'Investigació Biomèdica Sant Pau) ;
Arellano, J. L. Pérez (Universidad de Las Palmas de Gran Canaria. Departamento de Ciencias Médicas y Quirúrgicas) ;
Pérez-Molina, Jose A. (National Referral Centre for Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain) ;
Universitat Autònoma de Barcelona
Chagas disease has spread beyond its original borders on the American continent with migration. It can be transmitted from mother to child, through organ transplantation and transfusion of blood and blood products. [...]
2020 - 10.2807/1560-7917.ES.2020.25.8.1900393
Eurosurveillance, Vol. 25 (february 2020)
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7 p, 1.2 MB |
Immune reactivity to Trypanosoma cruzi chimeric proteins for Chagas disease diagnosis in immigrants living in a non-endemic setting
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Dopico, Eva (Institut Català de la Salut) ;
Del-Rei, Rodrigo Pimenta (Faculty of Technology and Sciences of Bahia) ;
Espinoza, Bertha (Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas) ;
Ubillos, Itziar (Institut Català de la Salut) ;
Zanchin, Nilson Ivo Tonin (Oswaldo Cruz Foundation. Carlos Chagas Institute) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron) ;
Moure García, Zaira (Hospital Universitari Vall d'Hebron) ;
Celedon, Paola Alejandra Fiorani (Molecular Biology Institute of Paraná) ;
Souza, Wayner Vieira (Oswaldo Cruz Foundation. Aggeu Magalhães Institute) ;
da Silva, Edimilson Domingos (Oswaldo Cruz Foundation. Immunobiological Technology Institute) ;
Gomes, Yara Miranda (Oswaldo Cruz Foundation. Aggeu Magalhães Institute) ;
Santos, Fred Luciano Neves (Oswaldo Cruz Foundation. Gonçalo Moniz Institute) ;
Universitat Autònoma de Barcelona
Chronic Chagas Disease (CD) diagnosis is based on serological methods employing crude, semipurified or recombinant antigens, which may result in low sensitivity or cross-reactivity. To reduce these restrictions, we developed a strategy involving use of molecules containing repetitive fragments of Trypanosoma cruzi conserved proteins. [...]
2019 - 10.1186/s12879-019-3872-z
BMC Infectious diseases, Vol. 19 (march 2019)
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12 p, 1.6 MB |
Immuno-metabolic profile of human macrophages after Leishmania and Trypanosoma cruzi infection
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Ty, M. C. (New York University School of Medicine. Department of Microbiology) ;
Loke, P. (New York University School of Medicine. Department of Microbiology) ;
Alberola, Jordi (Alberola i Domingo) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Rodriguez-Cortes, Alheli (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Macrophages can reprogram their metabolism in response to the surrounding stimuli, which affects their capacity to kill intracellular pathogens. We have investigated the metabolic and immune status of human macrophages after infection with the intracellular trypanosomatid parasites Leishmania donovani, L. [...]
2019 - 10.1371/journal.pone.0225588
PloS one, Vol. 14 Núm. 12 (december 2019) , p. e0225588
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16 p, 409.2 KB |
Epidemiology of congenital chagas disease 6 years after implementation of a public health surveillance system, Catalonia, 2010 to 2015
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Basile, Luca (Servei Català de la Salut) ;
Ciruela, Pilar (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Requena-Méndez, Ana (Barcelona Institute for Global Health (ISGlobal)) ;
José Vidal, M. A. (Servei Català de la Salut) ;
Dopico, Eva (Laboratori Clínic de l'Hospitalet. Hospitalet de Llobregat) ;
Martín-Nalda, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron) ;
Gascon, Joaquim (Barcelona Institute for Global Health (ISGlobal)) ;
Jané i Checa, Mireia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Universitat Autònoma de Barcelona
Background: Chagas disease is endemic in Latin America and affects 8 million people worldwide. In 2010, Catalonia introduced systematic public health surveillance to detect and treat congenital Chagas disease. [...]
2019 - 10.2807/1560-7917.ES.2019.24.26.19-00011
Eurosurveillance, Vol. 24 Núm. 26 (2019) , p. 1900011
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