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16 p, 3.4 MB |
CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors
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Dragon, Anna Christina (Hannover Medical School) ;
Beermann, Luca Marie (Hannover Medical School) ;
Umland, Melina (Hannover Medical School) ;
Bonifacius, Agnes (Hannover Medical School) ;
Malinconico, Chiara (Hannover Medical School) ;
Ruhl, Louisa (Hannover Medical School) ;
Kehler, Patrik (Glycotope GmbH) ;
Gellert, Johanna (Glycotope GmbH) ;
Weiß, Lisa (Glycotope GmbH) ;
Mayer-Hain, Sarah (Glycotope GmbH) ;
Zimmermann, Katharina (Hannover Medical School) ;
Riese, Sebastian (Hannover Medical School) ;
Thol, F. (Department of Hematology. Hannover Medical School) ;
Beutel, Gernot (Hannover Medical School) ;
Maecker-Kolhoff, B. (Department of Pediatric Hematology and Oncology. Hannover Medical School) ;
Yamamoto, Felicitas (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blasczyk, Rainer (Hannover Medical School) ;
Schambach, Axel (Hannover Medical School) ;
Hust, Michael (Department of Medical Biotechnology. Technical University of Braunschweig) ;
Hudecek, Michael (Department of Internal Medicine II. University Hospital of Würzburg) ;
Eiz-Vesper, Britta (Hannover Medical School) ;
Universitat Autònoma de Barcelona
Introduction: Chimeric antigen receptor-engineered T cells (CAR-Ts) are investigated in various clinical trials for the treatment of cancer entities beyond hematologic malignancies. A major hurdle is the identification of a target antigen with high expression on the tumor but no expression on healthy cells, since "on-target/off-tumor" cytotoxicity is usually intolerable. [...]
2023 -  10.3389/fimmu.2023.1219165
Frontiers in immunology, Vol. 14 (2023) , p. 1219165
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9 p, 506.2 KB |
How to Study the LocatMontesion and Size of Rectal Tumors That Are Candidates for Local Surgery : Rigid Rectoscopy, Magnetic Resonance, Endorectal Ultrasound or Colonoscopy? An Interobservational Study
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Serracant, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Consola, Beatriz (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ballesteros, Eva (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Sola, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Novell, Francesc (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Montes Ortega, Noemí (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Serra-Aracil, Xavier (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Universitat Autònoma de Barcelona
1. Background. Preoperative staging of rectal lesions for transanal endoscopic surgery (TES) comprises digital rectal examination, intraoperative rigid rectoscopy (IRR), endorectal ultrasound (EUS), colonoscopy and rectal magnetic resonance imaging (rMRI). [...]
2024 - 10.3390/diagnostics14030315
Diagnostics, Vol. 14 (january 2024)
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3.
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19 p, 837.6 KB |
Malignant bone tumors (other than Ewing's) : clinical practice guidelines for diagnosis, treatment and follow-up by Spanish Group for Research on Sarcomas (GEIS)
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Redondo, Andrés (Hospital Universitario La Paz (Madrid)) ;
Bagué Rosell, Sílvia (Institut d'Investigació Biomèdica Sant Pau) ;
Bernabeu, Daniel (Hospital Universitario La Paz (Madrid)) ;
Ortiz-Cruz, Eduardo (Hospital Universitario La Paz (Madrid)) ;
Valverde, Claudia (Hospital Universitari Vall d'Hebron) ;
Alvarez, Rosa (Hospital General Universitario Gregorio Marañón) ;
Martínez-Trufero, Javier (Hospital Universitario Miguel Servet (Saragossa)) ;
Lopez-Martin, Jose A. (Hospital 12 de Octubre (Madrid)) ;
Correa, Raquel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Cruz, Josefina (Hospital Universitario de Canarias (La Laguna)) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Santos, Aurelio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
García del Muro, Xavier (Institut Catalá d'Oncologia Hospitalet) ;
Martin-Broto, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Universitat Autònoma de Barcelona
Primary malignant bone tumors are uncommon and heterogeneous malignancies. This document is a guideline developed by the Spanish Group for Research on Sarcoma with the participation of different specialists involved in the diagnosis and treatment of bone sarcomas. [...]
2017 - 10.1007/s00280-017-3436-0
Cancer Chemotherapy and Pharmacology, Vol. 80 Núm. 6 (january 2017) , p. 1113-1131
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13 p, 828.8 KB |
Prospective detection of mutations in cerebrospinal fluid, pleural effusion, and ascites of advanced cancer patients to guide treatment decisions
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Villatoro, Sergi (Grup Quirónsalud (Barcelona, Catalunya)) ;
Mayo-de-las-Casas, Clara (Grup Quirónsalud (Barcelona, Catalunya)) ;
Jordana-Ariza, Núria (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri-Ramírez, Santiago (Grup Quirónsalud (Barcelona, Catalunya)) ;
Garzón-Ibañez, Mónica (Grup Quirónsalud (Barcelona, Catalunya)) ;
Moya-Horno, Irene (Hospital General de Catalunya) ;
García-Peláez, Beatrtiz (Grup Quirónsalud (Barcelona, Catalunya)) ;
González-Cao, María (Grup Quirónsalud (Barcelona, Catalunya)) ;
Malapelle, Umberto (University of Naples Federico II) ;
Balada-Bel, Ariadna (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
Campos, Raquel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Remei (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Blasco, Ana (Hospital General Universitari de València) ;
Catalán, María J. (Grup Quirónsalud (Barcelona, Catalunya)) ;
González, Xavier (Hospital General de Catalunya) ;
Troncone, Giancarlo (University of Naples Federico II) ;
Karachaliou, Niki (Hospital del Sagrat Cor (Barcelona, Catalunya)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina-Vila, Miguel Ángel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Many advanced cases of cancer show central nervous system, pleural, or peritoneal involvement. In this study, we prospectively analyzed if cerebrospinal fluid (CSF), pleural effusion (PE), and/or ascites (ASC) can be used to detect driver mutations and guide treatment decisions. [...]
2019 - 10.1002/1878-0261.12574
Molecular Oncology, Vol. 13 Núm. 12 (january 2019) , p. 2633-2645
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9 p, 924.3 KB |
Surgical treatment of retrorectal tumors : a plea for a laparoscopic approach
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Galan Martinez, Clara (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Hernández, M. Pilar (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez, M. Carmen (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Bollo, Jesús (Institut d'Investigació Biomèdica Sant Pau) ;
Targarona, Eduardo M. (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Introduction: Retrorectal tumors (RRTs) are rare and often surgically excised due to the risk of malignant degeneration and compressive or obstructive symptoms. The approach for excision has traditionally been based on tumor location and performed using either a transabdominal or perineal approach depending on the position of the tumor. [...]
2023 - 10.1007/s00464-023-10448-5
Surgical endoscopy, Vol.37, Num.12 (2023) , p.9080-9088
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10 p, 476.1 KB |
Two phase I studies of BI 836880, a vascular endothelial growth factor/angiopoietin-2 inhibitor, administered once every 3 weeks or once weekly in patients with advanced solid tumors
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Le Tourneau, C. (Paris-Saclay University) ;
Becker, H. (University of Freiburg) ;
Claus, R. (Medical Faculty Augsburg University) ;
Elez, Elena (Vall d'Hebron Institut d'Oncologia) ;
Ricci, F. (Paris-Saclay University) ;
Fritsch, R. (University of Freiburg) ;
Silber, Y. (Medical Faculty Augsburg University) ;
Hennequin, A. (Centre Georges-François Leclerc) ;
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia) ;
Jayadeva, G. (Boehringer Ingelheim International GmbH) ;
Luedtke, D. (Boehringer Ingelheim Pharma GmbH and Co KG) ;
He, M. (Boehringer Ingelheim Pharmaceuticals Inc.) ;
Isambert, N. (Centre Georges-François Leclerc) ;
Universitat Autònoma de Barcelona
BI 836880 is a humanized bispecific nanobody® that inhibits vascular endothelial growth factor and angiopoietin-2. Here, we report results from two phase I, nonrandomized, dose-escalation studies (NCT02674152 and NCT02689505; funded by Boehringer Ingelheim) evaluating BI 836880 in patients with confirmed locally advanced or metastatic solid tumors, refractory to standard therapy, or for which standard therapy was ineffective. [...]
2022 - 10.1016/j.esmoop.2022.100576
ESMO open, Vol. 7 (september 2022)
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7.
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24 p, 6.0 MB |
Using Single-Voxel Magnetic Resonance Spectroscopy Data Acquired at 1.5T to Classify Multivoxel Data at 3T : A Proof-of-Concept Study
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Ungan, Gulnur Semahat (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pons-Escoda, Albert (Institut d'Investigació Biomèdica de Bellvitge) ;
Ulinic, Daniel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vellido, Alfredo (Centro de Investigación Biomédica en Red) ;
Julià Sapé, Ma. Margarita (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
In vivo magnetic resonance spectroscopy (MRS) has two modalities, single-voxel (SV) and multivoxel (MV), in which one or more contiguous grids of SVs are acquired. Purpose: To test whether MV grids can be classified with models trained with SV. [...]
2023 - 10.3390/cancers15143709
Cancers, Vol. 15, Issue 14 (July 2023) , art. 3709
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12 p, 923.8 KB |
Small Cell Carcinoma of the Vagina : First Systematic Review of Case Reports and Proposal of a Management Algorithm
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Capote, Sira (Fundació Hospital de l'Esperit Sant) ;
Domènech, Marta (Institut Català d'Oncologia) ;
Valdivieso, Lorena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tuset, Victoria (Institut Català d'Oncologia) ;
Sanchez, Myriam (Fundació Hospital de l'Esperit Sant) ;
Carballas, Elvira (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teruel, Iris (Institut Català d'Oncologia) ;
Durany Lara, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Moragas, Gloria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina, Carlos (Fundació Hospital de l'Esperit Sant) ;
Lleberia, Judith (Fundació Hospital de l'Esperit Sant) ;
Martínez-Roman, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romeo, Margarita (Institut Català d'Oncologia) ;
Universitat Autònoma de Barcelona
Literature search in PubMed and Scopus was performed using the terms "small cell carcinoma" and "vagina. " English-language case reports of primary SmCCV up to January 2022 were included. Twenty-nine articles describing 44 cases met our inclusion criteria. [...]
2022 - 10.1097/LGT.0000000000000712
Journal of Lower Genital Tract Disease, Vol. 27 (october 2022) , p. 56-67
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10 p, 1.2 MB |
SELNET clinical practice guidelines for soft tissue sarcoma and GIST
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Blay, Jean-Yves (Léon Bérard Center (Lyon)) ;
Hindi, Nadia (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Bollard, Julien (Léon Bérard Center (Lyon)) ;
Aguiar Júnior, Samuel (A.C.Camargo Cancer Center (Brasil)) ;
Ángel, Martín Osvaldo (Instituto Alexander Fleming (Buenos Aires)) ;
Araya, Beatriz (Hospital Dr. R. A. Calderón Guardia (San José)) ;
Badilla-González, Ronald (Hospital Dr. Rafael Ángel Calderón Guardia (San José)) ;
Bernabeu, Daniel (Hospital Universitario La Paz (Madrid)) ;
Campos, Fernando (A.C.Camargo Cancer Center (Brasil)) ;
Caro-Sánchez, C.H.S. (Instituto Nacional de Cancerología (Tlalpan)) ;
Carvajal, B. (Fundación GIST México (Mexico)) ;
Carvajal Montoya, A. (Hospital Dr. Rafael Ángel Calderón Guardia (San José)) ;
Casavilca-Zambrano, Sandro (Instituto Nacional de Enfermedades Neoplásicas (Lima)) ;
Castro-Oliden, Victor (Instituto Nacional de Enfermedades Neoplásicas (Lima)) ;
Chacón, Matias (Instituto Alexander Fleming (Buenos Aires)) ;
Clara, Miguel (Instituto Nacional de Cancerología (Tlaplan)) ;
Collini, Paola (Fondazione IRCCS Istituto Nazionale dei Tumori (Milà)) ;
Correa Genoroso, Raquel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Costa, Felipe D. (A.C.Camargo Cancer Center (Brasil)) ;
Cuellar, M. (Fundación GIST México (Mexico)) ;
Dei Tos, Angelo (Treviso General Hospital Treviso (Padua)) ;
Dominguez Malagón, Hugo Ricardo (Instituto Nacional de Cancerología (Tlalpan)) ;
Donati, Davide Maria (IRCCS Istituto Ortopedico Rizzoli (Bologna)) ;
Dufresne, Armelle (Léon Bérard Center (Lyon)) ;
Eriksson, Mikael (Skane University Hospital (Lund)) ;
Farias-Loza, M. (Instituto Nacional de Enfermedades Neoplásicas (Lima)) ;
Fernandez, Piga (Fundación GIST (Xile)) ;
Frezza, Anna Maria (Fondazione IRCCS Istituto Nazionale dei Tumori (Milà)) ;
Frisoni, Tommaso (IRCCS Istituto Ortopedico Rizzoli (Bologna)) ;
Garcia-Ortega, Dorian Yarih (Instituto Nacional de Cancerología (Tlalpan)) ;
Gelderblom, Hans J (Leiden University Medical Center (Leiden)) ;
Gouin, François (Léon Bérard Center (Lyon)) ;
Gómez-Mateo, María Carmen (Hospital Universitario Miguel Servet (Saragossa)) ;
Gronchi, Alessandro (Fondazione IRCCS Istituto Nazionale dei Tumori (Milà)) ;
Haro-Varas, Juan (Instituto Nacional de Enfermedades Neoplásicas (Lima)) ;
Huanca, Lourdes (Instituto Nacional de Enfermedades Neoplásicas (Lima)) ;
Jimenez, Natalia (Hospital Dr. Rafael Ángel Calderón Guardia (San José)) ;
Karanian, Marie (Léon Bérard Center (Lyon)) ;
Kasper, Bernd (University of Heidelberg (Mannheim)) ;
Lopes David, B.B. (Fondazione IRCCS Istituto Nazionale dei Tumori) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Lutter, Guido (Instituto Alexander Fleming (Buenos Aires)) ;
Martinez-Said, Héctor (Hospital Medica Sur (Mexico)) ;
Martinez-Tlahuel, Jorge Luis (Instituto Nacional de Cancerología (Tlalpan)) ;
Mello, Celso A. (A.C.Camargo Cancer Center (Brasil)) ;
Morales Pérez, José Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Moura, David S. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Nascimento, Antônio Geraldo (A.C.Camargo Cancer Center (Brasil)) ;
Ortiz-Cruz, Eduardo J. (Hospital Universitario La Paz (Madrid)) ;
Palmerini, Emanuela (IRCCS Istituto Ortopedico Rizzoli (Bologna)) ;
Patel, Shreyaskumar (University of Texas MD Anderson Cancer Center (Houston)) ;
Pfluger, Yanina (Instituto Alexander Fleming (Buenos Aires)) ;
Provenzano, Salvatore (Fondazione IRCCS Istituto Nazionale dei Tumori (Milà)) ;
Righi, Alberto (IRCCS Istituto Ortopedico Rizzoli (Bologna)) ;
Rodriguez, Andrés (Instituto Alexander Fleming (Buenos Aires)) ;
Salas, Rodrigo (Fundación GIST México (Mexico)) ;
Santos, Telma G. (A.C.Camargo Cancer Center (Brasil)) ;
Scotlandi, Katia (IRCCS Istituto Ortopedico Rizzoli (Bologna)) ;
Soulé, Tomás (Instituto Alexander Fleming (Buenos Aires)) ;
Stacchiotti, Silvia (Fondazione IRCCS Istituto Nazionale dei Tumori (Milà)) ;
Valverde, Claudía María (Hospital Universitari Vall d'Hebron) ;
Waisberg, Federico Daniel (Instituto Alexander Fleming (Buenos Aires)) ;
Zamora Estrada, Esteban (Hospital Dr. Rafael Ángel Calderón Guardia (San José)) ;
Martín-Broto, Javier (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
2022 - 10.1016/j.ctrv.2021.102312
Cancer Treatment Reviews, Vol. 102 (january 2022) , p. 102312
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9 p, 838.3 KB |
SEOM Clinical Guideline of management of soft-tissue sarcoma (2020)
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de Juan Ferré, Ana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Alvarez, Rosa (Hospital General Universitario Gregorio Marañón) ;
Casado Herráez, Antonio (Hospital Universitario Clínico San Carlos (Madrid)) ;
Cruz-Jurado, Josefina (Hospital Universitario de Canarias (La Laguna)) ;
Estival, Anna (Institut Català d'Oncologia) ;
Martín-Broto, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Martínez Marín, Virginia (Hospital Universitario La Paz (Madrid)) ;
Moreno Vega, Alberto Luis (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Valverde Morales, Claudia (Hospital Universitari Vall d'Hebron)
Soft-tissue sarcomas constitute an uncommon and heterogeneous group of tumors of mesenchymal origin. Diagnosis, treatment, and management should be performed by an expert multidisciplinary team. MRI/CT of the primary tumor and biopsy is mandatory before any treatment. [...]
2021 - 10.1007/s12094-020-02534-0
Clinical & Translational Oncology, Vol. 23 Núm. 5 (may 2021) , p. 922-930
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