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1.
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13 p, 1.1 MB |
IgG4 Valency Modulates the Pathogenicity of Anti-Neurofascin-155 IgG4 in Autoimmune Nodopathy
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Jentzer, Alexandre (Department of Immunology. CHU Montpellier) ;
Attal, Arthur (Department of Neurology. CHU Montpellier. Hôpital Gui de Chauliac) ;
Roué, Clémence (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Raymond, Julie (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Lleixà, Cinta (Institut d'Investigació Biomèdica Sant Pau) ;
Illa, Isabel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Taieb, Guillaume (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Devaux, Jérôme (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Universitat Autònoma de Barcelona
Background and Objective s : IgG4 autoantibodies to neurofascin-155 (Nfasc155) are associated with a subgroup of patients with chronic inflammatory demyelinating polyneuropathy (CIDP), currently named autoimmune nodopathy. [...]
2022 -  10.1212/NXI.0000000000200014
Neurology® neuroimmunology & neuroinflammation, Vol. 9 Núm. 5 (october 2022) , p. e200014
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2.
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12 p, 1.0 MB |
An Immunochemical Approach to Detect the Quorum Sensing-Regulated Virulence Factor 2-Heptyl-4-Quinoline N-Oxide (HQNO) Produced by Clinical Isolates
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Montagut, Enrique J. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Raya, Juan (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Martin-Gomez, M. Teresa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vilaplana, Lluïsa (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Rodriguez-Urretavizcaya, Barbara (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Marco, María Pilar (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Understanding quorum sensing (QS) and its role in the development of pathogenesis may provide new avenues for diagnosing, surveillance, and treatment of infectious diseases. For this purpose, the availability of reliable and efficient analytical diagnostic tools suitable to specifically detect and quantify these essential QS small molecules and QS regulated virulence factors is crucial. [...]
2022 - 10.1128/spectrum.01073-21
Microbiology Spectrum, Vol. 10, Num. 4 (July 2022) , art. e01073-21
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3.
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13 p, 1.9 MB |
Pathogen Moonlighting Proteins : From Ancestral Key Metabolic Enzymes to Virulence Factors
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Franco Serrano, Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-Redondo, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Nájar-García, Araceli (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Hernández, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pérez-Pons, Josep A (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mozo-Villarias, Angel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cedano Rodríguez, Juan Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Moonlighting and multitasking proteins refer to proteins with two or more functions performed by a single polypeptide chain. An amazing example of the Gain of Function (GoF) phenomenon of these proteins is that 25% of the moonlighting functions of our Multitasking Proteins Database (MultitaskProtDB-II) are related to pathogen virulence activity. [...]
2021 - 10.3390/microorganisms9061300
Microorganisms, Vol. 9, Issue 6 (June 2021) , art. 1300
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4.
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18 p, 1.9 MB |
The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis
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Howell, Kate J. (University of Cambridge. Department of Veterinary Medicine) ;
Weinert, Lucy A. (University of Cambridge. Department of Veterinary Medicine) ;
Chaudhuri, Roy R. (University of Sheffield. Department of Molecular Biology and Biotechnology) ;
Luan, Shi-Lu (University of Cambridge. Department of Veterinary Medicine) ;
Peters, Sarah E. (University of Cambridge. Department of Veterinary Medicine) ;
Corander, Jukka (University of Helsinki. Department of Mathematics and Statistics) ;
Harris, David (Wellcome Trust Sanger Institute (Regne Unit)) ;
Angen, Øystein (Norwegian Veterinary Institute) ;
Aragon, Virginia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Bensaid, Albert (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Williamson, Susanna M. (Animal Health and Veterinary Laboratories Agency) ;
Parkhill, Julian (Wellcome Trust Sanger Institute (Regne Unit)) ;
Langford, Paul R. (Imperial College London. Department of Medicine, Section of Paediatrics) ;
Rycroft, Andrew N. (The Royal Veterinary College) ;
Wren, Brendan W. (London School of Hygiene & Tropical Medicine. Faculty of Infectious & Tropical Diseases) ;
Holden, Matthew T. G. (University of St. Andrews. School of Medicine) ;
Tucker, Alexander W. (University of Cambridge. Department of Veterinary Medicine) ;
Maskell, Duncan J.. (University of Cambridge. Department of Veterinary Medicine)
Haemophilus parasuis is the etiologic agent of Glässer's disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established. [...]
2014 - 10.1186/1471-2164-15-1179
BMC genomics, Vol. 15 (december 2014)
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5.
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13 p, 916.7 KB |
Foraging at Solid Urban Waste Disposal Sites as Risk Factor for Cephalosporin and Colistin Resistant Escherichia coli Carriage in White Storks (Ciconia ciconia)
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Höfle, Ursula (Instituto de Investigación en Recursos Cinéticos) ;
Jose Gonzalez-Lopez, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Camacho, Maria Cruz (Instituto de Investigación en Recursos Cinéticos) ;
Solà-Ginés, Marc (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Moreno-Mingorance, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Manuel Hernández, Jose (Independent Researcher) ;
De la Puente, Javier (Bird Monitoring Unit) ;
Pineda-Pampliega, Javier (Universidad Complutense de Madrid. Departamento de Biodiversidad, Ecología y Evolución) ;
Aguirre, José Ignacio (Universidad Complutense de Madrid. Departamento de Biodiversidad, Ecología y Evolución) ;
Torres-Medina, Fernando (University of Saskatchewan. Department of Biology) ;
Ramis Salva, Antonio José (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Majó i Masferrer, Natàlia (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Blas, Julio (Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana) ;
Migura-Garcia, Lourdes (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
White stork (Ciconia ciconia) may act as a reservoir and vehicle of cephalosporin resistant (CR) Escherichia coli. Between 2011 and 2014, we sampled white storks from colonies exposed to different degrees of anthropic pressure across the major areas of natural distribution of white storks in Spain. [...]
2020 - 10.3389/fmicb.2020.01397
Frontiers in microbiology, Vol. 11 (july 2020)
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6.
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18 p, 2.1 MB |
Dynamic expression of Ralstonia solanacearum virulence factors and metabolism-controlling genes during plant infection
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de Pedro Jové, Roger (Centre de Recerca en Agrigenòmica) ;
Puigvert, Marina (Centre de Recerca en Agrigenòmica) ;
Sebastià, Pau (Centre de Recerca en Agrigenòmica) ;
Macho, Alberto P. (Chinese Academy of Sciences) ;
Monteiro, Freddy (Universidade de São Paulo. Departamento de Bioquímica (Brazil)) ;
Sánchez Coll, Núria (Centre de Recerca en Agrigenòmica) ;
Setubal, João C. (Universidade de São Paulo. Departamento de Bioquímica (Brazil)) ;
Valls, Marc (Centre de Recerca en Agrigenòmica)
Background: Ralstonia solanacearum is the causal agent of bacterial wilt, a devastating plant disease responsible for serious economic losses especially on potato, tomato, and other solanaceous plant species in temperate countries. [...]
2021 - 10.1186/s12864-021-07457-w
BMC genomics, Vol. 22 (March 2021) , art. 170
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7.
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11 p, 3.5 MB |
Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors
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Aparicio Alarcón, David (Institut de Biologia Molecular de Barcelona) ;
Torres Puig, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ratera, Mercè (Institut de Biologia Molecular de Barcelona) ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Quijada Pich, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Fita Rodríguez, Ignasi (Institut de Biologia Molecular de Barcelona)
Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the cell membrane. [...]
2018 - 10.1038/s41467-018-06963-y
Nature communications, Vol. 9 (2018) , art. 4471
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8.
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12 p, 1.1 MB |
Mycobacteria clumping increase their capacity to damage macrophages
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Brambilla, Cecilia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Llorens Fons, Marta (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Noguera-Ortega, Estela (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Tomàs Martínez, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pérez-Trujillo, Míriam (Universitat Autònoma de Barcelona. Departament de Química) ;
Byrd, Thomas F. (The University of New Mexico School of Medicine) ;
Alcaide, Fernando (Universitat de Barcelona) ;
Luquín Fernández, Marina (Marina) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The rough morphotypes of non-tuberculous mycobacteria have been associated with the most severe illnesses in humans. This idea is consistent with the fact that Mycobacterium tuberculosis presents a stable rough morphotype. [...]
2016 - 10.3389/fmicb.2016.01562
Frontiers in microbiology, Vol. 7 (October 2016) , art. 1562
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9.
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15 p, 2.7 MB |
Trehalose polyphleates, external cell wall lipids in Mycobacterium abscessus, are associated with the formation of clumps with cording morphology, which have been associated with virulence
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Llorens Fons, Marta (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pérez-Trujillo, Míriam (Universitat Autònoma de Barcelona. Departament de Química) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Brambilla, Cecilia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Alcaide, Fernando (Institut d'Investigació Biomèdica de Bellvitge) ;
Byrd, Thomas F. (The University of New Mexico (EEUU)) ;
Luquín Fernández, Marina (Marina) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Mycobacterium abscessus is a reemerging pathogen that causes pulmonary diseases similar to tuberculosis, which is caused by Mycobacterium tuberculosis. When grown in agar medium, M. abscessus strains generate rough (R) or smooth colonies (S). [...]
2017 - 10.3389/fmicb.2017.01402
Frontiers in microbiology, Vol. 8, (July 2017) , art. 1402
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