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1.
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18 p, 1.4 MB |
Dickkopf Proteins and Their Role in Cancer : A Family of Wnt Antagonists with a Dual Role
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Giralt, Irina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallo-Oller, Gabriel (Vall d'Hebron Institut d'Oncologia) ;
Navarro Barea, Natalia (Vall d'Hebron Institut d'Oncologia) ;
Zarzosa, Patricia (Vall d'Hebron Institut d'Oncologia) ;
Pons, Guillem (Vall d'Hebron Institut d'Oncologia) ;
Magdaleno, Ainara (Vall d'Hebron Institut d'Oncologia) ;
Segura, Miguel F. (Vall d'Hebron Institut d'Oncologia) ;
Sánchez de Toledo, José (Vall d'Hebron Institut d'Oncologia) ;
Moreno, Lucas (Hospital Universitari Vall d'Hebron) ;
Gallego, Soledad (Hospital Universitari Vall d'Hebron) ;
Roma, Josep (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
The Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell polarity and organogenesis during embryonic development. Wnt pathway deregulation is a hallmark of several cancers such as lung, gastric and liver cancer, and has been reported to be altered in others. [...]
2021 -  10.3390/ph14080810
Pharmaceuticals, Vol. 14 (august 2021)
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2.
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17 p, 1.5 MB |
Pathophysiology of bone disease in chronic kidney disease : from basics to renal osteodystrophy and osteoporosis
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Aguilar, Armando (IMSS General Hospital of Zone No 2. Mexican Social Security) ;
Gifre, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ureña-Torres, Pablo (University of Paris Descartes) ;
Carrillo-López, Natalia (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Rodriguez-García, Minerva (Hospital Universitario Central Asturias) ;
Massó, Elisabeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
da Silva, Iara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Báez, Víctor Alfonso (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez-Baya, Maya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prior-Español, Águeda (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Urrutia, Marina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Paul, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bustos, Misael C. (Pontificia Catholic University of Chile) ;
Vila Santandreu, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Garnica-León, Isa (IMSS General Hospital of Zone No 2. Mexican Social Security) ;
Navarro-González, Juan F. (Universidad de La Laguna) ;
Mateo, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bover, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Chronic kidney disease (CKD) is a highly prevalent disease that has become a public health problem. Progression of CKD is associated with serious complications, including the systemic CKD-mineral and bone disorder (CKD-MBD). [...]
2023 - 10.3389/fphys.2023.1177829
Frontiers in physiology, Vol. 14 (june 2023)
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3.
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16 p, 903.0 KB |
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
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Shi, Liu (University of Oxford) ;
Winchester, Laura M. (University of Oxford) ;
Liu, Benjamine Y. (University of Oxford) ;
Killick, Richard (Maurice Wohl Institute Clinical Neuroscience Institute) ;
Ribe, Elena M. (University of Oxford) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison L. (University of Oxford) ;
Buckley, Noel J. (University of Oxford) ;
Hong, Shengjun (University of Lübeck) ;
Dobricic, Valerija (University of Lübeck) ;
Kilpert, Fabian (University of Lübeck) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Kiddle, Steven (King's College London) ;
Sattlecker, Martina (King's College London) ;
Dobson, Richard (University College London) ;
Cuadrado, Antonio ("Victor Babes" National Institute of Pathology) ;
Hye, Abdul (Maurice Wohl Institute Clinical Neuroscience Institute) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Amsterdam UMC. University Medical Center) ;
Vos, Stephanie J. B. (Maastricht University) ;
ten Kate, Mara (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (Universitair Ziekenhuis Brussel-UZ Brussel. Department of Neurology) ;
De Roeck, Ellen E. (University of Antwerp) ;
Sleegers, Kristel (Center for Molecular Neurology) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R&D. Neurosciences Therapeutic Area) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ;
Rami Gonzalez, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ;
Wallin, Anders (Sahlgrenska University Hospital (Suècia)) ;
Kettunen, Petronella (University of Oxford) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (University of Geneva) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation (San Sebastian)) ;
Tainta, Mikel (Organización Sanitaria Integrada Goierri) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ;
Freund-Levi, Yvonne (Department of Psychiatry, Örebro Universitetssjukhus) ;
Frölich, Lutz (University of Heidelberg) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Rasmussen, Katrine Laura (University of Copenhagen) ;
Nordestgaard, Børge Grønne (Copenhagen University Hospital) ;
Frikke-Schmidt, Ruth (University of Copenhagen) ;
Nielsen, Sune Fallgaard (Copenhagen University Hospital) ;
Soininen, Hilkka (University of Eastern Finland) ;
Vellas, Bruno (Univeriste Paul Sabatier) ;
Kloszewska, Iwona (Medical University of Lodz) ;
Mecocci, Patrizia (University of Perugia (Itàlia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Morgan, B. Paul (Cardiff University) ;
Streffer, Johannes (UCB Pharma (Braine-l'Alleud, Bèlgica)) ;
Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ;
Bertram, Lars (University of Oslo) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Lovestone, Simon (University of Oxford) ;
Universitat Autònoma de Barcelona
Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer's disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. [...]
2020 - 10.3233/JAD-200208
Journal of Alzheimer's disease, Vol. 77 (september 2020) , p. 1353-1368
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4.
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24 p, 3.9 MB |
Substrate specificity and structural modeling of human Carboxypeptidase Z : a unique protease with a Frizzled-like domain
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Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Tanco, Sebastián Martín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
García Guerrero, María del Carmen (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Dasgupta, Sayani (Albert Einstein College of Medicine. Department of Molecular Pharmacology) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fricker, Lloyd D. (Albert Einstein College of Medicine. Department of Molecular Pharmacology)
Metallocarboxypeptidase Z (CPZ) is a secreted enzyme that is distinguished from all other members of the M14 metallocarboxypeptidase family by the presence of an N-terminal cysteine-rich Frizzled-like (Fz) domain that binds Wnt proteins. [...]
2020 - 10.3390/ijms21228687
International journal of molecular sciences, Vol. 21, Issue 22 (November 2020) , art. 8687
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5.
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5 p, 753.9 KB |
Multiple immunofluorescence assay identifies upregulation of Active β-catenin in prostate cancer
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Puig Rosell, Pere (R&D Department, Atrys Health) ;
Erill, Nadina (R&D Department, Atrys Health) ;
Terricabras, Marta (R&D Department, Atrys Health) ;
Subirana, Isaac (R&D Department, Atrys Health) ;
González-García, Judit (R&D Department, Atrys Health) ;
Asensi-Puig, Adrià (R&D Department, Atrys Health) ;
Donovan, Michael J. (Icahn School of Medicine at Mount Sinai, MSSM) ;
Mengual, Lourdes (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Agulló-Ortuño, M. Teresa (Instituto de Investigación Hospital. Pathology Department, Urology Department and Laboratory of Translational Oncology) ;
Olivan, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alcaraz, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lopez-Martin, Jose A (Instituto de Investigación Hospital. Pathology Department, Urology Department and Laboratory of Translational Oncology) ;
de Torres, Inés (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Peralto, José Luis (Instituto de Investigación Hospital. Pathology Department, Urology Department and Laboratory of Translational Oncology) ;
Rodríguez-Antolín, Alfredo (Instituto de Investigación Hospital. Pathology Department, Urology Department and Laboratory of Translational Oncology) ;
Morote Robles, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González-Rumayor, Víctor (R&D Department, Atrys Health) ;
Universitat Autònoma de Barcelona
To apply a systems pathology-based approach to the quantification of nuclear Active β-catenin and human leukocyte antigen class I, and assess the biomarker involvement in a cohort of prostate tumor patients. [...]
2019 - 10.1186/s13104-019-4100-z
BMC research notes, Vol. 12 (january 2019)
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6.
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19 p, 2.2 MB |
1ε and p120-catenin control Ror2 function in noncanonical Wnt signaling
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Curto Navarro, Josué (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
del Valle Pérez, Beatriz (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Villarroel, Aida (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fuertes, Guillem (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Vinyoles, Meritxell (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Peña, Raúl (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garcia de Herreros, Antonio (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Dunach, Mireia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Canonical and noncanonical Wnt pathways share some common elements but differ in the responses they evoke. Similar to Wnt ligands acting through the canonical pathway, Wnts that activate the noncanonical signaling, such as Wnt5a, promote Disheveled (Dvl) phosphorylation and its binding to the Frizzled (Fz) Wnt receptor complex. [...]
2018 - 10.1002/1878-0261.12184
Molecular Oncology, Vol. 12, issue 5 (May 2018) , p. 611-629
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7.
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13 p, 2.5 MB |
Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control
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Ruiz-Riol, M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Berdnik, D. ;
Llano Montero, Anuska (Institut Germans Trias i Pujol) ;
Mothe, Beatriz. (Institut Germans Trias i Pujol) ;
Gálvez, Cristina (Institut Germans Trias i Pujol) ;
Pérez-Álvarez, Susana (Institut Germans Trias i Pujol) ;
Oriol-Tordera, B. (Institut Germans Trias i Pujol) ;
Olvera, A. (Institut Germans Trias i Pujol) ;
Silva-Arrieta, S. (Institut Germans Trias i Pujol) ;
Meulbroek, M. (Institut Germans Trias i Pujol) ;
Pujol Vila, Ferran (Projecte dels NOMS-HISPANOSIDA) ;
Coll, Josep (Institut Germans Trias i Pujol) ;
Martinez-Picado, J. (Institut Germans Trias i Pujol) ;
Ganoza, C. ;
Sanchez, J. ;
Gómez, G. ;
Wyss-Coray, T. ;
Brander, Christian. (Institut Germans Trias i Pujol)
Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but their relative contribution to HIV control remains unclear. We asked whether the proteome of secreted cytokines and signaling factors in peripheral blood can be used to discover specific pathways critical for host viral control. [...]
2017 - 10.1128/JVI.00441-17
Journal of Virology, Vol. 91 (july 2017)
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8.
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13 p, 3.4 MB |
Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells
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Altarche-Xifro, Wassim (Universitat Pompeu Fabra) ;
di Vicino, Umberto (Universitat Pompeu Fabra) ;
Muñoz-Martin, Maria Isabel (Universitat Pompeu Fabra) ;
Bortolozzi, Analía (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cosma, Maria Pia (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Parkinson's disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and for which no definitive cure is currently available. [...]
2016 - 10.1016/j.ebiom.2016.04.016
EBioMedicine, Vol. 8 (april 2016) , p. 83-95
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9.
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17 p, 38.6 MB |
Wnt signaling alteration in the spinal cord of Amyotrophic Lateral Sclerosis transgenic mice : special focus on Frizzled-5 cellular expression pattern
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González-Fernández, Carlos (Hospital Nacional de Parapléjicos (Toledo)) ;
Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Rodríguez, Francisco Javier (Hospital Nacional de Parapléjicos (Toledo))
Background: Amyotrophic lateral sclerosis is a chronic neurodegenerative disease characterized by progressive paralysis due to degeneration of motor neurons by unknown causes. Recent evidence shows that Wnt signaling is involved in neurodegenerative processes, including Amyotrophic Lateral Sclerosis. [...]
2016 - 10.1371/journal.pone.0155867
PloS one, Vol. 11, No 5 (May 2016) , p. e0155867
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