Dipòsit Digital de Documents de la UAB 10 registres trobats  La cerca s'ha fet en 0.01 segons. 
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11 p, 1.2 MB Alzheimer's disease in Down syndrome : An overlooked population for prevention trials / Strydom, André (South London and Maudsley NHS Foundation Trust) ; Coppus, Antonia (Department of Primary and Community Care, Radboud University Medical Center, Nijmegen) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Danek, Adrian (Department of Neurology, Ludwig-Maximilians-Universität München) ; Fortea, Juan (Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down) ; Hardy, John (Reta Lila Weston Institute, Institute of Neurology, University College London) ; Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) site Munich) ; Nuebling, Georg (Department of Neurology, Ludwig-Maximilians-Universität München) ; Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ; Ritchie, Craig (Centre for Clinical Brain Sciences. University of Edinburgh) ; van Duijn, Cornelia (Department of Epidemiology, Erasmus Medical Centre, Rotterdam) ; Zaman, Shahid (Cambridgeshire & Peterborough NHS Foundation Trust (CBFT), Fulbourn Hospital) ; Zetterberg, Henrik (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital) ; Universitat Autònoma de Barcelona
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. [...]
2018 - 10.1016/j.trci.2018.10.006
Alzheimer's & Dementia : Translational Research & Clinical Interventions, Vol. 4 (december 2018) , p. 703-713  
2.
11 p, 334.7 KB Survival curves and behavioral profiles of female 3xTg-AD mice surviving to 18-months of age as compared to mice with normal aging / Torres-Lista, Virginia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; De la Fuente, Mónica (Universidad Complutense de Madrid. Departamento de Fisiología Animal II) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
New evidence reveals a high degree of heterogeneity in Alzheimer's disease (AD) clinical and temporal patterns, supporting the existence of several subgroups of patients. Prognosticators of end-of-life dementia specific to elderly patients are necessary to address this heterogeneity. [...]
2017 - 10.3233/ADR-170011
Journal of Alzheimer's disease reports, Vol. 1, issue 1 (2017) , p. 47-57  
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13 p, 787.1 KB Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease / Dekker, Alain D. (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Vermeiren, Yannick (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Carmona-Iragui, Maria (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; Benejam, Bessy (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; Videla, Laura (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; Gelpi, Ellen (Neurological Tissue Bank—Biobanc, Hospital Clinic Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain) ; Aerts, Tony (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Van Dam, Debby (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Fernández, Susana (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; Lleó Bisa, Alberto (Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain) ; Videla, Sebastian (Faculty of Health and Life Sciences, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain) ; Sieben, Anne (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Martin, Jean-Jacques (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; De Deyn, Peter P. (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium)
People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS. [...]
2017 - 10.1016/j.dadm.2017.11.001
Alzheimer's Dementia : Diagnosis, Assessment Disease Monitoring, Vol. 10 (november 2017) , p. 99-111  
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23 p, 1.3 MB The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale : comprehensive assessment of psychopathology in Down syndrome / Dekker, Alain D. (Universitair Medisch Centrum Groningen) ; Sacco, Silvia (Institut Jérôme Lejeune) ; Carfi, Angelo (Universitá Cattolica del Sacro Cuore) ; Benejam, Bessy (Fundació Catalana Síndrome de Down) ; Vermeiren, Yannick (Universitair Medisch Centrum Groningen) ; Beugelsdijk, Gonny (Ipse de Bruggen) ; Schippers, Mieke (Ipse de Bruggen) ; Hassefras, Lyanne (Ipse de Bruggen) ; Eleveld, José (Cosis (Groningen)) ; Grefelman, Sharina (Cosis (Groningen)) ; Fopma, Roelie (Talant (Heerenveen)) ; Bomer-Veenboer, Monique (Pameijer (Rotterdam)) ; Boti, Mariángeles (Fundació Catalana Síndrome de Down) ; Oosterling, G. Danielle E. (Aveleijn (Borne)) ; Scholten, Esther (Elver (Nieuw-Wehl)) ; Tollenaere, Marleen (Institute Born-Bunge) ; Checkley, Laura (University College London. Division of Psychiatry) ; Strydom, André (University College London. Division of Psychiatry) ; Van Goethem, Gert (Het GielsBos (Gierle)) ; Onder, Graziano (Universitá Cattolica del Sacro Cuore) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; zu Eulenburg, Christine (Universitair Medisch Centrum Groningen) ; Coppus, Antonia M.W. (Dichterbij (Gennep)) ; Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ; Fortea, Juan (Fundació Catalana Síndrome de Down) ; De Deyn, Peter P. (Universitair Medisch Centrum Groningen) ; Universitat Autònoma de Barcelona
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. [...]
2018 - 10.3233/JAD-170920
Journal of Alzheimer's disease, Vol. 63, issue 2 (2018) , p. 797-819  
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10 p, 92.4 KB Social Representation of Dementia : An Analysis of 5,792 Consecutive Cases Evaluated in a Memory Clinic / Cañabate, Pilar (Institut Català de Neurociènces Aplicades) ; Martínez, Gabriel (University of Antofagasta) ; Rosende-Roca, Maitée (Institut Català de Neurociènces Aplicades) ; Moreno, Mariola (Institut Català de Neurociènces Aplicades) ; Preckler, Silvia (Institut Català de Neurociènces Aplicades) ; Valero Ventura, Sergi (Hospital Universitari Vall d'Hebron) ; Sotolongo Grau, Oscar (Institut Català de Neurociènces Aplicades) ; Hernández, Isabel (Institut Català de Neurociènces Aplicades) ; Alegret, Montserrat (Institut Català de Neurociènces Aplicades) ; Ortega Linares, Gemma (Institut Català de Neurociènces Aplicades) ; Espinosa, Ana (Institut Català de Neurociènces Aplicades) ; Mauleón, Ana (Institut Català de Neurociènces Aplicades) ; Vargas, Liliana (Institut Català de Neurociènces Aplicades) ; Rodríguez, Octavio (Institut Català de Neurociènces Aplicades) ; Abdelnour, Carla (Institut Català de Neurociènces Aplicades) ; Sánchez, Domingo (Institut Català de Neurociènces Aplicades) ; Martín, Elvira (Institut Català de Neurociènces Aplicades) ; Ruiz, Agustín (Institut Català de Neurociènces Aplicades) ; Tárraga, Lluís (Institut Català de Neurociènces Aplicades) ; Boada Rovira, Mercè (Institut Català de Neurociènces Aplicades) ; Universitat Autònoma de Barcelona
Background: Different interpretations of cognitive impairment and dementia due to differences in health structures, such as cultural differences could affect the diagnosis and treatment of the condition. [...]
2017 - 10.3233/JAD-161119
Journal of Alzheimer's Disease, Vol. 58, Núm. 4 (June 2017) , p. 1099-1108  
6.
10 p, 566.6 KB Cerebrospinal fluid biomarkers for Alzheimer's disease in Down syndrome / Dekker, Alain D. (University of Antwerp) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; De Deyn, Peter P. (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Universitat Autònoma de Barcelona
Down syndrome (DS), present in nearly six million people, is associated with an extremely high risk to develop Alzheimer's disease (AD). Amyloid-β and tau pathology are omnipresent from age 40 years onward, but clinical symptoms do not appear in all DS individuals. [...]
2017 - 10.1016/j.dadm.2017.02.006
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 8 (march 2017) , p. 1-10  
7.
13 p, 129.1 KB Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype / Espinosa, Ana (Institut Català de Neurociències Aplicades) ; Alegret, Montserrat (Institut Català de Neurociències Aplicades) ; Pesini, Pedro (Araclon Biotech S.L.) ; Valero Ventura, Sergi (Hospital Universitari Vall d'Hebron) ; Lafuente, Asunción (Institut Català de Neurociències Aplicades) ; Buendía, Mar (Institut Català de Neurociències Aplicades) ; San José, Itziar (Araclon Biotech S.L.) ; Ibarria, Marta (Institut Català de Neurociències Aplicades) ; Tejero, Miguel A. (Clínica Corachán) ; Giménez Ruiz, Joan (Clínica Corachán) ; Ruiz, Susana (Institut Català de Neurociències Aplicades) ; Hernández, Isabel (Institut Català de Neurociències Aplicades) ; Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ; Martínez Lage, Pablo (Fundación CITA) ; Munuera del Cerro, Josep (Hospital Universitari Germans Trias i Pujol) ; Arbizu, Javier (Clínica Universitaria de Pamplona) ; Tárraga, Lluís (Institut Català de Neurociències Aplicades) ; Hendrix, Suzanne B. (Pentara Corporation) ; Ruiz, Agustín (Institut Català de Neurociències Aplicades) ; Becker, James T. (University of Pittsburgh) ; Landau, Susan M. (University of California) ; Sotolongo Grau, Oscar (Institut Català de Neurociències Aplicades) ; Sarasa, Manuel (Araclon Biotech S.L.) ; Boada Rovira, Mercè (Institut Català de Neurociències Aplicades) ; Universitat Autònoma de Barcelona
The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8. 5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. [...]
2017 - 10.3233/JAD-161223
Journal of Alzheimer's Disease, Vol. 57, Núm. 2 (March 2017) , p. 447-459  
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9 p, 204.1 KB Effect Size Analyses of Souvenaid in Patients with Alzheimer's Disease / Cummings, Jeffrey (Cleveland Clinic Lou Ruvo Center for Brain Health) ; Scheltens, Philip (VU University Medical Center) ; McKeith, Ian (Newcastle University) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Harrison, John E. (Metis Cognition Ltd, Park House, Kilmington Common, Wiltshire) ; Bertolucci, Paulo H.F. (Behaviour Neurology Section – Universidade Federal de São Paulo) ; Rockwood, Kenneth (DGI Clinical, Halifax, NS) ; Wilkinson, David (University of Southampton) ; Wijker, Wouter (Auxiliis BV, Amsterdam) ; Bennett, David A. (Rush University Medical Center) ; Shah, Raj C. (Rush University Medical Center) ; Universitat Autònoma de Barcelona. Departament de Neurologia
Background: Souvenaid ® (uridine monophosphate, docosahexaenoic acid, eicosapentaenoic acid, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium), was developed to support the formation and function of neuronal membranes. [...]
2016 - 10.3233/JAD-160745
Journal of Alzheimer's Disease, Vol. 55 (december 2016) , p. 1131-1139  
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5 p, 722.3 KB Copper Modulation as a Therapy for Alzheimer's Disease? / Manso Sanz, Yasmina (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Comes Orpinell, Gemma (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bush, Ashley I. (The Mental Health Research Institute. Oxidation Biology Laboratory (Australia)) ; Adlard, Paul A. (The University of Melbourne. Department of Pathology (Australia)) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The role of metals in the pathophysiology of Alzheimer's disease (AD) has gained considerable support in recent years, with both in vitro and in vivo data demonstrating that a mis-metabolism of metal ions, such as copper and zinc, may affect various cellular cascades that ultimately leads to the development and/or potentiation of AD. [...]
2011 - 10.4061/2011/370345
International Journal of Alzheimer's Disease, Vol. 2011 (June 2011) , art. 370345  
10.
14 p, 335.5 KB Long-term exercise modulates hippocampal gene expression in sencescent females mice / Álvarez Torres, María Jesús (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Castro-Freire, Marco (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Cosín-Tomás, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Sanchez Roige, Sandra (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ferrer Lalanza, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle i Macià, Jaume (Universitat de Barcelona. Institut de Biomedicina) ; Párrizas, Marcelina (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)) ; Camins Espuny, Antoni (Universitat de Barcelona. Institut de Biomedicina) ; Pallàs i Llibería, Mercè, 1964- (Universitat de Barcelona. Institut de Biomedicina) ; Escorihuela, Rosa Maria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kaliman, Perla (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
The senescence-accelerated SAMP8 mouse is considered a useful non-transgenic model for studying aspects of progressive cognitive decline and Alzheimer's disease (AD). Using SAMR1 mice as controls, here we explored the effects of 6 months of voluntary wheel running in 10-month-old female SAMP8 mice. [...]
2013 - 10.3233/JAD-121264
Journal of Alzheimer's disease, Vol. 33, Num. 4 (2013) , p. 1177-1190  

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