UAB Digital Repository of Documents 10 records found  Search took 0.01 seconds. 
1.
7 p, 406.2 KB Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer : a case control study / Pavlidou, Evangelia. (Geneva University Hospitals. Department of Gynaecology and Obstetrics) ; Daponte, Alexandros (University of Thessaly. Department of Obstetrics and Gynaecology. Faculty of Medicine) ; Egea Sánchez, Raquel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Dardiotis, Efthimios (University of Thessaly. Department of Neurology) ; Hadjigeorgiou, Georgios M. (University of Thessaly. Department of Neurology) ; Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i Microbiologia) ; Agorastos, Theodoros (Hippokrateion General Hospital of Thessaloniki)
Background: the aim of the study was to evaluate the association of two SNPs of EVER1/2 genes' region (rs2290907, rs16970849) and the FAS-670 polymorphism with the susceptibility to precancerous lesions and cervical cancer in a Greek population. [...]
2016 - 10.1186/s12885-016-2960-3
BMC Cancer, Vol. 16 (2016) , art. 923  
2.
12 p, 2.8 MB Co-regulation analysis of closely linked genes identifies a highly recurrent gain on chromosome 17q25.3 in prostate cancer / Bermudo, Raquel (Institut de Biologia Molecular de Barcelona) ; Abia, David (Centro de Biología Molecular Severo Ochoa) ; Ferrer, Berta (Hospital Clínic de Barcelona. Departament de Patologia) ; Nayach, Iracema (Hospital Clínic de Barcelona. Departament de Patologia) ; Benguria, Alberto (Centro Nacional de Biotecnología. Departamento de Inmunología y Oncología) ; Zaballos, Ángel (Centro Nacional de Biotecnología. Departamento de Inmunología y Oncología) ; Del Rey Azpiri, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Miró, Rosa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Campo, Elias (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Martínez-A, Carlos (Centro Nacional de Biotecnología. Departamento de Inmunología y Oncología) ; Ortiz, Ángel R. (Centro de Biología Molecular Severo Ochoa) ; Fernández, Pedro L. (Hospital Clínic de Barcelona. Departament de Patologia) ; Thomson, Timothy M. (Institut de Biologia Molecular de Barcelona)
Background: transcriptional profiling of prostate cancer (PC) has unveiled new markers of neoplasia and allowed insights into mechanisms underlying this disease. Genomewide analyses have also identified new chromosomal abnormalities associated with PC. [...]
2008 - 10.1186/1471-2407-8-315
BMC Cancer, Vol. 8 (2008) , art. 315  
3.
11 p, 542.8 KB A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer / Reynolds, Kerry Lynn ; Bedard, Philippe L. (Toronto, ON Canada) ; Lee, Se-Hoon (Seoul, Republic of Korea) ; Lin, Chia-Chi (Taipei, Taiwan) ; Tabernero, Josep (Hospital Universitari Vall d'Hebron) ; Alsina, Maria (Hospital Universitari Vall d'Hebron) ; Cohen, Ezra (La Jolla, CA USA) ; Baselga, José (New York, NY USA) ; Blumenschein, George (Houston, TX USA) ; Graham, Donna M. (Toronto, ON Canada) ; Garrido-Laguna, Ignacio (Salt Lake City, UT USA) ; Juric, Dejan (Fruit Street, Boston, MA 02114 USA) ; Sharma, Sunil (Salt Lake City, UT USA) ; Salgia, Ravi (Duarte, CA USA) ; Seroutou, Abdelkader (Basel, Switzerland) ; Tian, Xianbin (East Hanover, NJ USA) ; Fernandez, Rose (East Hanover, NJ USA) ; Morozov, Alex (New York, NY USA) ; Sheng, Qing (Cambridge, MA USA) ; Ramkumar, Thiruvamoor (East Hanover, NJ USA) ; Zubel, Angela (Basel, Switzerland) ; Bang, Yung-Jue (Seoul, Republic of Korea) ; Universitat Autònoma de Barcelona
Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. A phase I study of anti-HER3 monoclonal antibody LJM716 was conducted with the primary objective to identify the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE), and dosing schedule. [...]
2017 - 10.1186/s12885-017-3641-6
BMC Cancer, Vol. 17 (september 2017)  
4.
11 p, 912.9 KB Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice : a retrospective cross-sectional analysis / Capdevila, Jaume (Hospital Universitari Vall d'Hebron) ; Sevilla, Isabel (Hospital Universitario Virgen de la Victoria) ; Alonso, Vicente (Medical Oncology Department, Hospital Universitario Miguel Servet) ; Antón Aparicio, Luís (Complejo Hospitalario Universitario A Coruña) ; Jiménez Fonseca, Paula (Hospital Universitario Central de Asturias) ; Grande, Enrique (Hospital Universitario Ramón y Cajal) ; Reina, Juan José (Hospital Universitario Virgen de la Macarena) ; Manzano, José Luís (Hospital Universitari Vall d'Hebron) ; Alonso Lájara, Juan Domingo (Hospital Universitario Virgen de la Arrixaca) ; Barriuso, Jorge (Hospital Universitario La Paz) ; Castellano, Daniel (Hospital Universitario 12 de Octubre) ; Medina, Javier (Complejo Hospitalario de Toledo) ; López, Carlos (Hospital Universitario Marqués de Valdecilla) ; Segura, Ángel (Hospital Universitario La Fe University Hospital) ; Carrera, Sergio (Hospital Universitario de Cruces) ; Crespo, Guillermo (Hospital Universitario de Burgos) ; Fuster, José (Hospital Universitario Son Dureta) ; Munarriz, Javier (Hospital Provincial de Castellón) ; García Alfonso, Pilar (Hospital Gregorio Marañon) ; Universitat Autònoma de Barcelona
Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). [...]
2015 - 10.1186/s12885-015-1512-6
BMC Cancer, Vol. 15 (july 2015)  
5.
14 p, 2.0 MB Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential : a molecular and clinicopathological study / Gonzalo Calvo, David de (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; López Vilaró, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Nasarre, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Perez Olabarria, Maitane (Institut d'Investigacions Biomèdiques Sant Pau) ; Vázquez, Tania (Institut d'Investigacions Biomèdiques Sant Pau) ; Escuin i Borràs, Daniel (Institut d'Investigacions Biomèdiques Sant Pau) ; Badimón Maestro, Lina (Institut de Ciències Cardiovasculars de Catalunya) ; Barnadas Molins, Agustí (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Servei d'Oncologia Mèdica) ; Lerma Puertas, Enrique (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ; Llorente Cortés, Vicenta (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Background: The metabolic effect of intratumor cholesteryl ester (CE) in breast cancer remains poorly understood. The objective was to analyze the relationship between intratumor CE content and clinicopathological variables in human breast carcinomas. [...]
2015 - 10.1186/s12885-015-1469-5
BMC Cancer, Vol. 15 N. 460 (June 2015) , p. 1-13  
6.
10 p, 288.5 KB Esophageal cancer risk by type of alcohol drinking and smoking : a case-control study in Spain / Vioque, Jesús (Universidad Miguel Hernández. Departamento de Salud Pública) ; Barber, Xavier (Universidad Miguel Hernández. Departamento de Estadística) ; Bolumar, Francisco (Universidad de Alcalá. Facultad de Medicina) ; Porta, Miquel, 1957- (Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva) ; Santibáñez, Miguel (Universidad Miguel Hernández. Departamento de Salud Pública) ; García de la Hera, Manuela (Universidad Miguel Hernández. Departamento de Salud Pública) ; Moreno-Osset, Eduardo (Hospital Universitario Dr. Peset (València)) ; PANESOES Study Group
Background: The effect of tobacco smoking and alcohol drinking on esophageal cancer (EC) has never been explored in Spain where black tobacco and wine consumptions are quite prevalent. We estimated the independent effect of different alcoholic beverages and type of tobacco smoking on the risk of EC and its main histological cell type (squamous cell carcinoma) in a hospital-based case-control study in a Mediterranean area of Spain. [...]
2008 - 10.1186/1471-2407-8-221
BMC Cancer, Vol. 8, Núm. 221 (August 2008), p. 1-10  
7.
11 p, 410.7 KB Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma / Lavarino, Cinzia (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ; Cheung, Nai-Kong V. (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ; García, Idoia (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ; Domènech Gómez, Gemma (Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva) ; Torres, Carmen de (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ; Alaminos, Miguel (Universidad de Granada. Departamento de Histología) ; Ríos Guillermo, José (Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva) ; Gerald, William L. (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ; Kushner, Brian (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ; LaQuaglia, Mike (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ; Mora, Jaume (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Background: Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficult, but critical for therapeutic decisions. [...]
2009 - 10.1186/1471-2407-9-44
BMC Cancer, Vol. 9, N. 44 (February 2009) , p. 1-11
5 documents
8.
10 p, 306.7 KB A single dose of pegfilgrastim compared with daily filgrastim for supporting neutrophil recovery in patients treated for low-tointermediate risk acute myeloid leukemia : results from a randomized, double-blind, phase 2 tria / Sierra Gil, Jorge (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Szer, Jeffrey (Royal Melbourne Hospital (Melbourne, Austràlia)) ; Kassis, Jeannine (Hospital Maisonneuve-Rosemont (Montreal, Canadà)) ; Herrmann, Richard (Royal Perth Hospital (Perth, Austràlia)) ; Lazzarino, Mario (University of Pavia (Itàlia)) ; Thomas, Xavier (Edouard Herriot Hospital (Lyon, França)) ; Noga, Stephen J. (Alvin and Lois Lapidus Cancer Institute (Baltimore, Estats Units d'Amèrica)) ; Baker, Nigel (Biostatistics, Amgen Ltd. (Cambridge, Regne Unit)) ; Dansey, Roger (Clinical Development, Amgen Inc. (Thousand Oaks, Estats Units d'Amèrica)) ; Bosi, Alberto (University of Florence (Itàlia). Department of Critical Care)
Background: Patients with acute myeloid leukemia (AML) are often neutropenic as a result of their disease. Furthermore, these patients typically experience profound neutropenia following induction and/or consolidation chemotherapy and this may result in serious, potentially life-threatening, infection. [...]
2008 - 10.1186/1471-2407-8-195
BMC Cancer, Vol. 8, N. 195 (July 2008) , p. 1-10  
9.
11 p, 1016.0 KB Centrosome clustering and Cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors / Del Rey Azpiri, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Prat Pedrola, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ponsa Arjona, Immaculada (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Lloreta, Josep, 1958- (Universitat Pompeu Fabra. Departament de Patologia) ; Gelabert Mas, Antonio (Hospital del Mar (Barcelona, Catalunya)) ; Algaba, Ferran (Universitat Autònoma de Barcelona. Departament de Patologia) ; Camps Polo, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Miró, Rosa (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Background: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tumor. [...]
2010 - 10.1186/1471-2407-10-280
BMC Cancer, Vol. 10, N. 280 (June 2010) , p. 1-11  
10.
12 p, 919.1 KB A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation / Castro, Jessica (Universitat de Girona. Departament de Biologia) ; Ribó i Panosa, Marc (Universitat de Girona. Departament de Biologia) ; Navarro Cantero, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Nogués i Bara, M. Victòria (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Vilanova i Brugués, Maria (Universitat de Girona. Departament de Biologia) ; Benito i Mundet, Antoni (Universitat de Girona. Departament de Biologia)
Background: Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effects, presents synergism with several kinds of anticancer drugs and is currently in phase II/III of its clinical trial as an anticancer drug against different types of cancer. [...]
2011 - 10.1186/1471-2407-11-9
BMC Cancer, Vol. 11, N. 9 (January 2011) , p. 1-12  

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