UAB Digital Repository of Documents 19 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
1.
11 p, 622.0 KB Definition of Castrate Resistant Prostate Cancer : New Insights / Morote Robles, Juan (Universitat Autònoma de Barcelona. Departament de Cirurgia) ; Aguilar, Adriana (Hospital Universitari Vall d'Hebron) ; Planas, Jacques (Hospital Universitari Vall d'Hebron) ; Trilla Herrera, Enrique (Universitat Autònoma de Barcelona. Departament de Cirurgia)
The term castrate resistant prostate cancer (CRPC) was initially proposed by the Prostate Cancer Working Group 2 in 2008 to define the state of clinical and/or biochemical progression of prostate cancer (PCa) in an environment with very low serum testosterone concentration. [...]
2022 - 10.3390/biomedicines10030689
Biomedicines, Vol. 10 (march 2022)  
2.
12 p, 3.7 MB Minimum Effective Dose of DPP-4 Inhibitors for Treating Early Stages of Diabetic Retinopathy in an Experimental Model / Bogdanov, Patricia (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Ramos, Hugo (Instituto de Salud Carlos III (ICSIII). Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)) ; Valeri, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Deàs-Just, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Huerta, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hernández, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina)
The neurovascular unit (NVU) plays an essential role in the development of diabetic retinopathy (DR). We previously reported that the topical administration (eye drops) of sitagliptin and saxagliptin, two dipeptidyl peptidase-4 inhibitors (DPP-4i), prevents retinal neurodegeneration and vascular leakage in db/db mice. [...]
2022 - 10.3390/biomedicines10020465
Biomedicines, Vol. 10 (february 2022)  
3.
17 p, 24.9 MB Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response / Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García-Martínez, Araceli (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Hostalot, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fajardo-Montañana, Carmen (Hospital Universitario de La Ribera (Valencia)) ; Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bernabeu, Ignacio (Hospital Clínico Universitario de Santiago) ; Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ; Rodríguez-Lloveras, Helena (Institut Germans Trias i Pujol) ; Cámara, Rosa (Hospital Universitari i Politècnic La Fe de Valencia) ; Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lamas, Cristina (Hospital General Universitario de Albacete) ; Biagetti, Betina (Hospital Universitari Vall d'Hebron) ; Simó-Servat, Andreu (Mútua de Terrassa) ; Webb, S. M (Institut d'Investigació Biomèdica Sant Pau) ; Picó, Antonio (Universidad de Miguel Hernández de Elche) ; Jordà, Mireia (Institut Germans Trias i Pujol) ; Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. [...]
2022 - 10.3390/biomedicines10020460
Biomedicines, Vol. 10 (february 2022)  
4.
16 p, 1.1 MB Sex-dependent signatures, time frames and longitudinal fine-tuning of the marble burying test in normal and ad-pathological aging mice / Santana-Santana, Mikel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
The marble burying (MB) test, a classical test based on the natural tendency of rodents to dig in diverse substrates and to bury small objects, is sensitive to some intrinsic and extrinsic factors. Here, under emerging neuroethological quantitative and qualitative analysis, the MB performance of 12-month-old male and female 3xTg-AD mice for Alzheimer's disease and age-matched counterparts of gold-standard C57BL6 strain with normal aging unveiled sex-dependent signatures. [...]
2021 - 10.3390/biomedicines9080994
Biomedicines, Vol. 9 Núm. 8 (august 2021) , p. 994  
5.
10 p, 2.4 MB Effects of the topical administration of semaglutide on retinal neuroinflammation and vascular leakage in experimental diabetes / Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bogdanov, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramos, Hugo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Huerta, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó-Servat, Olga (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Background: An unexpected increase in the rate of severe diabetic retinopathy was observed in the Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN)-6 clinical trial. Although this effect was attributed to a rapid decrease in blood glucose levels, a direct deleterious effect of semaglutide on the retina could not be ruled out. [...]
2021 - 10.3390/biomedicines9080926
Biomedicines, Vol. 9 Núm. 8 (august 2021) , p. 926  
6.
26 p, 7.0 MB Chronic Glaucoma Using Biodegradable Microspheres to Induce Intraocular Pressure Elevation. Six-Month Follow-Up / Rodrigo, Maria Jesus (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ; Garcia-Herranz, David (Hospital Clínico San Carlos (Madrid)) ; Subias, Manuel (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ; Martinez-Rincón, Teresa (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ; Mendez-Martínez, Silvia (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ; Bravo-Osuna, Irene (Hospital Clínico San Carlos (Madrid)) ; Carretero i Romay, Ana (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Ruberte, Jesús (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; García-Feijoo, Julián (Hospital Clínico San Carlos (Madrid)) ; Pablo, Luis Emilio (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ; Herrero-Vanrell, Rocío (Hospital Clínico San Carlos (Madrid)) ; Garcia-Martin, Elena (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group)
Background: To compare two prolonged animal models of glaucoma over 24 weeks of follow-up. A novel pre-trabecular model of chronic glaucoma was achieved by injection of biodegradable poly lactic-co-glycolic acid (PLGA) microspheres (10-20 µm) (Ms20/10) into the ocular anterior chamber to progressively increase ocular hypertension (OHT). [...]
2021 - 10.3390/biomedicines9060682
Biomedicines, Vol. 9 Núm. 6 (june 2021)  
7.
22 p, 3.2 MB Survival Bias and Crosstalk between Chronological and Behavioral Age : Age- and Genotype-Sensitivity Tests Define Behavioral Signatures in Middle-Aged, Old, and Long-Lived Mice with Normal and AD-Associated Aging / Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Marin-Pardo, Daniela (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Marazuela, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca)
New evidence refers to a high degree of heterogeneity in normal but also Alzheimer's disease (AD) clinical and temporal patterns, increased mortality, and the need to find specific end-of-life prognosticators. [...]
2021 - 10.3390/biomedicines9060636
Biomedicines, Vol. 9 (june 2021)  
8.
20 p, 14.1 MB In Vivo Evaluation of ECP Peptide Analogues for the Treatment of Acinetobacter baumannii Infection / Li, Jiarui (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Prats-Ejarque, Guillem (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Andreu Martínez, David (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Brandenburg, Klaus (Brandenburg Antiinfektiva GmbH) ; Fernández-Millán, Pablo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Antimicrobial peptides (AMPs) are alternative therapeutics to traditional antibiotics against bacterial resistance. Our previous work identified an antimicrobial region at the N-terminus of the eosinophil cationic protein (ECP). [...]
2022 - 10.3390/biomedicines10020386
Biomedicines, Vol. 10 Núm. 2 (february 2022) , p. 386  
9.
22 p, 6.2 MB Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients : Gender Differences / Wang, Xuejie (Institut Hospital del Mar d'Investigacions Mèdiques) ; Balaña, Ana (Parc de Salut MAR de Barcelona) ; Martinez-Llorens, J (Parc de Salut MAR de Barcelona) ; Qin, Liyun (Institut Hospital del Mar d'Investigacions Mèdiques) ; Xia, Yingchen (Institut Hospital del Mar d'Investigacions Mèdiques) ; Zha, Jianhua (First Affiliated Hospital of Nanchang University) ; Maiques, José María (Hospital del Mar (Barcelona, Catalunya)) ; Barreiro, E (Parc de Salut MAR de Barcelona) ; Universitat Autònoma de Barcelona
As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly altered in female than in males for identical age and disease severity. [...]
2022 - 10.3390/biomedicines10020334
Biomedicines, Vol. 10 Núm. 2 (february 2022) , p. 334  
10.
16 p, 2.9 MB Growth Factors Do Not Improve Muscle Function in Young or Adult mdx Mice / Nielsen, Tue L. (University of Copenhagen. Department of Neurology) ; Hornsyld, Tessa M. (University of Copenhagen. Department of Neurology) ; Pinós, Tomàs (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Brolin, Camilla (University of Copenhagen. Department of Cellular and Molecular Medicine) ; Vissing, John (University of Copenhagen. Department of Neurology) ; Krag, Thomas (University of Copenhagen. Department of Neurology) ; Universitat Autònoma de Barcelona
Muscular dystrophies constitute a broad group of genetic disorders leading to muscle wasting. We have previously demonstrated that treating a muscular atrophy mouse model with growth factors resulted in increased muscle mass. [...]
2022 - 10.3390/biomedicines10020304
Biomedicines, Vol. 10 Núm. 2 (january 2022)  

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