UAB Digital Repository of Documents 17 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
1.
16 p, 2.1 MB Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis / Varela-Eirín, Marta (Universidade da Coruña) ; Varela-Vázquez, Adrián (Universidade da Coruña) ; Guitián-Caamaño, Amanda ; Paíno, Carlos Luis (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Mato, Virginia (Universidade da Coruña) ; Largo, Raquel (IIS-Fundación Jiménez Díaz UAM) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tabernero, Arantxa (Universidad de Salamanca) ; Fonseca, Eduardo (Universidade da Coruña) ; Kandouz, Mustapha (Wayne State University. Department of Pathology, School of Medicine) ; Caeiro, José Ramón (Complejo Hospitalario Universitario de Santiago de Compostela) ; Blanco, Alfonso (University College Dublin C). CellCOM research) ; Mayán, María D. (Universidade da Coruña) ; Universitat Autònoma de Barcelona
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. [...]
2018 - 10.1038/s41419-018-1225-2
Cell death and disease, Vol. 9 (december 2018)  
2.
17 p, 2.7 MB Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease / Franco Iborra, Sandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cuadros, Thais (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Parent, Annabelle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Romero-Gimenez, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Perier, Celine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Mitochondria are the prime energy source in most eukaryotic cells, but these highly dynamic organelles are also involved in a multitude of cellular events. Disruption of mitochondrial homeostasis and the subsequent mitochondrial dysfunction plays a key role in the pathophysiology of Parkinson's disease (PD). [...]
2018 - 10.1038/s41419-018-1154-0
Cell death and disease, Vol. 9 (november 2018)  
3.
15 p, 3.0 MB Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy / Piñol-Jurado, Patricia (Institut d'Investigació Biomèdica Sant Pau) ; Suarez-Calvet, Xavier (Institut d'Investigació Biomèdica Sant Pau) ; Fernández-Simón, Esther (Institut d'Investigació Biomèdica Sant Pau) ; Gallardo, Eduard (Institut d'Investigació Biomèdica Sant Pau) ; de la Oliva, Natalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martínez-Muriana, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gómez-Gálvez, Pedro (Instituto de Biomedicina de Sevilla) ; Escudero, Luis M. (Instituto de Biomedicina de Sevilla) ; Pérez-Peiró, María (Institut d'Investigació Biomèdica Sant Pau) ; Wollin, Lutz (Immunology & Respiratory Diseases Research, Boehringer-Ingelheim, Biberach, Germany) ; de Luna Salva, Noemí (Institut d'Investigació Biomèdica Sant Pau) ; Navarro, Xavier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by fibro-adipose tissue. [...]
2018 - 10.1038/s41419-018-0792-6
Cell death and disease, Vol. 9 (july 2018)  
4.
10 p, 1.7 MB The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis / París-Coderch, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Soriano, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jiménez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Erazo, Tatiana (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Muñoz-Guardiola, Pau (Ability Pharmaceuticals) ; Masanas, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Antonelli, Roberta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Boloix, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alfón, José (Ability Pharmaceuticals) ; Pérez-Montoyo, Héctor (Ability Pharmaceuticals) ; Yeste-Velasco, Marc (Ability Pharmaceuticals) ; Domènech, Carles (Ability Pharmaceuticals) ; Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sánchez de Toledo Codin, Josep (Vall d'Hebron Institut d'Oncologia) ; Moreno, Lucas (Vall d'Hebron Institut d'Oncologia) ; Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gallego, Soledad (Vall d'Hebron Institut d'Oncologia) ; Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Neuroblastoma is the leading cause of cancer death in children aged 1 to 4 years. Particularly, five-year overall survival for high-risk neuroblastoma is below 50% with no curative options when refractory or relapsed. [...]
2020 - 10.1038/s41419-020-02986-w
Cell death and disease, Vol. 11 (september 2020)  
5.
13 p, 1.3 MB Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance / Alcon, Clara (Institut de Bioenginyeria de Catalunya) ; Manzano-Muñoz, Albert (Institut de Bioenginyeria de Catalunya) ; Prada, Estela (Hospital Sant Joan de Déu Barcelona) ; Mora, Jaume (Hospital Sant Joan de Déu Barcelona) ; Soriano, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Guillén, Gabriela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gallego, Soledad (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Samitier, Josep (Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine) ; Villanueva, A. (Institut d'Investigació Biomèdica de Bellvitge) ; Montero, Joan (Institut de Bioenginyeria de Catalunya) ; Universitat Autònoma de Barcelona
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood and adolescence. Refractory/relapsed RMS patients present a bad prognosis that combined with the lack of specific biomarkers impairs the development of new therapies. [...]
2020 - 10.1038/s41419-020-02887-y
Cell death and disease, Vol. 11 (august 2020)  
6.
11 p, 5.5 MB Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis / Oria Alonso, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Duru, Soner (Cincinnati Children's Hospital Medical Center) ; Figueira, Rebeca L. (University of Sao Paulo-USP) ; Scorletti, Federico (Ospedale Pediatrico Bambino Gesù) ; Turner, Lucas E. (Northwestern University) ; Fernandez-Alonso, Irati (Cincinnati Children's Hospital Medical Center) ; Fernandez-Martin, Alejandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Marotta, Mario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sbragia, Lourenco (University of Sao Paulo-USP) ; Shaaban, Aimen F. (Northwestern University) ; Peiro, Jose L. (Cincinnati Children's Hospital Medical Center) ; Universitat Autònoma de Barcelona
Exencephaly/anencephaly is one of the leading causes of neonatal mortality and the most extreme open neural tube defect with no current treatments and limited mechanistic understanding. We hypothesized that exencephaly leads to a local neurodegenerative process in the brain exposed to the amniotic fluid as well as diffuse degeneration in other encephalic areas and the spinal cord. [...]
2019 - 10.1038/s41419-019-1913-6
Cell death and disease, Vol. 10 (september 2019)  
7.
19 p, 5.0 MB SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L / Coccia, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Planells-Ferrer, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Badillos-Rodríguez, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pascual, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández-Hernández, Rita (Institut de Recerca Biomèdica de Lleida) ; López-Soriano, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garí, Eloi (Institut de Recerca Biomèdica de Lleida) ; Soriano García, Eduardo (Institució Catalana de Recerca i Estudis Avançats) ; Barneda Zahonero, Bruna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Moubarak, Rana S. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pérez-García, M. Jose (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comella i Carnicé, Joan Xavier 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona.Institut de Neurociències
The long isoform of Fas apoptosis inhibitory molecule (FAIM-L) is a neuron-specific death receptor antagonist that modulates apoptotic cell death and mechanisms of neuronal plasticity. FAIM-L exerts its antiapoptotic action by binding to X-linked inhibitor of apoptosis protein (XIAP), an inhibitor of caspases, which are the main effectors of apoptosis. [...]
2020 - 10.1038/s41419-020-2282-x
Cell death and disease, Vol. 11 (february 2020)  
8.
12 p, 3.1 MB Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis / Ejarque, Miriam (Hospital Universitari Joan XXIII de Tarragona) ; Ceperuelo Mallafré, Victòria (Hospital Universitari Joan XXIII de Tarragona) ; Serena, Carolina (Hospital Universitari Joan XXIII de Tarragona) ; Pachón, Gisela (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Núñez Álvarez, Yaiza (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Terrón Puig, Margarida (Hospital Universitari Joan XXIII de Tarragona) ; Calvo, Enrique (Hospital Universitari Joan XXIII de Tarragona) ; Núñez Roa, Catalina (Hospital Universitari Joan XXIII de Tarragona) ; Oliva Olivera, Wilfredo (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ; Tinahones, Francisco J. (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ; Peinado, Miguel Angel (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Vendrell, Joan (Hospital Universitari Joan XXIII de Tarragona) ; Fernández-Veledo, Sonia (Hospital Universitari Joan XXIII de Tarragona) ; Universitat Autònoma de Barcelona
Adipose tissue (AT) has a central role in obesity-related metabolic imbalance through the dysregulated production of cytokines and adipokines. In addition to its known risk for cardiovascular disease and diabetes, obesity is also a major risk for cancer. [...]
2017 - 10.1038/cddis.2017.209
Cell Death and Disease, Núm. 8 (2017) , p. 1-12  
9.
14 p, 1.9 MB Low doses of LPS exacerbate the inflammatory response and trigger death on TLR3-primed human monocytes / Monguió Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Franquesa, Marcella (Institut Germans Trias i Pujol) ; Sarrias, Maria-Rosa (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Borràs, Francesc E. (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
TLR sensing of pathogens triggers monocyte activation to initiate the host innate immune response to infection. Monocytes can dynamically adapt to different TLR agonists inducing different patterns of inflammatory response, and the sequence of exposure to TLRs can dramatically modulate cell activation. [...]
2018 - 10.1038/s41419-018-0520-2
Cell death and disease, Vol. 9 (May 2018) , art. 499  
10.
12 p, 2.7 MB Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain processing induced by excitotoxicity / Gamir-Morralla, A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; López-Menéndez, C. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ayuso-Dolado, S. (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Tejeda, G. S. (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Montaner, J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rosell, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Iglesias, T. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Díaz-Guerra, M. (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Universitat Autònoma de Barcelona
Kinase D-interacting substrate of 220 kDa (Kidins220), also known as ankyrin repeat-rich membrane spanning (ARMS), has a central role in the coordination of receptor crosstalk and the integration of signaling pathways essential for neuronal differentiation, survival and function. [...]
2015 - 10.1038/cddis.2015.307
Cell death and disease, Vol. 6 (october 2015) , p. e1939  

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