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33 p, 20.4 MB |
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells
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Zhang, Yu Wei (University of Freiburg, Germany) ;
Mess, Julian (University of Freiburg, Germany) ;
Aizarani, Nadim (University of Freiburg, Germany) ;
Mishra, Pankaj (University of Freiburg, Germany) ;
Johnson, Carys (University of Cambridge, UK) ;
Romero-Mulero, Mari Carmen (University of Freiburg, Germany) ;
Rettkowski, Jasmin (University of Freiburg, Germany) ;
Schönberger, Katharina (University of Freiburg, Germany) ;
Obier, Nadine (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Jäcklein, Karin (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Woessner, Nadine M. (University of Freiburg, Germany) ;
Lalioti, Maria Eleni (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Velasco-Hernandez, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sikora, Katarzyna (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Wäsch, Ralph (University of Freiburg, Germany) ;
Lehnertz, Bernhard (University of Montreal, Canada) ;
Sauvageau, Guy (University of Montreal, Canada) ;
Manke, Thomas (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Menendez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Walter, Sebastian Gottfried (University Hospital of Cologne, Germany) ;
Minguet, Susana (University of Freiburg, Germany) ;
Laurenti, Elisa (University of Cambridge, UK) ;
Günther, Stefan (University of Freiburg, Germany) ;
Grün, Dominic (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Cabezas-Wallscheid, Nina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSCs, which reversibly exit quiescence during stress. [...]
2022 -  10.1038/s41556-022-00931-x
Nature Cell Biology, Vol. 24 Núm. 7 (july 2022) , p. 1038-1048
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48 p, 12.9 MB |
MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis
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Llorente, Alicia (Centro de Investigación Biomédica en Red de Cáncer) ;
Blasco, María Teresa (Centro de Investigación Biomédica en Red de Cáncer) ;
Espuny, Irene (Cancer Science Program. Institute for Research in Biomedicine (IRB Barcelona)) ;
Guiu, Marc (Cancer Science Program. Institute for Research in Biomedicine (IRB Barcelona)) ;
Ballaré, Cecilia (Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ;
Blanco, Enrique (Centre de Regulació Genòmica) ;
Caballé, Adrià (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Bellmunt, Anna (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Salvador, Fernando (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Morales, Andrea (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Nuñez, Marc (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Loren, Guillem (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Imbastari, Francesca (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Fidalgo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Figueras-Puig, Cristina (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Gibler, Patrizia (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Graupera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Monteiro, Freddy (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Riera, Antoni (Universitat de Barcelona. Departament de Química Inorgànica i Orgànica) ;
Holen, Ingunn (University of Sheffield) ;
Avgustinova, Alexandra (Institut de Recerca Sant Joan de Déu) ;
Di Croce, Luciano (Universitat Pompeu Fabra) ;
Gomis, Roger R. (Universitat de Barcelona)
MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. [...]
2023 - 10.1038/s41556-023-01281-y
Nature Cell Biology, Vol. 25 Núm. 12 (december 2023) , p. 1833-1847
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10 p, 3.0 MB |
Applicability and validation of different prognostic scores in allogeneic hematopoietic cell transplant (HCT) in the post-transplant cyclophosphamide era
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Salas, María Queralt (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez Lobato, Luis Gerardo (Hospital Clínic i Provincial de Barcelona) ;
Charry, Paola (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó, Maria (Hospital Clínic i Provincial de Barcelona) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Solano, María Teresa (Hospital Clínic i Provincial de Barcelona) ;
Arcarons, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lozano, Miquel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rosiñol, Laura (Hospital Clínic i Provincial de Barcelona) ;
Esteve, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez Aviles, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Martínez, Carmen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
We investigated the predictive capacity of six prognostic indices [Karnofsky Performance Status (KPS), Hematopoietic Cell Transplant-Specific Comorbidity Index (HCT-CI), Disease Risk Index (DRI), European Bone Marrow Transplantation (EBMT) and Revised Pre-Transplantation Assessment of Mortality (rPAM) Scores and Endothelial Activation and Stress Index (EASIX)] in 205 adults undergoing post-transplant cyclophosphamide (PTCy)-based allo-HCT. [...]
2023 - 10.1016/j.htct.2023.07.008
Hematology, Transfusion and Cell Therapy, 2023
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24 p, 6.3 MB |
CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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Evans, Frances (Instituto Pasteur de Montevideo) ;
Alí-Ruiz, Daniela (Instituto Pasteur de Montevideo) ;
Rego, Natalia (Instituto Pasteur de Montevideo) ;
Negro-Demontel, Maria Luciana (Instituto Pasteur de Montevideo) ;
Lago, Natalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cawen, Fabio Andrés (Instituto Pasteur de Montevideo) ;
Pannunzio, Bruno (Instituto Pasteur de Montevideo) ;
Sanchez-Molina, Paula (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Reyes, Laura (Centro Uruguayo de Imagenología Molecular) ;
Paolino, Andrea (Centro Uruguayo de Imagenología Molecular) ;
Rodríguez-Duarte, Jorge (Instituto Pasteur de Montevideo) ;
Pérez-Torrado, Valentina (Instituto Pasteur de Montevideo) ;
Chicote-González, Almudena (Universitat de Barcelona. Departament de Biomedicina) ;
Quijano, Celia (Universidad de la República. Departamento de Bioquímica (Montevideo, Uruguay)) ;
Marmisolle, Inés (Universidad de la República. Departamento de Bioquímica (Montevideo, Uruguay)) ;
Mulet, Ana Paula (Instituto Pasteur de Montevideo) ;
Schlapp, Geraldine (Instituto Pasteur de Montevideo) ;
Meikle, Maria Noel (Instituto Pasteur de Montevideo) ;
Bresque, Mariana (Instituto Pasteur de Montevideo) ;
Crispo, Martina (Instituto Pasteur de Montevideo) ;
Savio, Eduardo (Centro Uruguayo de Imagenología Molecular) ;
Malagelada, Cristina (Universitat de Barcelona. Departament de Biomedicina) ;
Escande, Carlos (Instituto Pasteur de Montevideo) ;
Peluffo, Hugo (Instituto Pasteur de Montevideo) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pathways that modulate inflammation, efferocytosis, and microglial metabolic fitness. [...]
2023 - 10.1016/j.celrep.2023.113269
Cell reports, Vol. 42 Núm. 10 (2023) , p. 113269
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11 p, 1.9 MB |
A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin
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González Miranda, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bosch-Presegué, Laia (Institut de Recerca I Innovació en Ciències de La Vida i de La Salut a La Catalunya Central) ;
Marazuela Duque, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guitart-Solanes, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez, Agustín F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Brown, Jeremy P. (Department of Immunology and Inflammation. The Hammersmith Hospital) ;
Ausió, Juan (University of Victoria. Department of Biochemistry and Microbiology) ;
Vazquez Prat, Berta Nieves (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Singh, Prim B. (Nazarbayev University School of Medicine) ;
Fraga, Mario F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-specific histone modifications and interaction with a wide range of factors. [...]
2023 - 10.3389/fcell.2023.1293122
Frontiers in Cell and Developmental Biology, Vol. 11 (2023) , p. 1293122
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44 p, 10.1 MB |
Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes
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Mielczarek, O. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Rogers, C.H. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Zhan, Y. (Friedrich Miescher Institute for Biomedical Research) ;
Matheson, L.S. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Stubbington, M.J.T. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Schoenfelder, S. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Bolland, D.J. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Javierre, B. M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Wingett, S.W. (Bioinformatics Group. Babraham Institute. Babraham Research Campus) ;
Várnai, C. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Segonds-Pichon, A. (Bioinformatics Group. Babraham Institute. Babraham Research Campus) ;
Conn, S.J. (Flinders Health and Medical Research Institute. College of Medicine and Public Health. Flinders University) ;
Krueger, F. (Babraham Institute) ;
Andrews, S. (Babraham Institute) ;
Fraser, Peter (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Giorgetti, L. (Friedrich Miescher Institute for Biomedical Research) ;
Corcoran, A.E. (Immunology Programme. Babraham Institute. Babraham Research Campus)
To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V), diversity (D), and joining (J) genes. [...]
2023 - 10.1016/j.celrep.2023.113074
Cell reports, Vol. 42 Núm. 9 (26 2023) , p. 113074
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28 p, 8.7 MB |
Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
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Garcia-Diaz, Claudia (Samantha Dickson Brain Cancer Unit) ;
Pöysti, Anni (Samantha Dickson Brain Cancer Unit) ;
Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Clements, Melani P. (Samantha Dickson Brain Cancer Unit) ;
Brooks, Lucy J. (Samantha Dickson Brain Cancer Unit. UCL Cancer Institute) ;
Galvez-Cancino, Felipe (Cancer Immunology Unit. Research Department of Haematology) ;
Castillo, Simon P. (The Institute of Cancer Research) ;
Tang, Wenhao T. (Department of Mathematics. Imperial College London) ;
Beattie, Gordo (University College London) ;
Courtot, Lilas (Samantha Dickson Brain Cancer Unit) ;
Ruiz, Sara (Barcelona Institute of Science and Technology (BIST)) ;
Roncaroli, Federico (University of Manchester) ;
Yuan, Yinyin (The Institute of Cancer Research) ;
Marguerat, Samuel (University College London) ;
Quezada, Sergio A. (UCL Cancer Institute) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Parrinello, Simona (UCL Cancer Institute)
Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical debulking, but to what extent these cells resemble their bulk counterparts remains unclear. Here, we generated three immunocompetent somatic GBM mouse models, driven by subtype-associated mutations, to compare matched bulk and margin cells. [...]
2023 - 10.1016/j.celrep.2023.112472
Cell reports, Vol. 42 Núm. 5 (30 2023) , p. 112472
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23 p, 7.0 MB |
MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
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Alburquerque-Béjar, Juan Jos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Navajas-Chocarro, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Saigi, Maria (Department of Medical Oncology. Catalan Institute of Oncology (ICO)) ;
Ferrero-Andres, Ana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morillas, Juan M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vilarrubi, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gomez, Antonio (Universitat de Vic - Universitat Central de Catalunya) ;
Mate, José L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Munoz-Marmol, Ana M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romero, Octavio A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pros, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Llabata, Paula (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torres-Diz, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Sanchez-Cespedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to interferon-γ (IFNγ), a cytokine that promotes immunoresponse and modulates programmed death-ligand 1 (PD-L1) levels. [...]
2023 - 10.1016/j.xcrm.2023.101006
Cell Reports Medicine, Vol. 4 Núm. 4 (april 2023)
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