Dipòsit Digital de Documents de la UAB 79 registres trobats  1 - 10següentfinal  anar al registre: La cerca s'ha fet en 0.01 segons. 
1.
13 p, 3.5 MB Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations / Álvarez Pérez, Iñaki (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Tirado-Herranz, Adrián (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Alvarez-Palomo, Belén (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Osete, Jordi Requena (Oslo University Hospital (Oslo, Noruega)) ; Edel, Michael J (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Background: Proteins targeted by the ubiquitin proteasome system (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neurodegenerative diseases. Major histocompatibility complex (MHC) molecules present peptides broken down by the proteasome and are involved in neuronal plasticity, regulating the synapse number and axon regeneration in the central or peripheral nervous system during development and in brain diseases. [...]
2023 - 10.3390/cells12242800
Cells, Vol. 12 (december 2023)  
2.
20 p, 3.9 MB The role of lysyl oxidase enzymes in cardiac function and remodeling / Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1-4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly reactive aldehydes, which spontaneously react with surrounding amino groups and other aldehydes to form inter-and intra-catenary covalent cross-linkages. [...]
2019 - 10.3390/cells8121483
Cells, Vol. 8 Núm. 12 (december 2019) , p. 1483  
3.
17 p, 2.9 MB The E1a Adenoviral Gene Upregulates the Yamanaka Factors to Induce Partial Cellular Reprogramming / Mendoza, Gracia (Instituto de Investigación Sanitaria de Aragón) ; González-Pastor, Rebeca (Universidad UTE. Centro de Investigación Biomédica) ; Sánchez, Juan Miguel (Imperial College London. National Heart and Lung Institute) ; Arce Cerezo, Altamira (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Quintanilla, Miguel (Universidad Autónoma de Madrid. Departamento de Bioquímica) ; Moreno-Bueno, Gema (Instituto de Salud Carlos III. Centro de Investigación Biomédica en Red) ; Pujol i Altarriba, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Belmar-López, Carolina (Universidad Privada San Juan Bautista) ; de Martino, Alba (Instituto de Investigación Sanitaria de Aragón) ; Riu, Efrén (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodriguez, Tristan A. (Imperial College London. National Heart and Lung Institute) ; Martin-Duque, Pilar (Universidad de Zaragoza. Departamento de Cirugía)
The induction of pluripotency by enforced expression of different sets of genes in somatic cells has been achieved with reprogramming technologies first described by Yamanaka's group. Methodologies for generating induced pluripotent stem cells are as varied as the combinations of genes used. [...]
2023 - 10.3390/cells12091338
Cells, Vol. 12 (may 2023)  
4.
14 p, 3.9 MB Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis † / González-Ramos, S. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Fernández-García, V. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Recalde, M. (Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM)) ; Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ; Andrés, Vicente (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Martín-Sanz, P. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Boscá, Lisardo (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Universitat Autònoma de Barcelona
Atherothrombosis, the main cause of acute coronary syndromes (ACS), is characterized by the rupture of the atherosclerotic plaque followed by the formation of thrombi. Fatal plaque rupture sites show large necrotic cores combined with high levels of inflammation and thin layers of collagen. [...]
2020 - 10.3390/cells9092067
Cells, Vol. 9 Núm. 9 (october 2020) , p. 632  
5.
17 p, 2.1 MB LRP1-Mediated AggLDL Endocytosis Promotes Cholesteryl Ester Accumulation and Impairs Insulin Response in HL-1 Cells / Actis Dato, Virginia (Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI)) ; Benitez Amaro, Aleyda (Institut d'Investigació Biomèdica Sant Pau) ; De Gonzalo Calvo, David (Instituto de Salud Carlos III) ; Vazquez, M. (Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI)) ; Bonacci, G. (Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI)) ; Llorente-Cortés, V. (Instituto de Salud Carlos III) ; Chiabrando, G.A. (Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI)) ; Universitat Autònoma de Barcelona
The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization is mediated by low-density lipoprotein receptor-related protein-1 (LRP1) promoting intracellular cholesteryl ester (CE) accumulation. [...]
2020 - 10.3390/cells9010182
Cells, Vol. 9 Núm. 1 (october 2020) , p. 419  
6.
19 p, 5.8 MB Deep Learning Analyses to Delineate the Molecular Remodeling Process after Myocardial Infarction / Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rudilla, F (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ferrer-Curriu, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Segú-Vergés, Cristina (Anaxomics Biotech S.L.) ; Mellado-Bergillos, Araceli (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gomez-Puchades, Pol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Specific proteins and processes have been identified in post-myocardial infarction (MI) pathological remodeling, but a comprehensive understanding of the complete molecular evolution is lacking. We generated microarray data from swine heart biopsies at baseline and 6, 30, and 45 days after infarction to feed machine-learning algorithms. [...]
2021 - 10.3390/cells10123268
Cells, Vol. 10 (november 2021)  
7.
20 p, 4.0 MB Hepatic Oxi-Inflammation and Neophobia as Potential Liver-Brain Axis Targets for Alzheimer's Disease and Aging, with Strong Sensitivity to Sex, Isolation, and Obesity / Fraile-Ramos, Juan (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Garrit, Anna (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ; Reig-Vilallonga, Josep (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Universitat Autònoma de Barcelona. Institut de Neurociències
Research on Alzheimer's disease (AD) has classically focused on alterations that occur in the brain and their intra- and extracellular neuropathological hallmarks. However, the oxiinflammation hypothesis of aging may also play a role in neuroimmunoendocrine dysregulation and the disease's pathophysiology, where the liver emerges as a target organ due to its implication in regulating metabolism and supporting the immune system. [...]
2023 - 10.3390/cells12111517
Cells, Vol. 12 (may 2023)  
8.
16 p, 1.4 MB Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells / Lehmann, Guillermo L. (Regeneron Pharmaceuticals. Inc.) ; Ginsberg, Michael (Angiocrine Bioscience. Inc.) ; Nolan, Daniel J. (Angiocrine Bioscience. Inc.) ; Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ; Zeng, Shemin (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ; Voigt, Andrew P. (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ; Mullins, Robert F. (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ; Rafii, Shahin (Ansary Stem Cell Institute. Department of Medicine. Division of Regenerative Medicine. Weill Cornell Medicine) ; Rodriguez-Boulan, Enrique (Margaret Dyson Vision Research Institute. Department of Ophthalmology. Weill Cornell Medicine) ; Benedicto, Ignacio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by endothelial cells (ECs) from human eye choroid. [...]
2022 - 10.3390/cells11192975
Cells, Vol. 11 Núm. 19 (october 2022) , p. 2975  
9.
16 p, 3.3 MB Smoking Suppresses the Therapeutic Potential of Adipose Stem Cells in Crohn's Disease Patients through Epigenetic Changes / Boronat-Toscano, Albert (Hospital Universitari Joan XXIII de Tarragona) ; Vañó, Irene (Institut d'Investigació Sanitària Pere Virgili) ; Monfort-Ferré, Diandra (Hospital Universitari Joan XXIII de Tarragona) ; Menacho, Margarita (Hospital Universitari Joan XXIII de Tarragona) ; Valldosera, Gemma (Hospital Universitari Joan XXIII de Tarragona) ; Caro, Aleidis (Hospital Universitari Joan XXIII de Tarragona) ; Espina, Beatriz (Hospital Universitari Joan XXIII de Tarragona) ; Mañas, Maria José (Hospital Sant Pau i Santa Tecla (Tarragona)) ; Marti-Gallostra, Marc (Hospital Universitari Vall d'Hebron) ; Espin-Basany, Eloy (Hospital Universitari Vall d'Hebron) ; Saera-Vila, Alfonso (Sequentia Biotech) ; Serena, Carolina (Institut d'Investigació Sanitària Pere Virgili) ; Universitat Autònoma de Barcelona
Patients with Crohn's disease (CD) who smoke are known to have a worse prognosis than never-smokers and a higher risk for post-surgical recurrence, whereas patients who quit smoking after surgery have significantly lower post-operative recurrence. [...]
2023 - 10.3390/cells12071021
Cells, Vol. 12 (march 2023)  
10.
19 p, 365.1 KB Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis : Recent Developments and Therapeutic Applications / Sánchez-Tejerina, Daniel (Hospital Universitari Vall d'Hebron) ; Llaurado, Arnau (Hospital Universitari Vall d'Hebron) ; Sotoca Fernández, Javier (Hospital Universitari Vall d'Hebron) ; Lopez-Diego, Veronica (Hospital Universitari Vall d'Hebron) ; Vidal Taboada, Jose M. (Hospital Universitari Vall d'Hebron) ; Salvado, Maria (Hospital Universitari Vall d'Hebron) ; Juntas Morales, Raúl (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by the degeneration of motor neurons for which effective therapies are lacking. One of the most explored areas of research in ALS is the discovery and validation of biomarkers that can be applied to clinical practice and incorporated into the development of innovative therapies. [...]
2023 - 10.3390/cells12081180
Cells, Vol. 12 (april 2023)  

Dipòsit Digital de Documents de la UAB : 79 registres trobats   1 - 10següentfinal  anar al registre:
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