UAB Digital Repository of Documents 24 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
1.
18 p, 3.4 MB RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment / Torres-Gomez, A. (Department of Immunology. Ophthalmology and Otorhinolaryngology. School of Medicine. Universidad Complutense de Madrid) ; Sanchez-Trincado, J.L. (Department of Immunology. Ophthalmology and Otorhinolaryngology. School of Medicine. Universidad Complutense de Madrid) ; Toribio, V. (Departamento de Biología Molecular. Universidad Autónoma de Madrid (UAM) and Instituto de Investigación Sanitaria La Princesa (IIS-IP)) ; Torres, Raúl. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Torres, Raul (Molecular Cytogenetics and Genome Editing Unit. Human Cancer Genetics Program. Centro Nacional de Investigaciones Oncológicas (CNIO)) ; Yáñez-Mó, María (Departamento de Biología Molecular. Universidad Autónoma de Madrid (UAM) and Instituto de Investigación Sanitaria La Princesa (IIS-IP)) ; Reche, P.A. (Department of Immunology. Ophthalmology and Otorhinolaryngology. School of Medicine. Universidad Complutense de Madrid) ; Cabañas, C. (Severo Ochoa Center for Molecular Biology (CSIC-UAM)) ; Lafuente, E.M. (Department of Immunology. Ophthalmology and Otorhinolaryngology. School of Medicine. Universidad Complutense de Madrid) ; Universitat Autònoma de Barcelona
The phagocytic integrins and complement receptors αMβ2/CR3 and αXβ2/CR4 are classically associated with the phagocytosis of iC3b-opsonized particles. The activation of this receptor is dependent on signals derived from other receptors (inside-out signaling) with the crucial involvement of the Rap1-RIAM-Talin-1 pathway. [...]
2020 - 10.3390/cells9051166
Cells, Vol. 9 Núm. 5 (august 2020)  
2.
17 p, 1.9 MB The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner / Hurtado-Bagès, Sarah (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Posavec Marjanovic, Melanija (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Valero, Vanesa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bouvet, Philippe (Université de Lyon. Centre Léon Bérard. Centre de Recherche en Cancérologie de Lyon. INSERM 1052. CNRS 5286) ; Lavigne, A.C. (Center for Integrative Biology (CBI). LBME. University of Toulouse. UPS. CNRS) ; Bystricky, K. (Center for Integrative Biology (CBI). LBME. University of Toulouse. UPS. CNRS) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
MacroH2A histone variants have functions in differentiation, somatic cell reprogramming and cancer. However, at present, it is not clear how macroH2As affect gene regulation to exert these functions. [...]
2020 - 10.3390/cells9051109
Cells, Vol. 9 Núm. 5 (30 2020)  
3.
25 p, 1.2 MB MicroRNAs as Early Biomarkers of Alzheimer's Disease : a synaptic perspective / Siedlecki-Wullich, Dolores (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Pathogenic processes underlying Alzheimer's disease (AD) affect synaptic function from initial asymptomatic stages, long time before the onset of cognitive decline and neurodegeneration. Therefore, reliable biomarkers enabling early AD diagnosis and prognosis are needed to maximize the time window for therapeutic interventions. [...]
2021 - 10.3390/cells10010113
Cells, Vol. 10, Num. 1 (January 2021) , art. 113  
4.
29 p, 8.2 MB Unravelling the complex duplication history of deuterostome glycerol transporters / Yilmaz, Ozlem (Institute of Marine Research (Noruega)) ; Chauvigné, François (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferré, Alba (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Nilsen, Frank (University of Bergen. Bergen High Technology Centre. Department of Biological Sciences (Norway)) ; Fjelldal, Per Gunnar (Institute of Marine Research (Norway)) ; Cerdà, Joan (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Finn, Roderick Nigel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Transmembrane glycerol transport is an ancient biophysical property that evolved in selected subfamilies of water channel (aquaporin) proteins. Here, we conducted broad level genome (>550) and transcriptome (>300) analyses to unravel the duplication history of the glycerol-transporting channels (glps) in Deuterostomia. [...]
2020 - 10.3390/cells9071663
Cells, Vol. 9, Issue 7 (July 2020) , art. 1663  
5.
18 p, 1.4 MB Schwann Cell Role in Selectivity of Nerve Regeneration / Bolívar Martín, Sara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Institut de Neurociències)
Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. [...]
2020 - 10.3390/cells9092131
Cells, Vol. 9 Núm. 9 (2020) , p. 2131  
6.
20 p, 5.1 MB Cardiovascular Risk Factors and Differential Transcriptomic Profile of the Subcutaneous and Visceral Adipose Tissue and Their Resident Stem Cells / Arderiu, Gemma (Institut d'Investigació Biomèdica Sant Pau) ; Ballesta, Carlos (Centro Médico Teknon. Barcelona) ; Moscatiello, Fabrizio (Centro Médico Teknon. Barcelona) ; Vilahur García-Lisón, Gemma (Institut d'Investigació Biomèdica Sant Pau) ; Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ; Lambert, Carmen (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Background: The increase in the incidence of obesity and obesity-related cardiovascular risk factors (CVRFs) over the last decades has brought attention on adipose tissue (AT) pathobiology. The expansion of AT is associated with the development of new vasculature needed to perfuse the tissue; however, not all fat depots have the same ability to induce angiogenesis that requires recruitment of their own endothelial cells. [...]
2020
Cells, Vol. 9 Núm. 10 (2020) , p. 2235  
7.
28 p, 1.7 MB Conventional and Non-Conventional Roles of Non-Muscle Myosin II-Actin in Neuronal Development and Degeneration / Javier, Miriam (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Saura Antolín, Carlos A. (Carlos Alberto) (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Myosins are motor proteins that use chemical energy to produce mechanical forces driving actin cytoskeletal dynamics. In the brain, the conventional non-muscle myosin II (NMII) regulates actin filament cytoskeletal assembly and contractile forces during structural remodeling of axons and dendrites, contributing to morphology, polarization, and migration of neurons during brain development. [...]
neurological disorders. This knowledge is relevant for a deep understanding of NMIIs on the pathogenesis and therapeutics of neuropsychiatric and neurodegenerative diseases.

2020 - 10.3390/cells9091926
Cells, Vol. 9 Núm. 9 (2020)  
8.
8 p, 1.3 MB Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes / Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Perna-Barrull, David (Institut Germans Trias i Pujol) ; Bertran-Cobo, Cesc (Institut Germans Trias i Pujol) ; Ehrenberg, Clara (Institut Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) -a feature of apoptotic cells- loaded with insulin peptides to mimic apoptotic beta-cells. [...]
2020 - 10.1080/21691401.2019.1699812
Artificial Cells, Nanomedicine and Biotechnology, Vol. 48, issue 1 (2020) , p. 77-83  
9.
20 p, 3.2 MB Expression of Melatonin and Dopamine D Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension / Reyes-Resina, Irene (Instituto de Salud Carlos III. Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed) ; Awad Alkozi, Hanan (University Complutense of Madrid. Faculty of Optics and Optometry. Department of Biochemistry) ; del Ser-Badia, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sánchez-Naves, Juan (Balearic Islands Institute of Ophthalmology. Department of Ophthalmology) ; Lillo, Jaume (Instituto de Salud Carlos III. Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed) ; Jiménez, Jasmina (Instituto de Salud Carlos III. Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed) ; Pintor, Jesús (University Complutense of Madrid. Faculty of Optics and Optometry. Department of Biochemistry and Molecular Biology) ; Navarro, Gemma (Universitat de Barcelona. School of Pharmacy and Food Sciences. Department of Biochemistry and Physiology) ; Franco, Rafael (Universitat de Barcelona. School of Chemistry) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Background: Experiments in the late nineties showed an inverse relationship in the eye levels of melatonin and dopamine, thereby constituting an example of eye parameters that are prone to circadian variations. [...]
2020 - 10.3390/cells9010152
Cells, Vol. 9, Num. 1 (January 2020) , art. 152  
10.
13 p, 2.8 MB Global proteomic and methylome analysis in human induced pluripotent stem cells reveals overexpression of a human TLR3 affecting proper innate immune response signaling / Requena, Jordi (Universitat de Barcelona. Departament de Biomedicina) ; Álvarez Palomo, Ana Belén (Universitat de Barcelona. Departament de Biomedicina) ; Codina Pascual, Montserrat (Universitat de Barcelona. Departament de Biomedicina) ; Delgado Morales, Raul (Institut d'Investigació Biomèdica de Bellvitge) ; Moran, Sebastian (Institut d'Investigació Biomèdica de Bellvitge) ; Esteller, Manel (Institut d'Investigació Biomèdica de Bellvitge) ; Sal, Martí (Universitat de Barcelona. Departament de Biomedicina) ; Juan, Manel (Universitat de Barcelona. Hospital Clínic. Servei d'Immunologia) ; Boronat Barado, Anna (Universitat de Barcelona. Hospital Clínic. Servei d'Immunologia) ; Consiglio, Antonella (Institut d'Investigació Biomèdica de Bellvitge) ; Bogle, Orleigh Addeleccia (Universitat de Barcelona. Departament de Biomedicina) ; Wolvetang, Ernst (University of Queensland. Australian Institute for Bioengineering and Nanotechnology) ; Ovchinnikov, Dmitry (University of Queensland. Australian Institute for Bioengineering and Nanotechnology) ; Álvarez Angulo, Iñaki (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Jaraquemada, Dolores (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Mezquita Pla, Jovita (Universitat de Barcelona. Departament de Biomedicina) ; Oliva, R. (Universitat de Barcelona. Departament de Biomedicina) ; Edel, Michael J. (Universitat de Barcelona. Departament de Biomedicina)
When considering the clinical applications of autologous cell replacement therapy of human induced pluripotent stem cells (iPSC)-derived cells, there is a clear need to better understand what the immune response will be before we embark on extensive clinical trials to treat or model human disease. [...]
2019 - 10.1002/stem.2966
Stem Cells, Vol. 37, issue 4 (April 2019) , p. 476-488  

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