Dipòsit Digital de Documents de la UAB 6 registres trobats  La cerca s'ha fet en 0.00 segons. 
1.
14 p, 3.0 MB Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival / Cabezón, Marta (Universitat Autònoma de Barcelona. Departament de Medicina) ; Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bargay, Joan (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ; Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Marcé, Silvia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Garrido, A. (Institut d'Investigació Biomèdica Sant Pau) ; Tormo, M. (Hospital Clínic Universitari (València)) ; Arenillas, Leonor (Hospital del Mar (Barcelona, Catalunya)) ; Coll, R. (Hospital Universitari de Girona Doctor Josep Trueta) ; Borras, J. (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ; Jiménez, María José (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hoyos Colell, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ; Valcárcel, David (Hospital Universitari Vall d'Hebron) ; Escoda, L. (Hospital Universitari Joan XXIII de Tarragona) ; Vall-Llovera, F. (Hospital Universitari MútuaTerrassa) ; Garcia, A. (Hospital Arnau de Vilanova. Hematology Service) ; Font, L. L. (Hematology Service, Hospital Verge de La Cinta, Tortosa, Spain) ; Rámila, E. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who are not suitable for intensive chemotherapy and/or allogeneic stem cell transplantation. [...]
2021 - 10.1186/s13148-021-01002-y
Clinical Epigenetics, Vol. 13 (january 2021)  
2.
14 p, 3.9 MB Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome / Bereshchenko, O. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Lo Re, O. (Department of Biology. Faculty of Medicine. Masaryk University) ; Nikulenkov, F. (Department of Biology. Faculty of Medicine. Masaryk University) ; Flamini, S. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Kotaskova, J. (Department of Internal Medicine - Hematology and Oncology. Faculty of Medicine. University Hospital Brno. Masaryk University) ; Mazza, T. (IRCCS Casa Sollievo della Sofferenza. Bioinformatics Unit) ; Le Pannérer, Marguerite-Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Giallongo, C. (Division of Hematology. A.O.U. Policlinico-OVE. University of Catania) ; Palumbo, G. (Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia. University of Catania) ; Li Volti, G. (Department of Biomedical and Biotechnological Sciences. University of Catania) ; Pazienza, V. (Gastroenterology Unit. IRCCS Casa Sollievo della Sofferenza) ; Cervinek, L. (Department of Internal Medicine - Hematology and Oncology. Faculty of Medicine. University Hospital Brno. Masaryk University) ; Riccardi, C. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Krejci, L. (Department of Biology. Faculty of Medicine. Masaryk University) ; Pospisilova, S. (Department of Internal Medicine - Hematology and Oncology. Faculty of Medicine. University Hospital Brno. Masaryk University) ; Stewart, A.F. (Genomics. Biotechnology Center. Center for Molecular and Cellular Bioengineering. Technische Universität Dresden) ; Vinciguerra, M. (International Clinical Research Center. St'Anne University Hospital) ; Universitat Autònoma de Barcelona
Background: Epigenetic regulation is important in hematopoiesis, but the involvement of histone variants is poorly understood. Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem cell (HSC) disorders characterized by ineffective hematopoiesis. [...]
2019 - 10.1186/s13148-019-0724-z
Clinical Epigenetics, Vol. 11 Núm. 1 (22 2019) , p. 121  
3.
8 p, 1.0 MB DNA methylation levels are highly correlated between pooled samples and averaged values when analysed using the Infinium HumanMethylation450 BeadChip array / Gallego-Fabrega, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ; Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Muiño, Elena (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Krupinski, Jurek (School of Healthcare Science, Manchester Metropolitan University) ; Fernandez-Cadenas, Israel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
DNA methylation is a heritable and stable epigenetic mark implicated in complex human traits. Epigenome-wide association studies (EWAS) using array-based technology are becoming widely used to identify differentially methylated sites associated with complex diseases. [...]
2015 - 10.1186/s13148-015-0097-x
Clinical Epigenetics, Vol. 7 (july 2015)  
4.
11 p, 577.8 KB A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers / Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Zwick, Anabel (Technical University Munich. Department of Medicine) ; Garz, Anne-Kathrin (German Cancer Research Center (Heidelberg, Alemanya)) ; Palau, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Götze, Katharina S. (German Cancer Research Center (Heidelberg, Alemanya))
The azanucleosides azacitidine and decitabine are currently used for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in patients not only eligible for intensive chemotherapy but are also being explored in other hematologic and solid cancers. [...]
2016 - 10.1186/s13148-016-0237-y
Clinical epigenetics, Vol. 8 Núm. 71 (Juny 2016)  
5.
15 p, 3.0 MB Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer / Alonso, Sergio (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; González, Beatriz (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Ruiz-Larroya, Tatiana (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Durán Domínguez, Mercedes (Instituto de Biología y Genética Molecular (Valladolid)) ; Kato, Takaharu (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Matsunaga, Akihiro (Sanford Burnham Prebys Medical Discovery Institute (Califòrnia)) ; Suzuki, Koichi (Jichi Medical University (Japó)) ; Strongin, Alex Y. (Sanford Burnham Prebys Medical Discovery Institute (Califòrnia)) ; Giménez Bonafé, Pepita (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Perucho, Manuel (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
BACKGROUND: ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis. ADAMTS shares several distinct protein modules including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. [...]
2015 - 10.1186/s13148-015-0158-1
Clinical Epigenetics, Vol. 7, No. 124 (December 2015)  
6.
11 p, 2.6 MB Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer / Cebola, Inês (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Custodio Rojo, Joaquín (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Díez-Villanueva, Anna (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Paré, Laia (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Prieto, Patricia (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Aussó, Susanna (Institut Català d'Oncologia) ; Coll-Mulet, Llorenç (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Boscá, Lisardo (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Moreno Aguado, Víctor (Institut Català d'Oncologia) ; Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Background: Misregulation of the PTGS (prostaglandin endoperoxide synthase, also known as cyclooxygenase or COX) pathway may lead to the accumulation of pro-inflammatory signals, which constitutes a hallmark of cancer. [...]
2015 - 10.1186/s13148-015-0110-4
Clinical epigenetics, Vol. 7 Núm. 7 (July 2015)  

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