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47 p, 1.4 MB The circadian clock sets the time of DNA replication licensing to regulate growth in Arabidopsis / Fung, Jorge (Centre de Recerca en Agrigenòmica) ; Lee, Kyounghee (Sungkyunkwan University. Department of Biological Sciences) ; Seo, Pil Joon (Sungkyunkwan University. Department of Biological Sciences) ; Polyn, Stefanie (Universiteit Gent. Department of Plant Biotechnology and Bioinformatics) ; De Veylder, Lieven (Universiteit Gent. Department of Plant Biotechnology and Bioinformatics) ; Mas, Paloma (Centre de Recerca en Agrigenòmica)
The circadian clock and cell cycle as separate pathways have been well documented in plants. Elucidating whether these two oscillators are connected is critical for understanding plant growth. We found that a slow-running circadian clock decelerates the cell cycle and, conversely, a fast clock speeds it up. [...]
2018 - 10.1016/j.devcel.2018.02.022
Developmental Cell, Vol. 45, issue 1 (April 2018) , p. 101-113  
13 p, 1.2 MB Strategies to Inhibit Myc and Their Clinical Applicability / Whitfield, Jonathan R. (Vall d'Hebron Institut d'Oncologia) ; Beaulieu, Marie-Eve (Hospital Universitari Vall d'Hebron) ; Soucek, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Myc is an oncogene deregulated in most—perhaps all—human cancers. Each Myc family member, c-, L-, and N-Myc, has been connected to tumor progression and maintenance. Myc is recognized as a “most wanted” target for cancer therapy, but has for many years been considered undruggable, mainly due to its nuclear localization, lack of a defined ligand binding site, and physiological function essential to the maintenance of normal tissues. [...]
2017 - 10.3389/fcell.2017.00010
Frontiers in Cell and Developmental Biology, Vol. 5 (February 2017) , art. 10  
14 p, 4.8 MB Patterned anchorage to the apical extracellular matrix defines tissue shape in the developing appendages of Drosophila / Ray, Robert P. (University of Sussex. School of Life Sciences) ; Matamoro-Vidal, Alexis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ribeiro, Paulo S. (The Francis Crick Institute) ; Tapon, Nic (The Francis Crick Institute) ; Houle, David (Florida State University. Department of Biological Science) ; Salazar Ciudad, Isaac (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Thompson, Barry J. (The Francis Crick Institute)
How tissues acquire their characteristic shape is a fundamental unresolved question in biology. While genes have been characterized that control local mechanical forces to elongate epithelial tissues, genes controlling global forces in epithelia have yet to be identified. [...]
2015 - 10.1016/j.devcel.2015.06.019
Developmental cell, Vol. 34, issue 3 (Aug. 2015) , p. 310–322  

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