UAB Digital Repository of Documents 4 records found  Search took 0.00 seconds. 
1.
47 p, 1.4 MB The circadian clock sets the time of DNA replication licensing to regulate growth in Arabidopsis / Fung Uceda, Jorge Alberto (Centre de Recerca en Agrigenòmica) ; Lee, Kyounghee (Sungkyunkwan University. Department of Biological Sciences) ; Seo, Pil Joon (Sungkyunkwan University. Department of Biological Sciences) ; Polyn, Stefanie (Universiteit Gent. Department of Plant Biotechnology and Bioinformatics) ; De Veylder, Lieven (Universiteit Gent. Department of Plant Biotechnology and Bioinformatics) ; Mas, Paloma (Centre de Recerca en Agrigenòmica)
The circadian clock and cell cycle as separate pathways have been well documented in plants. Elucidating whether these two oscillators are connected is critical for understanding plant growth. We found that a slow-running circadian clock decelerates the cell cycle and, conversely, a fast clock speeds it up. [...]
2018 - 10.1016/j.devcel.2018.02.022
Developmental Cell, Vol. 45, issue 1 (April 2018) , p. 101-113  
2.
13 p, 1.2 MB Strategies to Inhibit Myc and Their Clinical Applicability / Whitfield, Jonathan R. (Vall d'Hebron Institut d'Oncologia) ; Beaulieu, Marie-Eve (Hospital Universitari Vall d'Hebron) ; Soucek, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Myc is an oncogene deregulated in most-perhaps all-human cancers. Each Myc family member, c-, L-, and N-Myc, has been connected to tumor progression and maintenance. Myc is recognized as a "most wanted" target for cancer therapy, but has for many years been considered undruggable, mainly due to its nuclear localization, lack of a defined ligand binding site, and physiological function essential to the maintenance of normal tissues. [...]
2017 - 10.3389/fcell.2017.00010
Frontiers in Cell and Developmental Biology, Vol. 5 (February 2017) , art. 10  
3.
7 p, 589.2 KB ERK5 and Cell Proliferation : Nuclear Localization Is What Matters / Gomez, Nestor (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Erazo, Tatiana (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lizcano, Jose M. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been associated to different cellular processes, playing a crucial role in cell proliferation in normal and cancer cells by mechanisms that are both dependent and independent of its kinase activity. [...]
2016 - 10.3389/fcell.2016.00105
Frontiers in Cell and Developmental Biology, Vol. 4 (september 2016)  
4.
14 p, 4.8 MB Patterned anchorage to the apical extracellular matrix defines tissue shape in the developing appendages of Drosophila / Ray, Robert P. (University of Sussex. School of Life Sciences) ; Matamoro-Vidal, Alexis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ribeiro, Paulo S. (The Francis Crick Institute) ; Tapon, Nic (The Francis Crick Institute) ; Houle, David (Florida State University. Department of Biological Science) ; Salazar Ciudad, Isaac (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Thompson, Barry J. (The Francis Crick Institute)
How tissues acquire their characteristic shape is a fundamental unresolved question in biology. While genes have been characterized that control local mechanical forces to elongate epithelial tissues, genes controlling global forces in epithelia have yet to be identified. [...]
2015 - 10.1016/j.devcel.2015.06.019
Developmental cell, Vol. 34, issue 3 (Aug. 2015) , p. 310-322  

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