UAB Digital Repository of Documents 9 records found  Search took 0.06 seconds. 
1.
18 p, 504.2 KB Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections / Ferrández, Olivia (Nursing Department, Universitat Pompeu Fabra, Barcelona, Spain) ; Urbina, Olatz (Hospital Universitari del Mar, Barcelona, Spain) ; Grau, Santiago (Universitat Autònoma de Barcelona, Department de Medicina)
Tedizolid phosphate has high activity against the Gram-positive microorganisms mainly involved in acute bacterial skin and skin structure infections, such as strains of Staphylococcus aureus (including methicillin-resistant S. [...]
2016 - 10.2147/DDDT.S84667
Drug Design, Development and Therapy, Vol. 11 (december 2016) , p. 65-82  
2.
7 p, 216.6 KB Profile of omalizumab in the treatment of chronic spontaneous urticaria / Labrador-Horrillo, Moises (Hospital Universitari Vall d'Hebron) ; Ferrer, Marta (Clínica Universidad de Navarra) ; Universitat Autònoma de Barcelona. Departament de Medicina
Chronic spontaneous urticaria (CSU) is a disease with significant morbidity and relative prevalence that has important effects on the quality of life (QoL) of those who suffer from it. Omalizumab is a recombinant humanized anti-immunoglobulin E (IgE) antibody that binds to the Cε3 domain of the IgE heavy chain and prevents it from binding to its high-affinity receptor FcεRI. [...]
2015 - 10.2147/DDDT.S56004
Drug Design, Development and Therapy, Vol. 9 (august 2015) , p. 4909-4915  
3.
12 p, 478.7 KB Modeling the longitudinal latent effect of pregabalin on self-reported changes in sleep disturbances in outpatients with generalized anxiety disorder managed in routine clinical practice / Ruiz, Miguel A (Universidad Autónoma de Madrid) ; Álvarez, Enrique (Institut d'Investigació Biomèdica Sant Pau) ; Carrasco, Jose L (Hospital Clínico San Carlos) ; Olivares, José M (Hospital Meixoeiro, Complejo Hospitalario Universitario, Vigo) ; Pérez, María (Medical Department, Pfizer, S.L.U.) ; Rejas, Javier (Health Economics and Outcomes Research Department, Pfizer, S.L.U.) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria
Anxiety disorders are among the most common psychiatric illnesses, with generalized anxiety disorder (GAD) being one of the most common. Sleep disturbances are highly prevalent in GAD patients. While treatment with pregabalin has been found to be associated with significant improvement in GAD-related sleep disturbance across many controlled clinical trials, mediational analysis has suggested that a substantial portion of this effect could be the result of a direct effect of pregabalin. [...]
2015 - 10.2147/DDDT.S88238
Drug Design, Development and Therapy, Vol. 9 (august 2015) , p. 4329-4340  
4.
12 p, 646.0 KB Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure / Ballester, Maria Rosa (Institut d'Investigació Biomèdica Sant Pau) ; Roig, Eulàlia (Institut d'Investigació Biomèdica Sant Pau) ; Gich Saladich, Ignasi (Institut d'Investigació Biomèdica Sant Pau) ; Puntes, Montse (Institut d'Investigació Biomèdica Sant Pau) ; Delgadillo, Joaquín (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Santos, Benjamín (Ferrer Internacional, S.A.) ; Antonijoan Arbós, Rosa Ma. (Rosa María) (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Diuretics are the primary treatment for the management of chronic heart failure (HF) symptoms and for the improvement of acute HF symptoms. The rate of delivery to the site of action has been suggested to affect diuretic pharmacodynamics. [...]
2015 - 10.2147/DDDT.S86300
Drug Design, Development and Therapy, Vol. 9 (august 2015) , p. 4291-4302  
5.
4 p, 1.4 MB Hidden costs of antiretroviral treatment : the public health efficiency of drug packaging / Andreu-Crespo, Àngels (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Llibre, Josep M (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Cardona-Peitx, Glòria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sala-Piñol, Ferran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Bonafont-Pujol, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol. Departament de Farmàcia)
While the overall percentage of unused antiretroviral medicines returned to the hospital pharmacy is low, their cost is quite high. Adverse events, treatment failure, pharmacokinetic interactions, pregnancy, or treatment simplification are common reasons for unplanned treatment changes. [...]
2015 - 10.2147/DDDT.S87075
Drug Design, Development and Therapy, Vol. 9 (august 2015) , p. 4287-4290  
6.
10 p, 376.3 KB Management of severe sepsis : advances, challenges, and current status / Martin-Loeches, Ignacio (St James's University Hospital) ; Levy, Mitchell M (Brown University) ; Artigas, Antonio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Universitat Autònoma de Barcelona
The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. [...]
2015 - 10.2147/DDDT.S78757
Drug Design, Development and Therapy, Vol. 9 (april 2015) , p. 2079-2088  
7.
18 p, 2.9 MB Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease : design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids / Bautista-Aguilera, Oscar M (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Esteban Conde, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Chioua, Mourad (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Nikolic, Katarina (University of Belgrade. Institute of Pharmaceutical Chemistry) ; Agbaba, Danica (University of Belgrade. Institute of Pharmaceutical Chemistry) ; Moraleda, Ignacio (Universidad de Alcalá. Facultat de Farmacia. Departamento de Química Orgánica) ; Iriepa, Isabel (Universidad de Alcalá. Facultat de Farmacia. Departamento de Química Orgánica) ; Soriano, Elena (Instituto de Química Orgánica General (IQOG-CSIC). Síntesis y estructura de compuestos orgánicos (SEPCO)) ; Samadi, Abdelouahid (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Marco-Contelles, José (Instituto de Química Orgánica General (IQOG-CSIC). Laboratorio de Química Médica) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
The design, synthesis, and biochemical evaluation of donepezil-pyridyl hybrids (DPHs) as multipotent cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors for the potential treatment of Alzheimer's disease (AD) is reported. [...]
2014 - 10.2147/DDDT.S69258
Drug Design, Development and Therapy, Vol. 8 (October 2014) , p. 1893-1910  
8.
9 p, 277.7 KB Naltrexone sustained-release/bupropion sustained-release for the management of obesity : review of the data to date / Caixàs, Assumpta (Parc Tauli. Departamen d'Endocrinologia i Nutrició) ; Albert, Lara (Parc Tauli. Departamen d'Endocrinologia i Nutrició) ; Capel, Ismael (Parc Tauli. Departamen d'Endocrinologia i Nutrició) ; Rigla, Mercedes (Parc Tauli. Departamen d'Endocrinologia i Nutrició) ; Universitat Autònoma de Barcelona
Obesity is an emerging disease worldwide. Changes in living habits, especially with increased consumption of high-calorie foods and decreased levels of physical activity, lead to an energy imbalance that brings weight gain. [...]
2014 - 10.2147/DDDT.S55587
Drug Design, Development and Therapy, Vol. 8 (september 2014) , p. 1419-1427  
9.
23 p, 918.8 KB Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections / Urbina, Olatz (Hospital del Mar (Barcelona)) ; Ferrández, Olivia (Hospital del Mar (Barcelona)) ; Espona, Mercè (Hospital del Mar (Barcelona)) ; Salas, Esther (Hospital del Mar (Barcelona)) ; Ferrández, Irene (Ciència i Tecnologia dels Aliments, Pharmacy Department, Universitat de Barcelona, Barcelona, Spain) ; Grau, Santiago (Hospital del Mar (Barcelona)) ; Universitat Autònoma de Barcelona
Tedizolid phosphate (TR-701), a prodrug of tedizolid (TR-700), is a next-generation oxazolidinone that has shown favorable results in the treatment of acute bacterial skin and skin-structure infections in its first Phase III clinical trial. [...]
2013 - 10.2147/DDDT.S30728
Drug Design, Development and Therapy, Vol. 7 (april 2013) , p. 243-265  

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