UAB Digital Repository of Documents 9 records found  Search took 0.00 seconds. 
1.
11 p, 2.3 MB First-in-human PeriCord cardiac bioimplant : Scalability and GMP manufacturing of an allogeneic engineered tissue graft / Prat-Vidal, Cristina (Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain) ; Rodríguez-Gómez, Luciano (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Aylagas, Miriam (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto-Nicolau, Nuria (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ; Gastelurrutia, Paloma (Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain) ; Agustí, Elba (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Jorba, Ignasi (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, CIBERES, University of Barcelona, Barcelona, Spain) ; Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roura, Santiago (CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain) ; Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ; Torrents-Zapata, Silvia (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Coca, María Isabel (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Reales, Laura (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Cámara-Rosell, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Coll, Ruth (Research and Education. Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Farré, Ramon (Unit of Biophysics and Bioengineering, School of Medicine and Health Sciences, University of Barcelona-IDIBAPS-CIBERES, Barcelona, Spain) ; Navajas, Daniel (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, CIBERES, University of Barcelona, Barcelona, Spain) ; Vilarrodona, Anna (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ; García-López, Joan (Research and Education. Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Querol, Sergi (Transfusional Medicine Group, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain) ; Bayes-Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Small cardiac tissue engineering constructs show promise for limiting post-infarct sequelae in animal models. This study sought to scale-up a 2-cm 2 preclinical construct into a human-size advanced therapy medicinal product (ATMP; PeriCord), and to test it in a first-in-human implantation. [...]
2020 - 10.1016/j.ebiom.2020.102729
EBioMedicine, Vol. 54 (april 2020)  
2.
11 p, 2.6 MB APOA1 oxidation is associated to dysfunctional high-density lipoproteins in human abdominal aortic aneurysm / Martínez-López, Diego (Laboratorio de Patología Vascular, FIIS-Fundación Jiménez Díaz-Universidad Autónoma, Madrid, Spain) ; Camafeita, Emilio (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; Cedó, Lídia (Institut d'Investigació Biomèdica Sant Pau) ; Roldan-Montero, Raquel (Laboratorio de Patología Vascular, FIIS-Fundación Jiménez Díaz-Universidad Autónoma, Madrid, Spain) ; Jorge, Inmaculada (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; García-Marqués, Fernando (Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain) ; Gómez-Serrano, María (Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain) ; Bonzon-Kulichenko, Elena (Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain) ; Blanco-Vaca, Francisco (Institut d'Investigació Biomèdica Sant Pau) ; Blanco-Colio, Luis Miguel (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; Michel, Jean-Baptiste (INSERM U698, Paris, France) ; Escola-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ; Vázquez, Jesús (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; Martin-Ventura, Jose Luis (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; Universitat Autònoma de Barcelona
High-density lipoproteins (HDL) are a complex mixture of lipids and proteins with vasculoprotective properties. However, HDL components could suffer post-translational modifications (PTMs) under pathological conditions, leading to dysfunctional HDL. [...]
2019 - 10.1016/j.ebiom.2019.04.012
EBioMedicine, Vol. 43 (april 2019) , p. 43-53  
3.
10 p, 1.3 MB Deep brain stimulation in treatment resistant schizophrenia : A pilot randomized cross-over clinical trial / Corripio, Iluminada (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Roldán, Alexandra (Institut d'Investigació Biomèdica Sant Pau) ; Sarró, Salvador (Psychiatry Department, Benito Menni CASM Hermanas Hospitalarias, Sant Boi de Llobregat, Spain) ; McKenna, Peter J. (FIDMAG Germanes Hospitalàries Research Foundation, C/. Dr. Antoni Pujadas 38, 08830 Sant Boi de Llobregat, Barcelona, Spain) ; Alonso-Solís, Anna (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Rabella, Mireia (Institut d'Investigació Biomèdica Sant Pau) ; Díaz, Anna (Institut d'Investigació Biomèdica Sant Pau) ; Puigdemont, Dolors (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Pérez-Solà, Víctor (Institut Hospital del Mar d'Investigacions Mèdiques) ; Álvarez, Enric (Institut d'Investigació Biomèdica Sant Pau) ; Arévalo, Antonio (Psychiatry Department, Hospital Sagrat Cor Hermanas Hospitalarias, Barcelona, Spain) ; Padilla, Pedro P. (Psychiatry Department, Centro Neuropsiquiátrico Nuestra Señora del Carmen Hermanas Hospitalarias, Zaragoza, Spain) ; Ruiz-Idiago, Jesus M. (Unitat Polivalent Barcelona Nord Hospital, Hospital Mare de Déu de la Mercè Hermanas Hospitalarias, Barcelona, Spain) ; Rodríguez, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ; Molet, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Pomarol-Clotet, Edith (FIDMAG Germanes Hospitalàries Research Foundation, C/. Dr. Antoni Pujadas 38, 08830 Sant Boi de Llobregat, Barcelona, Spain) ; Portella, Maria J. (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Up to 30% of patients with schizophrenia are resistant to antipsychotic drug treatment, with 60% of such cases also failing to respond to clozapine. Deep brain stimulation (DBS) has been used in treatment resistant patients with other psychiatric disorders, but there is a lack of trials in schizophrenia, partly due to uncertainties over where to site the electrodes. [...]
2020 - 10.1016/j.ebiom.2019.11.029
EBioMedicine, Vol. 51 (january 2020)  
4.
10 p, 2.2 MB Evidence for positive selection of hepatitis A virus antigenic variants in vaccinated men-having-sex-with men patients : Implications for immunization policies / Sabrià, Aurora (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Gregori, Josep (Roche Diagnostics, S.L., Sant Cugat del Vallés, Barcelona, Spain) ; Garcia-Cehic, Damir (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain) ; Guix, Susana (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Pumarola, Tomàs (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Manzanares-Laya, Sandra (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBEResp) del Instituto de Salud Carlos III, Madrid, Spain) ; Caylà, Joan A. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBEResp) del Instituto de Salud Carlos III, Madrid, Spain) ; Bosch, Albert (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Quer, Josep (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain) ; Pintó, Rosa M. (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
A huge outbreak in the men-having-sex-with-men (MSM) has hit Europe during the years 2016-2018. Outbreak control has been hampered by vaccine shortages in many countries, and to minimize their impact, reduction of antigen doses has been implemented. [...]
2018 - 10.1016/j.ebiom.2018.11.023
EBioMedicine, Vol. 39 (november 2018) , p. 348-357  
5.
11 p, 779.0 KB Antitubercular drugs for an old target : GSK693 as a promising InhA direct inhibitor / Martínez-Hoyos, María (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Perez-Herran, Esther (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Gulten, Gulcin (Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA) ; Encinas, Lourdes (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Álvarez-Gómez, Daniel (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Alvarez, Emilio (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Ferrer-Bazaga, Santiago (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; García-Pérez, Adolfo (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Ortega, Fátima (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Angulo-Barturen, Iñigo (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Rullas-Trincado, Joaquin (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Blanco Ruano, Delia (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Torres, Pedro (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Castañeda, Pablo (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Huss, Sophie (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Fernández Menéndez, Raquel (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; González del Valle, Silvia (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Ballell, Lluis (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Barros, David (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Modha, Sundip (Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK) ; Dhar, Neeraj (School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne 1015, Switzerland) ; Signorino-Gelo, François (Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK) ; McKinney, John D. (Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK) ; García-Bustos, Jose Francisco (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Lavandera, Jose Luis (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Sacchettini, James C. (Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA) ; Jimenez, M. Soledad (ISCIII, Crta. Majadahonda-Pozuelo Km 2, Majadahonda 28220, Madrid) ; Martín-Casabona, Nuria (Hospital Universitari Vall d'Hebron) ; Castro-Pichel, Julia (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Mendoza-Losana, Alfonso (Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain) ; Universitat Autònoma de Barcelona
Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. [...]
2016 - 10.1016/j.ebiom.2016.05.006
EBioMedicine, Vol. 8 (may 2016) , p. 291-301  
6.
13 p, 3.4 MB Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells / Altarche-Xifro, Wassim (Universitat Pompeu Fabra (UPF), Dr Aiguader 88, 08003 Barcelona, Spain) ; di Vicino, Umberto (Universitat Pompeu Fabra (UPF), Dr Aiguader 88, 08003 Barcelona, Spain) ; Muñoz-Martin, Maria Isabel (Universitat Pompeu Fabra (UPF), Dr Aiguader 88, 08003 Barcelona, Spain) ; Bortolozzi, Analía (Department of Neurochemistry and Neuropharmacology, IIBB-CSIC (Consejo Superior de Investigaciones Científicas), Barcelona, Spain) ; Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cosma, Maria Pia (Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain) ; Universitat Autònoma de Barcelona
Parkinson's disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and for which no definitive cure is currently available. [...]
2016 - 10.1016/j.ebiom.2016.04.016
EBioMedicine, Vol. 8 (april 2016) , p. 83-95  
7.
7 p, 970.6 KB First-in-man Safety and Efficacy of the Adipose Graft Transposition Procedure (AGTP) in Patients With a Myocardial Scar / Bayes-Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cámara, Maria-Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Teis, Albert (Clínica Creu Blanca, Barcelona, Spain) ; Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Llibre, Cinta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Zamora, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Alomar, Xavier (Clínica Creu Blanca, Barcelona, Spain) ; Ruyra, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roura, Santiago (Center of Regenerative Medicine in Barcelona, Barcelona, Spain) ; Revilla, Ana (ICICORELAB, Clinic University Hospital, Valladolid, Spain) ; San Román, José Alberto (ICICORELAB, Clinic University Hospital, Valladolid, Spain) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The present study evaluates the safety and efficacy of the Adipose Graft Transposition Procedure (AGTP) as a biological regenerative innovation for patients with a chronic myocardial scar. This prospective, randomized single-center controlled study included 10 patients with established chronic transmural myocardial scars. [...]
2016 - 10.1016/j.ebiom.2016.03.027
EBioMedicine, Vol. 7 (april 2016) , p. 248-254  
8.
12 p, 2.8 MB Gut microbiota linked to sexual preference and HIV infection / Noguera-Julian, Marc (Institut Germans Trias i Pujol. IrsiCaixa) ; Rocafort, Muntsa (Institut Germans Trias i Pujol. IrsiCaixa) ; Guillén, Yolanda (Institut Germans Trias i Pujol. IrsiCaixa) ; Rivera, Javier (Institut Germans Trias i Pujol. IrsiCaixa) ; Casadellà, Maria (Institut Germans Trias i Pujol. IrsiCaixa) ; Nowak, Piotr (Karolinska Universitetssjukhuset) ; Hildebrand, Falk (European Molecular Biology Laboratory) ; Zeller, Georg (European Molecular Biology Laboratory) ; Parera, Mariona (Institut Germans Trias i Pujol. IrsiCaixa) ; Bellido, Rocío (Institut Germans Trias i Pujol. IrsiCaixa) ; Rodríguez, Cristina (Institut Germans Trias i Pujol. IrsiCaixa) ; Carrillo, Jorge (Institut Germans Trias i Pujol. IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. IrsiCaixa) ; Coll, Josep (Institut Germans Trias i Pujol. IrsiCaixa) ; Bravo, Isabel (Hospital Universitari Germans Trias i Pujol) ; Estany, Carla (Hospital Universitari Germans Trias i Pujol) ; Herrero, Cristina (Hospital Universitari Germans Trias i Pujol) ; Saz, Jorge (BCN Checkpoint,) ; Sirera, Guillem (Hospital Universitari Germans Trias i Pujol) ; Torrela, Ariadna (Hospital Universitari Vall d'Hebrón) ; Navarro, Jordi (Hospital Universitari Vall d'Hebrón) ; Crespo, Manel (Hospital Universitari Vall d'Hebrón) ; Brander, Christian (Institut Germans Trias i Pujol. IrsiCaixa) ; Negredo, Eugènia (Universitat de Vic) ; Blanco, Julià (Institut Germans Trias i Pujol. IrsiCaixa) ; Guarner, Francisco (Hospital Universitari Vall d'Hebrón) ; Calle, Maria Luz (Universitat de Vic) ; Bork, Peer (European Molecular Biology Laboratory) ; Sönnerborg, Anders (Karolinska Universitetssjukhuset) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. IrsiCaixa) ; Paredes, Roger (Institut Germans Trias i Pujol. IrsiCaixa)
The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. [...]
2016 - 10.1016/j.ebiom.2016.01.032
EBioMedicine, Vol. 5 (March 2016) , p. 135-146  
9.
2 p, 158.6 KB Dormancy antigens as biomarkers of latent tuberculosis infection / Latorre, Irene (Molecular Microbiology Department, Hospital Universitari Sant Joan de Déu, University of Barcelona) ; Domínguez, Jose (Institut Germans Trias i Pujol CIBER Enfermedades Respiratorias (CIBERES)) ; Universitat Autònoma de Barcelona ; CIBER Enfermedades Respiratorias (CIBERES)
2015 - 10.1016/j.ebiom.2015.06.017
EBioMedicine, Vol. 2 (june 2015) , p. 790-791  

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