Depósito Digital de Documentos de la UAB Encontrados 16 registros  1 - 10siguiente  ir al registro: La búsqueda tardó 0.00 segundos. 
1.
12 p, 2.8 MB Efficacy of adeno-associated virus gene therapy in a MNGIE murine model enhanced by chronic exposure to nucleosides / Vila-Julià, Ferran (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cabrera-Pérez, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cámara, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Molina-Berenguer, Miguel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lope-Piedrafita, Silvia (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Hirano, Michio (Department of Neurology, H. Houston Merritt Neuromuscular Research Center, Columbia University Irving Medical Center) ; Mingozzi, Federico (Spark Therapeutics) ; Torres-Torronteras, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martí Seves, Ramon (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Preclinical studies have shown that gene therapy is a feasible approach to treat mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). However, the genetic murine model of the disease (Tymp/Upp1 double knockout, dKO) has a limited functional phenotype beyond the metabolic imbalances, and so the studies showing efficacy of gene therapy have relied almost exclusively on demonstrating correction of the biochemical phenotype. [...]
2020 - 10.1016/j.ebiom.2020.103133
EBioMedicine, Vol. 62 (november 2020)  
2.
10 p, 757.2 KB Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males / Baldassarri, Margherita (University of Siena. Department of Medical Biotechnologies) ; Picchiotti, Nicola (University of Pavia. Department of Mathematics) ; Fava, Francesca (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Fallerini, Chiara (University of Siena. Department of Medical Biotechnologies) ; Benetti, Elisa (University of Siena. Department of Medical Biotechnologies) ; Daga, Sergio (University of Siena. Department of Medical Biotechnologies) ; Valentino, Floriana (University of Siena. Department of Medical Biotechnologies) ; Doddato, Gabriella (University of Siena. Department of Medical Biotechnologies) ; Furini, Simone (University of Siena. Department of Medical Biotechnologies) ; Giliberti, Annarita (University of Siena. Department of Medical Biotechnologies) ; Tita, Rossella (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Amitrano, Sara (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Bruttini, Mirella (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Croci, Susanna (University of Siena. Department of Medical Biotechnologies) ; Meloni, Ilaria (University of Siena. Department of Medical Biotechnologies) ; Pinto, Anna Maria (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Iuso, Nicola (University of Siena. Department of Medical Biotechnologies) ; Gabbi, Chiara ; Sciarra, Francesca (Sapienza University of Rome. Department of Experimental Medicine) ; Venneri, Mary Anna (Sapienza University of Rome. Department of Experimental Medicine) ; Gori, Marco (Université Côte d'Azur) ; Sanarico, Maurizio ; Crawley, Francis P. (Good Clinical Practice Alliance-Europe (GCPA) and Strategic Initiative for Developing Capacity in Ethical Review-Europe (SIDCER) (Leuven, Bèlgica)) ; Pagotto, Uberto (University of Bologna. Department of Medical and Surgical Sciences) ; Fanelli, Flaminia (University of Bologna. Department of Medical and Surgical Sciences) ; Mezzullo, Marco (University of Bologna. Department of Medical and Surgical Sciences) ; Dominguez-Garrido, Elena (Fundación Rioja Salud. Molecular Diagnostic Unit) ; Planas-Serra, Laura (Spanish Covid HGE) ; Schlüter, Agatha (Spanish Covid HGE) ; Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lapunzina, Pablo (Universidad Autónoma de Madrid. Hospital Universitario La Paz) ; Tenorio, Jair (Universidad Autónoma de Madrid. Hospital Universitario La Paz) ; Pujol, Aurora (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Castagna, Maria Grazia (University of Siena. Department of Medical, Surgical and Neurological Sciences) ; Marcelli, Marco (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Department of Medicine) ; Isidori, Andrea M. (Sapienza University of Rome. Department of Experimental Medicine) ; Renieri, Alessandra (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Frullanti, Elisa (University of Siena. Department of Medical, Surgical and Neurological Sciences) ; Mari, Francesca (Azienda Ospedaliero-Universitaria Senese (Itàlia)) ; Universitat Autònoma de Barcelona
While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. [...]
2021 - 10.1016/j.ebiom.2021.103246
EBioMedicine, Vol. 65 (february 2021) , p. 103246  
3.
12 p, 1.1 MB Extremely low viral reservoir in treated chronically HIV-1-infected individuals / Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Jiménez Valero, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Monceaux, Valérie (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ; Huot, Nicolas (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ; Leal, Lorna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; González Soler, Victoria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; González-Cao, Maria (Translational Cancer Research Unit, Instituto Oncológico Dr Rosell, Dexeus University Hospital, Barcelona, Spain) ; Müller-Trutwin, Michaela (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ; Sáez-Cirión, Asier (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ; García, Felipe (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ; Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Small viral reservoirs are found predominantly in HIV-1 controllers and individuals treated during acute/early HIV-1 infection. However, other HIV + individuals could naturally also harbour low viral reservoirs. [...]
2020 - 10.1016/j.ebiom.2020.102830
EBioMedicine, Vol. 57 (june 2020)  
4.
11 p, 2.3 MB First-in-human PeriCord cardiac bioimplant : scalability and GMP manufacturing of an allogeneic engineered tissue graft / Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Rodríguez-Gómez, Luciano (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà) ; Aylagas, Miriam (Hospital Universitari Vall d'Hebron) ; Nieto-Nicolau, Nuria (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Gastelurrutia, Paloma (Institut d'Investigació Biomèdica de Bellvitge) ; Agustí, Elba (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Jorba, Ignasi (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, CIBERES, University of Barcelona) ; Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rudilla, F (CIBER Cardiovascular, Instituto de Salud Carlos III) ; Vives Armengol, Joaquim ; Torrents-Zapata, Silvia (Cell Therapy Service, Banc de Sang i Teixits) ; Coca, María Isabel (Cell Therapy Service, Banc de Sang i Teixits) ; Reales, Laura (Cell Therapy Service, Banc de Sang i Teixits) ; Cámara-Rosell, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Farré, Ramon (Research and Education. Banc de Sang i Teixits700 10) ; Navajas, Daniel (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, CIBERES, University of Barcelona) ; Vilarrodona, Anna (Banc de Sang i Teixits (Barcelona, Catalunya)) ; García-López, Joan (Research and Education. Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Querol, Sergi (Hospital Universitari Vall d'Hebron) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol ; VHIR Vall d'Hebron Institut de Recerca ; Universitat Autònoma de Barcelona. Departament de Medicina
Small cardiac tissue engineering constructs show promise for limiting post-infarct sequelae in animal models. This study sought to scale-up a 2-cm 2 preclinical construct into a human-size advanced therapy medicinal product (ATMP; PeriCord), and to test it in a first-in-human implantation. [...]
2020 - 10.1016/j.ebiom.2020.102729
EBioMedicine, Vol. 54 (april 2020)  
5.
11 p, 2.6 MB APOA1 oxidation is associated to dysfunctional high-density lipoproteins in human abdominal aortic aneurysm / Martínez-López, Diego (Universidad Autónoma de Madrid. Instituto de Investigación Sanitaria-Fundación Jiménez Díaz) ; Camafeita, Emilio (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; Cedó, Lídia (Institut d'Investigació Biomèdica Sant Pau) ; Roldan-Montero, Raquel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Jorge, Inmaculada (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; García-Marqués, Fernando (Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain) ; Gómez-Serrano, María (Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain) ; Bonzon-Kulichenko, Elena (Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain) ; Blanco-Vaca, Francisco (Institut d'Investigació Biomèdica Sant Pau) ; Blanco-Colio, Luis Miguel (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; Michel, Jean-Baptiste (INSERM U698, Paris, France) ; Escola-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ; Vázquez, Jesús (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; Martin-Ventura, Jose Luis (CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain) ; Universitat Autònoma de Barcelona
High-density lipoproteins (HDL) are a complex mixture of lipids and proteins with vasculoprotective properties. However, HDL components could suffer post-translational modifications (PTMs) under pathological conditions, leading to dysfunctional HDL. [...]
2019 - 10.1016/j.ebiom.2019.04.012
EBioMedicine, Vol. 43 (april 2019) , p. 43-53  
6.
10 p, 1.3 MB Deep brain stimulation in treatment resistant schizophrenia : A pilot randomized cross-over clinical trial / Corripio, Iluminada (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Roldán, Alexandra (Institut d'Investigació Biomèdica Sant Pau) ; Sarró, Salvador (Psychiatry Department, Benito Menni CASM Hermanas Hospitalarias, Sant Boi de Llobregat, Spain) ; McKenna, Peter J. (FIDMAG Germanes Hospitalàries Research Foundation, C/. Dr. Antoni Pujadas 38, 08830 Sant Boi de Llobregat, Barcelona, Spain) ; Alonso-Solís, Anna (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Rabella, Mireia (Institut d'Investigació Biomèdica Sant Pau) ; Díaz, Anna (Institut d'Investigació Biomèdica Sant Pau) ; Puigdemont, Dolors (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Pérez-Solà, Víctor (Institut Hospital del Mar d'Investigacions Mèdiques) ; Álvarez, Enric (Institut d'Investigació Biomèdica Sant Pau) ; Arévalo, Antonio (Psychiatry Department, Hospital Sagrat Cor Hermanas Hospitalarias, Barcelona, Spain) ; Padilla, Pedro P. (Psychiatry Department, Centro Neuropsiquiátrico Nuestra Señora del Carmen Hermanas Hospitalarias, Zaragoza, Spain) ; Ruiz-Idiago, Jesus M. (Unitat Polivalent Barcelona Nord Hospital, Hospital Mare de Déu de la Mercè Hermanas Hospitalarias, Barcelona, Spain) ; Rodríguez, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ; Molet, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Pomarol-Clotet, Edith (FIDMAG Germanes Hospitalàries Research Foundation, C/. Dr. Antoni Pujadas 38, 08830 Sant Boi de Llobregat, Barcelona, Spain) ; Portella, Maria J. (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Up to 30% of patients with schizophrenia are resistant to antipsychotic drug treatment, with 60% of such cases also failing to respond to clozapine. Deep brain stimulation (DBS) has been used in treatment resistant patients with other psychiatric disorders, but there is a lack of trials in schizophrenia, partly due to uncertainties over where to site the electrodes. [...]
2020 - 10.1016/j.ebiom.2019.11.029
EBioMedicine, Vol. 51 (january 2020)  
7.
14 p, 2.6 MB Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells / Cornet-Masana, Josep Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Banús, Antònia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Carbó, José M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Torrente, M.Á. (Hospital Clinic, CIBERehd. Department of Pathology) ; Guijarro, F. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Cuesta-Casanovas, Laia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteve Reyner, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; M. Risueño, Ruth (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Background: Despite great efforts to identify druggable molecular targets for AML, there remains an unmet need for more effective therapies. Methods: An in silico screening was performed using Connectivity Maps to identify FDA-approved drugs that may revert an early leukaemic transformation gene signature. [...]
2019 - 10.1016/j.ebiom.2019.08.021
EBioMedicine, Vol. 47 (september 2019) , p. 221-234  
8.
A single faecal microbiota transplantation modulates the microbiome and improves clinical manifestations in a rat model of colitis / Lleal, Marina (Hospital Universitari Vall d'Hebron) ; Sarrabayrouse, Guillaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Willamil, Joseane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Santiago, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; ; Manichanh, Chaysavanh (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Background: Faecal microbiota transplantation (FMT) is a novel potential therapy for inflammatory bowel diseases, but it is poorly characterised. Methods: We evaluated the performance of the mouse and rat as a pre-clinical model for human microbiota engraftment. [...]
2019 - 10.1016/j.ebiom.2019.10.002
EBioMedicine, Vol. 48 (october 2019) , p. 630-641  
9.
14 p, 2.3 MB Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion / Penela, Petronila (CIBER de Enfermedades Cardiovasculares (CIBERCV)) ; Inserte, Javier (Universitat Autònoma de Barcelona) ; Ramos, Paula (Departamento de Biología Molecular. Centro de Biología Molecular "Severo Ochoa" (UAM-CSIC)) ; Rodriguez-Sinovas, Antonio (Universitat Autònoma de Barcelona) ; Garcia-Dorado, David (Universitat Autònoma de Barcelona) ; Mayor, F. (CIBER de Enfermedades Cardiovasculares (CIBERCV))
Background: Identification of signaling pathways altered at early stages after cardiac ischemia/reperfusion (I/R) is crucial to develop timely therapies aimed at reducing I/R injury. The expression of G protein-coupled receptor kinase 2 (GRK2), a key signaling hub, is up-regulated in the long-term in patients and in experimental models of heart failure. [...]
2019 - 10.1016/j.ebiom.2019.09.019
EBioMedicine, Vol. 48 (october 2019) , p. 605-618  
10.
13 p, 3.6 MB Metabolic adaptation in the human gut microbiota during pregnancy and the first year of life / Gosalbes, María José (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Compte, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Moriano-Gutierrez, Silvia (Pacific Biosciences Research Center. School of Ocean and Earth Science and Technology. University of Hawaii at Mānoa) ; Vallès, Yvonne (Department of Biological and Chemical Sciences. The University of the West Indies) ; Jiménez-Hernández, Núria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Pons, Xavier (Unitat Mixta d'Investigació en Genòmica i Salut. Fundació per al Foment de la Investigació Sanitària i Biomèdica de la Comunitat Valenciana (FISABIO-Salut Pública). Institut de Biologia Integrativa de Sistemes (Universitat de València)) ; Artacho, A. (Unitat Mixta d'Investigació en Genòmica i Salut. Fundació per al Foment de la Investigació Sanitària i Biomèdica de la Comunitat Valenciana (FISABIO-Salut Pública). Institut de Biologia Integrativa de Sistemes (Universitat de València)) ; Francino, M.Pilar (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Universitat Autònoma de Barcelona
Background: The relationship between the gut microbiome and the human host is dynamic and we may expect adjustments in microbiome function if host physiology changes. Metatranscriptomic approaches should be key in unraveling how such adjustments occur. [...]
2019 - 10.1016/j.ebiom.2018.10.071
EBioMedicine, Vol. 39 (january 2019) , p. 497-509  

Depósito Digital de Documentos de la UAB : Encontrados 16 registros   1 - 10siguiente  ir al registro:
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