Dipòsit Digital de Documents de la UAB 11 registres trobats  1 - 10següent  anar al registre: La cerca s'ha fet en 0.01 segons. 
1.
22 p, 7.1 MB Selective depletion of metastatic stem cells as therapy for human colorectal cancer / Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ; Unzueta, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ; Aviñó, Anna (Institut de Química Avançada de Catalunya) ; Gallardo, Alberto (CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)) ; Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ; Sala, Rita (Institut d'Investigació Biomèdica Sant Pau) ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Casanova Rigat, Isolda (Institut d'Investigació Biomèdica Sant Pau) ; Mangues, Maria Antònia (Institut d'Investigació Biomèdica Sant Pau) ; Lopez Pousa, Antonio (CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)) ; Eritja, Ramon (Institut de Química Avançada de Catalunya) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau)
Selective elimination of metastatic stem cells (MetSCs) promises to block metastatic dissemination. Colorectal cancer (CRC) cells overexpressing CXCR4 display trafficking functions and metastasis-initiating capacity. [...]
2018 - 10.15252/emmm.201708772
EMBO Molecular Medicine, Vol. 10 Núm. 10 (october 2018) , p. e8772  
2.
21 p, 965.2 KB CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline / Suárez-Calvet, Marc (Ludwig Maximilians Universität München) ; Capell, Anja (Ludwig Maximilians Universität München) ; Araque Caballero, Miguel Ángel (Ludwig Maximilians Universität München) ; Morenas-Rodríguez, Estrella (Universitat Autònoma de Barcelona) ; Fellerer, Katrin (Ludwig Maximilians Universität München) ; Franzmeier, Nicolai (Ludwig Maximilians Universität München) ; Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ; Eren, Erden (Dokuz Eylul University, Turkey) ; Deming, Yuetiva (Washington University School of Medicine) ; Piccio, Laura (Washington University School of Medicine) ; Karch, Celeste M (Washington University School of Medicine) ; Cruchaga, Carlos (Washington University School of Medicine) ; Paumier, Katrina (Washington University School of Medicine) ; Bateman, Randall J (Washington University School of Medicine) ; Fagan, Anne M (Washington University School of Medicine) ; Morris, John C (Washington University School of Medicine) ; Levin, Johannes (Ludwig Maximilians Universität München) ; Danek, Adrian (Ludwig Maximilians Universität München) ; Jucker, Mathias (University of Tübingen) ; Masters, Colin L (University of Melbourne) ; Rossor, Martin N (UCL Institute of Neurology) ; Ringman, John M (University of Southern California) ; Shaw, Leslie M (University of Pennsylvania) ; Trojanowski, John Q (University of Pennsylvania) ; Weiner, Michael (University of California at San Francisco) ; Ewers, Michael (Ludwig Maximilians Universität München) ; Haass, Christian (Munich Cluster for Systems Neurology (SyNergy))
Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether expression is changed in a disease severity-specific manner in . [...]
2018 - 10.15252/emmm.201809712
EMBO Molecular Medicine, Vol. 10 (november 2018)  
3.
13 p, 1.6 MB Delivery is key: lessons learnt from developing splice-switching antisense therapies / Godfrey, Caroline (University of Oxford. Department of Physiology, Anatomy and Genetics) ; Desviat, Lourdes R (Centro de Biología Molecular Severo Ochoa UAM-CSIC) ; Smedsrød, Bård (University of TromsØ. Department of Medical Biology) ; Piétri-Rouxel, France (Institut de Myologie, Paris) ; Denti, Michela A (Università di Trento. Centre for Integrative Biology) ; Disterer, Petra (University College London. Centre for Amyloidosis and Acute Phase Proteins) ; Lorain, Stéphanie (Institut de Myologie, Paris) ; Nogales Gadea, Gisela (Institut Germans Trias i Pujol. Grup d'Investigació en Malalties Neuromuscular i Neuropediàtriques) ; Sardone, Valentina (University College London) ; Anwar, Rayan (Drug Discovery Informatics Lap, Qasemi-Research Center, Al-Qasemi Academic College) ; EL Andaloussi, Samir (Karolinska Institute. Department of Laboratory Medicine) ; Lehto, Taavi (University of Tartu. Institute of Technology) ; Khoo, Bernard (University College London. Centre for Neuroendocrinology) ; Brolin, Camilla (University of Copenhagen. Department of Cellular and Molecular Medicine) ; van Roon-Mom, Willeke MC (Leiden University Medical Center. DEpartment of Human Genetics) ; Goyenvalle, Aurélie (Université Versailles Saint Quentin) ; Aartsma-Rus, Annemieke (Leiden University Medical Center. Department of Human Genetics) ; Arechavala-Gomeza, Virginia (Neuromuscular Disorders Group. BioCruces Health Research Insitute, Bizkaia) ; Universitat Autònoma de Barcelona
The use of splice-switching antisense therapy is highly promising, with a wealth of pre-clinical data and numerous clinical trials ongoing. Nevertheless, its potential to treat a variety of disorders has yet to be realized. [...]
2017 - 10.15252/emmm.201607199
EMBO Molecular Medicine, Vol. 9 Núm. 5 (2017) , p. 545-557  
4.
21 p, 4.8 MB A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss / Servián Morilla, Emilia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Takeuchi, Hideyuki (The University of Georgia) ; Lee, Tom V. (Baylor College of Medicine) ; Clarimon, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Mavillard, Fabiola (Universidad de Sevilla) ; Area Gómez, Estela (Columbia University Medical Center) ; Rivas, Eloy (Universidad de Sevilla) ; Nieto González, José L. (Universidad de Sevilla) ; Rivero, María C. (Universidad de Sevilla) ; Cabrera Serrano, Macarena (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Gómez Sánchez, Leonardo (Universidad de Sevilla) ; Martínez López, José A. (Universidad de Sevilla) ; Estrada, Beatriz (Universidad Pablo Olavide) ; Márquez, Celedonio (Universidad de Sevilla) ; Morgado, Yolanda (Hospital U. Valme) ; Suárez Calvet, Xavier (Centro de Investigación Biomédica en Red sobre Enfermedades Raras (CIBERER)) ; Pita, Guillermo (Centro Nacional de Investigaciones Oncológicas) ; Bigot, Anne (Sorbonne Universités) ; Gallardo Vigo, Eduard (Centro de Investigación Biomédica en Red sobre Enfermedades Raras (CIBERER)) ; Fernández Chacón, Rafael (Universidad de Sevilla) ; Hirano, Michio (Columbia University Medical Center) ; Haltiwanger, Robert S. (The University of Georgia) ; Jafar-Nejad, Hamed (Baylor College of Medicine) ; Paradas, Carmen (Columbia University Medical Center) ; Universitat Autònoma de Barcelona
Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limb-girdle muscular dystrophy, we identified a missense mutation in 1 (protein O -glucosyltransferase 1), an enzyme involved in Notch posttranslational modification and function. [...]
2016 - 10.15252/emmm.201505815
EMBO Molecular Medicine, Vol. 8, Issue 11 (November 2016) , p. 1289-1309  
5.
11 p, 519.1 KB 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers / Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich) ; Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ; Araque Caballero, Miguel Ángel (Ludwig-Maximilians-University Munich) ; Brendel, Matthias (Ludwig-Maximilians-University Munich) ; Rominger, Axel (Ludwig-Maximilians-University Munich) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau. Departament de Neurociències) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau. Departament de Neurociències) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau. Departament de Neurociències) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau. Departament de Neurociències) ; Gispert, Juan Domingo (Institut d'Investigació Biomèdica Sant Pau. Departament de Neurociències) ; Sánchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Antonell, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Rami, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Molinuevo, José L (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Brosseron, Frederic (German Center for Neurodegenerative Diseases (DZNE)) ; Traschütz, Andreas (Universitätsklinikum Bonn) ; Heneka, Michael T (Universitätsklinikum Bonn) ; Struyfs, Hanne (Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ; Engelborghs, Sebastiaan (Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ; Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ; Van Broeckhoven, Christine (University of Antwerp. Institute Born-Bunge) ; Zetterberg, Henrik (UCL Institute of Neurology) ; Nellgård, Bengt (Gothenburg University. Sahlgrenska Academy. Institute of Clinical Sciences) ; Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg. Institute of Neuroscience and Physiology) ; Crispin, Alexander (Institute of Medical Informatics, Biometry, and Epidemiology) ; Ewers, Michael (Ludwig-Maximilians-University Munich) ; Haass, Christian (BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich) ; Universitat Autònoma de Barcelona
2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (2), which can be measured in the cerebrospinal fluid (). [...]
2016 - 10.15252/emmm.201506123
EMBO Molecular Medicine, Vol. 8 (march 2016) , p. 466-476  
6.
15 p, 3.7 MB 2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue / Albert, Verena (Biozentrum, University of Basel) ; Svensson, Kristoffer (Biozentrum, University of Basel) ; Shimobayashi, Mitsugu (Biozentrum, University of Basel) ; Colombi, Marco (Biozentrum, University of Basel) ; Muñoz, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Jimenez, Veronica (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Handschin, Christoph (Biozentrum, University of Basel) ; Bosch, Fatima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Hall, Michael N (Biozentrum, University of Basel) ; Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica
Activation of non-shivering thermogenesis () in brown adipose tissue () has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients. [...]
2016 - 10.15252/emmm.201505610
EMBO Molecular Medicine, Vol. 8 (january 2016) , p. 232-246  
7.
18 p, 2.2 MB Aberrant epigenome in -derived dopaminergic neurons from Parkinson's disease patients / Fernández-Santiago, Rubén (Universitat de Barcelona) ; Carballo-Carbajal, Iria (Vall d'Hebron Institut de Recerca (VHIR)) ; Castellano, Giancarlo (Universitat de Barcelona. Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Torrent, Roger (Universitat de Barcelona. Institut de Biomedicina (IBUB)) ; Richaud, Yvonne (Biomaterials and Nanomedicine (CIBER-BBN). Centre for Networked Biomedical Research on Bioengineering) ; Sánchez-Danés, Adriana (Universitat de Barcelona. Institut de Biomedicina (IBUB)) ; Vilarrasa-Blasi, Roser (Universitat de Barcelona. Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Sánchez-Pla, Alex (Vall d'Hebron Institut de Recerca (VHIR)) ; Mosquera, José Luis (Universitat de Barcelona) ; Soriano, Jordi (Universitat de Barcelona) ; López-Barneo, José (Universidad de Sevilla. Hospital Universitario Virgen del Rocío.) ; Canals, Josep M (Universitat de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Alberch i Vié, Jordi (Universitat de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Vila Bover, Miquel (Vall d'Hebron Institut de Recerca (VHIR)) ; Consiglio, Antonella (University of Brescia and National Institute of Neuroscience) ; Martín-Subero, José I (Universitat de Barcelona. Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Ezquerra, Mario (Universitat de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Tolosa, Eduardo (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)) ; Universitat Autònoma de Barcelona
The epigenomic landscape of Parkinson's disease () remains unknown. We performed a genomewide methylation and a transcriptome studies in induced pluripotent stem cell ()-derived dopaminergic neurons (n) generated by cell reprogramming of somatic skin cells from patients with monogenic 2-associated (L2) or sporadic (), and healthy subjects. [...]
2015 - 10.15252/emmm.201505439
EMBO Molecular Medicine, Vol. 7, Núm. 12 (October 2015) , p. 1529-1546  
8.
2 p, 334.3 KB Glucocorticoids and antibiotics, how do they get together? / Reidl, Joachim (Institute of Molecular Biosciences, University of Graz) ; Monsó, Eduard (Universitat Autònoma de Barcelona. Departament de Medicina)
Antibiotic therapy in patients currently treated with corticosteroids is common in chronic respiratory diseases when exacerbation symptoms attributable to infection appear. Among them, obstructive diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major health issues affecting hundreds of million people worldwide that are frequently treated with inhaled corticosteroids. [...]
2015 - 10.15252/emmm.201505336
EMBO Molecular Medicine, Vol. 7 (june 2015) , p. 992-993  
9.
17 p, 4.2 MB RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation / Morales, Mònica (Institut de Recerca Biomèdica) ; Arenas, Enrique J (Institut de Recerca Biomèdica) ; Urosevic, Jelena (Institut de Recerca Biomèdica) ; Guiu, Marc (Institut de Recerca Biomèdica) ; Fernández, Esther (Institut de Recerca Biomèdica) ; Planet, Evarist (Institut de Recerca Biomèdica) ; Fenwick, Robert Bryn (Institut de Recerca Biomèdica) ; Fernández Ruiz, Sonia (CIC bioGUNE) ; Salvatella, Xavier (Institut de Recerca Biomèdica) ; Reverter i Cendrós, David (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Carracedo, Arkaitz (CIC bioGUNE) ; Massagué, Joan (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ; Gomis, Roger R (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
In estrogen receptor-negative breast cancer patients, metastatic relapse usually occurs in the lung and is responsible for the fatal outcome of the disease. Thus, a better understanding of the biology of metastasis is needed. [...]
2014 - 10.15252/emmm.201303675
EMBO Molecular Medicine, Vol. 6, issue 7 (Jul. 2014) , p. 865-881  
10.
20 p, 4.0 MB Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine / Castellsagué, Joan (Institut Català d'Oncologia) ; Gel, Bernat (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Fernández-Rodríguez, Juana (Institut Català d'Oncologia) ; Llatjós, Roger (Institut d'Investigació Biomèdica de Bellvitge (L'Hospitalet del Llobregat, Catalunya)) ; Blanco Guillermo, Ignacio (Institut Català d'Oncologia) ; Benavente, Yolanda (Institut Català d'Oncologia) ; Pérez-Sidelnikova, Diana (Institut d'Investigació Biomèdica de Bellvitge (L'Hospitalet del Llobregat, Catalunya)) ; García del Muro Solans, Xavier (Institut Català d'Oncologia) ; Viñals, Joan Maria (Institut d'Investigació Biomèdica de Bellvitge (L'Hospitalet del Llobregat, Catalunya)) ; Vidal, August (Institut d'Investigació Biomèdica de Bellvitge (L'Hospitalet del Llobregat, Catalunya)) ; Valdés-Mas, Rafael (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ; Terribas, Ernest (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; López-Doriga, Adriana (Institut Català d'Oncologia) ; Pujana, Miguel Angel (Institut Català d'Oncologia) ; Capellá, G. (Gabriel) (Institut Català d'Oncologia) ; Puente, Xose S. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ; Serra, Eduard (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Villanueva Garatachea, Alberto (Institut Català d'Oncologia) ; Lázaro, Conxi (Institut Català d'Oncologia)
Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 (NF1). These aggressive malignancies confer poor survival, with no effective therapy available. [...]
2015 - 10.15252/emmm.201404430
EMBO molecular medicine, Vol. 7, No. 5 (2015) , p. 608-627  

Dipòsit Digital de Documents de la UAB : 11 registres trobats   1 - 10següent  anar al registre:
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