Depósito Digital de Documentos de la UAB Encontrados 19 registros  1 - 10siguiente  ir al registro: La búsqueda tardó 0.02 segundos. 
1.
25 p, 2.6 MB Mitochondrial Quality Control in Neurodegenerative Diseases : Focus on Parkinson's Disease and Huntington's Disease / Franco-Iborra, Sandra (Vall d'Hebron. Institut de Recerca (VHIR)) ; Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Perier, Celine (Vall d'Hebron. Institut de Recerca (VHIR))
In recent years, several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and Huntington's disease (HD). Despite distinct clinical and pathological features, these two neurodegenerative diseases share critical processes, such as the presence of misfolded and/or aggregated proteins, oxidative stress, and mitochondrial anomalies. [...]
2018 - 10.3389/fnins.2018.00342
Frontiers in Neuroscience, Vol. 12 (May 2018) , art. 342  
2.
10 p, 3.4 MB Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy / Oliván, Sara (Universidad de Zaragoza. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina. Grupo AMB.) ; Calvo, Ana C. (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ; Rando, Amaya (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ; Herrando Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano, Raquel (University of Oxford. Department of Physiology, Anatomy and Genetics) ; Zaragoza, Pilar (Universidad de Zaragoza. Instituto Agroalimentario de Aragón (IA2)) ; Tizzano, Eduardo F. (Hospital Vall d'Hebron. Àrea de Genètica Clínica i Molecular. Centros de Investigación Biomédica en Red) ; Aguilera Ávila, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Osta, Rosario (Universidad de Zaragoza. Centro de Investigación y Tecnología Agroalimentaria de Aragón) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. SMA is associated with reduced levels of full-length Survival of Motor Neuron (SMN) protein, due to mutations in the Survival of Motor Neuron 1 gene. [...]
2016 - 10.3389/fnmol.2016.00076
Frontiers in Molecular Neuroscience, Vol. 9 (August 2016) , art. 76  
3.
24 p, 5.9 MB Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease / Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Esteban, Gerard (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fogel, Wieslawa A. (Medical University of Lodz. Department of Hormone Biochemistry) ; Ramsay, Rona R. (University of St Andrews. Biomedical Sciences Research Complex) ; Youdim, Moussa B. H. (Ruth and Bruce Rappaport Faculty of Medicine. Department of Pharmacology) ; Tipton, Keith F. (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ; Marco-Contelles, José (Spanish National Research Council. Institute of General Organic Chemistry) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
HIGHLIGHTS Alzheimer's disease (AD), the most common form of adult onset dementia, is an age-related neurodegenerative disorder characterized by progressive memory loss, decline in language skills, and other cognitive impairments. [...]
2016 - 10.3389/fnins.2016.00205
Frontiers in Neuroscience, Vol. 10 (May 2016) , art. 205  
4.
2 p, 165.1 KB Editorial - Glial Cells : Managers of Neuro-Immunity / Barcia González, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Guillemin, Gilles J. (Macquarie University. Department of Biomedical Sciences) ; Curtin, James F. (Dublin Institute of Technology. School of Food Science & Environmental Health) ; Zirger, Jeffrey M. (U.S. Centers for Disease Control and Prevention) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
After many decades of study in the field of Neuroscience that were mostly centered on the neuron there is a mounting interest in the study of the function of the glial cells in many aspects and functions of the central nervous system. [...]
2016 - 10.3389/fncel.2016.00060
Frontiers in Cellular Neuroscience, Vol. 10 (March 2016) , art.60  
5.
10 p, 1.8 MB Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease / González-Marrero, Ibrahim (Universidad de La Laguna. Departamento de Anatomía Humana) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Johanson, Conrad E. (Alpert Medical School at Brown University. Department of Neurosurgery) ; Carmona-Calero, Emilia María (Universidad de La Laguna. Departamento de Anatomía Humana) ; Castañeyra-Ruiz, Leandro (Universidad de La Laguna. Departamento de Anatomía Humana) ; Brito-Armas, José Miguel (Universidad de La Laguna. Departamento de Psicología) ; Castañeyra-Perdomo, Agustín (Universidad de La Laguna. Departamento de Anatomía Humana) ; Castro-Fuentes, Rafael (Universidad de La Laguna. Departamento de Psicología) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Aβ) peptides at the blood-CSF barrier (BCSFB), contribute to complications of Alzheimer's disease (AD). [...]
2015 - 10.3389/fncel.2015.00017
Frontiers in Cellular Neuroscience, Vol. 9 (February 2015) , art. 17  
6.
18 p, 3.4 MB Learning improvement after PI3K activation correlates with de novo formation of functional small spines / Enriquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cuesto, Germán (Centro de Investigación Biomédica (La Rioja)) ; Dominguez-Iturza, Nuria (Centro de Investigación Biomédica (La Rioja)) ; Gavilán, Elena (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ; Ruano, Diego (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ; Sandi, Carmen (École Polytechnique Fédérale de Lausanne. Brain Mind Institute) ; Fernández-Ruiz, Antonio (Instituto Cajal-CSIC) ; Martín-Vázquez, Gonzalo (Instituto Cajal-CSIC) ; Herreras, Oscar (Instituto Cajal-CSIC) ; Morales, Miguel (Centro de Investigación Biomédica (La Rioja)) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide that activates the PI3K signaling pathway increases spine density in the rat hippocampus and enhances the animals' cognitive abilities, while in vivo electrophysiological recordings show that PI3K activation results in synaptic enhancement of Schaffer and stratum lacunosum moleculare inputs. [...]
2014 - 10.3389/fnmol.2013.00054
Frontiers in Molecular Neuroscience, Vol. 6 (January 2014) , art. 54  
7.
19 p, 7.5 MB Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides / Yang, Shaobin (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pascual-Guiral, Sònia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ponce, Rebeca (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Arancio, Ottavio (Columbia University) ; Palacio Cornide, José Ramón (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Clos Guillén, Victoria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Yuste Mateos, Víctor J. (Víctor José) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Institut de Neurociències)
The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. This notion was however challenged by the finding that neuronal survival responses were still preserved in mice with reduced Akt activity. [...]
2018 - 10.3389/fnagi.2017.00435
Frontiers in aging neuroscience, Vol. 9 (January 2018) , art. 435  
8.
8 p, 2.2 MB Loss of mitochondrial Ndufs4 in striatal medium spiny neurons mediates progressive motor impairment in a mouse model of leigh syndrome / Chen, Byron (University of Washington. Howard Hughes Medical Institute) ; Hui, Jessica (Seattle Children's Research Institute (Seattle, Estats Units d'Amèrica)) ; Montgomery, Kelsey S. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ; Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Inability of mitochondria to generate energy leads to severe and often fatal myoencephalopathies. Among these, Leigh syndrome (LS) is one of the most common childhood mitochondrial diseases; it is characterized by hypotonia, failure to thrive, respiratory insufficiency and progressive mental and motor dysfunction, leading to early death. [...]
2017 - 10.3389/fnmol.2017.00265
Frontiers in molecular neuroscience, Vol. 10 (August 2017) , article 265  
9.
12 p, 418.6 KB Are microglial cells the regulators of lymphocyte responses in the CNS? / Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Castellano López, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The infiltration of immune cells in the central nervous system is a common hallmark in different neuroinflammatory conditions. Accumulating evidence indicates that resident glial cells can establish a cross-talk with infiltrated immune cells, including T-cells, regulating their recruitment, activation and function within the CNS. [...]
2015 - 10.3389/fncel.2015.00440
Frontiers in cellular neuroscience, Vol. 16 Núm. 9 (November 2015) , Article ID 440  
10.
12 p, 505.7 KB Potential of adipose-derived stem cells in muscular regenerative therapies / Forcales, Sonia-V (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Abstract. Regenerative capacity of skeletal muscles resides in satellite cells, a self-renewing population of muscle cells. Several studies are investigating epigenetic mechanisms that control myogenic proliferation and differentiation to find new approaches that could boost regeneration of endogenous myogenic progenitor populations. [...]
2015 - 10.3389/fnagi.2015.00123
Frontiers in aging neuroscience, Vol. 7 Núm. 123 (2015)  

Depósito Digital de Documentos de la UAB : Encontrados 19 registros   1 - 10siguiente  ir al registro:
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