Dipòsit Digital de Documents de la UAB 6 registres trobats  La cerca s'ha fet en 0.01 segons. 
1.
19 p, 7.5 MB Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides / Yang, Shaobin (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pascual-Guiral, Sònia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ponce, Rebeca (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Arancio, Ottavio (Columbia University) ; Palacio Cornide, José Ramón (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Clos Guillén, Victoria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Yuste Mateos, Víctor J. (Víctor José) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Institut de Neurociències)
The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. This notion was however challenged by the finding that neuronal survival responses were still preserved in mice with reduced Akt activity. [...]
2018 - 10.3389/fnagi.2017.00435
Frontiers in aging neuroscience, Vol. 9 (January 2018) , art. 435  
2.
12 p, 505.7 KB Potential of adipose-derived stem cells in muscular regenerative therapies / Forcales, Sonia-V (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Abstract. Regenerative capacity of skeletal muscles resides in satellite cells, a self-renewing population of muscle cells. Several studies are investigating epigenetic mechanisms that control myogenic proliferation and differentiation to find new approaches that could boost regeneration of endogenous myogenic progenitor populations. [...]
2015 - 10.3389/fnagi.2015.00123
Frontiers in aging neuroscience, Vol. 7 Núm. 123 (2015)  
3.
12 p, 1.5 MB DNA methylation dynamics in muscle development and disease / Carrió Gaspar, Elvira (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Suelves Esteban, Mònica (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
DNA methylation is an essential epigenetic modification for mammalian development and is crucial for the establishment and maintenance of cellular identity. Traditionally, DNA methylation has been considered as a permanent repressive epigenetic mark. [...]
2015 - 10.3389/fnagi.2015.00019
Frontiers in aging neuroscience, Vol. 7 Núm. 19 (2015)  
4.
6 p, 958.9 KB Staging anti-inflammatory therapy in Alzheimer’s disease / Lichtenstein, Mathieu (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Carriba, Paulina (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Masgrau Juanola, Roser (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Pujol, Aurora (Institució Catalana de Recerca i Estudis Avançats) ; Galea Rodríguez de Velasco, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències)
The use of non-steroidal anti-inflammatory drugs (NSAIDs)in Alzheimer’s disease (AD) is controversial because conclusions from numerous epidemiological studies reporting delayed onset of AD in NSAID users have not been corroborated in clinical trials. [...]
2010 - 10.3389/fnagi.2010.00142
Frontiers in aging neuroscience, Vol. 2, article 142 (October 2010) , p. 1-6  
5.
11 p, 640.5 KB Presenilin/γ-secretase and inflammation / Saura Antolín, Carlos A. (Carlos Alberto) (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins. Specially relevant is the γ-secretase-dependent cleavage of the β-amyloid precursor protein (APP) since generates the β-amyloid (Aβ) peptides that aggregate and accumulate in the brain of Alzheimer’s disease (AD) patients. [...]
2010 - 10.3389/fnagi.2010.00016
Frontiers in aging neuroscience, Vol. 2, article 16 (May 2010) , p. 1-11  
6.
10 p, 1.1 MB Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise / Cosín-Tomás, Marta (Universitat de Barcelona. Institut de Biomedicina) ; Alvarez López, María J. (Universitat de Barcelona. Institut de Biomedicina) ; Sanchez Roige, Sandra (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ferrer Lalanza, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bayod, Sergi (Universitat de Barcelona. Institut de Biomedicina) ; Sanfeliu i Pujol, Coral (Institut d’Investigacions Biomèdiques de Barcelona) ; Pallàs i Lliberia, Mercè (Universitat de Barcelona. Institut de Biomedicina) ; Escorihuela, Rosa Maria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kaliman, Perla (Institut d’Investigacions Biomèdiques de Barcelona)
The senescence-accelerated SAMP8 mouse model displays features of cognitive decline and Alzheimer’s disease. With the purpose of identifying potential epigenetic markers involved in aging and neurodegeneration, here we analyzed the expression of 84 mature miRNAs, the expression of histone-acetylation regulatory genes and the global histone acetylation in the hippocampus of 8-month-old SAMP8 mice, using SAMR1 mice as control. [...]
2014 - 10.3389/fnagi.2014.00051
Frontiers in aging neuroscience, Vol. 6, article 51 (March 2014) , article 51  

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