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Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors
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Kilpeläinen, Athina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez-Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Quirant-Sanchez, Bibiana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perez-Caballero, Raul (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Chamorro, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Cáceres, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mateu, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The role of T cells in the control of SARS-CoV-2 infection has been underestimated in favor of neutralizing antibodies. However, cellular immunity is essential for long-term viral control and protection from disease severity. [...]
2022 -  10.3389/fimmu.2022.815041
Frontiers in immunology, Vol. 13 (may 2022)
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2.
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Brief Research Report : Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination
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Sisteré-Oró, Marta (Universitat Pompeu Fabra) ;
Wortmann, Diana D. J. (Universitat Pompeu Fabra) ;
Andrade, Naína (Universitat Pompeu Fabra) ;
Aguilar, Andres (Hospital Quiron-Dexeus Barcelona) ;
Mayo de las Casas, Clara (Hospital Universitario Dexeus) ;
Casabal, Florencia Garcia (Hospital Quiron-Dexeus Barcelona) ;
Torres, Susana (Hospital Quiron-Dexeus Barcelona) ;
Bona Salinas, Eduardo (Hospital Quiron-Dexeus Barcelona) ;
Raventos Soler, Laura (Hospital Quiron-Dexeus Barcelona) ;
Arcas, Andrea (Hospital Quiron-Dexeus Barcelona) ;
Esparre, Carlos (Hospital Quiron-Dexeus Barcelona) ;
Garcia, Beatriz (Hospital Universitario Dexeus) ;
Valarezo, Joselyn (Hospital Universitario Dexeus) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Güerri-Fernández, Robert (Hospital del Mar (Barcelona, Catalunya)) ;
Gonzalez-Cao, Maria (Hospital Quiron-Dexeus Barcelona) ;
Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
Universitat Autònoma de Barcelona
Cancer patients (CPs) have been identified as particularly vulnerable to SARS-CoV-2 infection, and therefore are a priority group for receiving COVID-19 vaccination. From the patients with advanced solid tumors, about 20% respond very efficiently to immunotherapy with anti-PD1/PD-L1 antibodies and achieve long lasting cancer responses. [...]
2022 - 10.3389/fimmu.2022.908108
Frontiers in immunology, Vol. 13 (july 2022)
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4.
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19 p, 7.0 MB |
Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study
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Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron) ;
Álvarez-Sierra, Daniel (Hospital Universitari Vall d'Hebron) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron) ;
Perurena-Prieto, Janire (Hospital Universitari Vall d'Hebron) ;
Arrese-Muñoz, Iria (Hospital Universitari Vall d'Hebron) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Espinosa-Pereiro, Juan (Hospital Universitari Vall d'Hebron) ;
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron) ;
Martínez Gómez, Xavier (Hospital Universitari Vall d'Hebron) ;
Antón, Andrés (Hospital Universitari Vall d'Hebron) ;
Martínez-Valle, Ferran (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Blanco-Grau, Albert (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Castellano-Escuder, Pol (Universitat de Barcelona) ;
Poyatos Cantón, E (Hospital Universitari de Bellvitge) ;
Bas, Jordi (Hospital Universitari de Bellvitge) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron) ;
Zurera-Egea, Coral (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-González, Manuel (Hospital Universitari Vall d'Hebron) ;
Pujol-Borrell, Ricardo (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Two years since the onset of the COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms the contribution of laboratory variables is limited. [...]
2022 - 10.3389/fimmu.2022.902837
Frontiers in immunology, Vol. 13 (june 2022)
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5.
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12 p, 1.3 MB |
On the clinical relevance of using complete high-resolution HLA typing for an accurate interpretation of posttransplant immune-mediated graft outcomes
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Meneghini, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Perona, Anna (Universitat de Barcelona) ;
Crespo, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bemelman, Frederike (Amsterdam University Medical Centers) ;
Reinke, Petra (Berlin Center for Advanced Therapies) ;
Viklicky, Ondrej (Institute for Clinical and Experimental Medicine) ;
Giral, Magali (Nantes Université) ;
Palou, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Torija, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Donadeu, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Melilli, Edoardo (Hospital Universitari de Bellvitge) ;
Zuñiga, Jose (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sefrin, Anett (Berlin Center for Advanced Therapies) ;
Lachmann, Nils (Charité - Universitätsmedizin Berlin) ;
Hu, Liu (Amsterdam University Medical Centers) ;
Hruba, Petra (Institute for Clinical and Experimental Medicine) ;
Guillot-Gueguen, Cécile (Nantes Université) ;
Brouard, Sophie (Nantes Université) ;
Grinyo, Josep (Universitat de Barcelona) ;
Bestard, Oriol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Complete and high-resolution (HR) HLA typing improves the accurate assessment of donor-recipient compatibility and pre-transplant donor-specific antibodies (DSA). However, the value of this information to identify de novo immune-mediated graft events and its impact on outcomes has not been assessed. [...]
2022 - 10.3389/fimmu.2022.924825
Frontiers in immunology, Vol. 13 (september 2022)
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18 p, 6.6 MB |
IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation
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Ezeonwumelu, I.J (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Felip, Eudald (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gohr, André (Max Planck Institute of Molecular Cell Biology and Genetics) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contribute to the clearing of HIV reservoir. [...]
2022 - 10.3389/fimmu.2022.1001068
Frontiers in immunology, Vol. 13 (september 2022)
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15 p, 8.8 MB |
Mesenchymal stromal cells induced regulatory B cells are enriched in extracellular matrix genes and IL-10 independent modulators
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Garcia, Sergio G. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sandoval-Hellín, Noelia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clos Sansalvador, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carreras-Planella, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Regulatory B cells (Breg) are essential players in tolerance and immune homeostasis. However, lack of specific Breg markers limit their potential in clinical settings. Mesenchymal stromal cells (MSC) modulate B cell responses and are described to induce Breg in vitro. [...]
2022 - 10.3389/fimmu.2022.957797
Frontiers in immunology, Vol. 13 (september 2022)
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20 p, 11.4 MB |
Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections
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Romero-Martín, Luis (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olivella, Mireia (Universitat de Vic - Universitat Central de Catalunya) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Impacta) ;
Hartigan-O'Connor, Dennis (University of California) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The contribution of the HLA-E/NKG2X axis in NK-mediated control of HIV infection remains unclear. We have studied the relationship between HLA-E expression and phenotypical as well as functional characteristics of NK cells, in the context of chronic HIV infection and in an in vitro model of acute infection. [...]
2022 - 10.3389/fimmu.2022.1027855
Frontiers in immunology, Vol. 13 (november 2022)
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21 p, 9.6 MB |
Women for science and science for women : Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention
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Karim, Quarraisha Abdool (Department of Epidemiology, Mailman School of Public Health, Columbia University) ;
Archary, Derseree (Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal) ;
Barré-Sinoussi, Françoise (Institut Pasteur) ;
Broliden, Kristina (Karolinska Institutet (Estocolm, Suècia)) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Chiodi, Francesca (Karolinska Institutet (Estocolm, Suècia)) ;
Fidler, Sarah J. (Imperial College London) ;
Gengiah, Tanuja N. (Centre for the AIDS Programme of Research in South Africa (CAPRISA)) ;
Herrera, Carolina (Imperial College London) ;
Kharsany, Ayesha B. M. (University of KwaZulu-Natal) ;
Liebenberg, Lenine J. P. (University of KwaZulu-Natal) ;
Mahomed, Sharana (University of KwaZulu-Natal) ;
Menu, Elisabeth (Institut Pasteur) ;
Moog, Christiane (Université de Strasbourg) ;
Scarlatti, Gabriella (IRCCS Ospedale San Raffaele) ;
Seddiki, Nabila (Université Paris-Saclay) ;
Sivro, Aida (Public Health Agency of Canada) ;
Cavarelli, Mariangela (Université Paris-Saclay) ;
Universitat Autònoma de Barcelona
Preventing new HIV infections remains a global challenge. Young women continue to bear a disproportionate burden of infection. Oral pre-exposure prophylaxis (PrEP), offers a novel women-initiated prevention technology and PrEP trials completed to date underscore the importance of their inclusion early in trials evaluating new HIV PrEP technologies. [...]
2022 - 10.3389/fimmu.2022.1055042
Frontiers in immunology, Vol. 13 (december 2022)
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