UAB Digital Repository of Documents 3 records found  Search took 0.00 seconds. 
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12 p, 1.1 MB Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients / Joksic, Ivana (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ; Vujic, Dragana (University of Belgrade. School of Medicine (Belgrad, Sèrbia)) ; Guc-Scekic, Marija (Mother and Child Health Care Institute of Serbia "Dr Vukan Cupic" (Belgrad, Sèrbia)) ; Leskovac, Andreja (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ; Petrovic, Sandra (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ; Ojani, Maryam (Brunel University (Londres, Regne Unit)) ; Trujillo Quintero, Juan Pablo (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Surrallés i Calonge, Jordi (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Zivkovic, Maja (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ; Stankovic, Aleksandra (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ; Slijepcevic, Pedrag (Brunel University (Londres, Regne Unit)) ; Joksic, Gordana (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia))
Background: Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized primary cells (lymphocytes and fibroblasts) derived from FA patients of the FA-D2 complementation group, which provides a more accurate physiological assessment than is possible with transformed cells or animal models. [...]
2012 - 10.1186/2041-9414-3-6
Genome integrity, Vol. 3, N. 6 (September 2012) , p. 1-12  
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10 p, 2.1 MB Gene amplification in human cells knocked down for RAD54 / Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Smirnova, Alexandra (Università di Pavia. Dipartimento di Genetica e Microbiologia "Adriano Buzzati-Traverso") ; Khouriauli, Lela (Università di Pavia. Dipartimento di Genetica e Microbiologia "Adriano Buzzati-Traverso") ; Nergadze, Solomon G. (Università di Pavia. Dipartimento di Genetica e Microbiologia "Adriano Buzzati-Traverso") ; Mondello, Chiara (Istituto di Genetica Molecolare (Pàvia, Itàlia)) ; Giulotto, Elena (Università di Pavia. Dipartimento di Genetica e Microbiologia "Adriano Buzzati-Traverso")
Background: In mammalian cells gene amplification is a common manifestation of genome instability promoted by DNA double-strand breaks (DSBs). The repair of DSBs mainly occurs through two mechanisms: non-homologous end-joining (NHEJ) and homologous recombination (HR). [...]
2011
Genome integrity, Vol. 2, N. 5 (March 2011) , p. 1-10
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10 p, 531.4 KB Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner / Lyakhovich, Alex (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ramírez, María José (Duke-NUS Graduate Medical School. Cancer and Stem Cell Research Program) ; Castellanos, Andrés (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Castella, Maria (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Simons, A. M. (Harvard Medical School. Department of Pathology) ; Parvin, J. D. (Harvard Medical School. Department of Pathology) ; Surrallés i Calonge, Jordi (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia)
Background: Fanconi anemia (FA) is a rare autosomal recessive syndrome characterized by developmental abnormalities, progressive bone marrow failure, and predisposition to cancer. The key FA protein FANCD2 crosstalks with members of DNA damage and repair pathways that also play a role at telomeres. [...]
2011 - 10.1186/2041-9414-2-4
Genome integrity, Vol. 2, N. 4 (February 2011) , p. 1-10  

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