Depósito Digital de Documentos de la UAB Encontrados 12 registros  1 - 10siguiente  ir al registro: La búsqueda tardó 0.02 segundos. 
1.
13 p, 610.0 KB White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers / van Waalwijk van Doorn, Linda J.C. ; Ghafoorian, Mohsen ; van Leijsen, Esther M.C. ; Claassen, Jurgen A.H.R. ; Arighi, Andrea ; Bozzali, Marco ; Cannas, Jorge ; Cavedo, Enrica ; Eusebi, Paolo ; Farotti, Lucia ; Fenoglio, Chiara ; Fortea, Juan Institut d'Investigació Biomèdica Sant Pau ; Frisoni, Giovanni B. ; Galimberti, Daniela ; Greco, Viviana ; Herukka, Sanna-Kaisa ; Liu, Yawu ; Lleó, Alberto Institut d'Investigació Biomèdica Sant Pau ; de Mendonça, Alexandre ; Nobili, Flavio M. ; Parnetti, Lucilla ; Picco, Agnese ; Pikkarainen, Maria ; Salvadori, Nicola ; Scarpini, Elio ; Soininen, Hilkka ; Tarducci, Roberto ; Urbani, Andrea ; Vilaplana, Eduard Institut d'Investigació Biomèdica Sant Pau ; Meulenbroek, Olga ; Platel, Bram ; Verbeek, Marcel M. ; Kuiperij, H. Bea ; Universitat Autònoma de Barcelona
The cerebrospinal fluid (CSF) biomarkers amyloid-β 1-42 (Aβ), total and phosphorylated tau (t-tau, p-tau) are increasingly used to assist in the clinical diagnosis of Alzheimer's disease (AD). However, CSF biomarker levels can be affected by confounding factors. [...]
2021 - 10.3233/JAD-200496
Journal of Alzheimer's disease, Vol. 79 (january 2021) , p. 163-175  
2.
16 p, 903.0 KB Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology / Shi, Liu (University of Oxford) ; Winchester, Laura M. (University of Oxford) ; Liu, Benjamine Y. (University of Oxford) ; Killick, Richard (Maurice Wohl Institute Clinical Neuroscience Institute) ; Ribe, Elena M. (University of Oxford) ; Westwood, Sarah (University of Oxford) ; Baird, Alison L. (University of Oxford) ; Buckley, Noel J. (University of Oxford) ; Hong, Shengjun (University of Lübeck) ; Dobricic, Valerija (University of Lübeck) ; Kilpert, Fabian (University of Lübeck) ; Franke, Andre (Christian-Albrechts-University of Kiel) ; Kiddle, Steven (King's College London) ; Sattlecker, Martina (King's College London) ; Dobson, Richard (University College London) ; Cuadrado, Antonio ("Victor Babes" National Institute of Pathology) ; Hye, Abdul (Maurice Wohl Institute Clinical Neuroscience Institute) ; Ashton, Nicholas J. (University of Gothenburg) ; Morgan, Angharad R. (Cardiff University) ; Bos, Isabelle (Amsterdam UMC. University Medical Center) ; Vos, Stephanie J.B. (Maastricht University) ; ten Kate, Mara (Amsterdam UMC. University Medical Center) ; Scheltens, Philip (Amsterdam UMC. University Medical Center) ; Vandenberghe, Rik (University Hospital Leuven) ; Gabel, Silvy (Laboratory for Cognitive Neurology) ; Meersmans, Karen (Laboratory for Cognitive Neurology) ; Engelborghs, Sebastiaan (Universitair Ziekenhuis Brussel-UZ Brussel. Department of Neurology) ; De Roeck, Ellen E. (University of Antwerp) ; Sleegers, Kristel (Center for Molecular Neurology) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Aix-Marseille Université) ; Richardson, Jill C. (GlaxoSmithKline R&D. Neurosciences Therapeutic Area) ; Bordet, Régis (University of Lille) ; Molinuevo, José L. (Barcelonaβeta Brain Research Center (BBRC)) ; Rami, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ; Wallin, Anders (Sahlgrenska University Hospital) ; Kettunen, Petronella (University of Oxford) ; Tsolaki, Magda (Aristotle University of Thessaloniki) ; Verhey, Frans (Maastricht University) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (University of Geneva) ; Peyratout, Gwendoline (University Hospital of Lausanne) ; Martinez-Lage, Pablo (CITA-Alzheimer Foundation (San Sebastian)) ; Tainta, Mikel (Organización Sanitaria Integrada Goierri) ; Johannsen, Peter (Copenhagen University Hospital) ; Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ; Freund-Levi, Yvonne (Department of Psychiatry, Örebro Universitetssjukhus) ; Frölich, Lutz (University of Heidelberg) ; Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ; Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ; Blennow, Kaj (Sahlgrenska University Hospital) ; Rasmussen, Katrine Laura (University of Copenhagen) ; Nordestgaard, Børge Grønne (Copenhagen University Hospital) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Nielsen, Sune Fallgaard (Copenhagen University Hospital) ; Soininen, Hilkka (University of Eastern Finland) ; Vellas, Bruno (Univeriste Paul Sabatier) ; Kloszewska, Iwona (Medical University of Lodz) ; Mecocci, Patrizia (University of Perugia) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Morgan, B. Paul (Cardiff University) ; Streffer, Johannes (UCB Pharma (Braine-l'Alleud, Bèlgica)) ; Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ; Bertram, Lars (University of Oslo) ; Nevado-Holgado, Alejo (University of Oxford) ; Lovestone, Simon (University of Oxford) ; Universitat Autònoma de Barcelona
Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer's disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. [...]
2020 - 10.3233/JAD-200208
Journal of Alzheimer's disease, Vol. 77 (september 2020) , p. 1353-1368  
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9 p, 306.3 KB Vibrating Tail, Digging, Body/Face Interaction, and Lack of Barbering : Sex-Dependent Behavioral Signatures of Social Dysfunction in 3xTg-AD Mice as Compared to Mice with Normal Aging / Torres-Lista, Virginia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giménez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Modeling of Alzheimer's disease (AD), classically focused on the subject-environment interaction, foresees current social neuroscience efforts as improving the predictive validity of new strategies. Here we studied social functioning among congeners in 13-14-month-old mice with normal aging in naturalistic and experimental conditions and depicted behavioral signatures of dysfunction in age-matched 3xTg-AD mice. [...]
2019 - 10.3233/JAD-190253
Journal of Alzheimer's disease, Vol. 69 (june 2019) , p. 969-977  
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11 p, 334.7 KB Survival curves and behavioral profiles of female 3xTg-AD mice surviving to 18-months of age as compared to mice with normal aging / Torres-Lista, Virginia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; De la Fuente, Mónica (Universidad Complutense de Madrid. Departamento de Fisiología Animal II) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
New evidence reveals a high degree of heterogeneity in Alzheimer's disease (AD) clinical and temporal patterns, supporting the existence of several subgroups of patients. Prognosticators of end-of-life dementia specific to elderly patients are necessary to address this heterogeneity. [...]
2017 - 10.3233/ADR-170011
Journal of Alzheimer's disease reports, Vol. 1, issue 1 (2017) , p. 47-57  
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23 p, 1.3 MB The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale : comprehensive assessment of psychopathology in Down syndrome / Dekker, Alain D. (Universitair Medisch Centrum Groningen) ; Sacco, Silvia (Institut Jérôme Lejeune) ; Carfi, Angelo (Universitá Cattolica del Sacro Cuore) ; Benejam, Bessy (Fundació Catalana Síndrome de Down) ; Vermeiren, Yannick (Universitair Medisch Centrum Groningen) ; Beugelsdijk, Gonny (Ipse de Bruggen) ; Schippers, Mieke (Ipse de Bruggen) ; Hassefras, Lyanne (Ipse de Bruggen) ; Eleveld, José (Cosis (Groningen)) ; Grefelman, Sharina (Cosis (Groningen)) ; Fopma, Roelie (Talant (Heerenveen)) ; Bomer-Veenboer, Monique (Pameijer (Rotterdam)) ; Botí, M. Ángeles (Fundació Catalana Síndrome de Down) ; Oosterling, G. Danielle E. (Aveleijn (Borne)) ; Scholten, Esther (Elver (Nieuw-Wehl)) ; Tollenaere, Marleen (Institute Born-Bunge) ; Checkley, Laura (University College London. Division of Psychiatry) ; Strydom, André (University College London. Division of Psychiatry) ; Van Goethem, Gert (Het GielsBos (Gierle)) ; Onder, Graziano (Universitá Cattolica del Sacro Cuore) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; zu Eulenburg, Christine (Universitair Medisch Centrum Groningen) ; Coppus, Antonia M.W. (Dichterbij (Gennep)) ; Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ; Fortea, Juan (Fundació Catalana Síndrome de Down) ; De Deyn, Peter P. (Universitair Medisch Centrum Groningen) ; Universitat Autònoma de Barcelona
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. [...]
2018 - 10.3233/JAD-170920
Journal of Alzheimer's disease, Vol. 63, issue 2 (2018) , p. 797-819  
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12 p, 1000.7 KB Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin / Cuberas-Borrós, Gemma (Hospital Universitari Vall d'Hebron) ; Roca Bielsa, María Isabel (Hospital Universitari Vall d'Hebron) ; Boada, Mercè (Hospital Universitari Vall d'Hebron) ; Tárraga, Lluís (Institut Català de Neurociènces Aplicades) ; Hernández, Isabel (Institut Català de Neurociènces Aplicades) ; Buendia, Mar (Institut Català de Neurociènces Aplicades) ; Rubio, Lourdes (Gammagrafía Corachan, Barcelona) ; Torres, Gustavo (Gammagrafía Corachan, Barcelona) ; Bittini, Ángel (Hospital General Universitario Gregorio Marañón) ; Guzmán-de-Villoria, Juan A. (Hospital General Universitario Gregorio Marañón) ; Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ; Torres, Mireia (Instituto Grifols) ; Núñez, Laura (Instituto Grifols) ; Castell Conesa, Joan (Hospital Universitari Vall d'Hebron) ; Páez, Antonio (Instituto Grifols) ; Universitat Autònoma de Barcelona
Recently, modifications of Aβ levels in CSF and plasma associated with improvement in memory and language functions have been observed in patients with mild-moderate Alzheimer's disease (AD) treated with plasma exchange (PE) with albumin replacement. [...]
2017 - 10.3233/JAD-170693
Journal of Alzheimer's disease, Vol. 61 (november 2017) , p. 321-332  
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10 p, 92.4 KB Social Representation of Dementia : An Analysis of 5,792 Consecutive Cases Evaluated in a Memory Clinic / Cañabate, Pilar (Institut Català de Neurociènces Aplicades) ; Martínez, Gabriel (University of Antofagasta) ; Rosende-Roca, Maitée (Institut Català de Neurociènces Aplicades) ; Moreno, Mariola (Institut Català de Neurociènces Aplicades) ; Preckler, Silvia (Institut Català de Neurociènces Aplicades) ; Valero Ventura, Sergi (Hospital Universitari Vall d'Hebron) ; Sotolongo Grau, Oscar (Institut Català de Neurociènces Aplicades) ; Hernández, Isabel (Institut Català de Neurociènces Aplicades) ; Alegret, Montserrat (Institut Català de Neurociènces Aplicades) ; Ortega Linares, Gemma (Institut Català de Neurociènces Aplicades) ; Espinosa, Ana (Institut Català de Neurociènces Aplicades) ; Mauleón, Ana (Institut Català de Neurociènces Aplicades) ; Vargas, Liliana (Institut Català de Neurociènces Aplicades) ; Rodríguez, Octavio (Institut Català de Neurociènces Aplicades) ; Abdelnour, Carla (Institut Català de Neurociènces Aplicades) ; Sánchez, Domingo (Institut Català de Neurociènces Aplicades) ; Martín, Elvira (Institut Català de Neurociènces Aplicades) ; Ruiz, Agustín (Institut Català de Neurociènces Aplicades) ; Tárraga, Lluís (Institut Català de Neurociènces Aplicades) ; Boada, Mercè (Institut Català de Neurociènces Aplicades) ; Universitat Autònoma de Barcelona
Background: Different interpretations of cognitive impairment and dementia due to differences in health structures, such as cultural differences could affect the diagnosis and treatment of the condition. [...]
2017 - 10.3233/JAD-161119
Journal of Alzheimer's disease, Vol. 58, Núm. 4 (June 2017) , p. 1099-1108  
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13 p, 129.1 KB Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype / Espinosa, Ana (Institut Català de Neurociènces Aplicades) ; Alegret, Montserrat (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Pesini, Pedro (Araclon Biotech S.L.) ; Valero Ventura, Sergi (Hospital Universitari Vall d'Hebron) ; Lafuente, Asunción (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Buendía, Mar (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; San José, Itziar (Araclon Biotech S.L.) ; Ibarria, Marta (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Tejero, Miguel Ángel (Clínica Corachán) ; Giménez Ruiz, Joan (Clínica Corachán) ; Ruiz, Susana (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Hernández, Isabel (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ; Martínez Lage, Pablo (Fundación CITA) ; Munuera, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Arbizu, Javier (Clínica Universidad de Navarra) ; Tárraga, Lluís (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Hendrix, Suzanne B. (Pentara Corporation) ; Ruiz, Agustín (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Becker, James T. (University of Pittsburgh) ; Landau, Susan M. (University of California) ; Sotolongo Grau, Oscar (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Sarasa, Manuel (Araclon Biotech S.L.) ; Boada, Mercè (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Universitat Autònoma de Barcelona
The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8. 5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. [...]
2017 - 10.3233/JAD-161223
Journal of Alzheimer's disease, Vol. 57, Núm. 2 (March 2017) , p. 447-459  
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9 p, 204.1 KB Effect Size Analyses of Souvenaid in Patients with Alzheimer's Disease / Cummings, Jeffrey (Cleveland Clinic Lou Ruvo Center for Brain Health) ; Scheltens, Philip (Amsterdam UMC. University Medical Center) ; McKeith, Ian (Newcastle University) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Harrison, John E. (Metis Cognition Ltd, Park House, Kilmington Common, Wiltshire) ; Bertolucci, Paulo H.F. (Behaviour Neurology Section - Universidade Federal de São Paulo) ; Rockwood, Kenneth (DGI Clinical, Halifax, NS) ; Wilkinson, David (University of Southampton) ; Wijker, Wouter (Auxiliis BV, Amsterdam) ; Bennett, David A. (Rush University Medical Center) ; Shah, Raj C. (Rush University Medical Center) ; Universitat Autònoma de Barcelona. Departament de Neurologia
Background: Souvenaid ® (uridine monophosphate, docosahexaenoic acid, eicosapentaenoic acid, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium), was developed to support the formation and function of neuronal membranes. [...]
2016 - 10.3233/JAD-160745
Journal of Alzheimer's disease, Vol. 55 (december 2016) , p. 1131-1139  
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5 p, 722.3 KB Copper Modulation as a Therapy for Alzheimer's Disease? / Manso Sanz, Yasmina (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Comes Orpinell, Gemma (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bush, Ashley I. (The Mental Health Research Institute. Oxidation Biology Laboratory (Australia)) ; Adlard, Paul A. (The University of Melbourne. Department of Pathology (Australia)) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The role of metals in the pathophysiology of Alzheimer's disease (AD) has gained considerable support in recent years, with both in vitro and in vivo data demonstrating that a mis-metabolism of metal ions, such as copper and zinc, may affect various cellular cascades that ultimately leads to the development and/or potentiation of AD. [...]
2011 - 10.4061/2011/370345
International Journal of Alzheimer's Disease, Vol. 2011 (June 2011) , art. 370345  

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