UAB Digital Repository of Documents 15 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
1.
13 p, 1.6 MB Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition / Flores-Aguilar, Lisi (McGill University) ; Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ; Orciani, Chiara (McGill University) ; Tanna, Neil (McGill University) ; Yang, Jingyun (Rush University Medical Center) ; Bennett, David A. (Rush University Medical Center) ; Cuello, A.C. (Oxford University) ; Universitat Autònoma de Barcelona
Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer's disease models; however, evidence of its occurrence in humans remains scarce. To elucidate whether amyloid deposition is associated with neuroinflammation and cognitive deficits, we studied brain inflammatory cytokine expression and cognitive decline in non-demented elderly individuals with and without cerebral amyloid-beta deposition. [...]
2021 - 10.1186/s12974-021-02169-0
Journal of neuroinflammation, Vol. 18 (july 2021)  
2.
10 p, 1.7 MB Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD : how much retina do you really need to see well? / Havla, Joachim (Ludwig-Maximilians-Universität München) ; Pakeerathan, Thivya (Ruhr-University Bochum) ; Schwake, Carolin (Ruhr-University Bochum) ; Bennett, Jeffrey L. (University of Colorado Anschutz Medical Campu) ; Kleiter, Ingo (Marianne-Strauß-Klinik) ; Felipe-Rucián, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Joachim, Stephanie C. (Ruhr-University Bochum) ; Lotz-Havla, Amelie S. (Ludwig-Maximilians-Universität München) ; Kümpfel, Tania (Ludwig-Maximilians-Universität München) ; Krumbholz, Markus (University Hospital of Tübingen (Alemanya)) ; Wendel, Eva M. (Olgaspital Stuttgart) ; Reindl, Markus (Medical University of Innsbruck) ; Thiels, Charlotte (Ruhr-University) ; Lücke, Thomas (Ruhr-University) ; Hellwig, Kerstin (Ruhr-University Bochum) ; Gold, Ralf (Ruhr-University Bochum) ; Rostasy, Kevin (University Witten/Herdecke) ; Ayzenberg, Ilya (Sechenov First Moscow State Medical University) ; Universitat Autònoma de Barcelona
To investigate age-related severity, patterns of retinal structural damage, and functional visual recovery in pediatric and adult cohorts of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) optic neuritis (ON). [...]
2021 - 10.1186/s12974-021-02160-9
Journal of neuroinflammation, Vol. 18 (may 2021)  
3.
22 p, 6.8 MB Chronic exposure to IL-6 induces a desensitized phenotype of the microglia / Recasens, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Pérez-Clausell, Jeús (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Campbell, Iain L. (University of Sydney. School of Life and Environmental Sciences and Charles Perkins Centre) ; González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Castellano, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
When the homeostasis of the central nervous system (CNS) is altered, microglial cells become activated displaying a wide range of phenotypes that depend on the specific site, the nature of the activator, and particularly the microenvironment generated by the lesion. [...]
2021 - 10.1186/s12974-020-02063-1
Journal of neuroinflammation, Vol. 18 (january 2021)  
4.
10 p, 1.6 MB Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course / Gil-Varea, Elia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Vilariño-Güell, Carles (University of British Columbia. Department of Medical Genetics) ; Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra") ; Rodríguez-Antigüedad, Alfredo (Hospital de Basurto (Bilbao, Biscaia)) ; Oksenberg, Jorge (University of California. Department of Neurology) ; Espino-Paisan, Laura (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Dessa Sadovnick, A. (University of British Columbia. Department of Medical Genetics) ; Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Villar, Luisa M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; García-Merino, Juan Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Ramió-Torrentà, Lluís (Hospital Universitari de Girona Doctor Josep Trueta) ; Triviño, Juan Carlos (Genomic Systems, Valencia, Spain) ; Quintana, Ester (Hospital Universitari de Girona Doctor Josep Trueta) ; Robles, René (Hospital Universitari de Girona Doctor Josep Trueta) ; Sánchez-López, Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Arroyo, Rafael (Hospital Universitario Quirón Salud. Servicio de Neurología) ; Alvarez-Cermeño, Jose C. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
It remains unclear whether disease course in multiple sclerosis (MS) is influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated with benign and aggressive disease courses in MS patients. [...]
2018 - 10.1186/s12974-018-1307-1
Journal of neuroinflammation, Vol. 15 (september 2018)  
5.
8 p, 2.1 MB Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis / Zabalza, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ; Vera, Andrea (Institut Hospital del Mar d'Investigacions Mèdiques) ; Alari-Pahissa, Elisenda (Universitat Pompeu Fabra) ; Munteis, Elvira (Institut Hospital del Mar d'Investigacions Mèdiques) ; Moreira Villanueva, Antía (Althaia Xarxa Assistencial Universitària de Manresa) ; Yélamos, Jose (Institut Hospital del Mar d'Investigacions Mèdiques) ; Llop, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques) ; López-Botet, Miguel (Institut Hospital del Mar d'Investigacions Mèdiques) ; Martínez-Rodríguez, Jose E. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Universitat Autònoma de Barcelona. Departament de Medicina
Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in MS patients whether HCMV induces modifications in the peripheral B cell compartment. [...]
2020 - 10.1186/s12974-020-01840-2
Journal of neuroinflammation, Vol. 17 (may 2020)  
6.
12 p, 3.0 MB BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury / Sánchez-Ventura, Judith (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Amo-Aparicio, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, Xavier (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Penas Pérez, Clara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Spinal cord injury (SCI) usually causes a devastating lifelong disability for patients. After a traumatic lesion, disruption of the blood-spinal cord barrier induces the infiltration of macrophages into the lesion site and the activation of resident glial cells, which release cytokines and chemokines. [...]
2019 - 10.1186/s12974-019-1511-7
Journal of neuroinflammation, Vol. 16 (June 2019) , art. 124  
7.
20 p, 3.2 MB Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA / Derdelinckx, Judith (University Hospital Antwerp (Bèlgica)) ; Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; De Laere, Maxime (University of Antwerp. Laboratory of Experimental Hematology) ; Lee, Wai-Ping (University Hospital Antwerp (Bèlgica)) ; Navarro-Barriuso, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Wens, Inez (University of Antwerp. Laboratory of Experimental Hematology) ; Nkansah, Irene (University of Antwerp. Laboratory of Experimental Hematology) ; Daans, Jasmijn (University of Antwerp. Laboratory of Experimental Hematology) ; De Reu, Hans (University of Antwerp. Laboratory of Experimental Hematology) ; Jolanta Keliris, Aneta (University of Antwerp. Bio-Imaging Lab) ; Van Audekerke, Johan (University of Antwerp. Bio-Imaging Lab) ; Vanreusel, Verdi (University of Antwerp. Bio-Imaging Lab) ; Pieters, Zoë (University of Antwerp. Laboratory of Experimental Hematology) ; Van Der Linden, Annemie (University of Antwerp. Bio-Imaging Lab) ; Verhoye, Maraleen (University of Antwerp. Bio-Imaging Lab) ; Molenberghs, Geert (L-BioStat. I-BioStat. KU Leuven) ; Hens, Niel (University of Antwerp. Centre for Health Economics Research and Modelling Infectious Diseases) ; Goossens, Herman (University of Antwerp. Laboratory of Medical Microbiology) ; Willekens, Barbara (University Hospital Antwerp (Bèlgica)) ; Cras, Patrick (University of Antwerp. Born Bunge Institute) ; Ponsaerts, Peter (University of Antwerp. Laboratory of Experimental Hematology) ; Berneman, Zwi N. (University Hospital Antwerp (Bèlgica)) ; Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cools, Nathalie (University Hospital Antwerp (Bèlgica))
Background: Although effective in reducing relapse rate and delaying progression, current therapies for multiple sclerosis (MS) do not completely halt disease progression. T cell autoimmunity to myelin antigens is considered one of the main mechanisms driving MS. [...]
2019 - 10.1186/s12974-019-1541-1
Journal of neuroinflammation, Vol. 16 (August 2019) , art. 167  
8.
6 p, 517.4 KB Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15 / Martinez Martinez, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Lleixà, Cinta (Institut d'Investigació Biomèdica Sant Pau) ; Boera-Carnicero, Gemma (Institut d'Investigació Biomèdica Sant Pau) ; Cortese, Andrea (IRCCS Foundation C. Mondino National Neurological Institute (Itàlia)) ; Devaux, Jérôme (Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille) ; Siles, Ana M. (Institut d'Investigació Biomèdica Sant Pau) ; Rajabally,Yusuf (Regional Neuromuscular Clinic, Queen Elizabeth Hospital) ; Martinez-Piñeiro, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carvajal, Alejandra (Hospital Universitario Virgen de las Nieves (Granada)) ; Pardo, Julio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ; Delmont, Emilien (Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille) ; Attarian,Shahram ; Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Callegari,Ilaria (IRCCS Foundation C. Mondino National Neurological Institute (Itàlia)) ; Marchioni, Enrico (IRCCS Foundation C. Mondino National Neurological Institute (Itàlia)) ; Franciotta, Diego (IRCCS Foundation C. Mondino National Neurological Institute (Itàlia)) ; Benedetti, Luana ; Lauria, Guiseppe ; Calle Martín, Óscar de la, (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Juarez, Candido (Institut d'Investigació Biomèdica Sant Pau) ; Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Querol, Luis ; Universitat Autònoma de Barcelona
Background: The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. [...]
2017 - 10.1186/s12974-017-0996-1
Journal of neuroinflammation, Vol. 14 Núm. 224 (2017) , p. 1-6  
9.
10 p, 8.8 MB YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies / Querol-Vilaseca, Marta (Institut d'Investigació Biomèdica Sant Pau) ; Colom-Cadena, Martí (Institut d'Investigació Biomèdica Sant Pau) ; Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; San Martín-Paniello, Carla (Institut d'Investigació Biomèdica Sant Pau) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
The innate immune system is known to be involved early in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. The inflammatory response in the central nervous system can be measured postmortem or through a series of inflammatory mediator surrogates. [...]
2017 - 10.1186/s12974-017-0893-7
Journal of neuroinflammation, Vol. 14 (june 2017)  
10.
15 p, 2.7 MB TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide / Burgueño Banús, Juan Francisco (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Barba, Albert (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Eyre Sánchez, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Romero Prada, Carolina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Neunlist, Michel (INSERM, UMR913) ; Fernandez, Ester (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Accumulating evidence suggest that the enteric nervous system (ENS) plays important roles in gastrointestinal inflammatory responses, which could be in part mediated by Toll-like receptor (TLR) activation. [...]
2016 - 10.1186/s12974-016-0653-0
Journal of neuroinflammation, Vol. 13 (August 2016) , art.187  

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