Depósito Digital de Documentos de la UAB Encontrados 52 registros  1 - 10siguientefinal  ir al registro: La búsqueda tardó 0.01 segundos. 
1.
10 p, 1.3 MB Title : insoluble proteins catch heterologous soluble proteins into inclusion bodies by intermolecular interaction of aggregating peptides / Carratalá, Jose Vicente (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cisneros, Andrés (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Hellman, Elijah (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
Protein aggregation is a biological event observed in expression systems in which the recombinant protein is produced under stressful conditions surpassing the homeostasis of the protein quality control system. [...]
2021 - 10.1186/s12934-021-01524-3
Microbial cell factories, Vol. 20 (February 2021)  
2.
12 p, 3.2 MB Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli / Rueda, Fabian (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Seras-Franzoso, Joaquin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Rinas, Ursula (Helmholtz Centre for Infection Research) ; Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ; Mamat, Uwe (Airway Research Center North) ; Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ; García Fruitós, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Universitat Autònoma de Barcelona
Background: production of recombinant drugs in process-friendly endotoxin-free bacterial factories targets to a lessened complexity of the purification process combined with minimized biological hazards during product application. [...]
2016 - 10.1186/s12934-016-0457-z
Microbial cell factories, Vol. 15 (2016) , art. 59  
3.
12 p, 1.7 MB Functional inclusion bodies produced in the yeast Pichia pastoris / Rueda, Fabián (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gasser, Brigitte (Austrian Centre of Industrial Biotechnology (ACIB)) ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Roldán, Mónica (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Puxbaum, Verena (Austrian Centre of Industrial Biotechnology (ACIB)) ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; García Fruitós, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ; Mattanovich, Diethard (Austrian Centre of Industrial Biotechnology (ACIB)) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Universitat Autònoma de Barcelona
Background: Bacterial inclusion bodies (IBs) are non-toxic protein aggregates commonly produced in recombinant bacteria. They are formed by a mixture of highly stable amyloid-like fibrils and releasable protein species with a significant extent of secondary structure, and are often functional. [...]
2016 - 10.1186/s12934-016-0565-9
Microbial cell factories, Vol. 15 (2016) , art. 166  
4.
16 p, 3.8 MB Mammalian prion protein (PrP) forms conformationally different amyloid intracellular aggregates in bacteria / Macedo, Bruno (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sant'Anna, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cordeiro, Yraima (Universidade Federal do Rio de Janeiro. Faculdade de Farmácia) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Background: An increasing number of proteins are being shown to assemble into amyloid structures that lead to pathological states. Among them, mammalian prions outstand due to their ability to transmit the pathogenic conformation, becoming thus infectious. [...]
2015 - 10.1186/s12934-015-0361-y
Microbial cell factories, Vol. 14 (2015) , art. 174  
5.
3 p, 133.1 KB Modeling amyloids in bacteria / Villar Piqué, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. [...]
2012 - 10.1186/1475-2859-11-166
Microbial cell factories, Vol. 11 (2012) , art. 166  
6.
14 p, 3.5 MB The prion-like RNA-processing protein HNRPDL forms inherently toxic amyloid-like inclusion bodies in bacteria / Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marinelli, Patrizia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Díaz-Caballero, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Background: rhe formation of protein inclusions is connected to the onset of many human diseases. Human RNA binding proteins containing intrinsically disordered regions with an amino acid composition resembling those of yeast prion domains, like TDP-43 or FUS, are being found to aggregate in different neurodegenerative disorders. [...]
2015 - 10.1186/s12934-015-0284-7
Microbial cell factories, Vol. 14 (2015) , art. 102  
7.
3 p, 196.8 KB Lactic acid bacteria : a promising alternative for recombinant protein production / García Fruitós, Elena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Editorial about lactic acid bacteria.
2012 - 10.1186/1475-2859-11-157
Microbial cell factories, Vol. 11 (2012) , art. 157  
8.
12 p, 1.8 MB Lactic acid bacteria : reviewing the potential of a promising delivery live vector for biomedical purposes / Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Seras-Franzoso, Joaquin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; García Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Lactic acid bacteria (LAB) have a long history of safe exploitation by humans, being used for centuries in food production and preservation and as probiotic agents to promote human health. Interestingly, some species of these Gram-positive bacteria, which are generally recognized as safe organisms by the US Food and Drug Administration (FDA), are able to survive through the gastrointestinal tract (GIT), being capable to reach and colonize the intestine, where they play an important role. [...]
2015 - 10.1186/s12934-015-0313-6
Microbial cell factories, Vol. 14 (2015) , art. 137  
9.
14 p, 1.7 MB Engineering Pseudomonas putida for isoprenoid production by manipulating endogenous and shunt pathways supplying precursors / Hernandez-Arranz, Sofia (Centre de Recerca en Agrigenòmica) ; Pérez-Gil, Jordi (Centre de Recerca en Agrigenòmica) ; Marshall-Sabey, D. (Centre de Recerca en Agrigenòmica) ; Rodríguez Concepción, Manuel (Centre de Recerca en Agrigenòmica)
Background: The soil bacterium Pseudomonas putida is a promising platform for the production of industrially valuable natural compounds. In the case of isoprenoids, the availability of biosynthetic precursors is a major limiting factor. [...]
2019 - 10.1186/s12934-019-1204-z
Microbial cell factories, Vol. 18 (September 2019) , art. 152  
10.
13 p, 1.4 MB An improved secretion signal enhances the secretion of model proteins from Pichia pastoris / Barrero, Juan J. (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Casler, Jason C. (University of Chicago. Department of Molecular Genetics and Cell Biology) ; Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Glick, Benjamin S. (University of Chicago. Department of Molecular Genetics and Cell Biology)
Background: proteins can be secreted from a host organism with the aid of N-terminal secretion signals. The budding yeast Pichia pastoris (Komagataella sp. ) is widely employed to secrete proteins of academic and industrial interest. [...]
2018 - 10.1186/s12934-018-1009-5
Microbial cell factories, Vol. 17 (2018) , art. 161  

Depósito Digital de Documentos de la UAB : Encontrados 52 registros   1 - 10siguientefinal  ir al registro:
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