|
1.
|
|
23 p, 4.3 MB |
Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
/
Larramona-Arcas, Raquel (Universitat Autónoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
González-Arias, Candela (Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC)) ;
Perea, Gertrudis (Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC)) ;
Gutiérrez, Antonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ;
Vitorica, Javier (Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia) ;
García-Barrera, Tamara (Universidad de Huelva. Departamento de Química, Facultad de Ciencias Experimentales, Campus de El Carmen, Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA)) ;
Gómez-Ariza, José Luis (Universidad de Huelva. Departamento de Química, Facultad de Ciencias Experimentales, Campus de El Carmen, Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA)) ;
Pascua-Maestro, Raquel (Instituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC. Departamento de Bioquímica y Biología Molecular y Fisiología) ;
Ganfornina, María Dolores (Instituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC. Departamento de Bioquímica y Biología Molecular y Fisiología) ;
Kara, Eleanna (Present Address: Institute of Neuropathology, University Hospital of Zurich) ;
Hudry, Eloise (Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129 USA) ;
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vila Bover, Miquel (Universitat Autónoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Galea, Elena (Universitat Autónoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Masgrau, Roser (Universitat Autónoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alzheimer's disease (LOAD). [...]
2020 -  10.1186/s13024-020-00382-8
Molecular neurodegeneration, Vol. 15 (june 2020)
|
|
|
2.
|
|
14 p, 1.2 MB |
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
/
Suárez Calvet, Marc (Ludwig Maximilians Universität München) ;
Morenas Rodríguez, Estrella (Institut d'Investigació Biomèdica Sant Pau) ;
Kleinberger, Gernot (Ludwig Maximilians Universität München) ;
Schlepckow, Kai (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Araque Caballero, Miguel Ángel (Ludwig Maximilians Universität München) ;
Franzmeier, Nicolai (Ludwig Maximilians Universität München) ;
Capell, Anja (Ludwig Maximilians Universität München) ;
Fellerer, Katrin (Ludwig Maximilians Universität München) ;
Nuscher, Brigitte (Ludwig Maximilians Universität München) ;
Eren, Erden (Ludwig Maximilians Universität München) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Deming, Yuetiva (Washington University School of Medicine) ;
Piccio, Laura (Washington University School of Medicine) ;
Karch, Celeste M. (Washington University School of Medicine) ;
Cruchaga, Carlos (Washington University School of Medicine) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Trojanowski, John Q. (University of Pennsylvania) ;
Weiner, Michael (University of California at San Francisco) ;
Ewers, Michael (Ludwig Maximilians Universität München) ;
Haass, Christian (Ludwig Maximilians Universität München) ;
Universitat Autònoma de Barcelona
TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). [...]
2019 - 10.1186/s13024-018-0301-5
Molecular neurodegeneration, Vol. 14 (january 2019)
|
|
|
3.
|
|
12 p, 841.2 KB |
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility
/
Sevlever, Daniel (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Zou, Fanggeng (Human Genetics Division, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio) ;
Ma, Li (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Carrasquillo, Sebastian (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Crump, Michael G (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Culley, Oliver J (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Hunter, Talisha A (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Bisceglio, Gina D (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Younkin, Linda (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Allen, Mariet (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Carrasquillo, Minerva M (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Sando, Sigrid B (Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway) ;
Aasly, Jan O (Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway) ;
Dickson, Dennis W (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ;
Graff-Radford, Neill R (Department of Neurology, Mayo Clinic College of Medicine, Jacksonville) ;
Petersen, Ronald C (Department of Neurology and the Mayo Alzheimer Disease Research Center, Mayo Clinic College of Medicine, Rochester, Minnesota) ;
Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ;
Institut d'Investigació Biomèdica Sant Pau
Ajuts: Programa Miguel Servet de l'Instituto de Salud Carlos III i FEDER (European Funds for Regional Development).
Alzheimer's disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and cell death. [...]
2015 - 10.1186/s13024-015-0015-x
Molecular neurodegeneration, Vol. 10 (april 2015)
|
|
|
4.
|
|
12 p, 1.1 MB |
Pleiotrophin over-expression rescues dopaminergic neurons in parkinsonian rats
/
Taravini, Irene R. E. (Instituto de Investigaciones Farmacológicas (Buenos Aires, Argentina)) ;
Chertoff, Mariela (Fundación Instituto Leloir (Buenos Aires, Argentina)) ;
Cafferata, Eduardo G. (Fundación Instituto Leloir (Buenos Aires, Argentina)) ;
Courty, José (Centre national de la recherche scientifique (França)) ;
Murer, Mario G. (Universidad de Buenos Aires. Departamento de Fisiología y Biofísica) ;
Pitossi, Fernando J. (Fundación Instituto Leloir (Buenos Aires, Argentina)) ;
Gershanik, Oscar S. (Instituto de Investigaciones Farmacológicas (Buenos Aires, Argentina))
Background: Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients. To establish whether pleiotrophin has a trophic effect on nigrostriatal dopaminergic neurons in vivo, we injected a recombinant adenovirus expressing pleiotrophin in the substantia nigra of 6-hydroxydopamine lesioned rats. [...]
2011 - 10.1186/1750-1326-6-40
Molecular neurodegeneration, Vol. 6, N. 40 (June 2011) , p. 1-12
|
|
guest ::
email alert
or subscribe to the 
RSS feed.
