UAB Digital Repository of Documents 4 records found  Search took 0.01 seconds. 
1.
23 p, 4.3 MB Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice / Larramona-Arcas, Raquel (Universitat Autónoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; González-Arias, Candela (Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC)) ; Perea, Gertrudis (Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC)) ; Gutiérrez, Antonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Vitorica, Javier (Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia) ; García-Barrera, Tamara (Universidad de Huelva. Departamento de Química, Facultad de Ciencias Experimentales, Campus de El Carmen, Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA)) ; Gómez-Ariza, José Luis (Universidad de Huelva. Departamento de Química, Facultad de Ciencias Experimentales, Campus de El Carmen, Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA)) ; Pascua-Maestro, Raquel (Instituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC. Departamento de Bioquímica y Biología Molecular y Fisiología) ; Ganfornina, María Dolores (Instituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC. Departamento de Bioquímica y Biología Molecular y Fisiología) ; Kara, Eleanna (Present Address: Institute of Neuropathology, University Hospital of Zurich) ; Hudry, Eloise (Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129 USA) ; Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vila Bover, Miquel (Universitat Autónoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Galea, Elena (Universitat Autónoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Masgrau, Roser (Universitat Autónoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alzheimer's disease (LOAD). [...]
2020 - 10.1186/s13024-020-00382-8
Molecular neurodegeneration, Vol. 15 (june 2020)  
2.
14 p, 1.2 MB Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology / Suárez Calvet, Marc (Ludwig Maximilians Universität München) ; Morenas Rodríguez, Estrella (Institut d'Investigació Biomèdica Sant Pau) ; Kleinberger, Gernot (Ludwig Maximilians Universität München) ; Schlepckow, Kai (German Center for Neurodegenerative Diseases (DZNE) Munich) ; Araque Caballero, Miguel Ángel (Ludwig Maximilians Universität München) ; Franzmeier, Nicolai (Ludwig Maximilians Universität München) ; Capell, Anja (Ludwig Maximilians Universität München) ; Fellerer, Katrin (Ludwig Maximilians Universität München) ; Nuscher, Brigitte (Ludwig Maximilians Universität München) ; Eren, Erden (Ludwig Maximilians Universität München) ; Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) Munich) ; Deming, Yuetiva (Washington University School of Medicine) ; Piccio, Laura (Washington University School of Medicine) ; Karch, Celeste M. (Washington University School of Medicine) ; Cruchaga, Carlos (Washington University School of Medicine) ; Shaw, Leslie M. (University of Pennsylvania) ; Trojanowski, John Q. (University of Pennsylvania) ; Weiner, Michael (University of California at San Francisco) ; Ewers, Michael (Ludwig Maximilians Universität München) ; Haass, Christian (Ludwig Maximilians Universität München) ; Universitat Autònoma de Barcelona
TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). [...]
2019 - 10.1186/s13024-018-0301-5
Molecular neurodegeneration, Vol. 14 (january 2019)  
3.
12 p, 841.2 KB Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility / Sevlever, Daniel (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Zou, Fanggeng (Human Genetics Division, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio) ; Ma, Li (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Carrasquillo, Sebastian (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Crump, Michael G (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Culley, Oliver J (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Hunter, Talisha A (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Bisceglio, Gina D (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Younkin, Linda (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Allen, Mariet (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Carrasquillo, Minerva M (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Sando, Sigrid B (Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway) ; Aasly, Jan O (Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway) ; Dickson, Dennis W (Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville) ; Graff-Radford, Neill R (Department of Neurology, Mayo Clinic College of Medicine, Jacksonville) ; Petersen, Ronald C (Department of Neurology and the Mayo Alzheimer Disease Research Center, Mayo Clinic College of Medicine, Rochester, Minnesota) ; Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ; Institut d'Investigació Biomèdica Sant Pau
Ajuts: Programa Miguel Servet de l'Instituto de Salud Carlos III i FEDER (European Funds for Regional Development).
Alzheimer's disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and cell death. [...]

2015 - 10.1186/s13024-015-0015-x
Molecular neurodegeneration, Vol. 10 (april 2015)  
4.
12 p, 1.1 MB Pleiotrophin over-expression rescues dopaminergic neurons in parkinsonian rats / Taravini, Irene R. E. (Instituto de Investigaciones Farmacológicas (Buenos Aires, Argentina)) ; Chertoff, Mariela (Fundación Instituto Leloir (Buenos Aires, Argentina)) ; Cafferata, Eduardo G. (Fundación Instituto Leloir (Buenos Aires, Argentina)) ; Courty, José (Centre national de la recherche scientifique (França)) ; Murer, Mario G. (Universidad de Buenos Aires. Departamento de Fisiología y Biofísica) ; Pitossi, Fernando J. (Fundación Instituto Leloir (Buenos Aires, Argentina)) ; Gershanik, Oscar S. (Instituto de Investigaciones Farmacológicas (Buenos Aires, Argentina))
Background: Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients. To establish whether pleiotrophin has a trophic effect on nigrostriatal dopaminergic neurons in vivo, we injected a recombinant adenovirus expressing pleiotrophin in the substantia nigra of 6-hydroxydopamine lesioned rats. [...]
2011 - 10.1186/1750-1326-6-40
Molecular neurodegeneration, Vol. 6, N. 40 (June 2011) , p. 1-12  

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