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9 p, 1.3 MB Mechanisms of action of sacubitril/valsartan on cardiac remodeling : a systems biology approach / Iborra-Egea, Oriol (Institut Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol) ; Perea-Gil, Isaac (Institut Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol) ; Bayes-Genis, Antoni (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Sacubitril/Valsartan, proved superiority over other conventional heart failure management treatments, but its mechanisms of action remains obscure. In this study, we sought to explore the mechanistic details for Sacubitril/Valsartan in heart failure and post-myocardial infarction remodeling, using an in silico, systems biology approach. [...]
2017 - 10.1038/s41540-017-0013-4
NPJ Systems Biology and Applications, Vol. 3 (april 2017)  

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