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13 p, 7.0 MB Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning / Mueller, Yvonne M. (Erasmus University Medical Center) ; Schrama, Thijs J. (Erasmus University Medical Center) ; Ruijten, Rik (Erasmus University Medical Center) ; Schreurs, Marco W. J. (Erasmus University Medical Center) ; Grashof, Dwin G. B. (Erasmus University Medical Center) ; van de Werken, Harmen J. G. (Erasmus University Medical Center) ; Lasinio, Giovanna Jona (University of Rome "La Sapienza") ; Álvarez-Sierra, Daniel (Hospital Universitari Vall d'Hebron) ; Kiernan, Caoimhe H. (Erasmus University Medical Center) ; Castro Eiro, Melisa D. (Erasmus University Medical Center) ; van Meurs, Marjan (Erasmus University Medical Center) ; Brouwers-Haspels, Inge (Erasmus University Medical Center) ; Zhao, Manzhi (Erasmus University Medical Center) ; Li, Ling (Erasmus University Medical Center) ; de Wit, Harm (Erasmus University Medical Center) ; Ouzounis, Christos A. (Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thermi) ; Wilmsen, Merel E. P. (Erasmus University Medical Center) ; Alofs, Tessa M. (Erasmus University Medical Center) ; Laport, Danique A. (Erasmus University Medical Center) ; van Wees, Tamara (Erasmus University Medical Center) ; Kraker, Geoffrey (Cytek Biosciences, Fremont, CA USA) ; Jaimes, Maria C. (Cytek Biosciences, Fremont, CA USA) ; Van Bockstael, Sebastiaan (Cytek Biosciences, Fremont, CA USA) ; Hernández-González, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rokx, Casper (Erasmus University Medical Center) ; Rijnders, Bart J. A. (Erasmus University Medical Center) ; Pujol-Borrell, Ricardo (Vall d'Hebron Institut d'Oncologia) ; Katsikis, Peter D. (Erasmus University Medical Center) ; Universitat Autònoma de Barcelona
Quantitative or qualitative differences in immunity may drive clinical severity in COVID-19. Although longitudinal studies to record the course of immunological changes are ample, they do not necessarily predict clinical progression at the time of hospital admission. [...]
2022 - 10.1038/s41467-022-28621-0
Nature communications, Vol. 13 (february 2022)  
2.
8 p, 15.2 MB Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome / Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Karikari, Thomas K. (University of Gothenburg.) ; Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ; Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation) ; Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ; Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Lantero-Rodríguez, Juan (University of Gothenburg) ; Videla Toro, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ; Benejam, Bessy (Institut d'Investigació Biomèdica Sant Pau) ; Fernandez, Susana (Fundació Catalana de Síndrome de Down) ; Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ; Garzón, Diana (Institut d'Investigació Biomèdica Sant Pau) ; Bejanin, Alexandre (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ; Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ; Medrano-Martorell, Santiago (Hospital del Mar (Barcelona, Catalunya)) ; Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ; Clarimón, Jordi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Lehmann, Sylvain (Université de Montpellier) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Blennow, Kaj (Sahlgrenska University Hospital) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Universitat Autònoma de Barcelona
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). [...]
2021 - 10.1038/s41467-021-24319-x
Nature communications, Vol. 12 (july 2021)  
3.
16 p, 4.3 MB Common variants in Alzheimer's disease and risk stratification by polygenic risk scores / de Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tesi, Niccolo (Delft Univeristy of Technology) ; Grenier-Boley, Benjamin (Institut Pasteur de Lille) ; Andrade, Victor (University Clinic Bonn) ; Jansen, Iris E. (Vrije Universiteit Amsterdam) ; Pedersen, Nancy L. (Karolinska Institutet.) ; Stringa, Najada (Amsterdam UMC-Vrije Universiteit Amsterdam) ; Zettergren, Anna (University of Gothenburg) ; Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Montrreal, Laura (Universitat Internacional de Catalunya) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Antonell, Anna (Universitat de Barcelona) ; Tankard, Rick M. (Murdoch University) ; Bis, Joshua C. (University of Washington) ; Sims, Rebecca (Cardiff University) ; Bellenguez, Céline (Institut Pasteur de Lille) ; Quintela, Inés (Universidade de Santiago de Compostela) ; González-Perez, Antonio (Centro Andaluz de Estudios Bioinformáticos, Sevilla) ; Calero, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Franco-Macías, Emilio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Cervera-Carles, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Menéndez-González, Manuel (Universidad de Oviedo) ; Frank-García, Ana (Universidad Autónoma de Madrid) ; Royo, Jose Luís (Universidad de Málaga) ; Moreno, Fermin (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Huerto Vilas, Raquel (Institut de Recerca Biomedica de Lleida) ; Baquero, Miquel (Hospital Universitari i Politècnic La Fe de València) ; Diez-Fairen, Monica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Lage, Carmen (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; García-Madrona, Sebastián (Hospital Universitario Ramón y Cajal (Madrid)) ; García-González, Pablo (Universitat Internacional de Catalunya) ; Alarcón-Martín, Emilio (Universidad de Málaga) ; Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sotolongo-Grau, Oscar (Universitat Internacional de Catalunya) ; Ullgren, Abbe (Karolinska University Hospital-Solna) ; Naj, Adam C. (University of Pennsylvania) ; Lemstra, Afina W. (Vrije Universiteit Amsterdam) ; Benaque, Alba (Universitat Internacional de Catalunya) ; Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ; Benussi, Alberto (University of Brescia) ; Rábano, Alberto (BT-CIEN, Madrid, Spain) ; Padovani, Alessandro (University of Brescia) ; Squassina, Alessio (University of Cagliari) ; de Mendonça, Alexandre (University of Lisbon) ; Arias Pastor, Alfonso (Institut de Recerca Biomedica de Lleida) ; Kok, Almar A. L. (Vrije Universiteit Amsterdam) ; Meggy, Alun (Cardiff University) ; Pastor, Ana Belén (BT-CIEN, Madrid, Spain) ; Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Corma-Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Martín Montes, Angel (Hospital Universitario La Paz (Madrid)) ; Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; DeStefano, Anita L. (Boston University) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE)) ; Haapasalo, Annakaisa (University of Eastern Finland) ; Kinhult Ståhlbom, Anne (Karolinska University Hospital-Solna) ; Tybjærg-Hansen, Anne (University of Copenhagen) ; Hartmann, Annette M. (Martin-Luther-University Halle-Wittenberg) ; Spottke, Annika (University of Bonn) ; Corbatón-Anchuelo, Arturo (CIBERDEM) ; Rongve, Arvid (University of Bergen) ; Borroni, Barbara (University of Brescia) ; Arosio, Beatrice (IRCCS Ospedale Maggiore Policlinico) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Nordestgaard, Børge G. (Herlev Gentofte Hospital) ; Kunkle, Brian W. (University of Miami) ; Charbonnier, Camille (Normandie Univ, UNIROUEN) ; Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Masullo, Carlo (Catholic University of the Sacred Heart) ; Martínez Rodríguez, Carmen (Hospital de Cabueñes) ; Muñoz-Fernandez, Carmen (Hospital Universitario de Gran Canaria Dr. Negrín) ; Dufouil, Carole (CHU de Bordeaux) ; Graff, Caroline (Karolinska University Hospital-Solna) ; Ferreira, Catarina B. (Universidade de Lisboa) ; Chillotti, Caterina (University Hospital of Cagliari) ; Reynolds, Chandra A. (University of California-Riverside) ; Fenoglio, Chiara (Dino Ferrari Center. University of Milan) ; Van Broeckhoven, Christine (University of Antwerp) ; Clark, Christopher (University of Zürich) ; Pisanu, Claudia (University of Cagliari) ; Satizabal, Claudia L. (UT Health San Antonio) ; Holmes, Clive (University of Southampton) ; Buiza-Rueda, Dolores (Universidad de Sevilla) ; Aarsland, Dag (Stavanger University Hospital) ; Rujescu, Dan (Martin-Luther-University Halle-Wittenberg) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Galimberti, Daniela (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Wallon, David (Normandie Univ, UNIROUEN) ; Seripa, Davide (Fondazione IRCCS Casa Sollievo della Sofferenza) ; Grünblatt, Edna (University of Zurich) ; Dardiotis, Efthimios (University of Thessaly. School of Medicine) ; Düzel, Emrah (Otto-von-Guericke University) ; Scarpini, Elio (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Conti, Elisa (University of Milano-Bicocca) ; Rubino, Elisa (AOU Città della Salute e della Scienza di Torino) ; Gelpi, Ellen (Medical University of Vienna) ; Rodriguez-Rodriguez, Eloy (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Duron, Emmanuelle (APHP, Hôpital Broca) ; Boerwinkle, Eric (Baylor College of Medicine) ; Ferri, Evelyn (IRCCS Ospedale Maggiore Policlinico) ; Tagliavini, Fabrizio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Küçükali, Fahri (University of Antwerp) ; Pasquier, Florence (CHU CNR-MAJ, Lille) ; Sanchez-Garcia, Florentino (Hospital Universitario de Gran Canaria Dr. Negrín) ; Mangialasche, Francesca (Karolinska Institutet) ; Jessen, Frank (University of Cologne) ; Nicolas, Gaël (Hospital de Cabueñes) ; Selbæk, Geir (University of Oslo) ; Ortega, Gemma (National Institute of Health Carlos III) ; Chêne, Geneviève (CHU de Bordeaux, Pole de Santé Publique) ; Hadjigeorgiou, Georgios (University of Cyprus) ; Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Spalletta, Gianfranco (Baylor College of Medicine) ; Giaccone, Giorgio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Grande, Giulia (Karolinska Institutet and Stockholm University) ; Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Papenberg, Goran (Karolinska Institutet and Stockholm University) ; Hampel, Harald (Pitié-Salpêtrière Hospital) ; Bailly, Henri (Université Paris Descartes) ; Zetterberg, Henrik (UK Dementia Research Institute at UCL) ; Soininen, Hilkka (Kuopio University Hospital) ; Karlsson, Ida K. (Jönköping University) ; Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Appollonio, Ildebrando (San Gerardo hospital) ; Giegling, Ina (Martin-Luther-University Halle-Wittenberg) ; Skoog, Ingmar (University of Gothenburg) ; Saltvedt, Ingvild (Norwegian University of Science and Technhology) ; Rainero, Innocenzo (University of Torino) ; Rosas Allende, Irene (Hospital Universitario Central de Asturias) ; Hort, Jakub (St. Anne's University Hospital Brno) ; Diehl-Schmid, Janine (Technical University of Munich) ; Van Dongen, Jasper (Institute Born-Bunge) ; Vidal, Jean-Sebastien (Université Paris Descartes) ; Lehtisalo, Jenni (Finnish Institute for Health and Welfare) ; Wiltfang, Jens (University of Aveiro) ; Thomassen, Jesper Qvist (Rigshospitalet. Department of Clinical Biochemistry) ; Kornhuber, Johannes (Friedrich-Alexander Universität Erlangen-Nürnberg) ; Haines, Jonathan L. (Case Western Reserve University) ; Vogelgsang, Jonathan (Harvard Medical School) ; Pineda, Juan A. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Lausanne University Hospital) ; Deckert, Jürgen (University Hospital, Wuerzburg) ; Buerger, Katharina (German Center for Neurodegenerative Diseases) ; Morgan, Kevin (University of Nottingham) ; Fließbach, Klaus (University Clinic Bonn) ; Sleegers, Kristel (University of Antwerp) ; Molina-Porcel, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Kilander, Lena (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Weinhold, Leonie (University Hospital of Bonn) ; Farrer, Lindsay A. (Boston University) ; Wang, Li-San (University of Pennsylvania) ; Kleineidam, Luca (University Clinic Bonn) ; Farotti, Lucia (University of Perugia) ; Parnetti, Lucilla (University of Perugia) ; Tremolizzo, Lucio (Neurology Unit, 'San Gerardo' hospital) ; Hausner, Lucrezia (University of Heidelberg) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Froelich, Lutz (University of Heidelberg) ; Ikram, M. Arfan (Erasmus Medical Center) ; Deniz-Naranjo, M. Candida (Hospital Universitario de Gran Canaria Dr. Negrín) ; Tsolaki, Magda (University of Thessaloniki) ; Rosende-Roca, Maitée (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Löwenmark, Malin (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Hulsman, Marc (Vrije Universiteit Amsterdam) ; Spallazzi, Marco (Azienda Ospedaliero-Universitaria) ; Pericak-Vance, Margaret A. (University of Miami) ; Esiri, Margaret (Nuffield Department of Clinical Neurosciences) ; Bernal Sánchez-Arjona, María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Dalmasso, Maria Carolina (University of Cologne) ; Martínez-Larrad, María Teresa (CIBERDEM) ; Arcaro, Marina (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Nöthen, Markus M. (University of Bonn) ; Fernández-Fuertes, Marta (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Dichgans, Martin (Munich Cluster for Systems Neurology) ; Ingelsson, Martin (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Herrmann, Martin J. (University Hospital, Wuerzburg) ; Scherer, Martin (University Medical Centre Hamburg-Eppendorf) ; Vyhnalek, Martin (St. Anne's University Hospital Brno) ; Kosmidis, Mary H. (Aristotle University of Thessaloniki) ; Yannakoulia, Mary (Harokopio University) ; Schmid, Matthias (University Hospital of Bonn) ; Ewers, Michael (German Center for Neurodegenerative Diseases) ; Heneka, Michael T. (German Center for Neurodegenerative Diseases) ; Wagner, Michael (German Center for Neurodegenerative Diseases) ; Scamosci, Michela (University of Perugia) ; Kivipelto, Miia (Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden) ; Hiltunen, Mikko (University of Eastern Finland. Institute of Biomedicine) ; Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Fornage, Myriam (University of Texas) ; Roberto, Natalia (Universitat Internacional de Catalunya) ; van Schoor, Natasja M. (Vrije Universiteit Amsterdam) ; Seidu, Nazib M. (University of Gothenburg) ; Banaj, Nerisa (IRCCS Santa Lucia Foundation) ; Armstrong, Nicola J. (Murdoch University) ; Scarmeas, Nikolaos (Columbia University) ; Scherbaum, Norbert (University of Duisburg-Essen) ; Goldhardt, Oliver (Technical University of Munich) ; Hanon, Oliver (Université Paris Descartes) ; Peters, Oliver (German Center for Neurodegenerative Diseases) ; Skrobot, Olivia Anna (University of Bristol) ; Quenez, Olivier (FHU G4 Génomique. Normandie Univ) ; Lerch, Ondrej (St. Anne's University Hospital Brno) ; Bossù, Paola (IRCCS Santa Lucia Foundation) ; Caffarra, Paolo (University of Parma) ; Dionigi Rossi, Paolo (IRCCS Ospedale Maggiore Policlinico) ; Sakka, Paraskevi (Athens Association of Alzheimer's disease and Related Disorders) ; Hoffmann, Per (University Hospital Basel (Basilea, Suïssa)) ; Holmans, Peter A. (Cardiff University) ; Fischer, Peter (Social Medicine Center East- Donauspital) ; Riederer, Peter (University Hospital of Würzburg) ; Yang, Qiong (Boston University) ; Marshall, Rachel (Cardiff University) ; Kalaria, Rajesh N. (Campus for Ageing anf Vitality, Newcastle upon Tyne) ; Mayeux, Richard (Columbia University) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Cecchetti, Roberta (University of Perugia) ; Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; Hägg, Sara (Karolinska Institutet) ; Engelborghs, Sebastiaan (VUB University Hospital Brussels) ; Helisalmi, Seppo (University of Eastern Finland) ; Botne Sando, Sigrid (Norwegian University of Science and Technology) ; Kern, Silke (University of Gothenburg) ; Archetti, Silvana (Brescia Hospital) ; Boschi, Silvia (University of Torino) ; Fostinelli, Silvia (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Gil, Silvia (Universitat Internacional de Catalunya) ; Mendoza, Silvia (Instituto Andaluz de Neurociencia) ; Mead, Simon (Institute of Prion Diseases. MRC Prion Unit at UCL) ; Ciccone, Simona (IRCCS Ospedale Maggiore Policlinico) ; Djurovic, Srdjan (University of Bergen) ; Heilmann-Heimbach, Stefanie (University of Bonn) ; Riedel-Heller, Steffi (University of Leipzig) ; Kuulasmaa, Teemu (University of Eastern Finland) ; del Ser, Teodoro (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Lebouvier, Thibaud (CHU CNR-MAJ, Lille, France) ; Polak, Thomas (University Hospital, Wuerzburg) ; Ngandu, Tiia (Finnish Institute for Health and Welfare. Population Health Unit) ; Grimmer, Timo (Technical University of Munich) ; Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi Largo Brambilla) ; Escott-Price, Valentina (Cardiff University) ; Giedraitis, Vilmantas (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Deramecourt, Vincent (CHU CNR-MAJ, Lille, France) ; Maier, Wolfgang (German Center for Neurodegenerative Diseases) ; Jian, Xueqiu (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Pijnenburg, Yolande A. L. (Vrije Universiteit Amsterdam) ; Kehoe, Patrick Gavin (German Center for Neurodegenerative Diseases) ; García-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Sánchez-Juan, Pascual (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Pérez-Tur, Jordi (Instituto de Investigación Sanitaria La Fe) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomedica de Lleida) ; Lopez de Munain, Adolfo (Universidad del País Vasco) ; García-Alberca, Jose María (Instituto Andaluz de Neurociencia) ; Bullido, María J. (Hospital Universitario La Paz (Madrid)) ; Álvarez, Victoria (Hospital Universitario Central de Asturias) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Real, Luis M. (Universidad de Málaga) ; Mir, Pablo (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Medina, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Holstege, Henne (Vrije Universiteit Amsterdam) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sáez, María Eugenia (Centro Andaluz de Estudios Bioinformáticos, Sevilla) ; Carracedo, Ángel (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Schellenberg, Gerard D. (University of Pennsylvania) ; Williams, Julie (Cardiff University) ; Seshadri, Sudha (Framingham Heart Study) ; van Duijn, Cornelia M. (University of Oxford) ; Mather, Karen A. (Neuroscience Research Australia) ; Sánchez-Valle, Raquel (Universitat de Barcelona) ; Serrano-Ríos, Manuel (CIBERDEM) ; Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Blennow, Kaj (University of Gothenburg) ; Huisman, Martijn (Vrije Universiteit Amsterdam) ; Andreassen, Ole A. (Oslo University Hospital (Oslo, Noruega)) ; Posthuma, Danielle (Vrije Universiteit Amsterdam) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; van der Flier, Wiesje M. (Vrije Universiteit Amsterdam) ; Ramirez, Alfredo (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Lambert, Jean-Charles (Institut Pasteur de Lille) ; van der Lee, Sven J. (Vrije Universiteit Amsterdam) ; Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. [...]
2021 - 10.1038/s41467-021-22491-8
Nature communications, Vol. 12 (june 2021)  
4.
11 p, 2.8 MB A high-entropy manganite in an ordered nanocomposite for long-term application in solid oxide cells / Baiutti, Federico (Institut de Recerca en Energia de Catalunya) ; Chiabrera, Francesco Maria (Institut de Recerca en Energia de Catalunya) ; Acosta, Matias (University of Cambridge. Department of Materials Science and Metallurgy) ; Diercks, David (Colorado School of Mines. Department of Metallurgical and Materials Engineering) ; Parfitt, D. (Coventry University. Faculty of Engineering, Environment and Computing) ; Santiso, José (Institut Català de Nanociència i Nanotecnologia) ; Wang, X. (Purdue University. School of Materials Engineering) ; Cavallaro, Andrea (Imperial College London. Department of Materials) ; Morata, A. (Institut de Recerca en Energia de Catalunya) ; Wang, Haiyan (Purdue University. School of Materials Engineering) ; Chroneos, A. (Coventry University. Faculty of Engineering, Environment and Computing) ; Driscoll, Judith (University of Cambridge. Department of Materials Science and Metallurgy) ; Tarancón Rubio, Albert (Institució Catalana de Recerca i Estudis Avançats)
The implementation of nano-engineered composite oxides opens up the way towards the development of a novel class of functional materials with enhanced electrochemical properties. Here we report on the realization of vertically aligned nanocomposites of lanthanum strontium manganite and doped ceria with straight applicability as functional layers in high-temperature energy conversion devices. [...]
2021 - 10.1038/s41467-021-22916-4
Nature communications, Vol. 12 (May 2021) , art. 2660  
5.
1 p, 361.3 KB Author correction : Graphene active sensor arrays for long-term and wireless mapping of wide frequency band epicortical brain activity / Garcia Cortadella, Ramon (Institut Català de Nanociència i Nanotecnologia) ; Schwesig, G. (Ludwig-Maximilians-Universität München. Bernstein Center for Computational Neuroscience Munich) ; Jeschke, C. (Multi Channel Systems GmbH) ; Illa, Xavi (Institut de Microelectrònica de Barcelona) ; Gray, Anna L. (University of Manchester. National Graphene Institute. Nanomedicine Lab) ; Savage, S. (University of Manchester. National Graphene Institute. Nanomedicine Lab) ; Stamatidou, E. (University of Manchester. National Graphene Institute. Nanomedicine Lab) ; Schiessl, I. (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Masvidal-Codina, E. (Institut de Microelectrònica de Barcelona) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Guimerà-Brunet, A. (Institut de Microelectrònica de Barcelona) ; Sirota, Anton (Ludwig-Maximilians-Universität München. Bernstein Center for Computational Neuroscience Munich) ; Garrido, Jose (Institut Català de Nanociència i Nanotecnologia)
The original version of this article included an incorrectly named funding source "Graphene Flagship", and omitted the names of GrapheneCore 2 and GrapheneCore3 as funding sources, from the Acknowledgements. [...]
2021 - 10.1038/s41467-021-23078-z
Nature communications, Vol. 12 (April 2021) , art. 2568  
6.
13 p, 2.3 MB Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation / Arenas, Enrique J. (Centro de Investigación Biomédica en Red de Cáncer) ; Martínez-Sabadell, Alex (Vall d'Hebron Institut d'Oncologia) ; Rius Ruiz, Irene (Centro de Investigación Biomédica en Red de Cáncer) ; Román Alonso, Macarena (Vall d'Hebron Institut d'Oncologia) ; Escorihuela, Marta (Vall d'Hebron Institut d'Oncologia) ; Luque, Antonio (Vall d'Hebron Institut d'Oncologia) ; Fajardo, Carlos Alberto (Vall d'Hebron Institut d'Oncologia) ; Gros, Alena (Vall d'Hebron Institut d'Oncologia) ; Klein, Christian (Roche Innovation Center Zurich) ; Arribas, Joaquín V (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
Immunotherapy has raised high expectations in the treatment of virtually every cancer. Many current efforts are focused on ensuring the efficient delivery of active cytotoxic cells to tumors. It is assumed that, once these active cytotoxic cells are correctly engaged to cancer cells, they will unfailingly eliminate the latter, provided that inhibitory factors are in check. [...]
2021 - 10.1038/s41467-021-21445-4
Nature communications, Vol. 12 (february 2021)  
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6 p, 916.0 KB Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma / De Mattos-Arruda, Leticia (Universitat Autònoma de Barcelona) ; Mayor, Regina (Vall d'Hebron Institut d'Oncologia) ; Ng, Charlotte K. Y. (Memorial Sloan Kettering Cancer Center) ; Weigelt, Britta (Memorial Sloan Kettering Cancer Center) ; Martínez-Ricarte, Francisco (Universitat Autònoma de Barcelona) ; Torrejon, Davis (Vall d'Hebron Institut d'Oncologia) ; Oliveira, Mafalda (Vall d'Hebron Institut d'Oncologia) ; Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ; Raventós, Carolina (Vall d'Hebron Institut d'Oncologia) ; Tang, Jiabin (Memorial Sloan Kettering Cancer Center) ; Guerini-Rocco, Elena (Memorial Sloan Kettering Cancer Center) ; Martínez-Sáez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lois, Sergio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Marín, Oscar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de la Cruz, Xavier (Institució Catalana de Recerca i Estudis Avançats) ; Piscuoglio, Salvatore (Memorial Sloan Kettering Cancer Center) ; Towers, Russel (Department of Surgery, Memorial Sloan Kettering Cancer Center) ; Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ; Peg, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cajal, Santiago Ramon y (Universitat Autònoma de Barcelona) ; Carles, Joan (Vall d'Hebron Institut d'Oncologia) ; Rodon, Jordi (Vall d'Hebron Institut d'Oncologia) ; González-Cao, María (Quirón Dexeus University Hospital) ; Tabernero, Josep (Universitat Autònoma de Barcelona) ; Felip, Enriqueta (Universitat Autònoma de Barcelona) ; Sahuquillo, Joan (Universitat Autònoma de Barcelona) ; Berger, Michael F. (Memorial Sloan Kettering Cancer Center) ; Cortés, Javier (Universitat Autònoma de Barcelona) ; Reis-Filho, Jorge S. (Memorial Sloan Kettering Cancer Center) ; Seoane, Joan (Universitat Autònoma de Barcelona)
Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the genomic alterations present in tumours and has been used to monitor tumour progression and response to treatments. [...]
2015 - 10.1038/ncomms9839
Nature communications, Vol. 6 (november 2015)  
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22 p, 1.6 MB Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus / Lawrenson, Kate (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Kar, Siddhartha (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; McCue, Karen (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Kuchenbaeker, Karoline (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Michailidou, Kyriaki (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Tyrer, Jonathan (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Beesley, Jonathan (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Li, Qiyuan (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute) ; Delgado, Melissa K. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Lee, Janet M. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Aittomäki, Kristiina (Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki) ; Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto) ; Anton-Culver, Hoda (Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine) ; Arndt, Volker (Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)) ; Arun, Banu K. (University of Texas MD Anderson Cancer Center) ; Arver, Brita (Department of Oncology, Karolinska University Hospital) ; Bandera, Elisa V. (Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey) ; Barile, Monica (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia) ; Barkardottir, Rosa B. (Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland) ; Barrowdale, Daniel (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Beckmann, Matthias W. (University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN) ; Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Berchuck, Andrew (Department of Obstetrics and Gynecology, Duke University Medical Center) ; Bisogna, Maria (Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center) ; Bjorge, Line (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen) ; Blomqvist, Carl (Department of Oncology, Helsinki University Hospital, University of Helsinki) ; Blot, William (International Epidemiology Institute) ; Bogdanova, Natalia (Gynaecology Research Unit, Hannover Medical School) ; Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital) ; Bojesen, Stig E. (Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital) ; Bolla, Manjeet K. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia) ; Børresen-Dale, Anne-Lise (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo) ; Brauch, Hiltrud (German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)) ; Brennan, Paul (International Agency for Research on Cancer) ; Brenner, Hermann (Division of Preventive Oncology, German Cancer Research Center (DKFZ)) ; Bruinsma, Fiona (Cancer Epidemiology Centre, Cancer Council Victoria) ; Brunet, Joan (Institut d'Investigació Biomèdica (Girona)) ; Buhari, Shaik Ahmad (Department of Surgery, National University Health System) ; Burwinkel, Barbara (Department of Obstetrics and Gynecology, University of Heidelberg) ; Butzow, Ralf (Department of Pathology, Helsinki University Central Hospital) ; Buys, Saundra S. (Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine) ; Cai, Qiuyin (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Campbell, Ian (Cancer Genetics Laboratory, Peter MacCallum Cancer Centre) ; Canniotto, Rikki (Cancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute) ; Chang-Claude, Jenny (University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf) ; Chiquette, Jocelyne (Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec) ; Choi, Ji-Yeob (Department of Biomedical Sciences, Seoul National University College of Medicine) ; Claes, Kathleen B. M. (Center for Medical Genetics, Ghent University) ; Cook, Linda S. (Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico) ; Cox, Angela (Sheffield Cancer Research, Department of Oncology, University of Sheffield) ; Cramer, Daniel W. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Cross, Simon S. (Academic Unit of Pathology, Department of Neuroscience, University of Sheffield) ; Cybulski, Cezary (Department of Genetics and Pathology, Pomeranian Medical University) ; Czene, Kamila (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Daly, Mary B. (Department of Clinical Genetics, Fox Chase Cancer Center) ; Damiola, Francesca (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ; Dansonka-Mieszkowska, Agnieszka (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology) ; Darabi, Hatef (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Dennis, Joe (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Devilee, Peter (Department of Human Genetics, Leiden University Medical Center) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Doherty, Jennifer A. (Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth) ; Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ; Dorfling, Cecilia M. (Department of Genetics, University of Pretoria) ; Dörk, Thilo (Gynaecology Research Unit, Hannover Medical School) ; Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Ehrencrona, Hans (Department of Clinical Genetics, Lund University Hospital) ; Ejlertsen, Bent (Department of Oncology, Rigshospitalet, Copenhagen University Hospital) ; Ellis, Steve (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig) ; Lee, Eunjung (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Evans, D. Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust) ; Fasching, Peter A. (University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology) ; Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ; Figueroa, Jonine (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Flesch-Janys, Dieter (Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf) ; Fletcher, Olivia (Division of Breast Cancer Research, The Institute of Cancer Research) ; Flyger, Henrik (Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital) ; Foretova, Lenka (Masaryk Memorial Cancer Institute and Medical Faculty MU) ; Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ; Foulkes, William D. (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal) ; Fridley, Brooke L. (Biostatistics and Informatics Shared Resource, University of Kansas Medical Center) ; Friedman, Eitan (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ; Frost, Debra (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Gambino, Gaetana (Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa) ; Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center) ; Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute) ; García-Closas, Montserrat (Division of Genetics and Epidemiology, The Institute of Cancer Research) ; Gentry-Maharaj, Aleksandra (Women's Cancer, UCL EGA Institute for Women's Health) ; Ghoussaini, Maya (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Giles, Graham G. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Glasspool, Rosalind (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre) ; Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center) ; Goldberg, Mark S. (Department of Medicine, McGill University) ; Goldgar, David E. (Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine) ; González-Neira, Anna (Human Cancer Genetics Program, Spanish National Cancer Research Centre) ; Goode, Ellen L. (Department of Health Sciences Research, Mayo Clinic) ; Goodman, Marc T. (Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center) ; Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ; Gronwald, Jacek (Department of Genetics and Pathology, Pomeranian Medical University) ; Guénel, Pascal (University Paris-Sud) ; Haiman, Christopher A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Hall, Per (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Hallberg, Emily (Department of Health Sciences Research, Mayo Clinic) ; Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ; Hansen, Thomas V. O. (Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital) ; Harrington, Patricia A. (Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory) ; Hartman, Mikael (Saw Swee Hock School of Public Health, National University of Singapore) ; Hassan, Norhashimah (Cancer Research Initiatives Foundation, Subang Jaya) ; Healey, Sue (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Heitz, Florian (Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden) ; Herzog, Josef (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ; Høgdall, Estrid (Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center) ; Høgdall, Claus K. (Department of Gynecology, Rigshospitalet, University of Copenhagen) ; Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute) ; Hollestelle, Antoinette (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; Hopper, John L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System) ; Huzarski, Tomasz (Department of Genetics and Pathology, Pomeranian Medical University) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University) ; Ito, Hidemi (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University) ; Janavicius, Ramunas (State Research Institute Centre for Innovative Medicine) ; Jensen, Allan (Department of Gynecology, Rigshospitalet, University of Copenhagen) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California) ; Johnson, Nichola (Division of Breast Cancer Research, The Institute of Cancer Research) ; Kabisch, Maria (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ; Kang, Daehee (Department of Preventive Medicine, Seoul National University College of Medicine) ; Kapuscinski, Miroslav (Centre for Epidemiology and Biostatistics, University of Melbourne) ; Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center) ; Khan, Sofia (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ; Kiemeney, Lambertus A. (Radboud University Medical Centre, Radboud Institute for Health Sciences) ; Kjaer, Susanne Kruger (Department of Gynecology, Rigshospitalet, University of Copenhagen) ; Knight, Julia A. (Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto) ; Konstantopoulou, Irene (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ; Kosma, Veli-Matti (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ; Kristensen, Vessela (Oslo University Hospital (Oslo, Noruega)) ; Kupryjanczyk, Jolanta (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology) ; Kwong, Ava (Department of Surgery, The University of Hong Kong) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Laitman, Yael (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ; Lambrechts, Diether (Laboratory for Translational Genetics, Department of Oncology, University of Leuven) ; Le, Nhu (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; De Leeneer, Kim (Center for Medical Genetics, Ghent University) ; Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center) ; Levine, Douglas A. (Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center) ; Li, Jingmei (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Lindblom, Annika (Department of Molecular Medicine and Surgery, Karolinska Institutet) ; Long, Jirong (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Lophatananon, Artitaya (Division of Health Sciences, Warwick Medical School, Warwick University) ; Loud, Jennifer T. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ; Lu, Karen (Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University) ; Mannermaa, Arto (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT)) ; Le Marchand, Loic (University of Hawaii Cancer Center) ; Margolin, Sara (Department of Oncology - Pathology, Karolinska Institutet) ; Marme, Frederik (National Center for Tumour Diseases, University of Heidelberg) ; Massuger, Leon F. A. G. (Department of Gynaecology, Radboud University Medical Centre) ; Matsuo, Keitaro (Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences) ; Mazoyer, Sylvie (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ; McGuffog, Lesley (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; McLean, Catriona (Anatomical Pathology, The Alfred Hospital) ; McNeish, Iain (Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research) ; Meindl, Alfons (Division of Gynaecology and Obstetrics, Technische Universität München) ; Menon, Usha (Women's Cancer, UCL EGA Institute for Women's Health) ; Mensenkamp, Arjen R. (Department of Human Genetics, Radboud University Medical Centre) ; Milne, Roger L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS) ; Moysich, Kirsten B. (Department of Cancer Prevention and Control, Roswell Park Cancer Institute) ; Muir, Kenneth (Institute of Population Health, University of Manchester) ; Mulligan, Anna Marie (Department of Laboratory Medicine and Pathobiology, University of Toronto) ; Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ; Ness, Roberta B. (The University of Texas School of Public Health) ; Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ; Nord, Silje (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo) ; Nussbaum, Robert L. (Department of Medicine and Genetics, University of California) ; Odunsi, Kunle (Department of Gynecological Oncology, Roswell Park Cancer Institute) ; Offit, Kenneth (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology) ; Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center) ; Olson, Janet E. (Department of Health Sciences Research, Mayo Clinic) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic) ; O'Malley, David (The Ohio State University and the James Cancer Center) ; Orlow, Irene (Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center) ; Orr, Nick (Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research) ; Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Park, Sue Kyung (Department of Surgery, Seoul National University College of Medicine) ; Pearce, Celeste L. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Pejovic, Tanja (Knight Cancer Institute, Oregon Health and Science University) ; Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology) ; Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center) ; Poole, Elizabeth M. (Department of Epidemiology, Harvard TH Chan School of Public Health) ; Pylkäs, Katri (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu) ; Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT)) ; Rantala, Johanna (Karolinska University Hospital) ; Rashid, Muhammad Usman (Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC)) ; Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine) ; Rhenius, Valerie (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Rhiem, Kerstin (Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne) ; Risch, Harvey A. (Department of Chronic Disease Epidemiology, Yale School of Public Health) ; Rodriguez, Gus (Division of Gynecologic Oncology, NorthShore University HealthSystem) ; Rossing, Mary Anne (Department of Epidemiology, University of Washington) ; Rudolph, Anja (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)) ; Salvesen, Helga B. (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen) ; Sangrajrang, Suleeporn (National Cancer Institute) ; Sawyer, Elinor J. (Research Oncology, Guy's Hospital, King's College London) ; Schildkraut, Joellen M. (Cancer Control and Population Sciences, Duke Cancer Institute) ; Schmidt, Marjanka K. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ; Schmutzler, Rita K. (Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne) ; Sellers, Thomas A. (Department of Cancer Epidemiology, Moffitt Cancer Center) ; Seynaeve, Caroline (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; Shah, Mitul (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Shen, Chen-Yang (School of Public Health, China Medical University) ; Shu, Xiao-Ou (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Sieh, Weiva (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine) ; Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ; Sinilnikova, Olga M. (INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon) ; Slager, Susan (Department of Health Sciences Research, Mayo Clinic) ; Song, Honglin (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Southey, Melissa C. (Department of Pathology, University of Melbourne) ; Stenmark-Askmalm, Marie (Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité) ; Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg) ; Swerdlow, Anthony (Division of Genetics and Epidemiology, The Institute of Cancer Research) ; Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital) ; Teixeira, Manuel R. (Biomedical Sciences Institute (ICBAS), Porto University) ; Teo, Soo H. (Cancer Research Initiatives Foundation, Subang Jaya) ; Terry, Kathryn L. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Terry, Mary Beth (Department of Epidemiology, Mailman School of Public Health, Columbia University) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ; Tognazzo, Silvia (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico)) ; Toland, Amanda Ewart (Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University) ; Tomlinson, Ian (Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford) ; Torres, Diana (Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62) ; Truong, Thérèse (University Paris-Sud) ; Tseng, Chiu-chen (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Tung, Nadine (Department of Medical Oncology, Beth Israel Deaconess Medical Center) ; Tworoger, Shelley S. (Department of Epidemiology, Harvard TH Chan School of Public Health) ; Vachon, Celine (Department of Health Sciences Research, Mayo Clinic) ; van den Ouweland, Ans M. W. (Department of Clinical Genetics, Erasmus University Medical Center) ; van Doorn, Helena C. (Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; van Rensburg, Elizabeth J. (Department of Genetics, University of Pretoria) ; Van't Veer, Laura J. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ; Vanderstichele, Adriaan (University Hospitals Leuven (Bèlgica)) ; Vergote, Ignace (University Hospitals Leuven (Bèlgica)) ; Vijai, Joseph (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ; Wang, Qin (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Wang-Gohrke, Shan (University Hospital Ulm, 89069 Ulm) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ; Wentzensen, Nicolas (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Whittemore, Alice S. (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine) ; Wildiers, Hans (Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven) ; Winqvist, Robert (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu) ; Wu, Anna H. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Yannoukakos, Drakoulis (Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos') ; Yoon, Sook-Yee (University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya) ; Yu, Jyh-Cherng (Department of Surgery, Tri-Service General Hospital, National Defense Medical Center) ; Zheng, Wei (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Zheng, Ying (Shanghai Center for Disease Control and Prevention) ; Khanna, Kum Kum (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Monteiro, Alvaro N. (Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute) ; French, Juliet D. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic) ; Freedman, Matthew L. (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute) ; Easton, Douglas F. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Dunning, Alison M. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Pharoah, Paul D. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Edwards, Stacey L. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Chenevix-Trench, Georgia (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Antoniou, Antonis C. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Gayther, Simon A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Universitat Autònoma de Barcelona
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P =9. [...]
2016 - 10.1038/ncomms12675
Nature communications, Vol. 7 (09 2016)  
9.
14 p, 7.9 MB Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis / Banushi, Blerida (University College London) ; Forneris, Federico (Utrecht University) ; Straatman-Iwanowska, Anna (University College London) ; Strange, Adam (University College London) ; Lyne, Anne-Marie (University College London) ; Rogerson, Clare (University College London) ; Burden, Jemima J. (University College London) ; Heywood, Wendy E. (University College London) ; Hanley, Joanna (University College London) ; Doykov, Ivan (University College London) ; Straatman, Kornelis R. (University of Leicester) ; Smith, Holly (University College London) ; Bem, Danai (College of Medical and Dental Sciences, University of Birmingham) ; Kriston-Vizi, Janos (University College London) ; Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Risteli, Maija (Oulu University Hospital (Finlàndia)) ; Wang, Chunguang (University of Oulu (Finlàndia)) ; Ardill, Rosalyn E. (Royal Hospital for Sick Children) ; Zaniew, Marcin (Children's Hospital) ; Latka-Grot, Julita (Children's Memorial Health Institute) ; Waddington, Simon N. (University College London) ; Howe, S. J. (University College London) ; Ferraro, Francesco (University College London) ; Gjinovci, Asllan (University College London) ; Lawrence, Scott (University College London) ; Marsh, Mark (University College London) ; Girolami, Mark (University of Warwick) ; Bozec, Laurent (University College London) ; Mills, Kevin (University College London) ; Gissen, Paul (Great Ormond Street Hospital for Children (Londres)) ; Universitat Autònoma de Barcelona
Post-translational modifications are necessary for collagen precursor molecules (procollagens) to acquire final shape and function. However, the mechanism and contribution of collagen modifications that occur outside the endoplasmic reticulum and Golgi are not understood. [...]
2016 - 10.1038/ncomms12111
Nature communications, Vol. 7 (07 2016)  
10.
17 p, 5.3 MB Associations of autozygosity with a broad range of human phenotypes / Clark, David W (University of Edinburgh) ; Okada, Yukinori (Osaka University, Suita) ; Moore, Kristjan H S (deCODE genetics/Amgen Inc., Reykjavik, Iceland) ; Mason, Dan (Bradford Teaching Hospitals NHS Trust, Bradford, UK) ; Pirastu, Nicola (University of Edinburgh, Usher Institute) ; Gandin, Ilaria (University of Trieste) ; Mattsson, Hannele (University of Helsinki) ; Barnes, Catriona L K (University of Edinburgh) ; Lin, Kuang (University of Oxford) ; Zhao, Jing Hua (University of Cambridge) ; Deelen, Patrick (University Medical Centre Groningen, University of Groningen) ; Rohde, Rebecca (University of North Carolina. Department of Epidemiology) ; Schurmann, Claudia (Ichan School of Medicine at Mount Sinai) ; Guo, Xiuqing (The Institute for Translational Genomics and Population Sciences, Torrance, California, USA) ; Giulianini, Franco (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Zhang, Weihua (Ealing Hospital, Middlesex) ; Medina-Gomez, Carolina (Erasmus University Medical Center) ; Karlsson, Robert (Karolinska Institutet, Estocolm, Suècia) ; Bao, Yanchun (University of Essex) ; Bartz, Traci M (University of Washington) ; Baumbach, Clemens (Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg) ; Biino, Ginevra (National Research Council of Italy) ; Bixley, Matthew J (University of Otago) ; Brumat, Marco (University of Trieste) ; Chai, Jin-Fang (National University of Singapore, Singapore) ; Corre, Tanguy (Swiss Institute of Bioinformatics) ; Cousminer, Diana L (University of Pennsylvania) ; Dekker, Annelot M (Utrecht University) ; Eccles, David A (Malaghan Institute of Medical Research) ; van Eijk, Kristel R (Utrecht University) ; Fuchsberger, Christian (Affiliated Institute of the University of Lübeck, Bolzano, Italy) ; Gao, He (Imperial College London) ; Germain, Marine (ICAN Institute for Cardiometabolism and Nutrition) ; Gordon, Scott D (QIMR Berghofer Institute of Medical Research) ; de Haan, Hugoline G (Leiden University Medical Center) ; Harris, Sarah E (University of Edinburgh) ; Hofer, Edith (Medical University of Graz) ; Huerta-Chagoya, Alicia (CONACyT, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, 03940 México) ; Igartua, Catherine (University of Chicago. Department of Human Genetics) ; Jansen, Iris E (VU University Medical Center, Amsterdam Neuroscience. Alzheimer Center Department of Neurology) ; Jia, Yucheng (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502 USA) ; Kacprowski, Tim (TUM School of Life Sciences Weihenstephan, Technical University of Munich. Chair of Experimental Bioinformatics) ; Karlsson, Torgny (Uppsala University. Department of Immunology, Genetics and Pathology, Science for Life Laboratory) ; Kleber, Marcus E (Heidelberg University. Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim) ; Li, Shengchao Alfred (Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research. Cancer Genomics Research Laboratory) ; Li-Gao, Ruifang (Leiden University Medical Center. Department of Clinical Epidemiology) ; Mahajan, Anubha (University of Oxford. Wellcome Centre for Human Genetics) ; Matsuda, Koichi (Graduate school of Frontier Sciences, The University of Tokyo. Department of Computational Biology and Medical Sciences) ; Meidtner, Karina (German Center for Diabetes Research (DZD)) ; Meng, Weihua (Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee) ; Montasser, May E (University of Maryland, School of Medicine. Program for Personalized and Genomic Medicine, Department of Medicine) ; van der Most, Peter J (University of Groningen, University Medical Center Groningen. Department of Epidemiology) ; Munz, Matthias (Humboldt-Universität zu Berlin) ; Nutile, Teresa (Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR) ; Palviainen, Teemu (Finnish Institute for Molecular Medicine, University of Helsinki) ; Prasad, Gauri (Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology) ; Prasad, Rashmi B (Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Skåne University Hospital, Malmö, 20502 Sweden) ; Priyanka, Tallapragada Divya Sri (CSIR-Centre for Cellular and Molecular Biology. Genomic Research on Complex diseases (GRC Group)) ; Rizzi, Federica (University of Milano. Department of Health Sciences) ; Salvi, Erika (IRCCS Foundation Carlo Besta Neurological Institute. Neuroalgology Unit) ; Sapkota, Bishwa R (University of Oklahoma Health Sciences Center. Department of Pediatrics, College of Medicine) ; Shriner, Daniel (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Skotte, Line (Statens Serum Institut. Department of Epidemiology Research) ; Smart, Melissa C (Institute for Social and Economic Research, University of Essex) ; Smith, Albert Vernon (University of Iceland. Faculty of Medicine, School of Health Sciences) ; van der Spek, Ashley (Erasmus University Medical Center. Department of Epidemiology) ; Spracklen, Cassandra N (University of North Carolina. Department of Genetics) ; Strawbridge, Rona J (Karolinska Institutet. Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine) ; Tajuddin, Salman M (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Trompet, Stella (Leiden University Medical Center. Section of Gerontology and Geriatrics, Department of Internal Medicine) ; Turman, Constance (Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health) ; Verweij, Niek (University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands) ; Viberti, Clara (University of Turin, Italy. Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences) ; Wang, Lihua (Washington University School of Medicine. Division of Statistical Genomics, Department of Genetics) ; Warren, Helen R (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London. Department of Clinical Pharmacology) ; Wootton, Robyn E (School of Psychological Science, University of Bristol) ; Yanek, Lisa R (Johns Hopkins University School of Medicine. Department of Medicine, GeneSTAR Research Program) ; Yao, Jie (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502 USA) ; Yousri, Noha A (Alexandria University. Computer and Systems Engineering) ; Zhao, Wei (University of Michigan. Department of Epidemiology, School of Public Health) ; Adeyemo, Adebowale A (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Afaq, Saima (Imperial College London. Department of Epidemiology and Biostatistics) ; Aguilar-Salinas, Carlos Alberto (Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud. Unidad de Investigacion de Enfermades Metabolicas) ; Akiyama, Masato (Graduate School of Medical Sciences, Kyushu University, Fukuoka. Department of Ophthalmology) ; Albert, Matthew L (Genentech Inc. Department of Cancer Immunology) ; Allison, Matthew A (UC San Diego School of Medicine. Division of Preventive Medicine, Department of Family Medicine and Public Health) ; Alver, Maris (University of Tartu, University of Tartu. Estonian Genome Center) ; Aung, Tin (Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Ophthalmology) ; Azizi, Fereidoun (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Endocrine Research Center) ; Bentley, Amy R (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Boeing, Heiner (German Institute of Human Nutrition Potsdam-Rehbruecke. Department of Epidemiology) ; Boerwinkle, Eric (UTHealth School of Public Health, University of Texas. Health Science Center at Houston) ; Borja, Judith B (USC-Office of Population Studies Foundation, Inc., Department of Nutrition and Dietetics, Talamban, University of San Carlos) ; de Borst, Gert J (Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX Netherlands) ; Bottinger, Erwin P (Hasso Plattner Institute, Universität Potsdam. Digital Health Center) ; Broer, Linda (Erasmus University Medical Center. Department of Internal Medicine) ; Campbell, Harry (University of Edinburgh. Centre for Global Health Research, Usher Institute) ; Chanock, Stephen (National Cancer Institute, National Institutes of Health. Division of Cancer Epidemiology & Genetics) ; Chee, Miao-Li (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore) ; Chen, Guanjie (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Chen, Yii-Der I (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA) ; Chen, Zhengming (University of Oxford. Nuffield Department of Population Health) ; Chiu, Yen-Feng (Institute of Population Health Sciences, National Health Research Institutes) ; Cocca, Massimiliano (Institute for Maternal and Child Health - IRCCS Burlo Garofolo) ; Collins, Francis S (National Human Genome Research Institute, National Institutes of Health) ; Concas, Maria Pina (Institute for Maternal and Child Health - IRCCS Burlo Garofolo) ; Corley, Janie (University of Edinburgh. Department of Psychology) ; Cugliari, Giovanni (University of Turin, Italy. Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences) ; van Dam, Rob M (Harvard T.H. Chan School of Public Health. Department of Nutrition) ; Damulina, Anna (Medical University of Graz. Clinical Division of Neurogeriatrics, Department of Neurology) ; Daneshpour, Maryam S (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Cellular and Molecular Endocrine Research Center) ; Day, Felix R (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Delgado, Graciela E (Heidelberg University. Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim) ; Dhana, Klodian (Rush University Medical Center. Department of Internal Medicine) ; Doney, Alexander S F (Molecular and Clinical Medicine, University of Dundee. MEMO Research) ; Dörr, Marcus (DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475 Germany) ; Doumatey, Ayo P (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Dzimiri, Nduna (King Faisal Specialist Hospital and Research Center. Department of Genetics) ; Ebenesersdóttir, S Sunna (University of Iceland. Department of Anthropology) ; Elliott, Joshua (Imperial College London. Department of Epidemiology and Biostatistics) ; Elliott, Paul (Health Data Research UK - London, London, England) ; Ewert, Ralf (University Medicine Greifswald. Department of Internal Medicine B) ; Felix, Janine F (Erasmus University Medical Center. Department of Pediatrics) ; Fischer, Krista (University of Tartu, University of Tartu. Estonian Genome Center) ; Freedman, Barry I (Wake Forest School of Medicine. Section on Nephrology, Department of Internal Medicine) ; Girotto, Giorgia (Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Medical Genetics) ; Goel, Anuj (University of Oxford. Division of Cardiovascular Medicine, Radcliffe Department of Medicine) ; Gögele, Martin (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100 Italy) ; Goodarzi, Mark O (Cedars-Sinai Medical Center. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine) ; Graff, Mariaelisa (University of North Carolina. Department of Epidemiology, Gillings School of Global Public Health) ; Granot-Hershkovitz, Einat (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Grodstein, Francine (Harvard T.H. Chan School of Public Health. Department of Epidemiology) ; Guarrera, Simonetta (University of Turin, Italy. Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences) ; Gudbjartsson, Daniel F (School of Engineering and Natural Sciences, University of Iceland) ; Guity, Kamran (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Cellular and Molecular Endocrine Research Center) ; Gunnarsson, Bjarni (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Guo, Yu (Chinese Academy of Medical Sciences) ; Hagenaars, Saskia P (Institute of Psychiatry, Psychology & Neuroscience, King's College London. Social, Genetic and Developmental Psychiatry Centre) ; Haiman, Christopher A (Keck School of Medicine, University of Southern California. Department of Preventive Medicine) ; Halevy, Avner (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Harris, Tamara B (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Hedayati, Mehdi (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Cellular and Molecular Endocrine Research Center) ; van Heel, David A (Blizard Institute, Queen Mary University of London) ; Hirata, Makoto (Institute of Medical Science, The University of Tokyo. Laboratory of Genome Technology) ; Höfer, Imo (Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX Netherlands) ; Hsiung, Chao Agnes (Institute of Population Health Sciences, National Health Research Institutes) ; Huang, Jinyan (Shanghai Institute of Hematology, State Key Laboratory Of Medical Genomics, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine) ; Hung, Yi-Jen (National Defense Medical Center. School of Medicine) ; Ikram, M. Arfan (Erasmus University Medical Center. Department of Epidemiology) ; Jagadeesan, Anuradha (University of Iceland. Department of Anthropology) ; Jousilahti, Pekka (National Institute for Health and Welfare. Unit of Public Health Promotion) ; Kamatani, Yoichiro (Kyoto University Graduate School of Medicine. Center for Genomic Medicine) ; Kanai, Masahiro (Harvard Medical School. Department of Biomedical Informatics) ; Kerrison, Nicola D (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Kessler, Thorsten (Klinik für Herz- und Kreislauferkrankungen, Technische Universität München. Deutsches Herzzentrum München) ; Khaw, Kay-Tee (University of Cambridge. Department of Public Health and Primary Care) ; Khor, Chiea Chuen (Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore. Human Genetics) ; de Kleijn, Dominique P V (Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX Netherlands) ; Koh, Woon-Puay (Duke-NUS Medical School. Health Services and Systems Research) ; Kolcic, Ivana (University of Split. Centre for Global Health, Faculty of Medicine) ; Kraft, Peter (Harvard T.H. Chan School of Public Health. Department of Nutrition) ; Krämer, Bernhard K (Heidelberg University. Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim) ; Kutalik, Zoltán (Swiss Institute of Bioinformatics) ; Kuusisto, Johanna (Kuopio University Hospital) ; Langenberg, Claudia (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Launer, Lenore J (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Lawlor, Deborah A (Population Health Science, Bristol Medical School, Bristol, BS8 2BY UK) ; Lee, I-Te (Chung Shan Medical University, Taichung, Taiwan. School of Medicine) ; Lee, Wen-Jane (Taichung Veterans General Hospital. Department of Medical Research) ; Lerch, Markus M (University Medicine Greifswald. Department of Internal Medicine A) ; Li, Liming (Peking University Health Science Centre, Peking University. Department of Epidemiology and Biostatistics) ; Liu, Jianjun (Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore. Human Genetics) ; Loh, Marie (Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Biochemistry) ; London, Stephanie J (National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services) ; Loomis, Stephanie (Johns Hopkins Bloomberg School of Public Health. Department of Epidemiology) ; Lu, Yingchang (Ichan School of Medicine at Mount Sinai. The Charles Bronfman Institute for Personalized Medicine) ; Luan, Jian'an (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Mägi, Reedik (University of Tartu, University of Tartu. Estonian Genome Center) ; Manichaikul, Ani W (University of Virginia School of Medicine. Center for Public Health Genomics) ; Manunta, Paolo (Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Università Vita Salute San Raffaele, Milano, 20132 Italy) ; Másson, Gísli (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Matoba, Nana (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan) ; Mei, Xue W (University of Oxford. Nuffield Department of Population Health) ; Meisinger, Christa (Helmholtz Zentrum München, Independent Research Group Clinical Epidemiology, Neuherberg, 85764 Germany) ; Meitinger, Thomas (DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance) ; Mezzavilla, Massimo (Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Medical Genetics) ; Milani, Lili (Institute of Genomics, University of Tartu. Estonian Genome Center) ; Millwood, Iona Y (University of Oxford. Nuffield Department of Population Health) ; Momozawa, Yukihide (Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan) ; Moore, Amy (National Cancer Institute, National Institutes of Health. Division of Cancer Epidemiology & Genetics) ; Morange, Pierre-Emmanuel (Aix-Marseille University. INSERM UMR_S 1263, Center for CardioVascular and Nutrition research (C2VN)) ; Moreno-Macías, Hortensia (Universidad Autónoma Metropolitana. Departamento de Economía) ; Mori, Trevor A (The University of Western Australia. Medical School) ; Morrison, Alanna C (The University of Texas Health Science Center at Houston, School of Public Health, Department of Epidemiology, Human Genetics and Environmental Sciences) ; Muka, Taulant (Institute of Social and Preventive Medicine (ISPM), University of Bern) ; Murakami, Yoshinori (Institute of Medical Science, The University of Tokyo. Division of Molecular Pathology) ; Murray, Alison D (The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen) ; de Mutsert, Renée (Leiden University Medical Center. Department of Clinical Epidemiology) ; Mychaleckyj, Josyf C (University of Virginia School of Medicine. Center for Public Health Genomics) ; Nalls, Mike A (Data Tecnica International LLC, Glen Echo, MD 20812 USA) ; Nauck, Matthias (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald) ; Neville, Matt J (Oxford University Hospitals Trust. Oxford NIHR Biomedical Research Centre) ; Nolte, Ilja M (University of Groningen, University Medical Center Groningen. Department of Epidemiology) ; Ong, Ken K (University of Cambridge School of Clinical Medicine. Department of Paediatrics) ; Orozco, Lorena (Instituto Nacional de Medicina Genómica) ; Padmanabhan, Sandosh (Institute of Cardiovascular and Medical Sciences, University of Glasgow) ; Pálsson, Gunnar (deCODE genetics/Amgen Inc., Reykjavik, Iceland) ; Pankow, James S (School of Public Health, University of Minnesota. Division of Epidemiology & Community Health) ; Pattaro, Cristian (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100 Italy) ; Pattie, Alison (University of Edinburgh. Department of Psychology) ; Polasek, Ozren (Gen-info Ltd, Zagreb, Croatia, Zagreb, Select a Province Croatia) ; Poulter, Neil (Imperial College London, London. Imperial Clinical Trials Unit) ; Pramstaller, Peter P (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100 Italy) ; Quintana-Murci, Lluis (Institut Pasteur. Center of Bioinformatics, Biostatistics and Integrative Biology) ; Räikkönen, Katri (University of Helsinki, University of Helsinki. Department of Psychology and Logopedics, Faculty of Medicine) ; Ralhan, Sarju (Hero Heart Institute and Dyanand Medical College and Hospital) ; Rao, Dabeeru C (Washington University School of Medicine. Division of Biostatistics) ; van Rheenen, Wouter (University Medical Centre Utrecht, Utrecht University. Department of Neurology, Brain Centre Rudolf Magnus) ; Rich, Stephen S (University of Virginia School of Medicine. Center for Public Health Genomics) ; Ridker, Paul M (Harvard Medical School) ; Rietveld, Cornelius A (Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus University Rotterdam) ; Robino, Antonietta (Institute for Maternal and Child Health - IRCCS Burlo Garofolo) ; van Rooij, Frank J A (Erasmus University Medical Center. Department of Epidemiology) ; Ruggiero, Daniela (IRCCS Neuromed) ; Saba, Yasaman (Medical University of Graz. Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry) ; Sabanayagam, Charumathi (Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Ophthalmology) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Sala, Cinzia Felicita (San Raffaele Research Institute, Milano, Italy) ; Salomaa, Veikko (National Institute for Health and Welfare. Department of Public Health Solutions) ; Sandow, Kevin (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA) ; Schmidt, Helena (Medical University of Graz. Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry) ; Scott, Laura J (University of Michigan. Department of Biostatistics, and Center for Statistical Genetics) ; Scott, William R (Imperial College London. Department of Epidemiology and Biostatistics) ; Sedaghati-Khayat, Bahareh (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Cellular and Molecular Endocrine Research Center) ; Sennblad, Bengt (National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala. Dept of Cell and Molecular Biology) ; van Setten, Jessica (Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3485 CX Netherlands) ; Sever, Peter J (International Centre for Circulatory Health, Imperial College London) ; Sheu, Wayne H-H (Institute of Medical Technology, National Chung-Hsing University) ; Shi, Yuan (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore) ; Shrestha, Smeeta (School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, Karnataka 560078 India) ; Shukla, Sharvari Rahul (Symbiosis Statistical Institute, Symbiosis International University) ; Sigurdsson, Jon K (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Sikka, Timo Tonis (University of Tartu, University of Tartu. Estonian Genome Center) ; Singh, Jai Rup (Panjab University) ; Smith, Blair H (Ninewells Hospital and Medical School, University of Dundee. Division of Population Health Sciences) ; Stančáková, Alena (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland) ; Stanton, Alice (RCSI Molecular & Cellular Therapeutics (MCT), Royal College of Surgeons in Ireland, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland) ; Starr, John M (University of Edinburgh. Alzheimer Scotland Dementia Research Centre) ; Stefansdottir, Lilja (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Straker, Leon (School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University) ; Sulem, Patrick (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Sveinbjornsson, Gardar (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Swertz, Morris A (Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB The Netherlands) ; Taylor, Adele M (University of Edinburgh. Department of Psychology) ; Taylor, Kent D (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA) ; Terzikhan, Natalie (Ghent University Hospital. Department of Respiratory Medicine) ; Tham, Yih-Chung (Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore) ; Thorleifsson, Gudmar (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Thorsteinsdottir, Unnur (University of Iceland. Faculty of Medicine, School of Health Sciences) ; Tillander, Annika (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Tracy, Russell P (University of Vermont. Department of Pathology) ; Tusié-Luna, Teresa (Unidad De Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ; Tzoulaki, Ioanna (University of Ioannina Medical School. Department of Hygiene and Epidemiology) ; Vaccargiu, Simona (Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy) ; Vangipurapu, Jagadish (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland) ; Veldink, Jan H (University Medical Centre Utrecht, Utrecht University. Department of Neurology, Brain Centre Rudolf Magnus) ; Vitart, Veronique (Institute of Genetics and Molecular Medicine, University of Edinburgh. MRC Human Genetics Unit) ; Völker, Uwe (DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475 Germany) ; Vuoksimaa, Eero (Institute for Molecular Medicine Finland (FIMM), University of Helsinki) ; Wakil, Salma M (King Faisal Specialist Hospital and Research Center. Department of Genetics) ; Waldenberger, Melanie (Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764 Germany) ; Wander, Gurpreet S (Hero DMC Heart Institute, Dayanand Medical College & Hospital. Department of Cardiology) ; Wang, Ya Xing (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab) ; Wareham, Nicholas J (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Wild, Sarah (Usher Institute of Population Health and Informatics, University of Edinburgh. Centre for Population Health Sciences) ; Yajnik, Chittaranjan S (Diabetes Unit, K.E.M. Hospital Research Centre) ; Yuan, Jian-Min (Graduate School of Public Health, University of Pittsburgh. Department of Epidemiology) ; Zeng, Lingyao (Klinik für Herz- und Kreislauferkrankungen, Technische Universität München. Deutsches Herzzentrum München) ; Zhang, Liang (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore) ; Zhou, Jie (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Amin, Najaf (Erasmus University Medical Center. Department of Epidemiology) ; Asselbergs, Folkert W (Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London) ; Bakker, Stephan J L (Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, 9713GZ The Netherlands) ; Becker, Diane M (Johns Hopkins University School of Medicine. Department of Medicine, GeneSTAR Research Program) ; Lehne, Benjamin (Imperial College London. Department of Epidemiology and Biostatistics) ; Bennett, David A (Rush University Medical Center. Department of Neurological Sciences) ; van den Berg, Leonard H (University Medical Centre Utrecht, Utrecht University. Department of Neurology, Brain Centre Rudolf Magnus) ; Berndt, Sonja I (National Cancer Institute, National Institutes of Health. Division of Cancer Epidemiology & Genetics) ; Bharadwaj, Dwaipayan (School of Biotechnology, Jawaharlal Nehru University. Systems Genomics Laboratory) ; Bielak, Lawrence F (University of Michigan. Department of Epidemiology, School of Public Health) ; Bochud, Murielle (University of Lausanne. Center for Primary Care and Public Health (Unisanté)) ; Boehnke, Mike (University of Michigan. Department of Biostatistics, and Center for Statistical Genetics) ; Bouchard, Claude (Pennington Biomedical Research Center) ; Bradfield, Jonathan P (Quantinuum Research LLC, San Diego, CA 92101 USA) ; Brody, Jennifer A (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Campbell, Archie (Institute of Genetics & Molecular Medicine, University of Edinburgh. Centre for Genomic & Experimental Medicine) ; Carmi, Shai (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Caulfield, Mark J (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London. Department of Clinical Pharmacology) ; Cesarini, David (Research Institute for Industrial Economics (IFN)) ; Chambers, John C (Imperial College Healthcare NHS Trust, London) ; Chandak, Giriraj Ratan (CSIR-Centre for Cellular and Molecular Biology. Genomic Research on Complex diseases (GRC Group)) ; Cheng, Ching-Yu (Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Ophthalmology) ; Ciullo, Marina (IRCCS Neuromed) ; Cornelis, Marilyn (Northwestern University Feinberg School of Medicine. Department of Preventive Medicine) ; Cusi, Daniele (Bio4Dreams Scientific Unit, Bio4Dreams SRL, Bio4Dreams - business nursery for life sciences, Milano, 20121 Italy) ; Smith, George Davey (Population Health Science, Bristol Medical School, Bristol, BS8 2BY UK) ; Deary, Ian J (University of Edinburgh. Department of Psychology) ; Dorajoo, Rajkumar (Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore. Human Genetics) ; van Duijn, Cornelia M (Erasmus University Medical Center. Department of Epidemiology) ; Ellinghaus, David (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel) ; Erdmann, Jeanette (Institute for Cardiogenetics, University of Lübeck) ; Eriksson, Johan G (Vasa Central Hospital) ; Evangelou, Evangelos (University of Ioannina Medical School. Department of Hygiene and Epidemiology) ; Evans, Michele K (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Faul, Jessica D (University of Michigan. Institute for Social Research) ; Feenstra, Bjarke (Statens Serum Institut. Department of Epidemiology Research) ; Feitosa, Mary (Washington University School of Medicine. Division of Statistical Genomics, Department of Genetics) ; Foisy, Sylvain (Montreal Heart Institute) ; Franke, Andre (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel) ; Friedlander, Yechiel (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Gasparini, Paolo (Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Medical Genetics) ; Gieger, Christian (German Center for Diabetes Research (DZD)) ; Gonzalez, Clicerio (Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica) ; Goyette, Philippe (Montreal Heart Institute) ; Grant, Struan F A (Perelman School of Medicine, University of Pennsylvania. Department of Pediatrics) ; Griffiths, Lyn R (Institute of Health and Biomedical Innovation, Queensland University of Technology. Genomics Research Centre, School of Biomedical Sciences) ; Groop, Leif (Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Skåne University Hospital, Malmö, Sweden) ; Gudnason, Vilmundur (University of Iceland. Faculty of Medicine, School of Health Sciences) ; Gyllensten, Ulf (Uppsala University. Department of Immunology, Genetics and Pathology, Science for Life Laboratory) ; Hakonarson, Hakon (Perelman School of Medicine, University of Pennsylvania. Department of Pediatrics) ; Hamsten, Anders (Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Stockholm, 171 76 Sweden) ; van der Harst, Pim (University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands) ; Heng, Chew-Kiat (Khoo Teck Puat - National University Children's Medical Institute, National University Health System) ; Hicks, Andrew A (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100 Italy) ; Hochner, Hagit (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Huikuri, Heikki (Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital) ; Hunt, Steven C (University of Utah School of Medicine. Division of Epidemiology, Department of Internal Medicine) ; Jaddoe, Vincent W V (Erasmus University Medical Center. Department of Pediatrics) ; De Jager, Philip L (Cell Circuits Program, Broad Institute) ; Johannesson, Magnus (Stockholm School of Economics. Department of Economics) ; Johansson, Åsa (Uppsala University. Department of Immunology, Genetics and Pathology, Science for Life Laboratory) ; Jonas, Jost B (Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, 698167 Germany) ; Jukema, J Wouter (Leiden University Medical Center. Department of Cardiology) ; Junttila, Juhani (Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital) ; Kaprio, Jaakko (University of Helsinki. Department of Public Health) ; Kardia, Sharon L. R. (University of Michigan. Department of Epidemiology, School of Public Health) ; Karpe, Fredrik (Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital) ; Kumari, Meena (Institute for Social and Economic Research, University of Essex) ; Laakso, Markku (Kuopio University Hospital) ; van der Laan, Sander W (Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, CX Netherlands) ; Lahti, Jari (University of Helsinki, University of Helsinki. Helsinki Collegium for Advanced Studies) ; Laudes, Matthias (University Hospital Schleswig-Holstein (UKSH)) ; Lea, Rodney A (Institute of Health and Biomedical Innovation, Queensland University of Technology. Genomics Research Centre, School of Biomedical Sciences) ; Lieb, Wolfgang (Institute of Epidemiology and PopGen Biobank, University of Kiel) ; Lumley, Thomas (University of Auckland. Department of Statistics) ; Martin, Nicholas G (QIMR Berghofer Institute of Medical Research) ; März, Winfried (Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany) ; Matullo, Giuseppe (University of Turin, Italy. Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences) ; McCarthy, Mark I (Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital) ; Medland, Sarah E (QIMR Berghofer Institute of Medical Research) ; Merriman, Tony R (University of Otago. Department of Biochemistry) ; Metspalu, Andres (University of Tartu, University of Tartu. Estonian Genome Center) ; Meyer, Brian F (King Faisal Specialist Hospital and Research Centre. Department of Genetics) ; Mohlke, Karen L (University of North Carolina. Department of Genetics) ; Montgomery, Grant W (Institute for Molecular Bioscience, The University of Queensland) ; Mook-Kanamori, Dennis (Leiden University Medical Center. Department of Public Health and Primary Care) ; Munroe, Patricia B (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London. Department of Clinical Pharmacology) ; North, Kari E (University of North Carolina. Department of Epidemiology, Gillings School of Global Public Health) ; Nyholt, Dale R (School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology) ; O'connell, Jeffery R (University of Maryland, School of Medicine. Program for Personalized and Genomic Medicine, Department of Medicine) ; Ober, Carole (University of Chicago. Department of Human Genetics) ; Oldehinkel, Albertine J (Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen. Department of Psychiatry) ; Palmas, Walter (Columbia University Medical Center. Department of Medicine) ; Palmer, Colin (Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, The School of Medicine, University of Dundee) ; Pasterkamp, Gerard G (Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX Netherlands) ; Patin, Etienne (Institut Pasteur. Center of Bioinformatics, Biostatistics and Integrative Biology) ; Pennell, Craig E (The University of Western Australia. Division of Obstetrics and Gynaecology) ; Perusse, Louis (Institute of Nutrition and Functional Foods, Laval University) ; Peyser, Patricia A (University of Michigan. Department of Epidemiology, School of Public Health) ; Pirastu, Mario (Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy) ; Polderman, Tinca J. C. (Vrije Universiteit Amsterdam. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research) ; Porteous, David J (Institute of Genetics & Molecular Medicine, University of Edinburgh. Centre for Genomic & Experimental Medicine) ; Posthuma, Danielle (Amsterdam Neuroscience, VU Medical Centre. Department of Clinical Genetics) ; Psaty, Bruce M (Kaiser Permanente Washington Health Research Institute) ; Rioux, John D (Université de Montréal. Department of Medicine, Faculty of Medicine) ; Rivadeneira, Fernando (The Generation R Study Group, Erasmus University Medical Center) ; Rotimi, Charles (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Rotter, Jerome I (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA) ; Rudan, Igor (University of Edinburgh. Centre for Global Health Research, Usher Institute) ; Den Ruijter, Hester M (Laboratory of Experimental Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht) ; Sanghera, Dharambir K (Oklahoma Center for Neuroscience, Oklahoma City, USA) ; Sattar, Naveed (Institute of Cardiovascular and Medical Sciences, University of Glasgow) ; Schmidt, Reinhold (Medical University of Graz. Clinical Division of Neurogeriatrics, Department of Neurology) ; Schulze, Matthias B (Institute of Nutritional Sciences, University of Potsdam) ; Schunkert, Heribert (Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Munich Heart Alliance, Munich, 80636 Germany) ; Scott, Robert A (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Shuldiner, Alan R (Regeneron Pharmaceuticals, Inc. Regeneron Genetics Center) ; Sim, Xueling (National University of Singapore, Singapore. Saw Swee Hock School of Public Health) ; Small, Neil (University of Bradford. Faculty of Health Studies) ; Smith, Jennifer A (University of Michigan. Institute for Social Research) ; Sotoodehnia, Nona (University of Washington) ; Tai, E-Shyong (National University of Singapore. Duke-NUS Medical School) ; Teumer, Alexander (University Medicine Greifswald) ; Timpson, Nicholas J (University of Bristol) ; Toniolo, Daniela (San Raffaele Research Institute, Milano, Italy) ; Tregouet, David-Alexandre (Sorbonne Universités) ; Tuomi, Tiinamaija (University of Helsinki. Research Program of Diabetes and Endocrinology) ; Vollenweider, Peter (Lausanne University Hospital) ; Wang, Carol A (The University of Western Australia. Division of Obstetrics and Gynaecology) ; Weir, David R (University of Michigan. Institute for Social Research) ; Whitfield, John B (QIMR Berghofer Institute of Medical Research) ; Wijmenga, Cisca (Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, RB The Netherlands) ; Wong, Tien-Yin (Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore) ; Wright, John (Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, UK) ; Yang, Jingyun (Rush University Medical Center. Department of Neurological Sciences) ; Yu, Lei (Rush University Medical Center. Department of Neurological Sciences) ; Zemel, Babette S (Children's Hospital of Philadelphia. Division of Gastroenterology, Hepatology and Nutrition) ; Zonderman, Alan B (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Perola, Markus (National Institute for Health and Welfare. Unit of Genomics and Biomarkers) ; Magnusson, Patrik K. E. (Karolinska Institutet (Estocolm, Suècia).) ; Uitterlinden, André G (The Generation R Study Group, Erasmus University Medical Center) ; Kooner, Jaspal S (Imperial College London) ; Chasman, Daniel I (Harvard Medical School) ; Loos, Ruth J. F. (The Icahn School of Medicine at Mount Sinai. The Mindich Child Health and Development Institute) ; Franceschini, Nora (University of North Carolina. Department of Epidemiology, Gillings School of Global Public Health) ; Franke, Lude (Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, The Netherlands) ; Haley, Chris S (Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, Scotland) ; Hayward, Caroline (Institute of Genetics and Molecular Medicine, University of Edinburgh. MRC Human Genetics Unit) ; Walters, Robin G (University of Oxford. Nuffield Department of Population Health) ; Perry, John R. B. (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Esko, Tōnu (Broad Institute, Broad Institute. Program in Medical and Population Genetics) ; Helgason, Agnar (University of Iceland. Department of Anthropology) ; Stefansson, Kari (University of Iceland. Faculty of Medicine, School of Health Sciences) ; Joshi, Peter K (University of Edinburgh. Centre for Global Health Research, Usher Institute) ; Kubo, Michiaki (Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan) ; Wilson, James F (Institute of Genetics and Molecular Medicine, University of Edinburgh. MRC Human Genetics Unit) ; Universitat Autònoma de Barcelona
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. [...]
2019 - 10.1038/s41467-019-12283-6
Nature communications, Vol. 10 (october 2019)  

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