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9 p, 1.4 MB |
Circuit-guided population acclimation of a synthetic microbial consortium for improved biochemical production
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Kang, Chae Won (Pohang University of Science and Technology. Department of Chemical Engineering) ;
Lim, Hyun Gyu (Pohang University of Science and Technology. Department of Chemical Engineering) ;
Won, Jaehyuk (Chung-Ang University. Department of Chemistry) ;
Cha, Sanghak (Pohang University of Science and Technology. Department of Chemical Engineering) ;
Shin, Giyoung (Pohang University of Science and Technology. School of Interdisciplinary Bioscience and Bioengineering) ;
Yang, Jae-Seong (Centre de Recerca en Agrigenòmica) ;
Sung, Jaeyoung (Chung-Ang University. Department of Chemistry) ;
Jung, Gyoo Yeol (Pohang University of Science and Technology. Department of Chemical Engineering)
Microbial consortia have been considered potential platforms for bioprocessing applications. However, the complexity in process control owing to the use of multiple strains necessitates the use of an efficient population control strategy. [...]
2022 -  10.1038/s41467-022-34190-z
Nature communications, Vol. 13 (November 2022) , art. 6506
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4 p, 869.2 KB |
Quantifying the recarbonization of post-agricultural landscapes
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Bell, Stephen Mackenzie (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Raymond, Samuel J. (Massachusetts Institute of Technology) ;
Yin, He (Kent State University) ;
Jiao, Wenzhe (Massachusetts Institute of Technology) ;
Goll, Daniel S. (Université Paris-Saclay) ;
Ciais, Philippe (Université Paris-Saclay) ;
Olivetti, Elsa (Massachusetts Institute of Technology) ;
Leshyk, Victor O. (Northern Arizona University) ;
Terrer, César (Massachusetts Institute of Technology)
Despite worldwide prevalence, post-agricultural landscapes remain one of the least constrained human-induced land carbon sinks. To appraise their role in rebuilding the planet's natural carbon stocks through ecosystem restoration, we need to better understand their spatial and temporal legacies.
2023 - 10.1038/s41467-023-37907-w
Nature communications, Vol. 14 (April 2023) , art. 2139
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3.
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19 p, 4.8 MB |
Evolution of cortical geometry and its link to function, behaviour and ecology
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Schwartz, Ernst (Medical University of Vienna. Department of Biomedical Imaging and Image-guided Therapy) ;
Nenning, Karl-Heinz (Medical University of Vienna. Department of Biomedical Imaging and Image-guided Therapy) ;
Heuer, Katja (Université Paris Cité. Institut Pasteur) ;
Jeffery, Nathan (University of Liverpool. Institute of Life Course & Medical Sciences) ;
Bertrand, Ornella C. (Institut Català de Paleontologia Miquel Crusafont) ;
Toro, Roberto (Université Paris Cité. Institut Pasteur) ;
Kasprian, Gregor (Medical University of Vienna. Department of Biomedical Imaging and Image-guided Therapy) ;
Prayer, Daniela (Medical University of Vienna. Department of Biomedical Imaging and Image-guided Therapy) ;
Langs, Georg (Medical University of Vienna. Department of Biomedical Imaging and Image-guided Therapy)
Studies in comparative neuroanatomy and of the fossil record demonstrate the influence of socio-ecological niches on the morphology of the cerebral cortex, but have led to oftentimes conflicting theories about its evolution. [...]
2023 - 10.1038/s41467-023-37574-x
Nature communications, Vol. 14 (April 2023) , art. 2252
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4.
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17 p, 16.8 MB |
Expression strategies for the efficient synthesis of antimicrobial peptides in plastids
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Hoelscher, Matthijs P. (Utrecht University) ;
Forner, Joachim (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Calderone, Silvia (Centre de Recerca en Agrigenòmica) ;
Krämer, Carolin (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Taylor, Zachary (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Loiacono, F. Vanessa (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Agrawal, Shreya (Neoplants (Gif-sur-Yvette)) ;
Karcher, Daniel (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Moratti, Fabio (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Kroop, Xenia (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Bock, Ralph (Max-Planck-Institut für Molekulare Pflanzenphysiologie)
Antimicrobial peptides (AMPs) kill microbes or inhibit their growth and are promising next-generation antibiotics. Harnessing their full potential as antimicrobial agents will require methods for cost-effective large-scale production and purification. [...]
2022 - 10.1038/s41467-022-33516-1
Nature communications, Vol. 13 (October 2022) , art. 5856
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5.
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14 p, 2.1 MB |
Pelagic calcium carbonate production and shallow dissolution in the North Pacific Ocean
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Ziveri, Patrizia (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Gray, William Robert (Université Paris-Saclay. Laboratoire des Sciences du Climat et de l'Environnement) ;
Anglada Ortiz, Griselda (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Manno, Clara (British Antarctic Survey) ;
Grelaud, Michael (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Incarbona, Alessandro (Università degli Studi di Palermo. Dipartimento di Scienze della Terra e del Mare) ;
Rae, James (University of St. Andrews. School of Earth and Environmental Sciences) ;
Subhas, Adam V. (Woods Hole Oceanographic Institution) ;
Pallacks, Sven (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
White, Angelicque (University of Hawaii Manoa. Department of Oceanography) ;
Adkins, Jess (California Institute of Technology (Estats Units d'Amèrica)) ;
Berelson, William (University of Southern California. Department of Earth Sciences)
Planktonic calcifying organisms play a key role in regulating ocean carbonate chemistry and atmospheric CO2. Surprisingly, references to the absolute and relative contribution of these organisms to calcium carbonate production are lacking. [...]
2023 - 10.1038/s41467-023-36177-w
Nature communications, Vol. 14, issue 1 (Jan. 2023) , art. 805
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7.
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16 p, 2.7 MB |
Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer
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Prat, Aleix (Hospital Clínic i Provincial de Barcelona) ;
Brasó-Maristany, Fara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez-Sáez, Olga (Universitat de Barcelona) ;
Sanfeliu, Esther (Hospital Clínic i Provincial de Barcelona) ;
Bellet, Meritxell (Vall d'Hebron Institut d'Oncologia) ;
Galván, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez, Débora (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pascual, Tomás (University of North Carolina) ;
Marín-Aguilera, Mercedes (Reveal Genomics (Barcelona)) ;
Rodríguez, Anna (Hospital Clínic i Provincial de Barcelona) ;
Chic, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Adamo, Barbara (Universitat de Barcelona) ;
Paré Brunet, Laia (Reveal Genomics (Barcelona)) ;
Vidal Losada, Maria (Universitat de Barcelona) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez-Rey, Marina (Vall d'Hebron Institut d'Oncologia) ;
Oliveira, Mafalda (Vall d'Hebron Institut d'Oncologia) ;
Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Matito, Judit (Vall d'Hebron Institut d'Oncologia) ;
Sánchez-Bayona, Rodrigo (Hospital Universitario 12 de Octubre (Madrid)) ;
Suñol, Anna (Vall d'Hebron Institut d'Oncologia) ;
Saura, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Ciruelos, Eva (Hospital Universitario 12 de Octubre (Madrid)) ;
Tolosa, Pablo (Hospital Universitario 12 de Octubre (Madrid)) ;
Muñoz, Montserrat (SOLTI cooperative group (Barcelona)) ;
González-Farré, Blanca (Hospital Clínic i Provincial de Barcelona) ;
Villagrasa, Patricia (Reveal Genomics (Barcelona)) ;
Parker, Joel S. (University of North Carolina) ;
Perou, Charles M. (University of North Carolina) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Liquid biopsy has proven valuable in identifying individual genetic alterations; however, the ability of plasma ctDNA to capture complex tumor phenotypes with clinical value is unknown. To address this question, we have performed 0. [...]
2023 - 10.1038/s41467-023-36801-9
Nature communications, Vol. 14 (march 2023)
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8.
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13 p, 2.4 MB |
Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
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Chen, Z. (Department of Genetics and Genomic Medicine. Great Ormond Street Institute of Child Health. University College London) ;
Zhang, D. (Department of Genetics and Genomic Medicine. Great Ormond Street Institute of Child Health. University College London) ;
Reynolds, R.H. (Department of Genetics and Genomic Medicine. Great Ormond Street Institute of Child Health. University College London) ;
Gustavsson, E.K. (Department of Genetics and Genomic Medicine. Great Ormond Street Institute of Child Health. University College London) ;
García-Ruiz, S. (Department of Genetics and Genomic Medicine. Great Ormond Street Institute of Child Health. University College London) ;
D'Sa, K. (Department of Genetics and Genomic Medicine. Great Ormond Street Institute of Child Health. University College London) ;
Fairbrother-Browne, A. (Department of Genetics and Genomic Medicine. Great Ormond Street Institute of Child Health. University College London) ;
Vandrovcova, J. (Department of Neurodegenerative Disease. Queen Square Institute of Neurology. University College London (UCL)) ;
Noyce, A.J. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Kaiyrzhanov, R. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Middlehurst, B. (Institute of Translational Medicine. University of Liverpool) ;
Kia, D.A. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Tan, M. (Department of Clinical and Movement Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Morris, H.R. (Department of Clinical and Movement Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Plun-Favreau, H. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Holmans, P. (MRC Centre for Neuropsychiatric Genetics & Genomics) ;
Trabzuni, D. (Department of Genetics. King Faisal Specialist Hospital and Research Centre) ;
Bras, J. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Quinn, J. (Institute of Translational Medicine. University of Liverpool) ;
Mok, K.Y. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Kinghorn, K.J. (Institute of Healthy Ageing. University College London (UCL)) ;
Billingsley, K. (Institute of Translational Medicine. University of Liverpool) ;
Wood, N.W. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Lewis, P. (University of Reading) ;
Schreglmann, S. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Guerreiro, Rita (UK Dementia Research Institute. University College London (UCL)) ;
Lovering, R. (Institute of Cardiovascular Science. University College London (UCL)) ;
R'Bibo, L. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Manzoni, C. (University of Reading) ;
Rizig, M. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Guelfi, S. (Department of Neurodegenerative Disease. Queen Square Institute of Neurology. University College London (UCL)) ;
Escott-Price, V. (MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University School of Medicine) ;
Chelban, V. (Department of Molecular Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Foltynie, T. (Department of Clinical and Movement Neuroscience. Queen Square Institute of Neurology. University College London (UCL)) ;
Williams, N. (MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University School of Medicine) ;
Brice, A. (Institut du Cerveau et de la Moelle épinière (París, França)) ;
Danjou, F. (Institut du Cerveau et de la Moelle épinière (París, França)) ;
Lesage, S. (Institut du Cerveau et de la Moelle épinière (París, França)) ;
Corvol, Jean-Christophe (Institut du Cerveau et de la Moelle épinière (París, França)) ;
Martinez, M. (INSERM UMR 1220 and Paul Sabatier University) ;
Schulte, C. (Department for Neurodegenerative Diseases. Hertie Institute for Clinical Brain Research. German Center for Neurodegenerative Diseases. DZNE. German Center for Neurodegenerative Diseases. University of Tübingen) ;
Brockmann, K. (Department for Neurodegenerative Diseases. Hertie Institute for Clinical Brain Research. German Center for Neurodegenerative Diseases. DZNE. German Center for Neurodegenerative Diseases. University of Tübingen) ;
Simón-Sánchez, J. (Department for Neurodegenerative Diseases. Hertie Institute for Clinical Brain Research. German Center for Neurodegenerative Diseases. DZNE. German Center for Neurodegenerative Diseases. University of Tübingen) ;
Heutink, P. (Department for Neurodegenerative Diseases. Hertie Institute for Clinical Brain Research. German Center for Neurodegenerative Diseases. DZNE. German Center for Neurodegenerative Diseases. University of Tübingen) ;
Rizzu, P. (Department for Neurodegenerative Diseases. Hertie Institute for Clinical Brain Research. German Center for Neurodegenerative Diseases. DZNE. German Center for Neurodegenerative Diseases. University of Tübingen) ;
Sharma, M. (Centre for Genetic Epidemiology. Institute for Clinical Epidemiology and Applied Biometry. University of Tubingen) ;
Gasser, T. (Department for Neurodegenerative Diseases. Hertie Institute for Clinical Brain Research. German Center for Neurodegenerative Diseases. DZNE. German Center for Neurodegenerative Diseases. University of Tübingen) ;
Nicolas, A. (Laboratory of Neurogenetics. National Institute on Aging) ;
Cookson, M. R (Laboratory of Neurogenetics. National Institute on Aging) ;
Bandres-Ciga, S. (Laboratory of Neurogenetics. National Institute on Aging) ;
Blauwendraat, Cornelis (National Institute of Neurological Disorders and Stroke) ;
Craig, David W (Department of Translational Genomics. Keck School of Medicine. University of Southern California) ;
Faghri, F. (Department of Computer Science. University of Illinois at Urbana-Champaign) ;
Gibbs, J.R. (Laboratory of Neurogenetics. National Institute on Aging) ;
Hernandez, D.G. (Laboratory of Neurogenetics. National Institute on Aging) ;
Van Keuren-Jensen, K. (Neurogenomics Division. TGen) ;
Shulman, J.M. (Jan and Dan Duncan Neurological Research Institute. Texas Children's Hospital) ;
Leonard, H.L. (Laboratory of Neurogenetics. National Institute on Aging) ;
Nalls, M.A. (Data Tecnica International) ;
Robak, L. (Jan and Dan Duncan Neurological Research Institute. Texas Children's Hospital) ;
Lubbe, S. (Ken and Ruth Davee Department of Neurology. Northwestern University Feinberg School of Medicine) ;
Finkbeiner, S. (Taube/Koret Center for Neurodegenerative Disease Research) ;
Mencacci, N.E. (Northwestern University Feinberg School of Medicine) ;
Lungu, C. (National Institutes of Health Division of Clinical Research. NINDS. National Institutes of Health) ;
Singleton, A. B. (Laboratory of Neurogenetics. National Institute on Aging) ;
Scholz, S.W. (Neurodegenerative Diseases Research Unit. National Institute of Neurological Disorders and Stroke) ;
Reed, X. (Laboratory of Neurogenetics. National Institute on Aging) ;
Alcalay, Roy N (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. College of Physicians and Surgeons. Columbia University Medical Center) ;
Gan-Or, Z. (Montreal Neurological Institute and Hospital. Department of Neurology & Neurosurgery. Department of Human Genetics. McGill University) ;
Rouleau, G.A. (Montreal Neurological Institute and Hospital. Department of Neurology & Neurosurgery. Department of Human Genetics. McGill University) ;
Krohn, L. (Montreal Neurological Institute and Hospital. Department of Neurology & Neurosurgery. Department of Human Genetics. McGill University) ;
van Hilten, J.J. (Department of Neurology. Leiden University Medical Center) ;
Marinus, J. (Department of Neurology. Leiden University Medical Center) ;
Adarmes-Gómez, A.D (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Aguilar Barberà, Miquel (Fundació Docència I Recerca Mútua de Terrassa and Movement Disorders Unit. Department of Neurology. University Hospital Mutua de Terrassa) ;
Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Alvarez, V. (Hospital Universitario Central de Asturias) ;
Barrero, F. J (Hospital Universitario San Cecilio de Granada. Universidad de Granada) ;
Yarza, J.A.B. (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Bernal-Bernal, I. (Hospital Clínic i Provincial de Barcelona) ;
Blazquez, M. (Hospital Universitario Central de Asturias) ;
Bonilla-Toribio, Marta (Hospital Clínic i Provincial de Barcelona) ;
Botía, J. (Universidad de Murcia. Departamento de Ingeniería de la Información y las Comunicaciones) ;
Boungiorno, M.T. (Fundació Docència I Recerca Mútua de Terrassa and Movement Disorders Unit. Department of Neurology. University Hospital Mutua de Terrassa) ;
Buiza-Rueda, Dolores (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Cámara, A. (Hospital Clínic i Provincial de Barcelona) ;
Carrillo, F. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Carrión-Claro, M. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Cerdan, D. (Hospital General de Segovia) ;
Clarimón, Jordi (Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas) ;
Compta, Yaroslau (Hospital Clínic i Provincial de Barcelona) ;
Diez-Fairen, M. (Fundació Docència I Recerca Mútua de Terrassa and Movement Disorders Unit. Department of Neurology. University Hospital Mutua de Terrassa) ;
Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ;
Duarte, J. (Hospital General de Segovia) ;
Duran, R. (Centro de Investigacion Biomedica. Universidad de Granada) ;
Escamilla-Sevilla, F. (Instituto de Investigación Sanitaria de Granada) ;
Ezquerra, M. (Hospital Clínic i Provincial de Barcelona) ;
Feliz, C. (Hospital Universitario Marqués de Valdecilla-IDIVALS. Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
Fernández, M. (Hospital Clínic i Provincial de Barcelona) ;
Fernández-Santiago, R. (Hospital Clínic i Provincial de Barcelona) ;
Garcia, C. (Hospital Universitario Central de Asturias) ;
García-Ruiz, P. (Hospital Universitario Marqués de Valdecilla-IDIVALS. Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
Gómez-Garre, P. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Heredia, M.J.G. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Gonzalez-Aramburu, I. (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Pagola, A.G. (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Hoenicka, J. (Institut de Recerca Sant Joan de Déu) ;
Infante, J. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Jesús, S. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Jimenez-Escrig, A. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Labrador-Espinosa, M.A. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Lopez-Sendon, J.L. (Hospital Universitario Ramón y Cajal (Madrid)) ;
de Munain Arregui, A.L. (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Macias, D. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Torres, I.M. (Hospital Universitari i Politècnic La Fe de València) ;
Marín, J. (Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas) ;
Marti, M.J. (Hospital Clínic i Provincial de Barcelona) ;
Martínez-Castrillo, J.C. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Méndez-del-Barrio, C. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
González, M.M. (Hospital Universitario Central de Asturias) ;
Mata, M. (Department of Neurology. Hospital Universitario Infanta Sofía) ;
Mínguez, A. (Instituto de Investigación Sanitaria de Granada) ;
Mir, P. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Rezola, E.M. (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Muñoz, E. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Pastor, P. (Fundació Docència I Recerca Mútua de Terrassa and Movement Disorders Unit. Department of Neurology. University Hospital Mutua de Terrassa) ;
Errazquin, F.P. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Periñán-Tocino, T. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Ruiz-Martínez, J. (Hospital Universitario Donostia. Instituto de Investigación Sanitaria Biodonostia) ;
Ruz, C. (Centro de Investigacion Biomedica. Universidad de Granada) ;
Rodriguez, A.S. (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Sierra, M. (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Suarez-Sanmartin, E. (Hospital Universitario Central de Asturias) ;
Tabernero, C. (Hospital General de Segovia) ;
Tartari, J. P. (Fundació Docència i Recerca Mútua de Terrassa and Movement Disorders Unit. Department of Neurology. University Hospital Mutua de Terrassa) ;
Tejera-Parrado, C. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Tolosa, E. (Hospital Clínic i Provincial de Barcelona) ;
Valldeoriola, F. (Hospital Clínic i Provincial de Barcelona) ;
Vargas-González, L. (Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ;
Vela, L. (Hospital Universitario Fundación Alcorcón) ;
Vives, F. (Centro de Investigacion Biomedica. Universidad de Granada) ;
Zimprich, Alexander (Department of Neurology. Medical University of Vienna) ;
Pihlstrom, L. (Oslo University Hospital (Oslo, Noruega)) ;
Toft, M. (Oslo University Hospital (Oslo, Noruega)) ;
Koks, S. (Department of Reproductive Biology. Estonian University of Life Sciences) ;
Taba, P. (Department of Neurology and Neurosurgery. University of Tartu) ;
Hassin-Baer, S. (Sackler Faculty of Medicine. Tel Aviv University) ;
Hardy, J. (Institute for Advanced Study. The Hong Kong University of Science and Technology. The Hong Kong University of Science and Technology) ;
Houlden, H. (Department of Neuromuscular Disease. Queen Square Institute of Neurology. UCL) ;
Gagliano Taliun, S. A. (Montréal Heart Institute) ;
Botía, J. (Universidad de Murcia. Departamento de Ingeniería de la Información y las Comunicaciones) ;
Ryten, M. (Department of Genetics and Genomic Medicine. Great Ormond Street Institute of Child Health. University College London) ;
Universitat Autònoma de Barcelona
Knowledge of genomic features specific to the human lineage may provide insights into brain-related diseases. We leverage high-depth whole genome sequencing data to generate a combined annotation identifying regions simultaneously depleted for genetic variation (constrained regions) and poorly conserved across primates. [...]
2021 - 10.1038/s41467-021-22262-5
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 2076
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12 p, 2.0 MB |
A multicentre validation study of the diagnostic value of plasma neurofilament light
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Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation) ;
Janelidze, Shorena (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ;
Al Khleifat, Ahmad (Department of Basic and Clinical Neuroscience. Maurice Wohl Clinical Neuroscience Institute. King's College London) ;
Leuzy, Antoine (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ;
van der Ende, Emma L. (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ;
Karikari, Thomas K (Department of Psychiatry and Neurochemistry. Institute of Neuroscience & Physiology. The Sahlgrenska Academy at the University of Gothenburg) ;
Benedet, AndreaL. (Montreal Neurological Institute) ;
Pascoal, Tharick A. (Montreal Neurological Institute) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Parnetti, Lucilla (Laboratory of Clinical Neurochemistry. Neurology Clinic. University of Perugia) ;
Galimberti, Daniela (University of Milan) ;
Bonanni, Laura (Department of Neuroscience. Imaging and Clinical Sciences. University G.d'Annunzio of Chieti-Pescara) ;
Pilotto, Andrea (Parkinson's Disease Rehabilitation Centre. FERB ONLUS) ;
Padovani, Alessandro (Neurology Unit. Department of Clinical and Experimental Sciences. University of Brescia) ;
Lycke, Jan (Sahlgrenska University Hospital (Suècia)) ;
Novakova, Lenka (Sahlgrenska University Hospital (Suècia)) ;
Axelsson, Markus (Sahlgrenska University Hospital (Suècia)) ;
Velayudhan, Latha (Department of Health Sciences. University of Leicester) ;
Rabinovici, Gil D. (Department of Radiology & Biomedical Imaging. University of California) ;
Miller, Bruce (Department of Neurology. University of California San Francisco. Memory and Aging Center) ;
Pariante, Carmine (Stress. Psychiatry and Immunology Lab & Perinatal Psychiatry. Maurice Wohl Clinical Neuroscience Institute. King's College London) ;
Nikkheslat, Naghmeh (Stress. Psychiatry and Immunology Lab & Perinatal Psychiatry. Maurice Wohl Clinical Neuroscience Institute. King's College London) ;
Resnick, Susan M. (Brain Aging and Behavior Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ;
Thambisetty, Madhav (Clinical and Translational Neuroscience Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ;
Schöll, Michael (Department of Neurodegenerative Disease. Queen Square Institute of Neurology. University College London) ;
Fernández-Eulate, Gorka (Department of Neurology. Donostia University Hospital. Osakidetza) ;
Gil-Bea, Francisco J. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
López de Munain, Adolfo (Universidad del País Vasco. Departamento de Neurociencias) ;
Al-Chalabi, Ammar (King's College Hospital. Department of Neurology) ;
Rosa-Neto, Pedro (Montreal Neurological Institute) ;
Strydom, Andre (London Down Syndrome Consortium (LonDowns)) ;
Svenningsson, Per (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Stomrud, Erik (Skåne University Hospital (Suècia)) ;
Santillo, Alexander (Lund University. Department of Clinical Sciences Malmö) ;
Aarsland, Dag (Stavanger University Hospital) ;
van Swieten, John C. (Erasmus University Medical Center) ;
Palmqvist, Sebastian (Lund University. Skåne University Hospital) ;
Zetterberg, Henrik (University College London. UK Dementia Research Institute) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Hye, Abdul (Stavanger University Hospital) ;
Hansson, Oskar (Skåne University Hospital (Suècia))
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). [...]
2021 - 10.1038/s41467-021-23620-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 3400
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11 p, 4.1 MB |
The evolution of hematopoietic cells under cancer therapy
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Pich, Oriol (Institut de Recerca Biomèdica) ;
Cortes-Bullich, A. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Muiños, Ferran (Institut de Recerca Biomèdica) ;
Pratcorona, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Gonzalez-Perez, A. (Universitat Pompeu Fabra) ;
Lopez-Bigas, N. (Institució Catalana de Recerca i Estudis Avançats)
Chemotherapies may increase mutagenesis of healthy cells and change the selective pressures in tissues, thus influencing their evolution. However, their contributions to the mutation burden and clonal expansions of healthy somatic tissues are not clear. [...]
2021 - 10.1038/s41467-021-24858-3
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 4803
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