UAB Digital Repository of Documents 138 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
1.
14 p, 6.4 MB ATR is required to complete meiotic recombination in mice / Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rojas, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fuentes-Lazaro, Judit (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Fernández-Capetillo, Oscar (Centro Nacional de Investigaciones Oncológicas.) ; Garcia-Caldés, Montserrat (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). [...]
2018 - 10.1038/s41467-018-04851-z
Nature Communications, Vol. 9 (2018) , art. 2622  
2.
13 p, 1.1 MB Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity / Sant'Anna, Ricardo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gallego Alonso, Pablo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Robinson, Lei Z. (Scripps Research Institute) ; Pereira-Henriques, Alda (Instituto de Ciências Biomédicas de Abel Salazar) ; Ferreira, Nelson (Instituto de Ciências Biomédicas de Abel Salazar) ; Pinheiro, Francisca (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Esperante, Sebastián (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Huertas, Oscar (SOM-Biotech) ; Almeida, Maria Rosário (Instituto de Ciências Biomédicas de Abel Salazar) ; Reixach, Natàlia (Scripps Research Institute) ; Insa, Raul (SOM-Biotech) ; Velazquez-Campoy, Adrián (Universidad de Zaragoza. Departamento de Bioquímica y Biología Celular y Molecular) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Reig, Núria (SOM-Biotech) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. [...]
2016 - 10.1038/ncomms10787
Nature Communications, Vol. 7 (2016) , art. 10787  
3.
12 p, 7.0 MB ATR is a multifunctional regulator of male mouse meiosis / Widger, Alexander (The Francis Crick Institute) ; Mahadevaiah, Shantha K. (Francis Crick Institute) ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Elinati, Elias (The Francis Crick Institute) ; Zohren, Jasmin (The Francis Crick Institute) ; Hirota, Takayuki (The Francis Crick Institute) ; Pacheco Piñol, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Stanzione, Marcello (TU Dresden. Faculty of Medicine) ; Ojarikre, Obah (The Francis Crick Institute) ; Maciulyte, Valdone (The Francis Crick Institute) ; De Rooij, Dirk G. (University of Amsterdam. Center for Reproductive Medicine) ; Tóth, Attila (TU Dresden. Faculty of Medicine) ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Turner, James M.A. (Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. [...]
2018 - 10.1038/s41467-018-04850-0
Nature Communications, Vol. 9 (2018) , art. 2621  
4.
13 p, 2.3 MB A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25 / Liu, Bing (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sureda-Gómez, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Zhen, Yang (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amador, Virginia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
USP25 deubiquitinating enzyme is a key member of the ubiquitin system, which acts as a positive regulator of the Wnt/β-catenin signaling by promoting the deubiquitination and stabilization of tankyrases. [...]
2018 - 10.1038/s41467-018-07510-5
Nature Communications, Vol. 9 (2018) , art. 4973  
5.
11 p, 3.5 MB Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors / Aparicio Alarcón, David (Institut de Biologia Molecular de Barcelona) ; Torres Puig, Sergi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ratera, Mercè (Institut de Biologia Molecular de Barcelona) ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Quijada Pich, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fita Rodríguez, Ignasi (Institut de Biologia Molecular de Barcelona)
Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the cell membrane. [...]
2018 - 10.1038/s41467-018-06963-y
Nature Communications, Vol. 9 (2018) , art. 4471  
6.
13 p, 6.6 MB Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination / Abreu, Carla M. (Memorial Sloan Kettering Cancer Center) ; Prakash, Rohit (Memorial Sloan Kettering Cancer Center) ; Romanienko, Peter J. (Rutgers-Cancer Institute of New Jersey) ; Roig, I. (Ignasi) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. [...]
2018 - 10.1038/s41467-018-06384-x
Nature Communications, Vol. 9 (2018) , art. 3961  
7.
12 p, 1.7 MB Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization / Haq, Tamanna (University of Leicester. Department of Biochemistry) ; Richards, Mark W. (University of Leicester. Department of Biochemistry) ; Burgess, Selena G. (University of Leicester. Department of Biochemistry) ; Gallego Alonso, Pablo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yeoh, Sharon (University of Leicester. Department of Biochemistry) ; O'Regan, Laura (University of Leicester. Department of Biochemistry) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Roig, Joan (Institut de Recerca Biomèdica) ; Fry, Andrew M. (University of Leicester. Department of Biochemistry) ; Bayliss, Richard (Cancer Research UK Leicester Centre)
Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by the Nek9 non-catalytic C-terminal domain (CTD). [...]
2015 - 10.1038/ncomms9771
Nature Communications, Vol. 6 (2015) , art. 8771  
8.
5 p, 788.2 KB Great ape genetic diversity and population history / Prado-Martinez, J. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Sudmant, P.H. (Department of Genome Sciences. University of Washington) ; Kidd, J.M. (Department of Genetics. Stanford University) ; Li, H. (Department of Genetics. Harvard Medical School, Boston) ; Kelley, J.L. (Department of Genetics. Stanford University) ; Lorente-Galdos, B. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Veeramah, K.R. (Arizona Research Laboratories. Division of Biotechnology. University of Arizona) ; Woerner, A.E. (Arizona Research Laboratories. Division of Biotechnology. University of Arizona) ; O'Connor, T.D. (Department of Genome Sciences. University of Washington) ; Santpere, G. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Cagan, A. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology) ; Theunert, C. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology) ; Casals, F. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Laayouni, H. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Munch, K. (Bioinformatics Research Centre. Aarhus University) ; Hobolth, A. (Bioinformatics Research Centre. Aarhus University) ; Halager, A.E. (Bioinformatics Research Centre. Aarhus University) ; Malig, M. (Department of Genome Sciences. University of Washington) ; Hernandez-Rodriguez, J. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Hernando-Herraez, I. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Prüfer, K. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology) ; Pybus, M. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Johnstone, L. (Arizona Research Laboratories. Division of Biotechnology. University of Arizona) ; Lachmann, M. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology) ; Alkan, C. (Bilkent University. Faculty of Engineering) ; Twigg, D. (Department of Human Genetics. University of Michigan) ; Petit, N. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Baker, C. (Department of Genome Sciences. University of Washington) ; Hormozdiari, F. (Department of Genome Sciences. University of Washington) ; Fernandez-Callejo, M. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Dabad, M. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Wilson, M.L. (Department of Anthropology. University of Minnesota) ; Stevison, L. (Institute for Human Genetics. University of California San Francisco) ; Camprubí Sánchez, Cristina (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, Fisiologia i Immunologia) ; Carvalho, T. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Ruiz-Herrera Moreno, Aurora (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Vives, L. (Department of Genome Sciences. University of Washington) ; Mele, M. (Centre for Genomic Regulation (CRG)) ; Abello, T. (Parc Zoològic de Barcelona) ; Kondova, I. (Biomedical Primate Research Centre) ; Bontrop, R.E. (Biomedical Primate Research Centre) ; Pusey, A. (Department of Evolutionary Anthropology. Duke University) ; Lankester, F. (Paul G. Allen School for Global Animal Health. Washington State University) ; Kiyang, J.A. (Limbe Wildlife Centre) ; Bergl, R.A. (North Carolina Zoological Park) ; Lonsdorf, E. (Department of Psychology. Franklin and Marshall College) ; Myers, S. (Department of Statistics. Oxford University) ; Ventura, M. (Department of Genetics and Microbiology. University of Bari) ; Gagneux, P. (Department of Cellular and Molecular Medicine. University of California San Diego) ; Comas, D. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Siegismund, H. (Department of Biology, Bioinformatics. University of Copenhagen) ; Blanc, J. (Centro Nacional de Análisis Genómico (CNAG). PCB) ; Agueda-Calpena, L. (Centro Nacional de Análisis Genómico (CNAG). PCB) ; Gut, M. (Centro Nacional de Análisis Genómico (CNAG). PCB) ; Fulton, L. (Genome Sequencing Center. Washington University School of Medicine) ; Tishkoff, S.A. (Department of Biology and Genetics. University of Pennsylvania) ; Mullikin, J.C. (National Institutes of Health Intramural Sequencing Center (NISC)) ; Wilson, R.K. (Genome Sequencing Center. Washington University School of Medicine) ; Gut, I.G. (Centro Nacional de Análisis Genómico (CNAG). PCB) ; Gonder, M.K. (Biological Sciences. University at Albany. State University of New York) ; Ryder, O.A. (Genetics Division. San Diego Zoo's Institute for Conservation Research) ; Hahn, B.H. (Departments of Medicine and Microbiology. Perelman School of Medicine. University of Pennsylvania) ; Navarro, A. (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Akey, J.M. (Department of Genome Sciences. University of Washington) ; Bertranpetit, J. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB) ; Reich, D. (Department of Genetics. Harvard Medical School, Boston) ; Mailund, T. (Bioinformatics Research Centre. Aarhus University) ; Schierup, M.H. (Department of Bioscience. Aarhus University) ; Hvilsom, C. (Copenhagen Zoo) ; Andrés, A.M. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology) ; Wall, J.D. (Institute for Human Genetics. University of California San Francisco) ; Bustamante, C.D. (Department of Genetics. Stanford University) ; Hammer, M.F. (Arizona Research Laboratories. Division of Biotechnology. University of Arizona) ; Eichler, E.E. (Howard Hughes Medical Institute) ; Marques-Bonet, T. (Institució Catalana de Recerca i Estudis Avançats (ICREA))
Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88. [...]
2013 - 10.1038/nature12228
Nature, Vol. 499, issue 7459 (July 2013) , p. 471-475  
9.
6 p, 807.2 KB The Drosophila melanogaster Genetic Reference Panel / MacKay, T.F.C. (Department of Genetics. North Carolina State University) ; Richards, S. (Human Genome Sequencing Center. Baylor College of Medicine) ; Stone, E.A. (Department of Genetics. North Carolina State University) ; Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i Microbiologia) ; Ayroles, J.F. (FAS Society of Fellows. Harvard University) ; Zhu, D. (Human Genome Sequencing Center. Baylor College of Medicine) ; Casillas Viladerrams, Sònia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasi") ; Han, Y. (Human Genome Sequencing Center. Baylor College of Medicine) ; Magwire, M.M. (Department of Genetics. North Carolina State University) ; Cridland, J.M. (Department of Ecology and Evolutionary Biology. University of California-Irvine) ; Richardson, M.F. (Faculty of Life Sciences. University of Manchester) ; Anholt, R.R.H. (Department of Biology. North Carolina State University) ; Barrón, Maite G. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasi") ; Bess, C. (Human Genome Sequencing Center. Baylor College of Medicine) ; Blankenburg, K.P. (Human Genome Sequencing Center. Baylor College of Medicine) ; Carbone, M.A. (Department of Genetics. North Carolina State University) ; Castellano Esteve, David (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Chaboub, L. (Human Genome Sequencing Center. Baylor College of Medicine) ; Duncan, L. (Department of Genetics. North Carolina State University) ; Harris, Z. (Department of Genetics. North Carolina State University) ; Javaid, M. (Human Genome Sequencing Center. Baylor College of Medicine) ; Jayaseelan, J.C. (Human Genome Sequencing Center. Baylor College of Medicine) ; Jhangiani, S.N. (Human Genome Sequencing Center. Baylor College of Medicine) ; Jordan, K.W. (Department of Genetics. North Carolina State University) ; Lara, F. (Human Genome Sequencing Center. Baylor College of Medicine) ; Lawrence, F. (Department of Genetics. North Carolina State University) ; Lee, S.L. (Human Genome Sequencing Center. Baylor College of Medicine) ; Librado, P. (Department of Genetics. Faculty of Biology. Universitat de Barcelona) ; Linheiro, R.S. (Faculty of Life Sciences. University of Manchester) ; Lyman, R.F. (Department of Genetics. North Carolina State University) ; MacKey, A.J. (Center for Public Health Genomics. University of Virginia) ; Munidasa, M. (Human Genome Sequencing Center. Baylor College of Medicine) ; Muzny, D.M. (Human Genome Sequencing Center. Baylor College of Medicine) ; Nazareth, L. (Human Genome Sequencing Center. Baylor College of Medicine) ; Newsham, I. (Human Genome Sequencing Center. Baylor College of Medicine) ; Perales, L. (Human Genome Sequencing Center. Baylor College of Medicine) ; Pu, L.L. (Human Genome Sequencing Center. Baylor College of Medicine) ; Qu, C. (Human Genome Sequencing Center. Baylor College of Medicine) ; Ràmia Jesús, Miquel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Reid, J.G. (Human Genome Sequencing Center. Baylor College of Medicine) ; Rollmann, S.M. (Department of Biological Sciences. University of Cincinnati) ; Rozas, J. (Department of Genetics. Faculty of Biology. Universitat de Barcelona) ; Saada, N. (Human Genome Sequencing Center. Baylor College of Medicine) ; Turlapati, L. (Department of Genetics. North Carolina State University) ; Worley, K.C. (Human Genome Sequencing Center. Baylor College of Medicine) ; Wu, Y.Q. (Human Genome Sequencing Center. Baylor College of Medicine) ; Yamamoto, A. (Department of Genetics. North Carolina State University) ; Zhu, Y. (Human Genome Sequencing Center. Baylor College of Medicine) ; Bergman, C.M. (Faculty of Life Sciences. University of Manchester) ; Thornton, K.R. (Department of Ecology and Evolutionary Biology. University of California-Irvine) ; Mittelman, D. (Virginia Bioinformatics Institute. Department of Biological Sciences. Virginia Tech) ; Gibbs, R.A. (Human Genome Sequencing Center. Baylor College of Medicine)
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. [...]
2012 - 10.1038/nature10811
Nature, Vol. 482, issue 7384 (Feb. 2012) , p. 173-178  
10.
4 p, 549.7 KB A barrier to spin filters / Valenzuela, Sergio O. (Institut Català de Nanociència i Nanotecnologia) ; Roche, Stephan (Institut Català de Nanociència i Nanotecnologia)
Electron tunnelling through a two-dimensional magnetic insulator is assisted by magnon inelastic processes that provide spin-filtering.
2018 - 10.1038/s41928-018-0089-x
Nature electronics, Vol. 1, Núm. 6 (June 2018) , p. 328-329  

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