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1.
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8 p, 1.0 MB |
Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species
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Oliveira, Francisco (University of Coimbra) ;
Leuzy, Antoine (Karolinska Institutet (Estocolm, Suècia)) ;
Castelhano, Joäo (University of Coimbra) ;
Chiotis, Konstantinos (Karolinska Institutet (Estocolm, Suècia)) ;
Hasselbalch, Steen Gregers (University of Copenhagen) ;
Rinne, Juha (University of Turku) ;
Mendonça, Alexandre (University of Lisbon) ;
Otto, Markus (University of Ulm) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Santana, Isabel (University of Coimbra) ;
Johansson, Jarkko (Turku University Hospital (Finlàndia)) ;
Anderl-Straub, Sarah (University of Ulm) ;
Arnim, Christine (University of Ulm) ;
Beer, Ambros (Ulleval University Hospital (Norway)) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Sanna-Kaisa, Herukka (University of Eastern Finland and Kuopio University Hospital) ;
Portelius, Erik (Sahlgrenska University Hospital (Suècia)) ;
Pannee, Josef (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik. (UK Dementia Research Institute) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Moreira, Ana P. (University of Coimbra) ;
Abrunhosa, Antero (University of Coimbra) ;
Nordberg, Agneta (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Castelo-Branco, Miguel (University of Coimbra) ;
Universitat Autònoma de Barcelona
Positron emission tomography (PET) neuroimaging with the Pittsburgh Compound_B (PiB) is widely used to assess amyloid plaque burden. Standard quantification approaches normalize PiB-PET by mean cerebellar gray matter uptake. [...]
2018 -  10.1016/j.nicl.2018.08.023
NeuroImage, Vol. 20 (january 2018) , p. 603-610
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2.
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9 p, 1.3 MB |
Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations
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Perez-Rando, Marta (Institute of Research of the Clinic Hospital from Valencia) ;
Elvira, Uriel K.A. (University of La Laguna) ;
García-Martí, Gracian (Quironsalud Hospital) ;
Gadea, Marien (Universitat de València) ;
Aguilar, Eduardo J. (Universitat de València) ;
Escarti, Maria J (Universitat de València) ;
Ahulló-Fuster, Mónica Alba (Universidad Complutense de Madrid) ;
Grasa, Eva (Institut d'Investigació Biomèdica Sant Pau) ;
Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau) ;
Sanjuan, Julio (Quironsalud Hospital (València)) ;
Nacher, Juan (Institute of Research of the Clinic Hospital from Valencia) ;
Universitat Autònoma de Barcelona. Departamento de Psiquiatría y Medicina Legal
The thalamus is a subcortical structure formed by different nuclei that relay information to the neocortex. Several reports have already described alterations of this structure in patients of schizophrenia that experience auditory hallucinations. [...]
2022 - 10.1016/j.nicl.2022.103070
NeuroImage, Vol. 35 (june 2022)
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3.
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4.
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8 p, 1.6 MB |
T1/T2-weighted ratio in multiple sclerosis : A longitudinal study with clinical associations
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Boaventura de Oliveira, Mateus (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Vidal, Aran (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quartana, Davide (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carvajal-Junco, René (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Background: T1w/T2-w ratio has been proposed as a clinically feasible MRI biomarker to assess tissue integrity in multiple sclerosis. However, no data is available in the earliest stages of the disease and longitudinal studies analysing clinical associations are scarce. [...]
2022 - 10.1016/j.nicl.2022.102967
NeuroImage, Vol. 34 (2022) , p. 102967
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5.
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12 p, 4.0 MB |
Deciphering multiple sclerosis disability with deep learning attention maps on clinical MRI
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Coll, Llucia (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Oliver, Arnau (Universitat de Girona. Institut de recerca en visió per computador i robòtica (VICOROB)) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Lladó, Xavier (Universitat de Girona. Institut de recerca en visió per computador i robòtica (VICOROB)) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The application of convolutional neural networks (CNNs) to MRI data has emerged as a promising approach to achieving unprecedented levels of accuracy when predicting the course of neurological conditions, including multiple sclerosis, by means of extracting image features not detectable through conventional methods. [...]
2023 - 10.1016/j.nicl.2023.103376
NeuroImage, Vol. 38 (march 2023)
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6.
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8 p, 1.4 MB |
Detection of lesions in the optic nerve with magnetic resonance imaging using a 3D convolutional neural network
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Martí-Juan, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Frías, Marcos (BCN Medtech) ;
Garcia-Vidal, Aran (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Calderon, Willem (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Piella, Gemma (BCN Medtech) ;
Camara, Oscar (BCN Medtech) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Optic neuritis (ON) is one of the first manifestations of multiple sclerosis, a disabling disease with rising prevalence. Detecting optic nerve lesions could be a relevant diagnostic marker in patients with multiple sclerosis. [...]
2022 - 10.1016/j.nicl.2022.103187
NeuroImage, Vol. 36 (september 2022)
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7.
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14 p, 1.0 MB |
MAGNIMS recommendations for harmonization of MRI data in MS multicenter studies
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De Stefano, Nicola (Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy) ;
Battaglini, Marco (University of Siena) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Cortese, Rosa (University of Siena) ;
Zhang, Jian (University of Siena) ;
Oesingmann, Niels (UK Biobank Stockport) ;
Prados Carrasco, Ferran (Universitat Oberta de Catalunya) ;
Rocca, Maria A. (Vita-Salute San Raffaele University) ;
Valsasina, Paola (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Vrenken, Hugo (MS Center Amsterdam) ;
Gandini Wheeler-Kingshott, Claudia A. M. (University of Pavia) ;
Filippi, Massimo (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Barkhof, Frederik (MS Center Amsterdam) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
There is an increasing need of sharing harmonized data from large, cooperative studies as this is essential to develop new diagnostic and prognostic biomarkers. In the field of multiple sclerosis (MS), the issue has become of paramount importance due to the need to translate into the clinical setting some of the most recent MRI achievements. [...]
2022 - 10.1016/j.nicl.2022.102972
NeuroImage, Vol. 34 (february 2022)
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8.
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9 p, 1.6 MB |
Locus coeruleus connectivity alterations in late-life major depressive disorder during a visual oddball task
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del Cerro, Inés (Centro de Investigación Biomédica en Red de Salud Mental) ;
Martínez-Zalacaín, Ignacio (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Guinea-Izquierdo, Andrés (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Gascon-Bayarri, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ;
Viñas-Diez, Vanesa (Institut d'Investigació Biomèdica de Bellvitge) ;
Urretavizcaya, Mikel (Centro de Investigación Biomédica en Red de Salud Mental) ;
Naval-Baudin, Pablo (Institut d'Investigació Biomèdica de Bellvitge) ;
Aguilera, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ;
Reñé-Ramírez, Ramón (Institut d'Investigació Biomèdica de Bellvitge) ;
Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Menchón, José M. (Centro de Investigación Biomédica en Red de Salud Mental) ;
Soria, Virginia (Centro de Investigación Biomédica en Red de Salud Mental) ;
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
The Locus Coeruleus (LC) is the major source of noradrenergic neurotransmission. Structural alterations in the LC have been observed in neurodegenerative disorders and at-risk individuals, although functional connectivity studies between the LC and other brain areas have not been yet performed in these populations. [...]
2020 - 10.1016/j.nicl.2020.102482
NeuroImage, Vol. 28 (october 2020)
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9.
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8 p, 2.0 MB |
Development and evaluation of a manual segmentation protocol for deep grey matter in multiple sclerosis : Towards accelerated semi-automated references
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de Sitter, Alexandra (MS Center Amsterdam) ;
Burggraaff, Jessica (MS Center Amsterdam) ;
Bartel, Fabian (MS Center Amsterdam) ;
Palotai, Miklos (Harvard Medical School) ;
Liu, Yaou (MS Center Amsterdam) ;
Simoes, Jorge (MS Center Amsterdam) ;
Ruggieri, Serena (San Camillo Forlanini Hospital) ;
Schregel, Katharina (University Medical Center Goettingen) ;
Ropele, Stefan (Medical University of Graz) ;
Rocca, Maria A. (San Raffaele Scientific Institute) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Gallo, Antonio (University of Campania "Luigi Vanvitelli", Naples) ;
Schoonheim, Menno M. (Amsterdam UMC) ;
Amann, Michael (University Hospital Basel (Basilea, Suïssa)) ;
Yiannakas, Marios (UCL Institute of Neurology (Regne Unit)) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Wattjes, Mike P. (Hannover Medical School) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Kappos, Ludwig (University Hospital Basel (Basilea, Suïssa)) ;
Filippi, Massimo (Vita-Salute San Raffaele University) ;
Enzinger, Christian (Medical University of Graz) ;
Frederiksen, Jette (Glostrup University Hospital Copenhagen) ;
Uitdehaag, Bernard (MS Center Amsterdam) ;
Guttmann, Charles R. G. (Harvard Medical School) ;
Barkhof, Frederik (Institutes of Neurology & Healthcare Engineering, London) ;
Vrenken, Hugo (Amsterdam UMC) ;
Universitat Autònoma de Barcelona
Deep grey matter (dGM) structures, particularly the thalamus, are clinically relevant in multiple sclerosis (MS). However, segmentation of dGM in MS is challenging; labeled MS-specific reference sets are needed for objective evaluation and training of new methods. [...]
2021 - 10.1016/j.nicl.2021.102659
NeuroImage, Vol. 30 (april 2021)
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10.
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12 p, 3.1 MB |
Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis : A multicenter study
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Burggraaff, Jessica (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Liu, Yao (Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Prieto, Juan C. (Harvard Medical School) ;
Simoes, Jorge (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
de Sitter, Alexandra (Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Ruggieri, Serena (San Camillo Forlanini Hospital) ;
Brouwer, Iman (Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Lissenberg-Witte, Birgit I. (Department of Epidemiology and Biostatistics, Amsterdam UMC, Location VUmc, De Boelelaan 1089a, 1081 HV Amsterdam, the Netherlands) ;
Rocca, Mara A. (Neurology Unit, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milano MI, Italy) ;
Valsasina, Paola (Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, and Neurology Unit, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milano MI, Italy) ;
Ropele, Stefan (Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Gallo, Antonio (Division of Neurology and 3T MRI Research Center, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Viale Abramo Lincoln, 5, 81100 Caserta, CE, Napoli, Italy) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Enzinger, Christian (Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria) ;
Filippi, Massimo (Department of Neurological and Behavioural Sciences, University of Siena, 53100 Siena SI, Italy) ;
De Stefano, Nicola (Department of Neurological and Behavioural Sciences, University of Siena, 53100 Siena SI, Italy) ;
Ciccarelli, Olga (UCL Institute of Neurology (Regne Unit)) ;
Hulst, Hanneke E. (Amsterdam UMC. University Medical Center) ;
Wattjes, Mike P. (Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Carl-Neuberg-Straße, 30625 Hannover, Germany) ;
Barkhof, Frederik (Institutes of Neurology & Healthcare Engineering, UCL, 235 Euston Rd, Bloomsbury, London NW1 2BU, United Kingdom) ;
Uitdehaag, Bernard M. J. (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Vrenken, Hugo (Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Guttmann, Charles R. G. (Harvard Medical School) ;
Universitat Autònoma de Barcelona
Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as fully manual outlining. [...]
2020 - 10.1016/j.nicl.2020.102549
NeuroImage, Vol. 29 (december 2020)
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