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47 p, 1.4 MB |
The benefits of voluntary physical exercise after traumatic brain injury on rat's object recognition memory : A comparison of different temporal schedules
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Amorós-Aguilar, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i Metodologia de les Ciències de la Salut) ;
Portell Cortés, Isabel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Costa Miserachs, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Torras Garcia, Meritxell (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Riubugent-Camps, Èlia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Coll-Andreu, Margalida (Universitat Autònoma de Barcelona. Institut de Neurociències)
Physical exercise can reduce the cognitive decline associated with traumatic brain injury, yet little is known about the optimal administration schedules. Here, different protocols of voluntary wheel running were evaluated for their effects on object recognition memory (ORM), neuroprotection (NeuN+ cells), microglial reactivity (Iba1 staining) and neurogenesis (DCX+ cells) after controlled cortical impact injury (CCI). [...]
2020 -  10.1016/j.expneurol.2020.113178
Experimental Neurology, Vol. 326 (2020)
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10 p, 567.2 KB |
Genotype-Phenotype Correlation in Progressive Supranuclear Palsy Syndromes : Clinical and Radiological Similarities and Specificities
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Ruiz Barrio, Iñigo (Institut d'Investigació Biomèdica Sant Pau) ;
Horta, Andrea (Institut d'Investigació Biomèdica Sant Pau) ;
Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The progressive supranuclear palsy (PSP) syndrome encompasses different entities. PSP disease of sporadic origin is the most frequent presentation, but different genetic mutations can lead either to monogenic variants of PSP disease, or to other conditions with a different pathophysiology that eventually may result in PSP phenotype. [...]
2022 - 10.3389/fneur.2022.861585
Frontiers in neurology, Vol. 13 (26 2022) , p. 861585
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9 p, 474.5 KB |
Clinical and functional characteristics, possible causes, and impact of chronic cough in patients with cerebellar ataxia, neuropathy, and bilateral vestibular areflexia syndrome (CANVAS)
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Palones, Esther (Institut d'Investigació Biomèdica Sant Pau) ;
Curto Sánchez, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Plaza, Vicente (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Gonzalez-Quereda, L (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Segarra Casas, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Querol, Luis (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Bertoletti, Federico (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rodriguez, María José (Institut d'Investigació Biomèdica Sant Pau) ;
Gallano, Pía (Institut d'Investigació Biomèdica Sant Pau) ;
Crespo Lessmann, Astrid (Universitat Autònoma de Barcelona. Departament de Medicina)
Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is an hereditary autosomal recessive disease. Recent studies propose including chronic cough (CC) as a symptom of CANVAS. [...]
2023 - 10.1007/s00415-023-12001-9
Journal of Neurology, 2023
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4 p, 649.0 KB |
Early gray matter volume loss in MAPT H1H1 de Novo PD patients : A possible association with cognitive decline
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Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau) ;
Marín-Lahoz, Juan (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Martinez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic profile. [...]
2018 - 10.3389/fneur.2018.00394
Frontiers in neurology, Vol. 9 Núm. MAY (30 2018) , p. 394
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9 p, 850.8 KB |
Intermittent hypoxia is associated with high hypoxia inducible factor-1α but not high vascular endothelial growth factor cell expression in tumors of cutaneous melanoma patients
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Almendros, Isaac (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez-García, Miguel Ángel (Hospital Universitari i Politècnic La Fe (València)) ;
Campos-Rodríguez, Francisco (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
Riveiro-Falkenbach, Erica (Hospital Universitario 12 de Octubre) ;
Rodríguez-Peralto, José L. (Hospital Universitario 12 de Octubre) ;
Nagore, Eduardo (Fundació Institut Valencià d'Oncologia) ;
Martorell-Calatayud, Antonio (Hospital de Manises (València)) ;
Blasco, Luis Hernández (Univ. Miguel Hernandez) ;
Roca, Jose Bañuls (Univ. Miguel Hernandez) ;
Vives, Eusebi Chiner (Hospital san Juan de Alicante) ;
Sánchez-de-la-Torre, Alicia (Hospital Universitari Arnau de Vilanova i Santa Maria) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Montserrat Canal, José Ma (Hospital Clínic i Provincial de Barcelona) ;
Pérez-Gil, Amalia (Hospital de Valme) ;
Cabriada-Nuño, Valentín (Hospital Universitario Cruces) ;
Cano-Pumarega, Irene (Hospital Universitario de Getafe) ;
Corral-Peñafiel, Jaime (Hospital Universitario S. Pedro Alcántara) ;
Diaz-Cambriles, Trinidad (Hospital 12 de Octubre (Madrid)) ;
Mediano, Olga (CIBER de enfermedades respiratorias) ;
Dalmau-Arias, Joan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Farré, Ramón (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gozal, David (The University of Chicago) ;
Herrera, Elidia Molina (Hospital 12 de octubre) ;
García Martín, Rosa M. (Hospital 12 de octubre) ;
de Jaime, Maria Niveiro (Universidad Miguel Hernandez) ;
Moreno, Sara (Hospital Universitario Arnau de Vilanova) ;
Ilia, Ferran Barbé (Hospital Universitari Arnau de Vilanova i Santa Maria) ;
de la Torre, Manuel Sánchez (Hospital Universitari Arnau de Vilanova i Santa Maria) ;
de Eusebio, Esther (Hospital Universitario de Guadalajara) ;
Landete, Pedro (Instituto de Investigación Hospital Universitario de la Princesa) ;
Gordon, Manuel Moragón (Hospital Universitario) ;
Arias, Eva (Hospital 12 de Octubre (Madrid)) ;
Masa, Fernando (Hospital Universitario S. Pedro Alcántara) ;
Herrada, Carlos González (Hospital Universitario de Getafe) ;
Carrera, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Muñoz Ferrer, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boada, Aram (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fortuna Gutiérrez, Ana Mª (Institut d'Investigació Biomèdica Sant Pau) ;
Mayos, Mercè (Institut d'Investigació Biomèdica Sant Pau) ;
García, Jesús Gardeazabal (Hospital Universitario Cruces) ;
Universitat Autònoma de Barcelona
Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in the tumor and altered immune functions via intermittent hypoxia (IH). [...]
2018 - 10.3389/fneur.2018.00272
Frontiers in neurology, Vol. 9 Núm. APR (26 2018) , p. 272
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7 p, 817.8 KB |
Hepatitis B reactivation is a rare event among patients with resolved infection undergoing anti-CD20 antibodies in monotherapy without antiviral prophylaxis : results from the HEBEM study
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Marzo Escartin, Blanca (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Robles-Sanchez, Miguel-Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina)
INTRODUCTION: Prospective data on the risk of hepatitis B reactivation (HBVr) among patients with resolved HBV infection undergoing anti-CD20 antibodies monotherapy is scarce. We aimed to assess the risk of HBVr in patients with resolved HBV infection treated with rituximab or ocrelizumab in monotherapy for multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) without antiviral prophylaxis. [...]
D. Steinkopff-Verlag, 2023 - 10.1007/s00415-023-11973-y
Journal of Neurology, Vol. 271 (2024) p. 134-140
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8 p, 391.2 KB |
Comparison of the Results of a Parkinson's Holter Monitor With Patient Diaries, in Real Conditions of Use : A Sub-analysis of the MoMoPa-EC Clinical Trial
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Pérez-López, Carlos (Consorci Sanitari de l'Alt Penedès i Garraf. Department of Investigation) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Caballol, Nuria (Hospital Quirón-Teknon. Unitat de Parkinson i Trastorns del moviment) ;
Bayés, Àngels (Hospital Quirón-Teknon. Unitat de Parkinson i Trastorns del moviment) ;
Buongiorno, María Teresa (Hospital Universitari Mútua Terrassa. Servei de Neurologia) ;
Lopez-Ariztegui, Núria (Hospital Universitario de Toledo. Servicio de Neurología) ;
Gironell, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
López-Sánchez, José (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Martínez-Castrillo, Juan Carlos (Hospital Ramón y Cajal. Unidad de Trastornos del Movimiento y Enfermedades Neurodegenerativas. IRYCIS) ;
Alvarez Sauco M. (Hospital General de Elche. Servicio de Neurología) ;
López-Manzanares, Lydia (Hospital Universitario de la Princesa. Servicio de Neurología) ;
Escalante-Arroyo, Sonia (Hospital de Tortosa Verge de la Cinta. Servicio de Neurología) ;
Pérez-Martínez, David A. (Hospital Universitario 12 de Octubre. Servicio de Neurología) ;
Rodríguez-Molinero, Alejandro (Consorci Sanitari de l'Alt Penedès i Garraf) ;
Universitat Autònoma de Barcelona
Background: For specialists in charge of Parkinson's disease (PD), one of the most time-consuming tasks of the consultations is the assessment of symptoms and motor fluctuations. This task is complex and is usually based on the information provided by the patients themselves, which in most cases is complex and biased. [...]
2022 - 10.3389/fneur.2022.835249
Frontiers in neurology, Vol. 13 (May 2022) , p. 835249
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16 p, 329.8 KB |
Impact of Neuromyelitis Optica Spectrum Disorder on Quality of Life from the Patients' Perspective : An Observational Cross-Sectional Study
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Meca-Lallana, José E. (Hospital Universitario Virgen de la Arrixaca. Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca. Unidad de Neuroinmunología Clínica y Esclerosis Múltiple CSUR. Servicio de Neurología) ;
Gómez-Ballesteros, Rocío (Medical Department. Roche Farma) ;
Pérez-Miralles, Francisco (Hospital Universitari i Politècnic La Fe (València)) ;
Forero, Lucía (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Sepúlveda, María (Hospital Clínic i Provincial de Barcelona) ;
Calles, Carmen (Hospital Universitario Son Espases. Servicio de Neurología) ;
Martínez-Ginés, María L. (Hospital General Universitario Gregorio Marañón) ;
González-Suárez, Inés (Hospital Universitario Álvaro Cunqueiro. Servicio de Neurología) ;
Boyero, Sabas (Hospital de Cruces (Barakaldo). Servicio de Neurología) ;
Romero-Pinel, Lucía (Hospital Universitari de Bellvitge) ;
Sempere, Ángel P. (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Meca-Lallana, Virginia (Department of Neurology. Hospital Universitario La Princesa) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid)) ;
Prefasi, Daniel (Medical Department. Roche Farma) ;
Maurino, Jorge (Medical Department. Roche Farma)
Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is associated with a reduced health-related quality of life (HRQoL). The purpose of this study was to describe the impact of NMOSD on HRQoL from the patients' perspective and its relationship with other disease factors. [...]
2022 - 10.1007/s40120-022-00356-6
Neurology and Therapy, Vol. 11 Núm. 3 (september 2022) , p. 1101-1116
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10 p, 1.7 MB |
Assessing the Relationship of Patient Reported Outcome Measures With Functional Status in Dysferlinopathy : A Rasch Analysis Approach
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Mayhew, Anna G. (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
James, Meredith K. (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Moore, Ursula (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Sutherland, Helen (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Jacobs, Marni (Pediatrics. Epidemiology and Biostatistics. George Washington University) ;
Feng, Jia (Center for Translational Science. Division of Biostatistics and Study Methodology. Children's National Health System) ;
Lowes, Linda Pax (The Abigail Wexner Research Institute at Nationwide Children's Hospital) ;
Alfano, Lindsay N. (The Abigail Wexner Research Institute at Nationwide Children's Hospital) ;
Muni Lofra, Robert (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Rufibach, Laura E. (The Jain Foundation) ;
Rose, Kristy (The Children's Hospital at Westmead. The University of Sydney) ;
Duong, Tina (Lucile Salter Packard Children's Hospital at Stanford. Neurology) ;
Bello, Luca (Department of Neuroscience. University of Padova) ;
Pedrosa-Hernández, Irene (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Holsten, S. (Neuroscience Institute. Carolinas Neuromuscular/ALS-MDA Center. Carolinas HealthCare System) ;
Sakamoto, C. (Department of Physical Rehabilitation. National Center Hospital. National Center of Neurology and Psychiatry Tokyo) ;
Canal, Aurélie (Institut de Myologie. AP-HP. GH Pitié-Salpêtrière) ;
Sánchez-Aguilera Práxedes, N. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Thiele, S. (Department of Neurology. Friedrich-Baur-Institute. Ludwig-Maximilians-University of Munich) ;
Siener, C. (Department of Neurology. Washington University School of Medicine) ;
Vandevelde, B. (Service des Maladies Neuromusculaire et de la SLA. Hôpital de La Timone) ;
DeWolf, Brittney (Cooperative International Neuromuscular Research Group. Children's National Health System) ;
Maron, E. (ELAN-PHYSIO. Praxis für Physiotherapie Maron) ;
Gordish-Dressman, H. (Pediatrics. Epidemiology and Biostatistics. George Washington University) ;
Hilsden, H. (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Guglieri, M. (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Hogrel, J.Y. (Institut de Myologie. AP-HP. GH Pitié-Salpêtrière) ;
Blamire, Andrew (Magnetic Resonance Centre. Institute for Cellular Medicine. Newcastle University) ;
Carlier, Pierre G. (Pitié-Salpêtrière University Hospital) ;
Spuler, S. (Charite Muscle Research Unit. Experimental and Clinical Research Center. A Joint Cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine) ;
Day, John W. (Stanford University School of Medicine) ;
Jones, K.J. (The Children's Hospital at Westmead. The University of Sydney) ;
Bharucha-Goebel, Diana (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Salort-Campana, E. (Service des Maladies Neuromusculaire et de la SLA. Hôpital de La Timone) ;
Pestronk, Alan (Washington University School of Medicine) ;
Walter, M.C. (Department of Neurology. Friedrich-Baur-Institute. Ludwig-Maximilians-University of Munich) ;
Paradas, C. (Instituto de Biomedicina de Sevilla) ;
Stojkovic, T. (Institut de Myologie. AP-HP. GH Pitié-Salpêtrière) ;
Mori-Yoshimura, Madoka (National Center of Neurology and Psychiatry Tokyo) ;
Bravver, Elena (Neuroscience Institute. Carolinas Neuromuscular/ALS-MDA Center. Carolinas HealthCare System) ;
Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Pegoraro, Elena (University of Padova) ;
Mendell, J. R. (The Abigail Wexner Research Institute at Nationwide Children's Hospital) ;
Jain COS Consortium, None (The Abigail Wexner Research Institute at Nationwide Children's Hospital) ;
Straub, V. (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust)
Dysferlinopathy is a muscular dystrophy with a highly variable functional disease progression in which the relationship of function to some patient reported outcome measures (PROMs) has not been previously reported. [...]
2022 - 10.3389/fneur.2022.828525
Frontiers in neurology, Vol. 13 (october 2022) , p. 828525
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