Dipòsit Digital de Documents de la UAB 26 registres trobats  1 - 10següentfinal  anar al registre: La cerca s'ha fet en 0.02 segons. 
1.
27 p, 1.9 MB Polygenic adaptation of rosette growth in Arabidopsis thaliana / Wieters, Benedict (University of Cologne. Institute of Botany (Germany)) ; Steige, Kim A. (University of Cologne. Institute of Botany (Germany)) ; He, Fei (University of Cologne. Institute of Botany (Germany)) ; Koch, Evan M. (Harvard Medical School. Department of Biomedical Informatics (USA)) ; Ramos-Onsins, Sebastian (Centre de Recerca en Agrigenòmica) ; Gu, Hongya (Peking University. State Key Laboratory for Protein and Plant Gene Research (China)) ; Guo, Ya-Long (Chinese Academy of Sciences. Institute of Botany. State Key Laboratory of Systematic and Evolutionary Botany (China)) ; Sunyaev, Shamil (Harvard Medical School. Department of Biomedical Informatics (USA)) ; de Meaux, Juliette (University of Cologne. Institute of Botany (Germany))
The rate at which plants grow is a major functional trait in plant ecology. However, little is known about its evolution in natural populations. Here, we investigate evolutionary and environmental factors shaping variation in the growth rate of Arabidopsis thaliana. [...]
2021 - 10.1371/journal.pgen.1008748
PLoS Genetics, Vol. 17, Issue 1 (January 2021) , art. e1008748  
2.
25 p, 24.0 MB AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer / Muñoz-Lorente, Miguel A. (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Martínez, Paula (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Tejera, Águeda (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Whittemore, Kurt (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Moisés-Silva, Ana Carolina (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO))
Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as "telomere syndromes", which are provoked by extremely short telomeres owing to germline mutations in telomere genes. [...]
2018 - 10.1371/journal.pgen.1007562
PLoS Genetics, Vol. 14 (august 2018)  
3.
35 p, 2.6 MB Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta) / Brasó-Vives, Marina (Laboratoire de Biométrie et Biologie Évolutive UMR 5558, Université de Lyon, Université Lyon 1, CNRS, Villeurbanne, France) ; Povolotskaya, Inna S. (Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia) ; Hartasánchez, Diego A. (Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Parc de Recerca Biomèdica de Barcelona, Barcelona, Catalonia, Spain) ; Farré, Xavier (Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Parc de Recerca Biomèdica de Barcelona, Barcelona, Catalonia, Spain) ; Fernández Callejo, Marcos (National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain) ; Raveendran, Muthuswamy (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Harris, R. Alan (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Rosene, Douglas L. (Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America) ; Lorente-Galdos, Belen (Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America) ; Navarro, A, 1969- (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Marques-Bonet, Tomas, 1975- (Institut Català de Paleontologia Miquel Crusafont) ; Rogers, Jeffrey (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Juan, David (Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Parc de Recerca Biomèdica de Barcelona, Barcelona, Catalonia, Spain)
The rhesus macaque is an abundant species of Old World monkeys and a valuable model organism for biomedical research due to its close phylogenetic relationship to humans. Copy number variation is one of the main sources of genomic diversity within and between species and a widely recognized cause of inter-individual differences in disease risk. [...]
2020 - 10.1371/journal.pgen.1008742
PLoS Genetics, Vol. 16 (may 2020)  
4.
24 p, 25.7 MB p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes / Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castillo, Helena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845  
5.
28 p, 2.6 MB Functional impact and evolution of a novel human polymorphic inversion that disrupts a gene and creates a fusion transcript / Puig Font, Marta (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castellano Esteve, David (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pantano, Lorena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Giner Delgado, Carla (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Izquierdo, David (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gayà Vidal, Magdalena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lucas Lledó, Jose Ignacio (Universitat de València. Institut Cavanilles de Biologia Evolutiva i Biodiversitat) ; Esko, Tõnu (Estonian Genome Center) ; Terao, Chikashi (Kyoto University Graduate School of Medicine) ; Matsuda, Fumihiko (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Cáceres Aguilar, Mario (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Despite many years of study into inversions, very little is known about their functional consequences, especially in humans. A common hypothesis is that the selective value of inversions stems in part from their effects on nearby genes, although evidence of this in natural populations is almost nonexistent. [...]
2015 - 10.1371/journal.pgen.1005495
PLoS Genetics, Vol. 11, issue 10 (2015) , art. e1005495  
6.
27 p, 21.8 MB The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes / Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017  
7.
31 p, 4.4 MB The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility / Gomez Hernández, Laura (Centro de Investigación del Cáncer) ; Felipe Medina, Natalia (Centro de Investigación del Cáncer) ; Bejarano Condezo, Yazmine (Centro de Investigación del Cáncer) ; Garcia Valiente, Rodrigo (Centro de Investigación del Cáncer) ; Ramos, Isabel (Centro de Investigación del Cáncer) ; Suja, José Ángel (Universidad Autónoma de Madrid. Unidad de Biologia Celular) ; Barbero, José Luis (Centro de Investigaciones Biológicas (Madrid)) ; Roig, I. (Ignasi) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sanchez Martin, Manuel. (Universidad de Salamanca. Departamento de Medicina) ; De Rooij, Dirk G. (Utrecht University. Departent of Biology) ; Llano, Elena (Departamento de Fisiologia y Farmacologia. Universidad de Salamanca) ; Martín Pendas, Alberto (Centro de Investigación del Cáncer)
The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. [...]
2019 - 10.1371/journal.pgen.1008316
PLoS Genetics, Vol. 15, issue 8 (August 2019) , e1008316  
8.
26 p, 3.5 MB A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs / Cho, In-Cheol (Rural Development Administration. National Institute of Animal Science) ; Park, Hee-Bok (Kongju National University. College of Industrial Sciences. Department of Animal Resources Science) ; Ahn, Jin Seop (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ; Han, Sang-Hyun (Jeju National University. Educational Science Research Institute) ; Lee, JaeBong (Chonbuk National University. Korea Zoonosis Research Institute) ; Lim, Hyun-Tae (Gyeongsang National University. College of Agriculture and Life Sciences) ; Yoo, Chae-Kyoung (Gyeongsang National University. Institute of Agriculture and Life Science.) ; Jung, Eun-Ji (Bio-Medical Science Co., Ltd) ; Kim, Dong-Hwan (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ; Sun, Wu-Sheng (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ; Ramayo-Caldas, Yuliaxis (Institut de Recerca i Tecnologia Agroalimentàries) ; Kim, Sang-Geum (Rural Development Administration. National Institute of Animal Science) ; Kang, Yong-Jun (Rural Development Administration. National Institute of Animal Science) ; Kim, YooKyung (Jeju National University. Educational Science Research Institute) ; Shin, Hyun-Sook (Rural Development Administration. National Institute of Animal Science) ; Seong, Pil-Nam (Rural Development Administration. National Institute of Animal Science) ; Hwang, In-Sul (Rural Development Administration. National Institute of Animal Science) ; Park, Beom-Young (Rural Development Administration. National Institute of Animal Science) ; Hwang, Seongsoo (Rural Development Administration. National Institute of Animal Science) ; Lee, Sung-Soo (Rural Development Administration. National Institute of Animal Science) ; Ryu, Youn-Chul (Jeju National University. Division of Biotechnology. SARI) ; Lee, Jun-Heon (Chungnam National University. Division of Animal and Dairy Science) ; Ko, MoonSuck (Rural Development Administration. National Institute of Animal Science) ; Lee, Kichoon (Ohio State University. College of Food Agricultural and Environmental Sciences) ; Andersson, Göran (Swedish University of Agricultural Sciences. Department of Animal Breeding and Genetics) ; Perez-Enciso, Miguel (Centre de Recerca en Agrigenòmica) ; Lee, JeongWoong (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center)
Muscle development and lipid accumulation in muscle critically affect meat quality of livestock. However, the genetic factors underlying myofiber-type specification and intramuscular fat (IMF) accumulation remain to be elucidated. [...]
2019 - 10.1371/journal.pgen.1008279
PLoS Genetics, Vol. 15, Núm. 10 (October 2019) , art. e1008279  
9.
23 p, 2.2 MB Discovery of a new family of relaxases in Firmicutes bacteria / Gayetri Ramachandran, Andrés (Centro de Biología Molecular Severo Ochoa) ; Miguel Arribas, Andrés (Centro de Biología Molecular Severo Ochoa) ; Abia, David (Centro de Biología Molecular Severo Ochoa) ; Singh, Praveen K. (Centro de Biología Molecular Severo Ochoa) ; Crespo, Isidro (ALBA Laboratori de Llum de Sincrotró) ; Gago-Córdoba, César (Centro de Biología Molecular Severo Ochoa) ; Hao, Jian An (Centro de Biología Molecular Severo Ochoa) ; Luque-Ortega, Juan Roman (Centro de Investigaciones Biológicas (Madrid)) ; Alfonso, Carlos (Centro de Investigaciones Biológicas (Madrid)) ; Wu, Ling J. (Newcastle University. Institute for Cell and Molecular Biosciences. Centre for Bacterial Cell Biology) ; Boer, Dirk Roeland (ALBA Laboratori de Llum de Sincrotró) ; Meijer, Wilfried J. J. (Centro de Biología Molecular Severo Ochoa)
Antibiotic resistance is a serious global problem. Antibiotic resistance genes (ARG), which are widespread in environmental bacteria, can be transferred to pathogenic bacteria via horizontal gene transfer (HGT). [...]
2017 - 10.1371/journal.pgen.1006586
PLoS Genetics, Vol. 13, issue 2 (Feb. 2017) , e1006586  
10.
23 p, 4.0 MB MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria / Dalla Rosa, Ilaria (MRC Mill Hill Laboratory, London, United Kingdom) ; Cámara, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Durigon, Romina (MRC Mill Hill Laboratory) ; Moss, Chloe F. (MRC Mill Hill Laboratory) ; Vidoni, Sara (MRC Mitochondrial Biology Unit, Wellcome Trust-MRC Building) ; Akman, Gokhan (MRC Mill Hill Laboratory) ; Hunt, Lilian (MRC Mill Hill Laboratory) ; Johnson, Mark A. (MRC Mitochondrial Biology Unit, Wellcome Trust-MRC Building) ; Grocott, Sarah (Mitochondrial Genetics Group, Nuffield Department of Obstetrics and Gynaecology, Women's Centre, The John Radcliffe Hospital, Oxford, United Kingdom) ; Wang, Liya (Department of Anatomy, Physiology and Biochemistry, The Swedish University of Agricultural Sciences, Biomedical Center) ; Thorburn, David R. (Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics, Royal Children's Hospital) ; Hirano, Michio (Department of Neurology, Columbia University Medical Center, New York, New York, United States of America) ; Poulton, Joanna (Mitochondrial Genetics Group, Nuffield Department of Obstetrics and Gynaecology, Women's Centre, The John Radcliffe Hospital) ; Taylor, Robert W. (Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School, Newcastle upon Tyne) ; Elgar, Greg (MRC Mill Hill Laboratory) ; Martí Seves, Ramon (Biomedical Network Research Centre on Rare Diseases, Instituto de Salud Carlos III) ; Voshol, Peter (Institute of Metabolic Science, University of Cambridge) ; Holt, Ian J. (MRC Mill Hill Laboratory, London) ; Spinazzola, Antonella (MRC Mill Hill Laboratory) ; Universitat Autònoma de Barcelona
MPV17 is a mitochondrial inner membrane protein whose dysfunction causes mitochondrial DNA abnormalities and disease by an unknown mechanism. Perturbations of deoxynucleoside triphosphate (dNTP) pools are a recognized cause of mitochondrial genomic instability; therefore, we determined DNA copy number and dNTP levels in mitochondria of two models of MPV17 deficiency. [...]
2016 - 10.1371/journal.pgen.1005779
PLoS Genetics, Vol. 12 (january 2016)  

Dipòsit Digital de Documents de la UAB : 26 registres trobats   1 - 10següentfinal  anar al registre:
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