Depósito Digital de Documentos de la UAB Encontrados 28 registros  1 - 10siguientefinal  ir al registro: La búsqueda tardó 0.00 segundos. 
1.
16 p, 1003.8 KB Ancient DNA Analysis of 8000 B.C. Near Eastern Farmers Supports an Early Neolithic Pioneer Maritime Colonization of Mainland Europe through Cyprus and the Aegean Islands / Fernández, Eva (Universidad Complutense de Madrid. Laboratorio de Genética Forense y Genética de Poblaciones) ; Pérez-Pérez, Alejandro (Universitat de Barcelona. Departament de Biologia Animal) ; Gamba, Cristina (Universidad Complutense de Madrid. Departamento de Toxicología y Legislación Sanitaria) ; Prats, Eva (Consejo Superior de Investigaciones Científicas (Espanya). Centro de Investigación y Desarrollo) ; Cuesta, Pedro (Universidad Complutense de Madrid. Servicios informáticos) ; Molist, Miquel 1956- (Universitat Autònoma de Barcelona. Departament de Prehistòria) ; Anfruns, Josep (Universitat Autònoma de Barcelona. Departament de Prehistòria) ; Arroyo-Pardo, Eduardo (Universidad Complutense de Madrid. Departamento de Toxicología y Legislación Sanitaria) ; Turbón, Daniel (Universitat de Barcelona. Departament de Biologia Animal)
The genetic impact associated to the Neolithic spread in Europe has been widely debated over the last 20 years. Within this context, ancient DNA studies have provided a more reliable picture by directly analyzing the protagonist populations at different regions in Europe. [...]
2014 - 10.1371/journal.pgen.1004401
PLoS Genetics, Vol. 10 (june 2014)  
2.
21 p, 3.4 MB The DNA damage response is required for oocyte cyst breakdown and follicle formation in mice / Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Huang, Yan (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, Fisiologia i Immunologia) ; Guillot-Ferriols, Maria Teresa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferrer-Roda, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, Fisiologia i Immunologia) ; Guixé, Anna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Garcia-Caldés, Montserrat (Universitat Autònoma de Barcelona. Unitat de Biologia Cel·lular) ; Roig, Ignasi (Universitat Autònoma de Barcelona. , Departament de Biologia Cel.lular, Fisiologia i Immunologia)
Mammalian oogonia proliferate without completing cytokinesis, forming cysts. Within these, oocytes differentiate and initiate meiosis, promoting double-strand break (DSBs) formation, which are repaired by homologous recombination (HR) causing the pairing and synapsis of the homologs. [...]
2020 - 10.1371/journal.pgen.1009067
PLoS Genetics, Vol. 16 (November 2020)  
3.
27 p, 1.9 MB Polygenic adaptation of rosette growth in Arabidopsis thaliana / Wieters, Benedict (University of Cologne. Institute of Botany (Germany)) ; Steige, Kim A. (University of Cologne. Institute of Botany (Germany)) ; He, Fei (University of Cologne. Institute of Botany (Germany)) ; Koch, Evan M. (Harvard Medical School. Department of Biomedical Informatics (USA)) ; Ramos-Onsins, Sebastian (Centre de Recerca en Agrigenòmica) ; Gu, Hongya (Peking University. State Key Laboratory for Protein and Plant Gene Research (China)) ; Guo, Ya-Long (Chinese Academy of Sciences. Institute of Botany. State Key Laboratory of Systematic and Evolutionary Botany (China)) ; Sunyaev, Shamil (Harvard Medical School. Department of Biomedical Informatics (USA)) ; de Meaux, Juliette (University of Cologne. Institute of Botany (Germany))
The rate at which plants grow is a major functional trait in plant ecology. However, little is known about its evolution in natural populations. Here, we investigate evolutionary and environmental factors shaping variation in the growth rate of Arabidopsis thaliana. [...]
2021 - 10.1371/journal.pgen.1008748
PLoS Genetics, Vol. 17, Issue 1 (January 2021) , art. e1008748  
4.
25 p, 24.0 MB AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer / Muñoz-Lorente, Miguel A. (Centro Nacional de Investigaciones Oncológicas) ; Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ; Tejera, Águeda (Centro Nacional de Investigaciones Oncológicas) ; Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ; Moisés-Silva, Ana Carolina (Centro Nacional de Investigaciones Oncológicas) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as "telomere syndromes", which are provoked by extremely short telomeres owing to germline mutations in telomere genes. [...]
2018 - 10.1371/journal.pgen.1007562
PLoS Genetics, Vol. 14 (august 2018)  
5.
35 p, 2.6 MB Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta) / Brasó-Vives, Marina (Laboratoire de Biométrie et Biologie Évolutive UMR 5558, Université de Lyon, Université Lyon 1, CNRS, Villeurbanne, France) ; Povolotskaya, Inna S. (Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia) ; Hartasánchez, Diego A. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Farré, Xavier (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Fernández , Marcos (National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain) ; Raveendran, Muthuswamy (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Harris, R. Alan (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Rosene, Douglas L. (Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America) ; Lorente-Galdos, Belen (Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America) ; Navarro, A, 1975- (Institució Catalana de Recerca i Estudis Avançats) ; Marques-Bonet, Tomas, 1975- (Institut Català de Paleontologia Miquel Crusafont) ; Rogers, Jeffrey (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Juan, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
The rhesus macaque is an abundant species of Old World monkeys and a valuable model organism for biomedical research due to its close phylogenetic relationship to humans. Copy number variation is one of the main sources of genomic diversity within and between species and a widely recognized cause of inter-individual differences in disease risk. [...]
2020 - 10.1371/journal.pgen.1008742
PLoS Genetics, Vol. 16 (may 2020)  
6.
24 p, 25.7 MB p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes / Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castillo, Helena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845  
7.
28 p, 2.6 MB Functional impact and evolution of a novel human polymorphic inversion that disrupts a gene and creates a fusion transcript / Puig Font, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pantano, Lorena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Giner Delgado, Carla (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Izquierdo, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gayà Vidal, Magdalena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lucas Lledó, Jose Ignacio (Universitat de València. Institut Cavanilles de Biodiversitat i Biologia Evolutiva) ; Esko, Tõnu (Estonian Genome Center) ; Terao, Chikashi (Kyoto University Graduate School of Medicine) ; Matsuda, Fumihiko (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Cáceres Aguilar, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Despite many years of study into inversions, very little is known about their functional consequences, especially in humans. A common hypothesis is that the selective value of inversions stems in part from their effects on nearby genes, although evidence of this in natural populations is almost nonexistent. [...]
2015 - 10.1371/journal.pgen.1005495
PLoS Genetics, Vol. 11, issue 10 (2015) , art. e1005495  
8.
27 p, 21.8 MB The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes / Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017  
9.
31 p, 4.4 MB The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility / Gomez Hernández, Laura (Centro de Investigación del Cáncer) ; Felipe Medina, Natalia (Centro de Investigación del Cáncer) ; Bejarano Condezo, Yazmine (Centro de Investigación del Cáncer) ; Garcia Valiente, Rodrigo (Centro de Investigación del Cáncer) ; Ramos, Isabel (Centro de Investigación del Cáncer) ; Suja, José Ángel (Universidad Autónoma de Madrid. Unidad de Biologia Celular) ; Barbero, José Luis (Centro de Investigaciones Biológicas (Madrid)) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sanchez Martin, Manuel. (Universidad de Salamanca. Departamento de Medicina) ; De Rooij, Dirk G. (Utrecht University. Departent of Biology) ; Llano, Elena (Universidad de Salamanca. Departamento de Fisiología y Farmacología) ; Martín Pendas, Alberto (Centro de Investigación del Cáncer)
The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. [...]
2019 - 10.1371/journal.pgen.1008316
PLoS Genetics, Vol. 15, issue 8 (August 2019) , e1008316  
10.
26 p, 3.5 MB A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs / Cho, In-Cheol (Rural Development Administration. National Institute of Animal Science) ; Park, Hee-Bok (Kongju National University. College of Industrial Sciences. Department of Animal Resources Science) ; Ahn, Jin Seop (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ; Han, Sang-Hyun (Jeju National University. Educational Science Research Institute) ; Lee, JaeBong (Chonbuk National University. Korea Zoonosis Research Institute) ; Lim, Hyun-Tae (Gyeongsang National University. College of Agriculture and Life Sciences) ; Yoo, Chae-Kyoung (Gyeongsang National University. Institute of Agriculture and Life Science.) ; Jung, Eun-Ji (Bio-Medical Science Co., Ltd) ; Kim, Dong-Hwan (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ; Sun, Wu-Sheng (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ; Ramayo-Caldas, Yuliaxis (Institut de Recerca i Tecnologia Agroalimentàries) ; Kim, Sang-Geum (Rural Development Administration. National Institute of Animal Science) ; Kang, Yong-Jun (Rural Development Administration. National Institute of Animal Science) ; Kim, YooKyung (Jeju National University. Educational Science Research Institute) ; Shin, Hyun-Sook (Rural Development Administration. National Institute of Animal Science) ; Seong, Pil-Nam (Rural Development Administration. National Institute of Animal Science) ; Hwang, In-Sul (Rural Development Administration. National Institute of Animal Science) ; Park, Beom-Young (Rural Development Administration. National Institute of Animal Science) ; Hwang, Seongsoo (Rural Development Administration. National Institute of Animal Science) ; Lee, Sung-Soo (Rural Development Administration. National Institute of Animal Science) ; Ryu, Youn-Chul (Jeju National University. Division of Biotechnology. SARI) ; Lee, Jun-Heon (Chungnam National University. Division of Animal and Dairy Science) ; Ko, MoonSuck (Rural Development Administration. National Institute of Animal Science) ; Lee, Kichoon (Ohio State University. College of Food Agricultural and Environmental Sciences) ; Andersson, Göran (Swedish University of Agricultural Sciences. Department of Animal Breeding and Genetics) ; Perez-Enciso, Miguel (Centre de Recerca en Agrigenòmica) ; Lee, JeongWoong (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center)
Muscle development and lipid accumulation in muscle critically affect meat quality of livestock. However, the genetic factors underlying myofiber-type specification and intramuscular fat (IMF) accumulation remain to be elucidated. [...]
2019 - 10.1371/journal.pgen.1008279
PLoS Genetics, Vol. 15, Núm. 10 (October 2019) , art. e1008279  

Depósito Digital de Documentos de la UAB : Encontrados 28 registros   1 - 10siguientefinal  ir al registro:
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