UAB Digital Repository of Documents 424 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
1.
29 p, 8.2 MB Highly diverse Bronze Age population dynamics in Central-Southern Europe and their response to regional climatic patterns / Capuzzo, Giacomo (Universitat Autònoma de Barcelona. Departament de Prehistòria) ; Zanon, Marco (Universität Kiel) ; Dal Corso, Marta (Universität Kiel) ; Kirleis, Wiebke (Universität Kiel) ; Barceló, Juan A. (Universitat Autònoma de Barcelona. Departament de Prehistòria)
The reconstruction of past demographic patterns is a fundamental step towards a better understanding of human-environment relations, especially in terms of quantifiable anthropic impact and population susceptibility to environmental changes. [...]
2018 - 10.1371/journal.pone.0200709
PloS one, Vol. 13 Núm. 8 (2018) , p. art. e0200709  
2.
15 p, 1.4 MB E-cigarettes : effects in phagocytosis and cytokines response against Mycobacterium tuberculosis / Gómez Camacho, Andromeda Celeste (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rodríguez Fernández, Pablo (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Villar Hernández, Raquel (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Muriel Moreno, Beatriz (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Lacoma, Alicia (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Prat Aymerich, Cristina (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Domínguez, José (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol)
Cigarette smoking and tuberculosis are a significant cause of death worldwide. Several epidemiological studies have demonstrated cigarette smoking is a risk factor for tuberculosis. Electronic cigarettes have recently appeared as a healthier alternative to conventional smoking, although their impact in tuberculosis is not well understood. [...]
2020 - 10.1371/journal.pone.0228919
PloS one, Vol. 15 issue 2 (2020) , p. e0228919  
3.
29 p, 9.5 MB Substrate specificity of human metallocarboxypeptidase D : comparison of the two active carboxypeptidase domains / Garcia-Pardo, Javier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tanco, Sebastián Martín (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Díaz, Lucía (Barcelona Supercomputing Center) ; Dasgupta, Sayani (Albert Einstein College of Medicine. Department of Molecular Pharmacology) ; Fernandez Recio, Juan (Barcelona Supercomputing Center) ; Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquimica i Biologia Molecular) ; Fricker, Lloyd D. (Albert Einstein College of Medicine. Department of Molecular Pharmacology)
Metallocarboxypeptidase D (CPD) is a membrane-bound component of the trans-Golgi network that cycles to the cell surface through exocytic and endocytic pathways. Unlike other members of the metallocarboxypeptidase family, CPD is a multicatalytic enzyme with three carboxypeptidase-like domains, although only the first two domains are predicted to be enzymatically active. [...]
2017 - 10.1371/journal.pone.0187778
PloS one, Vol. 12 issue 11 (2017) , art. e0187778  
4.
23 p, 2.8 MB Identification of specific effect of chloride on the spectral properties and structural stability of multiple extracellular glutamic acid mutants of bacteriorhodopsin / Lazarova, Tzvetana (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Mlynarczyk, Krzysztof (University of Warsaw. Faculty of Chemistry) ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tenchov, Boris (Medical University (Sofia, Bulgària). Department of Medical Physics and Biophysics) ; Filipek, Slawomir (University of Warsaw. Faculty of Chemistry) ; Padrós, Esteve (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecula)
In the present work we combine spectroscopic, DSC and computational approaches to examine the multiple extracellular Glu mutants E204Q/E194Q, E204Q/E194Q/E9Q and E204Q/E194Q/E9Q/E74Q of bacteriorhodopsin by varying solvent ionic strength and composition. [...]
2016 - 10.1371/journal.pone.0162952
PloS one, Vol. 11 issue 9 (2016) , art. e0162952  
5.
17 p, 1.7 MB Intradomain confinement of disulfides in the folding of two consecutive modules of the LDL receptor / Martínez-Oliván, Juan (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Fraga, Hugo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Arias-Moreno, Xabier (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sancho, Javier (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular)
The LDL receptor internalizes circulating LDL and VLDL particles for degradation. Its extracellular binding domain contains ten (seven LA and three EGF) cysteine-rich modules, each bearing three disulfide bonds. [...]
2015 - 10.1371/journal.pone.0132141
PloS one, Vol. 10, issue 7 (2015) , art. e0132141  
6.
14 p, 2.4 MB Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy / Ferreira, Priscila (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ; Sant'Anna, Ricardo (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ; Varejão, Nathalia (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ; Lima, Cinthia (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ; Novis, Shenia (Centro de Estudos de Paramiloidose Antônio Rodrigues de Mello) ; Barbosa, Renata V. (Centro de Estudos de Paramiloidose Antônio Rodrigues de Mello) ; Caldeira, Concy M. (SONDA. Universidade Federal do Rio de Janeiro) ; Rumjanek, Franklin D. (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cruz, Marcia W. (Centro de Estudos de Paramiloidose Antônio Rodrigues de Mello) ; Foguel, Debora (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Transthyretin (TTR) is a tetrameric beta-sheet-rich protein. Its deposits have been implicated in four different amyloid diseases. Although aggregation of the wild-type sequence is responsible for the senile form of the disease, more than one hundred variants have been described thus far, most of which confer a more amyloidogenic character to TTR, mainly because they compromise the stability of the protein in relation to monomer formation, which upon misfolding is intrinsically aggregation-prone. [...]
2013 - 10.1371/journal.pone.0082484
PloS one, Vol. 8, issue 12 (2013) , art. e82484  
7.
15 p, 1.8 MB A model of protein association based on their hydrophobic and electric interactions / Mozo Villarías, Angel (Institut de Recerca Biomèdica de Lleida) ; Cedano, Juan (Universidad de la República (Uruguai).Laboratorio de Inmunología) ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The propensity of many proteins to oligomerize and associate to form complex structures from their constituent monomers, is analyzed in terms of their hydrophobic (H), and electric pseudo-dipole (D) moment vectors. [...]
2014 - 10.1371/journal.pone.0110352
PloS one, Vol. 9 issue 10 (2014) , art. e110352  
8.
15 p, 1.9 MB The N-terminal helix controls the transition between the soluble and amyloid states of an FF domain / Castillo Cano, Virginia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Chiti, Fabrizio (Università di Firenze. Dipartimento di Scienze Biochimiche) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Background: Protein aggregation is linked to the onset of an increasing number of human nonneuropathic (either localized or systemic) and neurodegenerative disorders. In particular, misfolding of native α-helical structures and their self-assembly into nonnative intermolecular β-sheets has been proposed to trigger amyloid fibril formation in Alzheimer's and Parkinson's diseases. [...]
2013 - 10.1371/journal.pone.0058297
PloS one, Vol. 8 issue 3 (2013) , art. e58297  
9.
20 p, 940.6 KB An enriched European eel transcriptome sheds light upon host-pathogen interactions with Vibrio vulnificus / Callol, Agnes (Universitat Autònoma de Barcelona. Departament de Genètica i Microbiologia) ; Reyes-López, Felipe E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Roig, Francisco J. (Universitat de Valencia. Departament de Microbiologia i Ecologia) ; Goetz, Giles (Northwest Fisheries Science Center) ; Goetz, Frederick W. (Northwest Fisheries Science Center) ; Amaro, Carmen (Universitat de Valencia. Departament de Microbiologia i Ecologia) ; MacKenzie, Simon A. (Institut de Biologia Fonamental "Vicent Villar Palasí")
Infectious diseases are one of the principal bottlenecks for the European eel recovery. The aim of this study was to develop a new molecular tool to be used in host-pathogen interaction experiments in the eel. [...]
2015 - 10.1371/journal.pone.0133328
PloS one, Vol. 10, issue 7 (2015) , art. e0133328  
10.
10 p, 596.5 KB PeSV-fisher : identification of somatic and non-somatic structural variants using next generation sequencing data / Escaramís, Georgina (Centre de Regulació Genòmica) ; Tornador, Cristian (Centre de Regulació Genòmica) ; Bassaganyas, Laia (Centre de Regulació Genòmica) ; Rabionet, Raquel (Centre de Regulació Genòmica) ; Tubio, Jose M.C. (Centre de Regulació Genòmica) ; Martínez-Fundichely, Alexander (Centre de Regulació Genòmica) ; Cáceres Aguilar, Mario (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gut, Marta (Centre Nacional d'Anàlisi Genòmica) ; Ossowski, Stephan (Centre de Regulació Genòmica) ; Estivill, Xavier (Centre de Regulació Genòmica)
Next-generation sequencing technologies expedited research to develop efficient computational tools for the identification of structural variants (SVs) and their use to study human diseases. As deeper data is obtained, the existence of higher complexity SVs in some genomes becomes more evident, but the detection and definition of most of these complex rearrangements is still in its infancy. [...]
2013 - 10.1371/journal.pone.0063377
PloS one, Vol. 8 issue 5 (2013) , art. e63377  

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