Depósito Digital de Documentos de la UAB Encontrados 11 registros  1 - 10siguiente  ir al registro: La búsqueda tardó 0.01 segundos. 
1.
27 p, 3.0 MB A multiscale model of epigenetic heterogeneity-driven cell fate decision-making / Folguera Blasco, Núria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Pérez Carrasco, Rubén (University College London. Department of Mathematics) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Universitat Autònoma de Barcelona. Centre de Recerca Matemàtica
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entryexit mechanisms of phenotype reprogramming are established remains poorly understood. [...]
2019 - 10.1371/journal.pcbi.1006592
PLoS computational biology, Vol. 15, Issue 4 (April 2019) , art. e1006592  
2.
20 p, 10.3 MB Identifying human diamine sensors for death related putrescine and cadaverine molecules / Izquierdo, Cristina (Universitat Autònoma de Barcelona. Departament de Ciències de la Computació) ; Gómez-Tamayo, José C. (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Nebel, Jean-Christophe (Kingston University) ; Pardo, Leonardo (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; González, Angel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Pungent chemical compounds originating from decaying tissue are strong drivers of animal behavior. Two of the best-characterized death smell components are putrescine (PUT) and cadaverine (CAD), foul-smelling molecules produced by decarboxylation of amino acids during decomposition. [...]
2018 - 10.1371/journal.pcbi.1005945
PLoS computational biology, Vol. 14 (january 2018)  
3.
40 p, 5.5 MB Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB and Serotonin 5-HT Receptors / Viñals, Xavier (Universitat Pompeu Fabra. Laboratori de Neurofarmacologia) ; Moreno, Estefanía (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Lanfumey, Laurence (Université Paris Descartes. Institut de Psychiatrie et Neurosciences de Paris (UMR 894)) ; Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Pastor, Antoni (IMIM-Institut Hospital del Mar d'Investigacions Médiques. Integrative Pharmacology and Systems Neuroscience) ; de La Torre, Rafael (IMIM-Institut Hospital del Mar d'Investigacions Médiques. Integrative Pharmacology and Systems Neuroscience) ; Gasperini, Paola (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Navarro, Gemma (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Howell, Lesley A. (University of East Anglia. School of Pharmacy (United Kingdom)) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Lluís, Carmen (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Canela, Enric I. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; McCormick, Peter J. (University of East Anglia. School of Pharmacy (United Kingdom)) ; Maldonado, Rafael (Universitat Pompeu Fabra. Laboratori de Neurofarmacologia) ; Robledo, Patricia (IMIM-Institut Hospital del Mar d'Investigacions Médiques. Integrative Pharmacology and Systems Neuroscience)
Activation of cannabinoid CB1 receptors (CBR) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic agents. [...]
2015 - 10.1371/journal.pbio.1002194
PLoS biology, Vol. 13, Num. 7 (July 2015) , art. e1002194  
4.
9 p, 627.3 KB What makes a protein sequence a prion ? / Sabaté, Raimon (Universitat de Barcelona. Departament de Fisicoquímica) ; Rousseau, Frederic (KU Leuven. Department for Cellular and Molecular Medicine) ; Schymkowitz, Joost (KU Leuven. Departement for Cellular and Molecular Medicine) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Typical amyloid diseases such as Alzheimer's and Parkinson's were thought to exclusively result from de novo aggregation, but recently it was shown that amyloids formed in one cell can cross-seed aggregation in other cells, following a prion-like mechanism. [...]
2015 - 10.1371/journal.pcbi.1004013
PLoS computational biology, Vol. 11, Issue 1 (Jan. 2015) , art. e1004013  
5.
15 p, 1.4 MB Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1 / Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Contreras, F. Xabier (Heidelberg University Biochemistry Center (BZH), Heidelberg) ; Rodríguez Plata, María T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Casas, Josefina (Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain) ; Fabriàs, Gemma (Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain) ; Kräusslich, Hans Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain)
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes. [...]
2012 - 10.1371/journal.pbio.1001315
PLoS biology, Vol. 10 (april 2012)  
6.
12 p, 1.8 MB A dp53-Dependent Mechanism Involved in Coordinating Tissue Growth in Drosophila / Mesquita, Duarte (Institut d'Investigació Biomèdica Sant Pau) ; Dekanty, Andrés (Institut d'Investigació Biomèdica Sant Pau) ; Milán, Marco (ICREA, Barcelona, Spain) ; Universitat Autònoma de Barcelona
A study in the Drosophila wing suggests a crucial role of p53 in the coordination of growth between adjacent cell populations to maintain organ proportions and shape. Coordination of growth between and within organs contributes to the generation of well-proportioned organs and functionally integrated adults. [...]
2010 - 10.1371/journal.pbio.1000566
PLoS biology, Vol. 8 (12 2010)  
7.
25 p, 6.5 MB ATPase-Dependent Control of the Mms21 SUMO Ligase during DNA Repair / Bermúdez-López, Marcelino (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Pociño-Merino, Irene (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Sánchez, Humberto (Erasmus Medical Center, Department of Genetics and Radiation Oncology, Rotterdam) ; Bueno, Andrés (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Guasch, Clàudia (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Almedawar, Seba (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Bru-Virgili, Sergi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Garí, Eloi (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Wyman, Claire (Erasmus Medical Center, Department of Genetics and Radiation Oncology, Rotterdam) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Colomina, Neus (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Torres-Rosell, Jordi (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques)
Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. [...]
2015 - 10.1371/journal.pbio.1002089
PLoS biology, Vol. 13 Issue 3 (march 2015) , p. 1-25  
8.
11 p, 7.8 MB Understanding the molecular determinants driving the immunological specificity of the protective pilus 2a backbone protein of Group B Streptococcus / Nuccitelli, Annalisa (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Rinaudo, C. Daniela (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Brogioni, Barbara (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Cozzi, Roberta (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Ferrer Navarro, Mario (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Telford, John L. (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Grandi, Guido (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Zacharias, Martin (Technical University Munich. Physics Department) ; Maione, Domenico (Novartis Vaccines and Diagnostics (Siena, Itàlia))
The pilus 2a backbone protein (BP-2a) is one of the most structurally and functionally characterized components of a potential vaccine formulation against Group B Streptococcus. It is characterized by six main immunologically distinct allelic variants, each inducing variant-specific protection. [...]
2013 - 10.1371/journal.pcbi.1003115
PLOS Computational Biology, Vol. 9, Issue 6 (June 2013) , p. e1003115  
9.
11 p, 609.4 KB Potassium starvation in yeast : mechanisms of homeostasis revealed by mathematical modeling / Kahm, Matthias (University of Applied Sciences. Department of Mathematics and Technology (Koblenz, Alemanya)) ; Navarrete, Clara (Universidad de Córdoba. Departmento de Microbiologia) ; Llopis Torregrosa, Vicent (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya)) ; Herrera, Rito (Universidad de Córdoba. Departmento de Microbiologia) ; Barreto, Lina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yenush, Lynne (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya)) ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ramos, José (Universidad de Córdoba. Departmento de Microbiologia) ; Kschischo, Maik (University of Applied Sciences. Department of Mathematics and Technology (Koblenz, Alemanya))
The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesis. [...]
2012 - 10.1371/journal.pcbi.1002548
PLOS Computational Biology, Vol. 8, Issue 6 (June 2012) , p. e1002548  
10.
16 p, 1.6 MB Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases / Castillo Cano, Virginia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Protein aggregation underlies a wide range of human disorders. The polypeptides involved in these pathologies might be intrinsically unstructured or display a defined 3D-structure. Little is known about how globular proteins aggregate into toxic assemblies under physiological conditions, where they display an initially folded conformation. [...]
2009 - 10.1371/journal.pcbi.1000476
PLOS Computational Biology, Vol. 5, Issue 8 (August 2009) , p. e1000476  

Depósito Digital de Documentos de la UAB : Encontrados 11 registros   1 - 10siguiente  ir al registro:
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