UAB Digital Repository of Documents 22 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
1.
5 p, 190.8 KB In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction / Silva-Arrieta, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Goulder, Phillip J.R. (Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America) ; Brander, C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
2020 - 10.1371/journal.ppat.1008607
PLoS pathogens, Vol. 16 Núm. 6 (january 2020) , p. e1008607  
2.
34 p, 4.2 MB Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals / Taglialegna, Agustina (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología) ; Navarro Cantero, Susanna (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Garnett, James A. (Queen Mary University of London. School of Biological and Chemical Sciences) ; Matthews, Steve (Imperial College London. Department of Life Sciences) ; Penades, José R. (University of Glasgow. College of Medical, Veterinary and Life Sciences) ; Lasa, Iñigo (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología) ; Valle, Jaione (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología)
Biofilms are communities of bacteria that grow encased in an extracellular matrix that often contains proteins. The spatial organization and the molecular interactions between matrix scaffold proteins remain in most cases largely unknown. [...]
2016 - 10.1371/journal.ppat.1005711
PLoS pathogens, Vol. 12, issue 6 (June 2016) , p. e1005711  
3.
28 p, 7.6 MB Critical role for a promoter discriminator in RpoS control of virulence in Edwardsiella piscicida / Yin, Kaiyu (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Guan, Yunpeng (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Ma, Ruiqing (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Wei, Lifan (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Liu, Bing (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Liu, Xiaohong (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Zhou, Xiangshan (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Ma, Yue (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Zhang, Yuanxing (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Waldor, M.K. (Harvard Medical School) ; Wang, Qiyao (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Edwardsiella piscicida is a leading fish pathogen that causes significant economic loses in the aquaculture industry. The pathogen depends on type III and type VI secretion systems (T3/T6SS) for growth and virulence in fish and the expression of both systems is controlled by the EsrB transcription activator. [...]
2018 - 10.1371/journal.ppat.1007272
PLoS pathogens, Vol. 14 issue 8 (2018) , art. e1007272  
4.
37 p, 10.2 MB Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals / Trevijano-Contador, Núria (Centro Nacional de Microbiología (Espanya)) ; Oliveira, Haroldo César de (Universidade Estadual Paulista (UNESP). Departamento de Análises Clínicas) ; García-Rodas, Rocío (Centro Nacional de Microbiología (Espanya)) ; Rossi, Suélen Andreida (Centro Nacional de Microbiología (Espanya)) ; Llorente, Irene (Centro Nacional de Microbiología (Espanya)) ; Zaballos, Ángel (Instituto de Salud Carlos III. Unidad de Genómica) ; Janbon, Guilhem (Institut Pasteur. Département de Mycologie) ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Zaragoza, Óscar (Centro Nacional de Microbiología (Espanya)) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of the cells during infection. In particular, this process can occur by enlarging the size of the capsule without modifying the size of the cell body, or by increasing the diameter of the cell body, which is normally accompanied by an increase of the capsule too. [...]
2018 - 10.1371/journal.ppat.1007007
PLoS pathogens, Vol. 14 issue 5 (2018) , art. e1007007  
5.
26 p, 2.9 MB Structure-guided mutations in the terminal organelle protein MG491 cause major motility and morphologic alterations on mycoplasma genitalium / Martinelli, Luca (Consell Superior d'Investigacions Científiques. Institut de Biologia Molecular de Barcelona) ; García Morales, Luis (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Querol, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Piñol Ribas, Jaume, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Fita, Ignacio (Consell Superior d'Investigacions Científiques. Institut de Biologia Molecular de Barcelona) ; Calisto, Bárbara M. (Universidade do Porto. Instituto de Biologia Molecular e Celular)
The emergent human pathogen Mycoplasma genitalium, with one of the smallest genomes among cells capable of growing in axenic cultures, presents a flask-shaped morphology due to a protrusion of the cell membrane, known as the terminal organelle, that is involved in cell adhesion and motility and is an important virulence factor of this microorganism. [...]
2016 - 10.1371/journal.ppat.1005533
PLoS pathogens, Vol. 12 issue 4 (2016) , art. e1005533  
6.
14 p, 1.6 MB A trigger enzyme in mycoplasma pneumoniae : impact of the glycerophosphodiesterase glpq on virulence and gene expression / Schmidl, Sebastian R. (Georg-August-University Göttingen. Department of General Microbiology) ; Otto, Andreas (Ernst-Moritz-Arndt-Universität Greifswald. Institut für Mikrobiologie und Molekularbiologie) ; Lluch Senar, Maria (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Busse, Julia (Georg-August-University Göttingen. Department of General Microbiology) ; Becher, Dörte (Ernst-Moritz-Arndt-Universität Greifswald. Institut für Mikrobiologie und Molekularbiologie) ; Stülke, Jörg (Georg-August-University Göttingen. Department of General Microbiology)
Mycoplasma pneumoniae is a causative agent of atypical pneumonia. The formation of hydrogen peroxide, a product of glycerol metabolism, is essential for host cell cytotoxicity. Phosphatidylcholine is the major carbon source available on lung epithelia, and its utilization requires the cleavage of deacylated phospholipids to glycerol-3-phosphate and choline. [...]
2011 - 10.1371/journal.ppat.1002263
PLoS pathogens, Vol. 7 issue 9 (2011) , art. e1002263  
7.
33 p, 2.7 MB Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies / Eraña, Hasier (ATLAS Molecular Pharma S. L.) ; Charco, Jorge M. (CIC bioGUNE) ; Di Bari, Michele Angelo (CIC bioGUNE) ; Díaz-Domínguez, Carlos M. (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ; López-Moreno, R. (CIC bioGUNE) ; Vidal, Enric (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal (CReSA)) ; González-Miranda, E. (CIC bioGUNE) ; Pérez-Castro, Miguel A. (CIC bioGUNE) ; García-Martínez, Sandra (ATLAS Molecular Pharma S. L.) ; Bravo, Susana Belén (Proteomics Lab. IDIS) ; Fernández-Borges, N. (CIC bioGUNE) ; Geijo, Maria V. (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ; D'Agostino, C. (Department of Veterinary Public Health and Food Safety. Istituto Superiore di Sanità) ; Garrido, J. (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ; Bian, J. (Colorado State University. Prion Research Center (PRC).) ; König, A. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ; Uluca-Yazgi, B. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ; Sabate, R. (Universitat de Barcelona. Institute of Nanoscience and Nanotechnology (IN2UB).) ; Khaychuk, V. (Colorado State University. Prion Research Center (PRC).) ; Vanni, Ilaria (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ; Telling, G.C. (Colorado State University. Prion Research Center (PRC).) ; Heise, Henrike (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ; Nonno, Romolo (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ; Requena, J.R. (Universidad de Santiago de Compostela. CIMUS Biomedical Research Institute.) ; Castilla, Joaquín (IKERBasque. Basque Foundation for Science)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of these proteinaceous pathogens. [...]
2019 - 10.1371/journal.ppat.1008117
PLoS pathogens, Vol. 15 Núm. 10 (2019) , p. e1008117  
8.
12 p, 2.4 MB The Risk of sustained sexual transmission of Zika is underestimated / Allard, Antoine (Centre de Recerca Matemàtica) ; Althouse, Benjamin M. (New Mexico State University) ; Hébert-Dufresne, Laurent (University of Vermont) ; Scarpino, Samuel V. (Northeastern University (Boston, Mass.))
Pathogens often follow more than one transmission route during outbreaks-from needle sharing plus sexual transmission of HIV to small droplet aerosol plus fomite transmission of influenza. Thus, controlling an infectious disease outbreak often requires characterizing the risk associated with multiple mechanisms of transmission. [...]
2017 - 10.1371/journal.ppat.1006633
PLoS pathogens, Vol. 13, issue 9 (Sep. 2017) , e1006633  
9.
17 p, 719.5 KB Yeast as a heterologous model system to uncover type III effector function / Popa, Crina (Centre de Recerca en Agrigenòmica) ; Sánchez Coll, Núria (Centre de Recerca en Agrigenòmica) ; Valls, Marc (Centre de Recerca en Agrigenòmica) ; Sessa, Guido (Tel Aviv University. Department of Molecular Biology and Ecology of Plants)
Type III effectors (T3E) are key virulence proteins that are injected by bacterial pathogens inside the cells of their host to subvert cellular processes and contribute to disease. The budding yeast Saccharomyces cerevisiae represents an important heterologous system for the functional characterisation of T3E proteins in a eukaryotic environment. [...]
2016 - 10.1371/journal.ppat.1005360
PLoS pathogens, Vol. 12, issue 2 (Feb. 2016) , e1005360  
10.
20 p, 1.6 MB PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia / Peligero, Cristina (Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra) ; Argilaguet, Jordi (Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra) ; Güerri-Fernandez, Roberto (Parc de Salut Mar. Unitat de Malalties Infeccioses) ; Torres, Berta (Infectious Diseases Unit, Hospital Clínic) ; Ligero, Carmen (Infectious Diseases Unit, Hospital Clínic) ; Colomer, Pilar (Parc de Salut Mar. Unitat de Malalties Infeccioses) ; Plana, Montserrat (Retrovirology and Viral Immunopathology Laboratory, AIDS Research Group, IDIBAPS, Hospital Clínic, University of Barcelona) ; Knobel, Hernando (Parc de Salut Mar. Unitat de Malalties Infeccioses) ; García, Felipe (Infectious Diseases Unit, Hospital Clínic) ; Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Universitat Autònoma de Barcelona
Blocking the PD-1/PD-L1 pathway has emerged as a potential therapy to restore impaired immune responses in human immunodeficiency virus (HIV)-infected individuals. Most reports have studied the impact of the PD-L1 blockade on effector cells and neglected possible effects on regulatory T cells (Treg cells), which play an essential role in balancing immunopathology and antiviral effector responses. [...]
2015 - 10.1371/journal.ppat.1005270
PLoS pathogens, Vol. 11 (december 2015)  

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