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14 p, 308.2 KB |
At-Home Foscarnet Administration in Patients with Cytomegalovirus Infection Post-Allogeneic Stem Cell Transplantation : A Unicentric, Safe, and Feasible Program
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Ruiz-Boy, Sonia (Hospital Clínic i Provincial de Barcelona) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Prat, Marta (Hospital Clínic i Provincial de Barcelona) ;
Salas, María Queralt (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carcelero, Ester (Hospital Clínic i Provincial de Barcelona) ;
Riu-Viladoms, G (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó Grande, María (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Monge-Escartín, Inés (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez-Lobato, Luís Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez-Roca, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Rovira Argelagués, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez, Carmen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gallego, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Urbano-Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez, Juan (Hospital Clínic i Provincial de Barcelona) ;
Marcos, María Ángeles (Hospital Clínic i Provincial de Barcelona) ;
Fernández-Avilés, Francesc (Hospital Clínic i Provincial de Barcelona)
Cytomegalovirus (CMV) infection is a relevant cause of morbimortality in patients receiving allogeneic stem cell transplantation (allo-HCT). Foscarnet (FCN) is an effective drug against CMV administered intravenously and usually on an inpatient basis. [...]
2023 -  10.3390/ph16121741
Pharmaceuticals, Vol. 16 Núm. 12 (december 2023) , p. 1741
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31 p, 3.2 MB |
Recent Advances in Potential Health Benefits of Quercetin
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Aghababaei, Fatemeh (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Hadidi, Milad (Universidad de Castilla-La Mancha)
Quercetin, a flavonoid found in fruits and vegetables, has been a part of human diets for centuries. Its numerous health benefits, including antioxidant, antimicrobial, anti-inflammatory, antiviral, and anticancer properties, have been extensively studied. [...]
2023 - 10.3390/ph16071020
Pharmaceuticals, Vol. 16 (july 2023)
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3.
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18 p, 1.4 MB |
Dickkopf Proteins and Their Role in Cancer : A Family of Wnt Antagonists with a Dual Role
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Giralt, Irina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallo-Oller, Gabriel (Vall d'Hebron Institut d'Oncologia) ;
Navarro Barea, Natalia (Vall d'Hebron Institut d'Oncologia) ;
Zarzosa, Patricia (Vall d'Hebron Institut d'Oncologia) ;
Pons, Guillem (Vall d'Hebron Institut d'Oncologia) ;
Magdaleno, Ainara (Vall d'Hebron Institut d'Oncologia) ;
Segura, Miguel F. (Vall d'Hebron Institut d'Oncologia) ;
Sánchez de Toledo, José (Vall d'Hebron Institut d'Oncologia) ;
Moreno, Lucas (Hospital Universitari Vall d'Hebron) ;
Gallego, Soledad (Hospital Universitari Vall d'Hebron) ;
Roma, Josep (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
The Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell polarity and organogenesis during embryonic development. Wnt pathway deregulation is a hallmark of several cancers such as lung, gastric and liver cancer, and has been reported to be altered in others. [...]
2021 - 10.3390/ph14080810
Pharmaceuticals, Vol. 14 (august 2021)
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4.
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25 p, 3.8 MB |
Clinical Impact of Electronic Monitoring Devices of Inhalers in Adults with Asthma or COPD: A Systematic Review and Meta-Analysis
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Garin, Noe (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Zarate-Tamames, Borja (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gras-Martin, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Milà, Raimon (Universitat Ramon Llull) ;
Crespo Lessmann, Astrid (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Curto Sánchez, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Hernández Hernández, Marta (Universitat Ramon Llull) ;
Mestres, Concepció (Universitat Ramon Llull) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
We conducted a systematic review and meta-analysis to gain insight into the characteristics and clinical impact of electronic monitoring devices of inhalers (EMDs) and their clinical interventions in adult patients with asthma or COPD. [...]
2023 - 10.3390/ph16030414
Pharmaceuticals, Vol. 16 (march 2023)
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5.
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24 p, 5.6 MB |
Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency
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Fernández Cancio, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Camats Tarruella, Núria (University of Bern) ;
Flück, Christa E. (University of Bern) ;
Zalewski, Adam (University of Bern) ;
Dick, Bernhard (Department of Nephrology and Hypertension) ;
Frey, Brigitte M. (University of Bern) ;
Monné, Raquel (Hospital Universitari Joan XXIII de Tarragona) ;
Torán, Núria (Hospital Universitari Vall d'Hebron) ;
Audí, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pandey, Amit V. (University of Bern) ;
Universitat Autònoma de Barcelona
The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In a 46, XY patient with female external genitalia, together with a loss of function mutation S441P, we identified a novel missense mutation V366M at the catalytic center of CYP17A1 which preferentially impaired 17,20 lyase activity. [...]
2018 - 10.3390/ph11020037
Pharmaceuticals, Vol. 11 (april 2018)
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9 p, 1.2 MB |
Disposition of Cannabidiol Metabolites in Serum and Urine from Healthy Individuals Treated with Pharmaceutical Preparations of Medical Cannabis
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Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche, Italy) ;
Pacifici, Roberta (Istituto Superiore di Sanità, Rome, Italy) ;
Mannocchi, Giulio (University of Camerino, Italy) ;
Gottardi, Massimo (Comedical srl, Trento, Italy) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Di Trana, Annagiulia (Università Politecnica delle Marche, Ancona, Italy) ;
Pichini, Simona (Istituto Superiore di Sanità, Rome, Italy) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
The use of cannabis flowering tops with standardized amounts of active phytocannabinoids was recently authorized in several countries to treat several painful pathological conditions. The acute pharmacological effects and disposition of Δ-9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors and THC metabolites after oil and decoction administration have been already described. [...]
2020 - 10.3390/ph13120459
Pharmaceuticals, Vol. 13 (december 2020)
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16 p, 3.1 MB |
Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells
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Conway, Gillian E. (In-Vitro Toxicology Group, Institute of Life Science, Swansea University Medical School) ;
Zizyte, Deimante (School of Food Science and Environmental Health, Technological University Dublin) ;
Mondala, Julie Rose Mae (School of Food Science and Environmental Health, Technological University Dublin) ;
He, Zhonglei (Environmental Sustainability and Health Institute (ESHI) and FOCAS Research Institute, Technological University Dublin) ;
Lynam, Lorna (School of Food Science and Environmental Health, Technological University Dublin) ;
Lecourt, Mathilde (School of Food Science and Environmental Health, Technological University Dublin) ;
Barcia, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Howe, Orla (School of Biological Sciences and Health Sciences, Technological University Dublin) ;
Curtin, James (Dublin Institute of Technology. School of Food Science and Environmental Health)
Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. UA activates various signalling pathways in Glioblastoma multiforme (GBM) and offers a promising starting point in drug discovery; however, understanding the relationship between cell death and migration has yet to be elucidated. [...]
2021 - 10.3390/ph14020091
Pharmaceuticals, Vol. 14 (january 2021)
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11 p, 1.1 MB |
The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex
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García-Contreras, Consolación (SGIT-INIA) ;
Vázquez-Gómez, Marta (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Pesántez-Pacheco, José Luis (Universidad de Cuenca. Faculty of Agricultural Sciences, School of Veterinary Medicine and Zootechnics) ;
Heras-Molina, Ana (SGIT-INIA) ;
Encinas, Teresa (Universidad Complutense de Madrid. Facultad de Veterinaria) ;
Astiz, Susana (SGIT-INIA) ;
Gonzalez-Bulnes, Antonio (Universidad Complutense de Madrid. Facultad de Veterinaria)
Metformin is currently used to improve pregnancy outcome in women affected by polycystic ovary syndrome (PCOS) or diabetes. However, metformin may also be useful in pregnancies at risk of intrauterine growth restriction (IUGR) since it improves placental efficiency and the fetuses' developmental competence. [...]
2020 - 10.3390/ph13110363
Pharmaceuticals, Vol. 13 (november 2020)
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9.
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15 p, 1.8 MB |
L-ferritin : One gene, five diseases; from hereditary hyperferritinemia to hypoferritinemia-report of new cases
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Cadenas, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fita-Torró, Josep (BloodGenetics SL. Esplugues de Llobregat) ;
Bermúdez-Cortés, Mar (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Hernandez-Rodriguez, Inés (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fuster, José Luis (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Llinares, María Esther (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Galera, Ana (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Romero, Julia Lee (Biomedical Engineering Department. University of Texas at Austin) ;
Pérez-Montero, Santiago (BloodGenetics SL. Esplugues de Llobregat) ;
Tornador, Cristian (BloodGenetics SL. Esplugues de Llobregat) ;
Sánchez-Fernández, Mayka (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin subunit gene (FTL gene) that cause the following five diseases: (1) hereditary hyperferritinemia with cataract syndrome (HHCS), (2) neuroferritinopathy, a subtype of neurodegeneration with brain iron accumulation (NBIA), (3) benign hyperferritinemia, (4) L-ferritin deficiency with autosomal dominant inheritance, and (5) L-ferritin deficiency with autosomal recessive inheritance. [...]
2019 - 10.3390/ph12010017
Pharmaceuticals, Vol. 12 Núm. 1 (2019) , p. 17
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13 p, 1013.2 KB |
Acute Pharmacological Effects of Oral and Intranasal Mephedrone : an observational study in humans
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Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Olesti, Eulàlia (Universitat Pompeu Fabra) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fonseca, Francina 1972- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Grifell, Marc (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Ventura, Mireia (Associació Benestar i Desenvolupament) ;
De La Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Mephedrone (4-methylmethcathinone) is a synthetic cathinone with psychostimulant properties which remains one of the most popular new psychoactive substances (NPS). It is frequently used orally and/or intranasally. [...]
2021 - 10.3390/ph14020100
Pharmaceuticals, Vol. 14 Núm. 2 (2021) , p. 100
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