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23 p, 9.1 MB |
Reproduction, energy storage and metabolic requirements in a mesophotic population of the gorgonian Paramuricea macrospina
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Grinyó, Jordi (Consejo Superior de Investigaciones Científicas. Institut de Ciències del Mar) ;
Viladrich, Núria (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Díaz, David (Instituto Español de Oceanografía. Centre Oceanogràfic de les Balears) ;
Muñoz, Anabel (Instituto Español de Oceanografía. Centre Oceanogràfic de les Balears) ;
Mallol, Sandra (Instituto Español de Oceanografía. Centre Oceanogràfic de les Balears) ;
Salazar, Janire (Consejo Superior de Investigaciones Científicas. Institut de Ciències del Mar) ;
Castillo-Contreras, Raquel (Centre de Recerca Ecològica i Aplicacions Forestals) ;
Gili, Josep-Maria (Consejo Superior de Investigaciones Científicas. Institut de Ciències del Mar) ;
Gori, Andrea (Consejo Superior de Investigaciones Científicas. Institut de Ciències del Mar)
This study examined the sexual reproductive cycle, energy storage and metabolic requirements of a Mediterranean gorgonian in a mesophotic ecosystem (~70 m depth). Paramuricea macrospina resulted to be a gonochoric internal brooding species with a 1:1 population sex ratio. [...]
2018 -  10.1371/journal.pone.0203308
PloS one, Vol. 13 Núm. 9 (2018)
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8 p, 651.4 KB |
Long-Term Dynamics of Bluetongue Virus in Wild Ruminants : relationship with Outbreaks in Livestock in Spain, 2006-2011
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Lorca Oró, Cristina (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal (CReSA-IRTA)) ;
López Olvera, Jorge R. (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ;
Ruiz-Fons, Francisco (Instituto de Investigación en Recursos Cinegéticos) ;
Acevedo, Pelayo (Instituto de Investigación en Recursos Cinegéticos) ;
García-Bocanegra, Ignacio (Universidad de Córdoba. Departamento de Sanidad Animal) ;
Oleaga, Álvaro (Instituto de Investigación en Recursos Cinegéticos) ;
Gortázar, Christian ;
Pujols, Joan (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal (CReSA-IRTA))
Wild and domestic ruminants are susceptible to Bluetongue virus (BTV) infection. Three BTV serotypes (BTV-4, BTV-1 and BTV-8) have been detected in Spain in the last decade. Even though control strategies have been applied to livestock, BTV circulation has been frequently detected in wild ruminant populations in Spain. [...]
2014 - 10.1371/journal.pone.0100027
PloS one, Vol. 9 Núm. 6 (Juny 2014)
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19 p, 1.7 MB |
Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
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Alcaraz, Estefania (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Vilardell, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Borgo, Christian (University of Padova. Department of Biomedical Sciences) ;
Sarró, Eduard (CIBBIM-Nanomedicine. VHIR. Fisiopatología Renal) ;
Plana i Coll, Maria (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)) ;
Marin, Oriano (University of Padova. Department of Biomedical Sciences) ;
Pinna, Lorenzo A. (CNR Neuroscience Institute) ;
Bayascas, José R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Meseguer, Anna (Red de Investigación Renal (REDINREN), Instituto de Salud Carlos III-FEDER) ;
Salvi, Mauro (University of Padova. Department of Biomedical Sciences) ;
Itarte, Emilio (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)) ;
Ruzzene, Maria (CNR Neuroscience Institute)
The PI3K/Akt pathway is interconnected to protein kinase CK2, which directly phosphorylates Akt1 at S129. We have previously found that, in HK-2 renal cells, downregulation of the CK2 regulatory subunit β (shCK2β cells) reduces S129 Akt phosphorylation. [...]
2020 - 10.1371/journal.pone.0227340
PloS one, Vol. 15, Num. 1, (January 2020) , art. e0227340
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6.
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15 p, 1.4 MB |
E-cigarettes : effects in phagocytosis and cytokines response against Mycobacterium tuberculosis
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Gómez Camacho, Andromeda Celeste (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rodríguez Fernández, Pablo (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ;
Villar Hernández, Raquel (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Muriel Moreno, Beatriz (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ;
Lacoma, Alicia (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ;
Prat Aymerich, Cristina (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ;
Domínguez, José (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol)
Cigarette smoking and tuberculosis are a significant cause of death worldwide. Several epidemiological studies have demonstrated cigarette smoking is a risk factor for tuberculosis. Electronic cigarettes have recently appeared as a healthier alternative to conventional smoking, although their impact in tuberculosis is not well understood. [...]
2020 - 10.1371/journal.pone.0228919
PloS one, Vol. 15 issue 2 (2020) , p. e0228919
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29 p, 9.5 MB |
Substrate specificity of human metallocarboxypeptidase D : comparison of the two active carboxypeptidase domains
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Garcia-Pardo, Javier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Tanco, Sebastián Martín (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Díaz, Lucía (Barcelona Supercomputing Center) ;
Dasgupta, Sayani (Albert Einstein College of Medicine. Department of Molecular Pharmacology) ;
Fernandez Recio, Juan (Barcelona Supercomputing Center) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquimica i Biologia Molecular) ;
Fricker, Lloyd D. (Albert Einstein College of Medicine. Department of Molecular Pharmacology)
Metallocarboxypeptidase D (CPD) is a membrane-bound component of the trans-Golgi network that cycles to the cell surface through exocytic and endocytic pathways. Unlike other members of the metallocarboxypeptidase family, CPD is a multicatalytic enzyme with three carboxypeptidase-like domains, although only the first two domains are predicted to be enzymatically active. [...]
2017 - 10.1371/journal.pone.0187778
PloS one, Vol. 12 issue 11 (2017) , art. e0187778
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23 p, 2.8 MB |
Identification of specific effect of chloride on the spectral properties and structural stability of multiple extracellular glutamic acid mutants of bacteriorhodopsin
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Lazarova, Tzvetana (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Mlynarczyk, Krzysztof (University of Warsaw. Faculty of Chemistry) ;
Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Tenchov, Boris (Medical University (Sofia, Bulgària). Department of Medical Physics and Biophysics) ;
Filipek, Slawomir (University of Warsaw. Faculty of Chemistry) ;
Padrós, Esteve (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecula)
In the present work we combine spectroscopic, DSC and computational approaches to examine the multiple extracellular Glu mutants E204Q/E194Q, E204Q/E194Q/E9Q and E204Q/E194Q/E9Q/E74Q of bacteriorhodopsin by varying solvent ionic strength and composition. [...]
2016 - 10.1371/journal.pone.0162952
PloS one, Vol. 11 issue 9 (2016) , art. e0162952
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17 p, 1.7 MB |
Intradomain confinement of disulfides in the folding of two consecutive modules of the LDL receptor
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Martínez-Oliván, Juan (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ;
Fraga, Hugo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Arias-Moreno, Xabier (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Sancho, Javier (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular)
The LDL receptor internalizes circulating LDL and VLDL particles for degradation. Its extracellular binding domain contains ten (seven LA and three EGF) cysteine-rich modules, each bearing three disulfide bonds. [...]
2015 - 10.1371/journal.pone.0132141
PloS one, Vol. 10, issue 7 (2015) , art. e0132141
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14 p, 2.4 MB |
Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy
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Ferreira, Priscila (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ;
Sant'Anna, Ricardo (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ;
Varejão, Nathalia (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ;
Lima, Cinthia (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ;
Novis, Shenia (Centro de Estudos de Paramiloidose Antônio Rodrigues de Mello) ;
Barbosa, Renata V. (Centro de Estudos de Paramiloidose Antônio Rodrigues de Mello) ;
Caldeira, Concy M. (SONDA. Universidade Federal do Rio de Janeiro) ;
Rumjanek, Franklin D. (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ;
Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cruz, Marcia W. (Centro de Estudos de Paramiloidose Antônio Rodrigues de Mello) ;
Foguel, Debora (Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Transthyretin (TTR) is a tetrameric beta-sheet-rich protein. Its deposits have been implicated in four different amyloid diseases. Although aggregation of the wild-type sequence is responsible for the senile form of the disease, more than one hundred variants have been described thus far, most of which confer a more amyloidogenic character to TTR, mainly because they compromise the stability of the protein in relation to monomer formation, which upon misfolding is intrinsically aggregation-prone. [...]
2013 - 10.1371/journal.pone.0082484
PloS one, Vol. 8, issue 12 (2013) , art. e82484
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